Compounds > verapamil
Page last updated: 2024-10-24

verapamil and Carcinoma, Hepatocellular

verapamil has been researched along with Carcinoma, Hepatocellular in 40 studies

Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.

Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.

Research Excerpts

ExcerptRelevanceReference
"This study evaluates the clinical effectiveness of targeted arterial infusion of verapamil in interventional treatment of primary hepatocellular carcinoma."9.15Clinical evaluation of targeted arterial infusion of verapamil in the interventional chemotherapy of primary hepatocellular carcinoma. ( Duan, Q; Fan, P; Huang, J; Ji, C; Lin, X; Lv, Y; Qian, L; Yu, X, 2011)
"The purpose of the study is to evaluate the protective effects of Verapamil on hepatic ischemia-reperfusion injury in cirrhotic patients with HCC."9.14Protective effect of Verapamil on hepatic ischemia-reperfusion injury during hepatectomy in the cirrhotic patients with hepatocellular carcinoma. ( Chen, M; Dong, J; Feng, X; Wang, S; Wang, X; Xia, F, 2009)
"A prospective study was conducted to assess the safety and efficacy of the addition of oral verapamil to intravenous Adriamycin (doxorubicin) for the management of patients with unresectable hepatocellular carcinoma (HCC)."9.06Doxorubicin for unresectable hepatocellular carcinoma. A prospective study on the addition of verapamil. ( Cheng, CH; Choi, TK; Fan, ST; Lai, EC; Mok, FP; Tan, ES; Wong, J, 1990)
"This study aimed to investigate the potential role of co-treatment with doxorubicin (DOX) and verapamil (VRP) nanoparticles in experimentally induced hepatocellular carcinoma in mice and to investigate the possible mechanisms behind the potential favorable effect of the co-treatment."7.96Effect of co-treatment with doxorubicin and verapamil loaded into chitosan nanoparticles on diethylnitrosamine-induced hepatocellular carcinoma in mice. ( Abo Mansour, HE; Abo-Elmatty, DM; Badawy, NS; El-Batsh, MM; Mehanna, ET; Mesbah, NM, 2020)
"BACKGROUND The aim of this study was to investigate the role of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) in the reversal effect of verapamil (VER) on chemo-resistance to Adriamycin (ADM) in treatment of hepatocellular carcinoma (HCC)."7.88Upregulation of Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) Mediates the Reversal Effect of Verapamil on Chemo-Resistance to Adriamycin of Hepatocellular Carcinoma. ( Cheng, D; Fan, G; Fan, P; Huang, J; Liu, M; Ma, K; Teng, X; Xu, K; Yang, G; Zhang, T, 2018)
"Multidrug resistant H22 (H22/FAP) hepatocellular carcinoma cells were produced in vitro by continuous exposure to increasing doses of doxorubicin, cisplatin and 5-fluorouracil (FAP regimen)."7.79Association between reversal of multidrug resistance by methyl jasmonate and P-glycoprotein ATPase activity in hepatocellular carcinoma. ( Huang, FZ; Jiang, XZ; Liu, XY; Nie, WP; Wang, CF; Wang, YQ, 2013)
"Sepsis was induced in male Sprague-Dawley rats by implanting in their abdominal cavities fecal pellets impregnated with live Escherichia coli and Bacteroides fragilis."5.29Diltiazem and superoxide dismutase modulate hepatic acute phase response in gram-negative sepsis. ( Baumann, H; Jahreis, GP; Rose, S; Sayeed, MM, 1994)
"This study evaluates the clinical effectiveness of targeted arterial infusion of verapamil in interventional treatment of primary hepatocellular carcinoma."5.15Clinical evaluation of targeted arterial infusion of verapamil in the interventional chemotherapy of primary hepatocellular carcinoma. ( Duan, Q; Fan, P; Huang, J; Ji, C; Lin, X; Lv, Y; Qian, L; Yu, X, 2011)
