verapamil has been researched along with Carcinoma, Epidermoid in 25 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Verapamil was effective in combination with 5-FU, VCR or PEP on HSGc and with DTIC, VCR or PEP on KB." | 5.28 | [Chemo-sensitivity of a human salivary adenocarcinoma cell line to several anti-cancer drugs and enhancement of the antitumor effects by combination with filipin or verapamil]. ( Matsuya, T; Okura, M; Shirasuna, K; Sugiyama, M; Watatani, K, 1989) |
| "To determine whether aerodigestive squamous cell carcinomas (SCCs) contain a subpopulation of cancer stem cell-like cells, we performed Hoechst dye efflux assays using four independent cell lines." | 1.35 | Squamous cell cancers contain a side population of stem-like cells that are made chemosensitive by ABC transporter blockade. ( Allen, K; Bazley, L; Davies, D; Giangreco, A; Groot, KR; Janes, SM; Loebinger, MR; Navani, N; Prichard, L; Simpson, C; Tibrewal, S, 2008) |
| "Verapamil was found to enhance PYM-induced cytotoxicity and apoptosis in KB cells." | 1.34 | Synergistic effects of verapamil on pingyangmycin-induced cytotoxicity and apoptosis in KB cells. ( Chang, YC; Ho, YC; Tai, KW, 2007) |
| "Azidopine was the most potent inhibitor of ATP-dependent VBL uptake tested (ID50: concentration of inhibitor such that the transport of vinblastine is inhibited by 50%, less than 1 microM)." | 1.28 | Agents which reverse multidrug-resistance are inhibitors of [3H]vinblastine transport by isolated vesicles. ( Gottesman, MM; Horio, M; Lovelace, E; Pastan, I, 1991) |
| "Solutol HS 15 was relatively much more potent than the prototypic reversing agent, verapamil, for reversing colchicine resistance, compared to the ability of each agent to reverse colchicine resistance, compared to the ability of each agent to reverse vinblastine resistance." | 1.28 | Solutol HS 15, nontoxic polyoxyethylene esters of 12-hydroxystearic acid, reverses multidrug resistance. ( Clodfelter, K; Coon, JS; Knudson, W; Lu, B; Weinstein, RS, 1991) |
| "Verapamil was effective in combination with 5-FU, VCR or PEP on HSGc and with DTIC, VCR or PEP on KB." | 1.28 | [Chemo-sensitivity of a human salivary adenocarcinoma cell line to several anti-cancer drugs and enhancement of the antitumor effects by combination with filipin or verapamil]. ( Matsuya, T; Okura, M; Shirasuna, K; Sugiyama, M; Watatani, K, 1989) |
| "Verapamil, that was demonstrated previously to enhance the cell-killing activity of PE immunotoxins, enhanced the activity of several ricin A chain immunotoxins, including 454A12-rRTA, 260F9-rRTA, and 454C11-RTA." | 1.27 | Enhancement of the activity of immunotoxins made with either ricin A chain or Pseudomonas exotoxin in human ovarian and epidermoid carcinoma cell lines. ( FitzGerald, DJ; Pastan, I; Pirker, R; Willingham, MC, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (16.00) | 18.7374 |
| 1990's | 14 (56.00) | 18.2507 |
| 2000's | 5 (20.00) | 29.6817 |
| 2010's | 2 (8.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kobayashi, J | 1 |
| Hosoyama, H | 1 |
| Wang, XX | 1 |
| Shigemori, H | 1 |
| Sudo, Y | 1 |
| Tsuruo, T | 1 |
| da Silva, LM | 2 |
| Frión-Herrera, Y | 2 |
| Bartolomeu, AR | 2 |
