verapamil has been researched along with Carcinoma, Non-Small Cell Lung in 17 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dexverapamil was given for six days, 1500 mg a day divided into six doses of 250 mg every four hours starting 24 h prior to chemotherapy." | 2.68 | Randomised trial of vindesine and etoposide +/- dexverapamil in advanced non-small cell lung cancer: first results. ( Gatzemeier, U; Schneider, A; von Pawel, J, 1995) |
| "Verapamil 480 mg day-1 was given for 3 days starting 24 h prior to chemotherapy which consisted of bolus vindesine 7 mg followed by ifosfamide/mesna 5 g m-2 over 24 h, followed by mesna alone for a further 8 h." | 2.67 | Oral verapamil with chemotherapy for advanced non-small cell lung cancer: a randomised study. ( Cantwell, BM; Corris, PA; Harris, AL; Millward, MJ; Munro, NC; Robinson, A, 1993) |
| "Lung cancer is one of the foremost tumor-associated cause of death in the world." | 1.48 | Verapamil (VER) Enhances the Cytotoxic Effects of Docetaxel and Vinblastine Combined Therapy Against Non-Small Cell Lung Cancer Cell Lines. ( Daraee, H; Jaferian, S; Soleymaninejad, M, 2018) |
| "Etoposide efflux may have been inhibited, not because of (competitive) inhibition by BSO or disturbance of the energy required for this process, but probably because of plasma membrane alterations." | 1.28 | Modulation by D,L-buthionine-S,R-sulphoximine of etoposide cytotoxicity on human non-small cell lung, ovarian and breast carcinoma cell lines. ( Lafleur, MV; Lankelma, J; Mans, DR; Pinedo, HM; Retèl, J; Schuurhuis, GJ; Treskes, M, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.88) | 18.7374 |
| 1990's | 9 (52.94) | 18.2507 |
| 2000's | 2 (11.76) | 29.6817 |
| 2010's | 4 (23.53) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Yao, S | 1 |
| To, KK | 1 |
| Wang, YZ | 1 |
| Yin, C | 1 |
| Tang, C | 1 |
| Chai, S | 1 |
| Ke, CQ | 1 |
| Lin, G | 1 |
| Ye, Y | 1 |
| Shi, Y | 1 |
| Jin, Y | 1 |
| Liu, F | 1 |
| Jiang, J | 1 |
| Cao, J | 1 |
| Lu, Y | 1 |
| Yang, J | 1 |
| Wang, Y | 1 |
| He, J | 1 |
| Zhang, S | 1 |
| Yang, Q | 1 |
| Jaferian, S | 1 |
| Soleymaninejad, M | 1 |
| Daraee, H | 1 |
| Chen, YL | 1 |
| Yang, TY | 1 |
| Chen, KC | 1 |
| Wu, CL | 1 |
| Hsu, SL | 1 |
| Hsueh, CM | 1 |
| Bogush, TA | 1 |
| Konukhova, AV | 1 |
| Ravcheeva, AB | 1 |
| Zabotina, TN | 1 |
| Kadagidze, ZG | 1 |
| Bogush, EA | 1 |
| Komov, DV | 1 |
| Polotskiĭ, BE | 1 |
| Laktionov, KK | 1 |
| Davydov, MI | 1 |
| Pesic, M | 1 |
| Markovic, JZ | 1 |
| Jankovic, D | 1 |
| Kanazir, S | 1 |
| Markovic, ID | 1 |
| Rakic, L | 1 |
| Ruzdijic, S | 1 |
| Song, EJ | 1 |
| Yang, VC | 1 |
| Chiang, CD | 1 |
| Chao, CC | 1 |
| Spoelstra, EC | 1 |
| Westerhoff, HV | 2 |
| Pinedo, HM | 2 |
| Dekker, H | 1 |
| Lankelma, J | 3 |
| Coley, HM | 1 |
| Amos, WB | 1 |
| Twentyman, PR | 2 |
| Workman, P | 1 |
| Kirk, J | 1 |
| Carmichael, J | 1 |
| Stratford, IJ | 1 |
| Harris, AL | 2 |
| Mülder, HS | 1 |
| van Grondelle, R | 1 |
| Millward, MJ | 1 |
| Cantwell, BM | 1 |
| Munro, NC | 1 |
| Robinson, A | 1 |
| Corris, PA | 1 |
| Barrand, MA | 1 |
| Rhodes, T | 1 |
| Center, MS | 1 |
| Gatzemeier, U | 1 |
| Schneider, A | 1 |
| von Pawel, J | 1 |
| Mans, DR | 1 |
| Schuurhuis, GJ | 1 |
| Treskes, M | 1 |
| Lafleur, MV | 1 |
| Retèl, J | 1 |
| Merry, S | 1 |
| Courtney, ER | 1 |
| Fetherston, CA | 1 |
| Kaye, SB | 1 |
| Freshney, RI | 1 |
2 trials available for verapamil and Carcinoma, Non-Small Cell Lung
| Article | Year |
|---|---|
Oral verapamil with chemotherapy for advanced non-small cell lung cancer: a randomised study.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Sm | 1993 |
Randomised trial of vindesine and etoposide +/- dexverapamil in advanced non-small cell lung cancer: first results.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Calcium Channel Blockers; | 1995 |
15 other studies available for verapamil and Carcinoma, Non-Small Cell Lung
| Article | Year |
|---|---|
Polyoxypregnane steroids from the stems of Marsdenia tenacissima.
Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Erlotinib Hydrochloride; Gefitinib; Glycoside | 2014 |
Ceramide induces the apoptosis of non‑small cell lung cancer cells through the Txnip/Trx1 complex.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Carrier Proteins; Caspase 3; Cell Line, Tumor; Cell Survi | 2021 |
Intracellular calcium promotes radioresistance of non-small cell lung cancer A549 cells through activating Akt signaling.
Topics: A549 Cells; Apoptosis; Calcium; Calcium Signaling; Carcinoma, Non-Small-Cell Lung; Cell Proliferatio | 2017 |
Verapamil (VER) Enhances the Cytotoxic Effects of Docetaxel and Vinblastine Combined Therapy Against Non-Small Cell Lung Cancer Cell Lines.
Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Non-Small-Cell Lung; | 2018 |
Hypoxia can impair doxorubicin resistance of non-small cell lung cancer cells by inhibiting MRP1 and P-gp expression and boosting the chemosensitizing effects of MRP1 and P-gp blockers.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; C | 2016 |
[Inhibition of ABC-transporter(s)' function in non-small cell lung cancer cells by platinum drugs].
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette | 2003 |
Induced resistance in the human non small cell lung carcinoma (NCI-H460) cell line in vitro by anticancer drugs.
Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Curcumin; Doxorubicin; Drug Resistance, Multi | 2006 |
Potentiation of growth inhibition due to vincristine by ascorbic acid in a resistant human non-small cell lung cancer cell line.
Topics: Ascorbic Acid; Carcinoma, Non-Small-Cell Lung; Cell Division; Culture Media; Drug Resistance; Drug S | 1995 |
The multidrug-resistance-reverser verapamil interferes with cellular P-glycoprotein-mediated pumping of daunorubicin as a non-competing substrate.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Carcinoma, No | 1994 |
Examination by laser scanning confocal fluorescence imaging microscopy of the subcellular localisation of anthracyclines in parent and multidrug resistant cell lines.
Topics: Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carci | 1993 |
Selective toxicity of TGF-alpha-PE40 to EGFR-positive cell lines: selective protection of low EGFR-expressing cell lines by EGF.
Topics: Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Division; Cell Line; C | 1994 |
A plasma membrane 'vacuum cleaner' for daunorubicin in non-P-glycoprotein multidrug-resistant SW-1573 human non-small cell lung carcinoma cells. A study using fluorescence resonance energy transfer.
Topics: Biological Transport; Carcinoma, Non-Small-Cell Lung; Cell Membrane; Computer Simulation; Daunorubic | 1993 |
Chemosensitisation and drug accumulation effects of cyclosporin A, PSC-833 and verapamil in human MDR large cell lung cancer cells expressing a 190k membrane protein distinct from P-glycoprotein.
Topics: Carcinoma, Non-Small-Cell Lung; Cyclosporine; Cyclosporins; Daunorubicin; Humans; Lung Neoplasms; Me | 1993 |
Modulation by D,L-buthionine-S,R-sulphoximine of etoposide cytotoxicity on human non-small cell lung, ovarian and breast carcinoma cell lines.
Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Buthionine Sulfoximine; Carcinoma, Non-Small-Cell | 1992 |
Circumvention of drug resistance in human non-small cell lung cancer in vitro by verapamil.
Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Drug Resistance; Drug Screening Assays, Antit | 1987 |