"The purpose of the study is to evaluate the protective effects of Verapamil on hepatic ischemia-reperfusion injury in cirrhotic patients with HCC."5.14Protective effect of Verapamil on hepatic ischemia-reperfusion injury during hepatectomy in the cirrhotic patients with hepatocellular carcinoma. ( Chen, M; Dong, J; Feng, X; Wang, S; Wang, X; Xia, F, 2009)
"A prospective study was conducted to assess the safety and efficacy of the addition of oral verapamil to intravenous Adriamycin (doxorubicin) for the management of patients with unresectable hepatocellular carcinoma (HCC)."5.06Doxorubicin for unresectable hepatocellular carcinoma. A prospective study on the addition of verapamil. ( Cheng, CH; Choi, TK; Fan, ST; Lai, EC; Mok, FP; Tan, ES; Wong, J, 1990)
"This study aimed to investigate the potential role of co-treatment with doxorubicin (DOX) and verapamil (VRP) nanoparticles in experimentally induced hepatocellular carcinoma in mice and to investigate the possible mechanisms behind the potential favorable effect of the co-treatment."3.96Effect of co-treatment with doxorubicin and verapamil loaded into chitosan nanoparticles on diethylnitrosamine-induced hepatocellular carcinoma in mice. ( Abo Mansour, HE; Abo-Elmatty, DM; Badawy, NS; El-Batsh, MM; Mehanna, ET; Mesbah, NM, 2020)
"The aim of the present study was to examine changes in the expression and activity of P-glycoprotein (P-gp) in human hepatocellular carcinoma HepG2 cells after exposure to menthol, and their relationship to the cytotoxicity of and apoptotic responses to doxorubicin (DOX), a substrate of P-gp, in the cells."3.96Reduced cytotoxicity in doxorubicin-exposed HepG2 cells pretreated with menthol due to upregulation of P-glycoprotein. ( Fukuno, S; Konishi, H; Miura, T; Nagai, K; Sehara, N; Uchino, Y, 2020)
"BACKGROUND The aim of this study was to investigate the role of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) in the reversal effect of verapamil (VER) on chemo-resistance to Adriamycin (ADM) in treatment of hepatocellular carcinoma (HCC)."3.88Upregulation of Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) Mediates the Reversal Effect of Verapamil on Chemo-Resistance to Adriamycin of Hepatocellular Carcinoma. ( Cheng, D; Fan, G; Fan, P; Huang, J; Liu, M; Ma, K; Teng, X; Xu, K; Yang, G; Zhang, T, 2018)
"Multidrug resistant H22 (H22/FAP) hepatocellular carcinoma cells were produced in vitro by continuous exposure to increasing doses of doxorubicin, cisplatin and 5-fluorouracil (FAP regimen)."3.79Association between reversal of multidrug resistance by methyl jasmonate and P-glycoprotein ATPase activity in hepatocellular carcinoma. ( Huang, FZ; Jiang, XZ; Liu, XY; Nie, WP; Wang, CF; Wang, YQ, 2013)
"Mycophenolic acid was detected in all cats."2.61 ( Abrams, G; Adolfsson, E; Agarwal, PK; Akkan, AG; Al Alhareth, NS; Alves, VGL; Armentano, R; Bahroos, E; Baig, M; Baldridge, KK; Barman, S; Bartolucci, C; Basit, A; Bertoli, SV; Bian, L; Bigatti, G; Bobenko, AI; Boix, PP; Bokulic, T; Bolink, HJ; Borowiec, J; Bulski, W; Burciaga, J; Butt, NS; Cai, AL; Campos, AM; Cao, G; Cao, Y; Čapo, I; Caruso, ML; Chao, CT; Cheatum, CM; Chelminski, K; Chen, AJW; Chen, C; Chen, CH; Chen, D; Chen, G; Chen, H; Chen, LH; Chen, R; Chen, RX; Chen, X; Cherdtrakulkiat, R; Chirvony, VS; Cho, JG; Chu, K; Ciurlino, D; Coletta, S; Contaldo, G; Crispi, F; Cui, JF; D'Esposito, M; de