| Gorgulho, CM | 1 |
| Sforcin, JM | 2 |
| Romagnoli, GG | 1 |
| de Oliveira, DE | 1 |
| Márián, T | 1 |
| Szabó, G | 1 |
| Goda, K | 1 |
| Nagy, H | 1 |
| Szincsák, N | 1 |
| Juhász, I | 1 |
| Galuska, L | 1 |
| Balkay, L | 1 |
| Mikecz, P | 1 |
| Trón, L | 1 |
| Krasznai, Z | 1 |
| Hari, M | 1 |
| Loganzo, F | 1 |
| Annable, T | 1 |
| Tan, X | 1 |
| Musto, S | 1 |
| Morilla, DB | 1 |
| Nettles, JH | 1 |
| Snyder, JP | 1 |
| Greenberger, LM | 1 |
| Ho, YC | 1 |
| Tai, KW | 1 |
| Chang, YC | 1 |
| Loebinger, MR | 1 |
| Giangreco, A | 1 |
| Groot, KR | 1 |
| Prichard, L | 1 |
| Allen, K | 1 |
| Simpson, C | 1 |
| Bazley, L | 1 |
| Navani, N | 1 |
| Tibrewal, S | 1 |
| Davies, D | 1 |
| Janes, SM | 1 |
| Munkonge, FM | 1 |
| Osborne, LR | 1 |
| Geddes, DM | 1 |
| Alton, EW | 1 |
| Iinuma, S | 1 |
| Farshi, SS | 1 |
| Ortel, B | 1 |
| Hasan, T | 1 |
| Hori, Y | 1 |
| Kawamoto, K | 1 |
| Yamazaki, N | 1 |
| Kumazawa, H | 1 |
| Yamashita, T | 1 |
| Kumazawa, T | 1 |
| Chou, CY | 1 |
| Shen, MR | 1 |
| Wu, SN | 1 |
| Ghauharali, RI | 1 |
| Westerhoff, HV | 1 |
| Dekker, H | 1 |
| Lankelma, J | 1 |
| Pezzella, N | 1 |
| Bouchot, A | 1 |
| Bonhomme, A | 1 |
| Pingret, L | 1 |
| Klein, C | 1 |
| Burlet, H | 1 |
| Balossier, G | 1 |
| Bonhomme, P | 1 |
| Pinon, JM | 1 |
| Graves, R | 1 |
| Davies, R | 1 |
| Owen, P | 1 |
| Clynes, M | 1 |
| Cleary, I | 1 |
| O'Beirne, G | 1 |
| Watanabe, T | 1 |
| Uchiyama, N | 1 |
| Roninson, IB | 1 |
| Cohen, D | 1 |
| Atadja, P | 1 |
| Léonce, S | 1 |
| Pierré, A | 1 |
| Anstett, M | 1 |
| Pérez, V | 1 |
| Genton, A | 1 |
| Bizzari, JP | 1 |
| Atassi, G | 1 |
| Horio, M | 1 |
| Lovelace, E | 1 |
| Pastan, I | 2 |
| Gottesman, MM | 1 |
| Burkey, BB | 1 |
| Omann, GM | 1 |
| Wolf, GT | 1 |
| Bier, H | 1 |
| Shalinsky, DR | 1 |
| Andreeff, M | 1 |
| Howell, SB | 1 |
| Coon, JS | 1 |
| Knudson, W | 1 |
| Clodfelter, K | 1 |
| Lu, B | 1 |
| Weinstein, RS | 1 |
| Sugiyama, M | 1 |
| Shirasuna, K | 1 |
| Okura, M | 1 |
| Watatani, K | 1 |
| Matsuya, T | 1 |
| Pirker, R | 1 |
| FitzGerald, DJ | 1 |
| Willingham, MC | 1 |
| Mattern, J | 1 |
| Bak, M | 1 |
| Volm, M | 1 |
| Simmonds, AP | 1 |
| Moyes, P | 1 |
| Nicol, A | 1 |
| Davidson, KG | 1 |
| Faichney, A | 1 |
25 other studies available for verapamil and Carcinoma, Epidermoid
| Article | Year |
|---|---|
Modulation of multidrug resistance by taxuspine C and other taxoids from Japanese yew.
Topics: Animals; Bridged-Ring Compounds; Carcinoma, Squamous Cell; Drug Resistance, Multiple; Drug Resistanc | 1998 |
Mechanisms involved in the cytotoxic action of Brazilian propolis and caffeic acid against HEp-2 cells and modulation of P-glycoprotein activity.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B | 2017 |
Combinatorial effects of geopropolis produced by Melipona fasciculata Smith with anticancer drugs against human laryngeal epidermoid carcinoma (HEp-2) cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; | 2016 |
In vivo and in vitro multitracer analyses of P-glycoprotein expression-related multidrug resistance.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, | 2003 |
Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of beta-tubulin (Asp26Glu) and less stable microtubules.