Biase, S; Demir, B; Deng, W; Deng, Z; Di Pinto, F; Domenech-Ximenos, B; Dong, G; Drácz, L; Du, XJ; Duan, LJ; Duan, Y; Ekendahl, D; Fan, W; Fang, L; Feng, C; Followill, DS; Foreman, SC; Fortunato, G; Frew, R; Fu, M; Gaál, V; Ganzevoort, W; Gao, DM; Gao, X; Gao, ZW; Garcia-Alvarez, A; Garza, MS; Gauthier, L; Gazzaz, ZJ; Ge, RS; Geng, Y; Genovesi, S; Geoffroy, V; Georg, D; Gigli, GL; Gong, J; Gong, Q; Groeneveld, J; Guerra, V; Guo, Q; Guo, X; Güttinger, R; Guyo, U; Haldar, J; Han, DS; Han, S; Hao, W; Hayman, A; He, D; Heidari, A; Heller, S; Ho, CT; Ho, SL; Hong, SN; Hou, YJ; Hu, D; Hu, X; Hu, ZY; Huang, JW; Huang, KC; Huang, Q; Huang, T; Hwang, JK; Izewska, J; Jablonski, CL; Jameel, T; Jeong, HK; Ji, J; Jia, Z; Jiang, W; Jiang, Y; Kalumpha, M; Kang, JH; Kazantsev, P; Kazemier, BM; Kebede, B; Khan, SA; Kiss, J; Kohen, A; Kolbenheyer, E; Konai, MM; Koniarova, I; Kornblith, E; Krawetz, RJ; Kreouzis, T; Kry, SF; Laepple, T; Lalošević, D; Lan, Y; Lawung, R; Lechner, W; Lee, KH; Lee, YH; Leonard, C; Li, C; Li, CF; Li, CM; Li, F; Li, J; Li, L; Li, S; Li, X; Li, Y; Li, YB; Li, Z; Liang, C; Lin, J; Lin, XH; Ling, M; Link, TM; Liu, HH; Liu, J; Liu, M; Liu, W; Liu, YP; Lou, H; Lu, G; Lu, M; Lun, SM; Ma, Z; Mackensen, A; Majumdar, S; Martineau, C; Martínez-Pastor, JP; McQuaid, JR; Mehrabian, H; Meng, Y; Miao, T; Miljković, D; Mo, J; Mohamed, HSH; Mohtadi, M; Mol, BWJ; Moosavi, L; Mosdósi, B; Nabu, S; Nava, E; Ni, L; Novakovic-Agopian, T; Nyamunda, BC; Nyul, Z; Önal, B; Özen, D; Özyazgan, S; Pajkrt, E; Palazon, F; Park, HW; Patai, Á; Patai, ÁV; Patzke, GR; Payette, G; Pedoia, V; Peelen, MJCS; Pellitteri, G; Peng, J; Perea, RJ; Pérez-Del-Rey, D; Popović, DJ; Popović, JK; Popović, KJ; Posecion, L; Povall, J; Prachayasittikul, S; Prachayasittikul, V; Prat-González, S; Qi, B; Qu, B; Rakshit, S; Ravelli, ACJ; Ren, ZG; Rivera, SM; Salo, P; Samaddar, S; Samper, JLA; Samy El Gendy, NM; Schmitt, N; Sekerbayev, KS; Sepúlveda-Martínez, Á; Sessolo, M; Severi, S; Sha, Y; Shen, FF; Shen, X; Shen, Y; Singh, P; Sinthupoom, N; Siri, S; Sitges, M; Slovak, JE; Solymosi, N; Song, H; Song, J; Song, M; Spingler, B; Stewart, I; Su, BL; Su, JF; Suming, L; Sun, JX; Tantimavanich, S; Tashkandi, JM; Taurbayev, TI; Tedgren, AC; Tenhunen, M; Thwaites, DI; Tibrewala, R; Tomsejm, M; Triana, CA; Vakira, FM; Valdez, M; Valente, M; Valentini, AM; Van de Winckel, A; van der Lee, R; Varga, F; Varga, M; Villarino, NF; Villemur, R; Vinatha, SP; Vincenti, A; Voskamp, BJ; Wang, B; Wang, C; Wang, H; Wang, HT; Wang, J; Wang, M; Wang, N; Wang, NC; Wang, Q; Wang, S; Wang, X; Wang, Y; Wang, Z; Wen, N; Wesolowska, P; Willis, M; Wu, C; Wu, D; Wu, L; Wu, X; Wu, Z; Xia, JM; Xia, X; Xia, Y; Xiao, J; Xiao, Y; Xie, CL; Xie, LM; Xie, S; Xing, Z; Xu, C; Xu, J; Yan, D; Yan, K; Yang, S; Yang, X; Yang, XW; Ye, M; Yin, Z; Yoon, N; Yoon, Y; Yu, H; Yu, K; Yu, ZY; Zhang, B; Zhang, GY; Zhang, H; Zhang, J; Zhang, M; Zhang, Q; Zhang, S; Zhang, W; Zhang, X; Zhang, Y; Zhang, YW; Zhang, Z; Zhao, D; Zhao, F; Zhao, P; Zhao, W; Zhao, Z; Zheng, C; Zhi, D; Zhou, C; Zhou, FY; Zhu, D; Zhu, J; Zhu, Q; Zinyama, NP; Zou, M; Zou, Z, 2019)
" Toxicity studies with Diclofenac, Paracetamol and Verapamil in both cell lines show dose-response characteristics and EC(50) values similar to hHeps."1.38Comparative analysis of phase I and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism. ( Dooley, S; Ehnert, S; Hao, L; Lin, J; Liu, L; Mühl-Benninghaus, R; Neumann, J; Nussler, AK; Nussler, N; Schyschka, L; Stöckle, U, 2012)
" A concentration- or dose-response relationship was shown between the concentration and dose of CH and Rho123 accumulation or the antitumor activity."1.37Using rhodamine 123 accumulation in CD8 cells as a surrogate indicator to study the P-glycoprotein modulating effect of cepharanthine hydrochloride in vivo. ( Cai-Hong, Z; Fang, M; Jin-Hua, J; Li, H; Ning, W; Qing-Duan, W; Xiao-Juan, G; Yan, Z, 2011)
"18F-fluorodeoxyglucose (FDG) uptake in hepatocellular carcinoma (HCC) is associated with tumor differentiation and expression of P-glycoprotein (P-gp), a drug efflux pump that plays an important role in chemoresistance."1.35P-glycoprotein expression affects 18F-fluorodeoxyglucose accumulation in hepatocellular carcinoma in vivo and in vitro. ( Hatano, E; Higashi, T; Ikai, I; Iwaisako, K; Kitamura, K; Nakajima, A; Nakamoto, Y; Seo, S; Tada, M; Tamaki, N; Uemoto, S, 2009)
"Mercury is a non-essential heavy metal affecting intracellular Ca2+ dynamics."1.32Hg2+ signaling in trout hepatoma (RTH-149) cells: involvement of Ca2+-induced Ca2+ release. ( Bonomo, M; Burlando, B; Dondero, F; Fabbri, E; Viarengo, A, 2003)
"Diltiazem was only stimulatory on 125I-LDL processing in leukocytes."1.30Effects of antihypertensive drugs on cholesterol metabolism of human mononuclear leukocytes and hepatoma cells. ( Behnke, B; Gebhardt, A; Naegele, H; Strohbeck, M, 1998)
"Mitomycin C pretreatment also significantly increased the sensitivity of cancer cells to subsequent killing by the P-glycoprotein substrate doxorubicin, decreasing the ED50 by 5- to 10-fold."1.30Suppression of P-glycoprotein expression and multidrug resistance by DNA cross-linking agents. ( Blaxall, JR; Hamilton, JW; Ihnat, MA; La Ronde, N; Lariviere, JP; Pierre, KM; Turpie, BW; Warren, AJ, 1997)
"The innate drug resistance of human hepatocellular carcinoma (HCC) Bel7402 cell line was studied in vitro."1.30The study of innate drug resistance of human hepatocellular carcinoma Bel7402 cell line. ( Huang, M; Liu, G, 1999)
"Human and murine hepatoma cells were treated with berberine (0."1.30Up-regulation of multidrug resistance transporter expression by berberine in human and murine hepatoma cells. ( Chi, CW; Lin, HL; Liu, TY; Lui, WY, 1999)
"Sepsis was induced in male Sprague-Dawley rats by implanting in their abdominal cavities fecal pellets impregnated with live Escherichia coli and Bacteroides fragilis."1.29Diltiazem and superoxide dismutase modulate hepatic acute phase response in gram-negative sepsis. ( Baumann, H; Jahreis, GP; Rose, S; Sayeed, MM, 1994)
"These results show that rat hepatoma cells can display elevated levels of functional P-glycoprotein without any prior cytotoxic drug selection and suggest that these cells represent a useful model for analyzing P-glycoprotein regulation in intrinsically clinical drug-resistant cancers."1.29Constitutive expression of functional P-glycoprotein in rat hepatoma cells. ( Fardel, O; Glaise, D; Guillouzo, A; Lecureur, V; Loyer, P, 1994)
"All five hepatoma cell lines were resistant at different levels to these chemicals compared to human KB cells."1.28Human hepatocellular carcinoma cell lines exhibit multidrug resistance unrelated to MRD1 gene expression. ( Chin, KV; Gottesman, MM; Lu, YG; Pastan, I; Shen, DW, 1991)
"Verapamil induced an increase in the cellular cholesterol content in preloaded cells."1.28Verapamil enhances high-density lipoprotein processing in Hep G2 cells preloaded with cholesterol. ( Auclair, M; Chappey-Gillet, B; Mazière, C; Mazière, JC; Salmon, S, 1990)