Topics: Amino Acid Substitution; Animals; Antineoplastic Agents, Phytogenic; Aspartic Acid; ATP Binding Cass | 2006 |
Synergistic effects of verapamil on pingyangmycin-induced cytotoxicity and apoptosis in KB cells.
Topics: Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bleomycin; C | 2007 |
Squamous cell cancers contain a side population of stem-like cells that are made chemosensitive by ABC transporter blockade.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding | 2008 |
Lack of inhibition by dideoxy-forskolin and verapamil of DIDS-sensitive volume-activated Cl- secretion in human squamous lung carcinoma epithelial cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; ATP Binding Cassette Transporter, Subfamily B, Mem | 1994 |
A mechanistic study of cellular photodestruction with 5-aminolaevulinic acid-induced porphyrin.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Cell Division; | 1994 |
Establishment of a cisplatin-resistant KB cell line and its characterization.
Topics: Carcinoma, Squamous Cell; Cell Cycle; Cell Division; Cell Line; Cell Survival; Cisplatin; Dose-Respo | 1993 |
Volume-sensitive chloride channels associated with human cervical carcinogenesis.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; ATP Binding Cassette Transporter, Subfamily B, Mem | 1995 |
Saturable P-glycoprotein kinetics assayed by fluorescence studies of drug efflux from suspended human KB8-5 cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carcinoma, Squamous C | 1996 |
Involvement of calcium and calmodulin in Toxoplasma gondii tachyzoite invasion.
Topics: Animals; Calcimycin; Calcium; Calcium Channel Blockers; Calmodulin; Carcinoma, Squamous Cell; Cytoso | 1997 |
An homogeneous assay for measuring the uptake and efflux of radiolabelled drugs in adherent cells.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbon Radiois | 1997 |
Altered activity of MDR-reversing agents on KB3-1 cells transfected with Gly(185)-->Val human P-glycoprotein.
Topics: Adenosine Triphosphatases; Amino Acid Substitution; Antineoplastic Agents; ATP Binding Cassette Tran | 2000 |
Effects of a new triazinoaminopiperidine derivative on adriamycin accumulation and retention in cells displaying P-glycoprotein-mediated multidrug resistance.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Membe | 1992 |
Agents which reverse multidrug-resistance are inhibitors of [3H]vinblastine transport by isolated vesicles.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding, Competitive; Biological Tr | 1991 |
Intracellular calcium changes associated with in vitro lymphokine-activated killer and natural killer cell cytotoxicity.
Topics: Calcium; Carcinoma, Squamous Cell; Cell Line; Cytotoxicity, Immunologic; Head and Neck Neoplasms; Hu | 1991 |
Circumvention of drug resistance in cisplatin-resistant sublines of the human squamous carcinoma cell line HLac 79 in vitro and in vivo.
Topics: Animals; Antimetabolites, Antineoplastic; Aphidicolin; Buthionine Sulfoximine; Carcinoma, Squamous C | 1991 |
Modulation of drug sensitivity by dipyridamole in multidrug resistant tumor cells in vitro.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Squamous Cell; Cell Survival; Co | 1990 |
Solutol HS 15, nontoxic polyoxyethylene esters of 12-hydroxystearic acid, reverses multidrug resistance.
Topics: Carcinoma, Squamous Cell; Cell Membrane Permeability; Chromatography, Gel; Colchicine; Doxorubicin; | 1991 |
[Chemo-sensitivity of a human salivary adenocarcinoma cell line to several anti-cancer drugs and enhancement of the antitumor effects by combination with filipin or verapamil].
Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line; Drug Screening Assays, A | 1989 |
Enhancement of the activity of immunotoxins made with either ricin A chain or Pseudomonas exotoxin in human ovarian and epidermoid carcinoma cell lines.
Topics: ADP Ribose Transferases; Bacterial Toxins; Cadaverine; Calmodulin; Carcinoma, Squamous Cell; Cell Li | 1988 |
Occurrence of a multidrug-resistant phenotype in human lung xenografts.
Topics: Animals; Carcinoma, Squamous Cell; Dactinomycin; Doxorubicin; Drug Resistance; Female; Humans; Lung | 1987 |
Enhancement of cytotoxicity of vindesine and cis-platinum for human lung tumours by the use of verapamil in vitro.
Topics: Carcinoma, Squamous Cell; Cisplatin; Drug Resistance; Drug Synergism; Humans; In Vitro Techniques; L | 1986 |