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-19902 (5.00)18.7374
1990's15 (37.50)18.2507
2000's8 (20.00)29.6817
2010's13 (32.50)24.3611
2020's2 (5.00)2.80

Authors

AuthorsStudies
Lee, WY1
Cheung, CC1
Liu, KW1
Fung, KP2
Wong, J2
Lai, PB1
Yeung, JH1
Chen, D2
Soh, CK1
Goh, WH1
Wang, H2
Bobenko, AI1
Heller, S1
Schmitt, N1
Cherdtrakulkiat, R1
Lawung, R1
Nabu, S1
Tantimavanich, S1
Sinthupoom, N1
Prachayasittikul, S1
Prachayasittikul, V1
Zhang, B1
Wu, C1
Zhang, Z2
Yan, K1
Li, C2
Li, Y4
Li, L4
Zheng, C1
Xiao, Y1
He, D1
Zhao, F1
Su, JF1
Lun, SM1
Hou, YJ1
Duan, LJ1
Wang, NC1
Shen, FF1
Zhang, YW1
Gao, ZW1
Li, J5
Du, XJ1
Zhou, FY1
Yin, Z1
Zhu, J2
Yan, D1
Lou, H1
Yu, H1
Feng, C1
Wang, Z1
Wang, Y4
Hu, X1
Li, Z2
Shen, Y1
Hu, D1
Chen, H1
Wu, X1
Duan, Y1
Zhi, D1
Zou, M2
Zhao, Z1
Zhang, X2
Yang, X2
Zhang, J2
Popović, KJ1
Popović, DJ1
Miljković, D1
Lalošević, D1
Čapo, I1
Popović, JK1
Liu, M2
Song, H2
Xing, Z1
Lu, G1
Valentini, AM1
Di Pinto, F1
Coletta, S1
Guerra, V1
Armentano, R1
Caruso, ML1
Gong, J1
Wang, N1
Bian, L1
Wang, M1
Ye, M1
Wen, N1
Fu, M1
Fan, W1
Meng, Y1
Dong, G1
Lin, XH1
Liu, HH1
Gao, DM1
Cui, JF1
Ren, ZG1
Chen, RX1
Önal, B1
Özen, D1
Demir, B1
Akkan, AG1
Özyazgan, S1
Payette, G1
Geoffroy, V1
Martineau, C1
Villemur, R1
Jameel, T1
Baig, M1
Gazzaz, ZJ1
Tashkandi, JM1
Al Alhareth, NS1
Khan, SA1
Butt, NS1
Wang, J3
Geng, Y1
Zhang, Y3
Wang, X3
Liu, J3
Basit, A1
Miao, T1
Liu, W1
Jiang, W1
Yu, ZY1
Wu, L2
Qu, B1
Sun, JX1
Cai, AL1
Xie, LM1
Groeneveld, J1
Ho, SL1
Mackensen, A1
Mohtadi, M1
Laepple, T1
Genovesi, S1
Nava, E1
Bartolucci, C1
Severi, S1
Vincenti, A1
Contaldo, G1
Bigatti, G1
Ciurlino, D1
Bertoli, SV1
Slovak, JE1
Hwang, JK1
Rivera, SM1
Villarino, NF1
Li, S1
Cao, G1
Ling, M1
Ji, J1
Zhao, D1
Sha, Y1
Gao, X1
Liang, C2
Guo, Q1
Zhou, C1
Ma, Z1
Xu, J1
Wang, C1
Zhao, W1
Xia, X1
Jiang, Y1
Peng, J1
Jia, Z1
Li, F1
Chen, X2
Mo, J1
Zhang, S2
Li, X1
Huang, T1
Zhu, Q1
Wang, S2
Ge, RS1
Fortunato, G1
Lin, J3
Agarwal, PK1
Kohen, A1
Singh, P1
Cheatum, CM1
Zhu, D1
Hayman, A1
Kebede, B1
Stewart, I1
Chen, G1
Frew, R1
Guo, X1
Gong, Q1
Borowiec, J1
Han, S1
Zhang, M1
Willis, M1
Kreouzis, T1
Yu, K1
Chirvony, VS1
Sekerbayev, KS1
Pérez-Del-Rey, D1
Martínez-Pastor, JP1
Palazon, F1
Boix, PP1
Taurbayev, TI1
Sessolo, M1
Bolink, HJ1
Lu, M1
Lan, Y1
Xiao, J1
Song, M1
Chen, C1
Huang, Q1
Cao, Y1
Ho, CT1
Qi, B1
Wang, Q1
Zhang, W1
Fang, L1
Xie, CL1
Chen, R1
Yang, S1
Xia, JM1
Zhang, GY1
Chen, CH1
Yang, XW1
Domenech-Ximenos, B1
Garza, MS1
Prat-González, S1
Sepúlveda-Martínez, Á1
Crispi, F1
Perea, RJ1
Garcia-Alvarez, A1
Sitges, M1
Kalumpha, M1
Guyo, U1
Zinyama, NP1
Vakira, FM1
Nyamunda, BC1
Varga, M1
Drácz, L1
Kolbenheyer, E1
Varga, F1
Patai, ÁV1
Solymosi, N1
Patai, Á1
Kiss, J1
Gaál, V1
Nyul, Z1
Mosdósi, B1
Valdez, M1
Moosavi, L1
Heidari, A1
Novakovic-Agopian, T1
Kornblith, E1
Abrams, G1
McQuaid, JR1
Posecion, L1
Burciaga, J1
D'Esposito, M1
Chen, AJW1
Samy El Gendy, NM1
Wesolowska, P1
Georg, D1
Lechner, W1
Kazantsev, P1
Bokulic, T1
Tedgren, AC1
Adolfsson, E1
Campos, AM1
Alves, VGL1
Suming, L1
Hao, W1
Ekendahl, D1
Koniarova, I1
Bulski, W1
Chelminski, K1
Samper, JLA1
Vinatha, SP1
Rakshit, S1
Siri, S1
Tomsejm, M1
Tenhunen, M1
Povall, J1
Kry, SF1
Followill, DS1
Thwaites, DI1
Izewska, J1
Kang, JH1
Yoon, Y1
Song, J1
Van de Winckel, A1
Gauthier, L1
Chao, CT1
Lee, YH1
Li, CM1
Han, DS1
Huang, JW1
Huang, KC1
Ni, L1
Güttinger, R1
Triana, CA1
Spingler, B1
Baldridge, KK1
Patzke, GR1
Shen, X1
Wang, B1
Xie, S1
Deng, W1
Wu, D1
Zhang, Q1
Voskamp, BJ1
Peelen, MJCS1
Ravelli, ACJ1
van der Lee, R1
Mol, BWJ1
Pajkrt, E1
Ganzevoort, W1
Kazemier, BM1
Tibrewala, R1
Bahroos, E1
Mehrabian, H1
Foreman, SC1
Link, TM1
Pedoia, V1
Majumdar, S1
Jablonski, CL1
Leonard, C1
Salo, P1
Krawetz, RJ1
Yoon, N1
Hong, SN1
Cho, JG1
Jeong, HK1
Lee, KH1
Park, HW1
Barman, S1
Konai, MM1
Samaddar, S1
Haldar, J1
Mohamed, HSH1
Li, CF1
Hu, ZY1
Deng, Z1
Chen, LH1
Su, BL1
Chu, K1
Liu, YP1
Li, YB1
Zhang, H1
Xu, C1
Zou, Z1
Wu, Z1
Xia, Y1
Zhao, P1
Wang, HT1
de Biase, S1
Pellitteri, G1
Gigli, GL1
Valente, M1
Abo Mansour, HE1
El-Batsh, MM1
Badawy, NS1
Mehanna, ET1
Mesbah, NM1
Abo-Elmatty, DM1
Nagai, K1
Fukuno, S1
Miura, T1
Uchino, Y1
Sehara, N1
Konishi, H1
Yang, G1
Fan, G1
Zhang, T1
Ma, K1
Huang, J2
Teng, X1
Xu, K1
Fan, P2
Cheng, D1
Wang, CF1
Wang, YQ1
Huang, FZ1
Nie, WP1
Liu, XY1
Jiang, XZ1
Gu, W1
Liu, L2
Fang, FF1
Huang, F1
Cheng, BB1
Li, B1
Zhao, XY1
Wang, XB1
Fu, RJ1
Lv, YP1
Jin, W1
Meng, C1
Chen, GQ1
Huang, L1
Zhao, KW1
Xia, F1
Chen, M1
Feng, X1
Dong, J1
Seo, S1
Hatano, E1
Higashi, T1
Nakajima, A1
Nakamoto, Y1
Tada, M1
Tamaki, N1
Iwaisako, K1
Kitamura, K1
Ikai, I1
Uemoto, S1
Song, XR1
Zheng, Y1
He, G1
Yang, L1
Luo, YF1
He, ZY1
Li, SZ1
Li, JM1
Yu, S1
Luo, X1
Hou, SX1
Wei, YQ1
Duan, Q1
Ji, C1
Lv, Y1
Lin, X1
Qian, L1
Yu, X1
Tsang, TY1
Tang, WY1
Chan, JY1
Co, NN1
Au Yeung, CL1
Yau, PL1
Kong, SK1
Kwok, TT1
Schyschka, L1
Mühl-Benninghaus, R1
Neumann, J1
Hao, L1
Nussler, N1
Dooley, S1
Stöckle, U1
Nussler, AK1
Ehnert, S1
Li, H1
Yan, Z1
Ning, W1
Xiao-Juan, G1
Cai-Hong, Z1
Jin-Hua, J1
Fang, M1
Qing-Duan, W1
Zhang, DM1
Shu, C1
Chen, JJ1
Sodani, K1
Bhatnagar, J1
Lan, P1
Ruan, ZX1
Xiao, ZJ1
Ambudkar, SV1
Chen, WM1
Chen, ZS1
Ye, WC1
Burlando, B2
Bonomo, M1
Fabbri, E1
Dondero, F1
Viarengo, A2
Grube, M1
Kunert-Keil, C1
Sperker, B1
Kroemer, HK1
Manov, I1
Bashenko, Y1
Hirsh, M1
Iancu, TC1
Han, HK1
Han, CY1
Cheon, EP1
Lee, J1
Kang, KW1
Rose, S1
Baumann, H1
Jahreis, GP1
Sayeed, MM1
Fardel, O1
Loyer, P1
Lecureur, V1
Glaise, D1
Guillouzo, A1
Park, JG1
Lee, SK1
Hong, IG1
Kim, HS2
Lim, KH1
Choe, KJ1
Kim, WH1
Kim, YI1
Tsuruo, T1
Gottesman, MM2
Kim, JH1
Chung, JB1
Park, IS1
Kim, BS1
Yoo, NC1
Choi, JH1
Roh, JK1
Kwon, OH1
Lee, KS1
Asakura, T1
Takahashi, N1
Takada, K1
Inoue, T1
Ohkawa, K1
Naegele, H1
Behnke, B1
Gebhardt, A1
Strohbeck, M1
Ihnat, MA1
Lariviere, JP1
Warren, AJ1
La Ronde, N1
Blaxall, JR1
Pierre, KM1
Turpie, BW1
Hamilton, JW1
Huang, M1
Liu, G1
Gagandeep, S1
Novikoff, PM1
Ott, M1
Gupta, S1
Lin, HL1
Liu, TY1
Lui, WY1
Chi, CW1
Roman, RM1
Lomri, N1
Braunstein, G1
Feranchak, AP1
Simeoni, LA1
Davison, AK1
Mechetner, E1
Schwiebert, EM1
Fitz, JG1
Sato, C1
Liu, JH1
Tang, L1
Sakai, Y1
Yauchi, T1
Izumi, N1
Takano, T1
Marumo, F1
Shen, DW1
Lu, YG1
Chin, KV1
Pastan, I1
Hall, KS1
Endresen, L1
Rugstad, HE1
Chappey-Gillet, B1
Salmon, S1
Mazière, C1
Auclair, M1
Mazière, JC1
Lai, EC1
Choi, TK1
Cheng, CH1
Mok, FP1
Fan, ST1
Tan, ES1
Cairo, MS1
Siegel, S1
Anas, N1
Sender, L1
Corsini, A1
Granata, A1
Fumagalli, R1
Paoletti, R1

Reviews

1 review available for verapamil and Carcinoma, Hepatocellular

ArticleYear
    Proceedings. Mathematical, physical, and engineering sciences, 2019, Volume: 475, Issue:2227

    Topics: Acetylcholine; Acinetobacter baumannii; Actinobacteria; Action Potentials; Adalimumab; Adaptation, P

2019

Trials

4 trials available for verapamil and Carcinoma, Hepatocellular

ArticleYear
Protective effect of Verapamil on hepatic ischemia-reperfusion injury during hepatectomy in the cirrhotic patients with hepatocellular carcinoma.
    Langenbeck's archives of surgery, 2009, Volume: 394, Issue:6

    Topics: Adult; Aged; Calcium Channel Blockers; Carcinoma, Hepatocellular; Cohort Studies; Drug Administratio

2009
Clinical evaluation of targeted arterial infusion of verapamil in the interventional chemotherapy of primary hepatocellular carcinoma.
    Cell biochemistry and biophysics, 2011, Volume: 59, Issue:2

    Topics: Antineoplastic Agents; Body Weight; Carcinoma, Hepatocellular; Disease Progression; Drug Resistance,

2011
Doxorubicin for unresectable hepatocellular carcinoma. A prospective study on the addition of verapamil.
    Cancer, 1990, Oct-15, Volume: 66, Issue:8

    Topics: Carcinoma, Hepatocellular; Doxorubicin; Drug Therapy, Combination; Female; Humans; Liver Neoplasms;

1990
Clinical trial of continuous infusion verapamil, bolus vinblastine, and continuous infusion VP-16 in drug-resistant pediatric tumors.
    Cancer research, 1989, Feb-15, Volume: 49, Issue:4

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Child; Child,

1989

Other Studies

35 other studies available for verapamil and Carcinoma, Hepatocellular

ArticleYear
Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells.
    Journal of natural products, 2010, May-28, Volume: 73, Issue:5

    Topics: Abietanes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Doxor

2010
Design, Synthesis, and Preclinical Evaluation of Fused Pyrimidine-Based Hydroxamates for the Treatment of Hepatocellular Carcinoma.
    Journal of medicinal chemistry, 2018, 02-22, Volume: 61, Issue:4

    Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Screening Assays, Antitumor; Heterografts

2018
Effect of co-treatment with doxorubicin and verapamil loaded into chitosan nanoparticles on diethylnitrosamine-induced hepatocellular carcinoma in mice.
    Human & experimental toxicology, 2020, Volume: 39, Issue:11

    Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Calcium Channel Blockers; Carcinoma, Hepatocellular

2020
Reduced cytotoxicity in doxorubicin-exposed HepG2 cells pretreated with menthol due to upregulation of P-glycoprotein.
    Die Pharmazie, 2020, 10-01, Volume: 75, Issue:10

    Topics: Antibiotics, Antineoplastic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Car

2020
Upregulation of Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) Mediates the Reversal Effect of Verapamil on Chemo-Resistance to Adriamycin of Hepatocellular Carcinoma.
    Medical science monitor : international medical journal of experimental and clinical research, 2018, Apr-08, Volume: 24

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tum

2018
Association between reversal of multidrug resistance by methyl jasmonate and P-glycoprotein ATPase activity in hepatocellular carcinoma.
    The Journal of international medical research, 2013, Volume: 41, Issue:4

    Topics: Acetates; Adenosine Triphosphate; Animals; Antineoplastic Agents; Antineoplastic Combined Chemothera

2013
Reversal effect of bufalin on multidrug resistance in human hepatocellular carcinoma BEL-7402/5-FU cells.
    Oncology reports, 2014, Volume: 31, Issue:1

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter,

2014
Inhibition of Snail Family Transcriptional Repressor 2 (SNAI2) Enhances Multidrug Resistance of Hepatocellular Carcinoma Cells.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Animals; ATP-Binding Cassette Transporters; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Prolif

2016
P-glycoprotein expression affects 18F-fluorodeoxyglucose accumulation in hepatocellular carcinoma in vivo and in vitro.
    International journal of oncology, 2009, Volume: 34, Issue:5

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Carcinoma, Hepato

2009
Development of PLGA nanoparticles simultaneously loaded with vincristine and verapamil for treatment of hepatocellular carcinoma.
    Journal of pharmaceutical sciences, 2010, Volume: 99, Issue:12

    Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug

2010
P-glycoprotein enhances radiation-induced apoptotic cell death through the regulation of miR-16 and Bcl-2 expressions in hepatocellular carcinoma cells.
    Apoptosis : an international journal on programmed cell death, 2011, Volume: 16, Issue:5

    Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamil

2011
Comparative analysis of phase I and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism.
    Archives of toxicology, 2012, Volume: 86, Issue:1

    Topics: Acetaminophen; Carcinoma, Hepatocellular; Cell Line, Tumor; Cells, Cultured; Cytochrome P-450 Enzyme

2012
Using rhodamine 123 accumulation in CD8 cells as a surrogate indicator to study the P-glycoprotein modulating effect of cepharanthine hydrochloride in vivo.
    Journal of biomedicine & biotechnology, 2011, Volume: 2011

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzylisoquinolines; Carcinoma, He

2011
BBA, a derivative of 23-hydroxybetulinic acid, potently reverses ABCB1-mediated drug resistance in vitro and in vivo.
    Molecular pharmaceutics, 2012, Nov-05, Volume: 9, Issue:11

    Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apop

2012
Hg2+ signaling in trout hepatoma (RTH-149) cells: involvement of Ca2+-induced Ca2+ release.
    Cell calcium, 2003, Volume: 34, Issue:3

    Topics: Aniline Compounds; Animals; Ca(2+) Mg(2+)-ATPase; Calcium; Calcium Signaling; Carcinoma, Hepatocellu

2003
Verapamil regulates activity and mRNA-expression of human beta-glucuronidase in HepG2 cells.
    Naunyn-Schmiedeberg's archives of pharmacology, 2003, Volume: 368, Issue:6

    Topics: Blotting, Western; Calcium Channel Blockers; Carcinoma, Hepatocellular; Cell Line, Tumor; Down-Regul

2003
Ca2+ is mobilized by hydroxyl radical but not by superoxide in RTH-149 cells: the oxidative switching-on of Ca2+ signaling.
    Cell calcium, 2005, Volume: 38, Issue:5

    Topics: Animals; Calcium Signaling; Carcinoma, Hepatocellular; Cell Line, Tumor; Estrenes; Fluorescent Dyes;

2005
Involvement of the multidrug resistance P-glycoprotein in acetaminophen-induced toxicity in hepatoma-derived HepG2 and Hep3B cells.
    Basic & clinical pharmacology & toxicology, 2006, Volume: 99, Issue:3

    Topics: Acetaminophen; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carci

2006
Role of hypoxia-inducible factor-alpha in hepatitis-B-virus X protein-mediated MDR1 activation.
    Biochemical and biophysical research communications, 2007, Jun-01, Volume: 357, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Cell Li

2007
Diltiazem and superoxide dismutase modulate hepatic acute phase response in gram-negative sepsis.
    Shock (Augusta, Ga.), 1994, Volume: 1, Issue:2

    Topics: Acute-Phase Proteins; Acute-Phase Reaction; Animals; Bacteroides fragilis; Bacteroides Infections; B

1994
Constitutive expression of functional P-glycoprotein in rat hepatoma cells.
    European journal of biochemistry, 1994, Jan-15, Volume: 219, Issue:1-2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Carrier

1994
MDR1 gene expression: its effect on drug resistance to doxorubicin in human hepatocellular carcinoma cell lines.
    Journal of the National Cancer Institute, 1994, May-04, Volume: 86, Issue:9

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Carrier Proteins

1994
Combined use of tamoxifen, cyclosporin A, and verapamil for modulating multidrug resistance in human hepatocellular carcinoma cell lines.
    Yonsei medical journal, 1993, Volume: 34, Issue:1

    Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cyclosporine; Drug Resistance; Humans; Liver Neopl

1993
Drug conjugate of doxorubicin with glutathione is a potent reverser of multidrug resistance in rat hepatoma cells.
    Anti-cancer drugs, 1997, Volume: 8, Issue:2

    Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Divisio

1997
Effects of antihypertensive drugs on cholesterol metabolism of human mononuclear leukocytes and hepatoma cells.
    Clinical biochemistry, 1998, Volume: 31, Issue:1

    Topics: Antihypertensive Agents; Carcinoma, Hepatocellular; Cholesterol; Diltiazem; Humans; Leukocytes, Mono

1998
Suppression of P-glycoprotein expression and multidrug resistance by DNA cross-linking agents.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1997, Volume: 3, Issue:8

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; ATP Binding Cassette Transporter,

1997
The study of innate drug resistance of human hepatocellular carcinoma Bel7402 cell line.
    Cancer letters, 1999, Jan-08, Volume: 135, Issue:1

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; ATP Binding Casset

1999
Paclitaxel shows cytotoxic activity in human hepatocellular carcinoma cell lines.
    Cancer letters, 1999, Feb-08, Volume: 136, Issue:1

    Topics: Adolescent; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Dru

1999
Up-regulation of multidrug resistance transporter expression by berberine in human and murine hepatoma cells.
    Cancer, 1999, May-01, Volume: 85, Issue:9

    Topics: Animals; Antineoplastic Agents, Hormonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; B

1999
Evidence for multidrug resistance-1 P-glycoprotein-dependent regulation of cellular ATP permeability.
    The Journal of membrane biology, 2001, Oct-01, Volume: 183, Issue:3

    Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Antibodies; ATP Binding Cassette Transporter, Subfamily

2001
Possible involvement of protein kinase C and calcium in GSH efflux from Hep G2 cells.
    Life sciences, 1992, Volume: 51, Issue:26

    Topics: Adenosine Triphosphate; Alkaloids; Calcium; Carcinoma, Hepatocellular; Glutathione; Humans; Liver Ne

1992
Human hepatocellular carcinoma cell lines exhibit multidrug resistance unrelated to MRD1 gene expression.
    Journal of cell science, 1991, Volume: 98 ( Pt 3)

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport

1991
Verapamil potentiates 4'-epidoxorubicin cytotoxicity in a rat hepatoma cell line and in a substrain resistant to 4'-epidoxorubicin.
    Pharmacology & toxicology, 1990, Volume: 67, Issue:5

    Topics: Animals; Carcinoma, Hepatocellular; Cell Survival; Drug Resistance; Drug Synergism; Epirubicin; Live

1990
Verapamil enhances high-density lipoprotein processing in Hep G2 cells preloaded with cholesterol.
    Biochimica et biophysica acta, 1990, May-02, Volume: 1052, Issue:2

    Topics: Calcium Channel Blockers; Carcinoma, Hepatocellular; Cholesterol; Humans; Hydrolysis; Lipoproteins,

1990
Calcium antagonists and low density lipoproteins metabolism by human fibroblasts and by human hepatoma cell line HEP G2.
    Pharmacological research communications, 1986, Volume: 18, Issue:1

    Topics: Amanitins; Biotransformation; Calcium Channel Blockers; Carcinoma, Hepatocellular; Cell Line; Cycloh

1986