verapamil has been researched along with Carcinoma, Anaplastic in 22 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Human lung carcinoma A549-T27 cells were used to determine the effect of diamide on cadmium accumulation." | 7.68 | Diamide reduces cadmium accumulation by human lung carcinoma A549 cells. ( Enger, MD; Kang, YJ; Liu, MS, 1990) |
| " We determined the cytotoxicity of methotrexate and the lipid-soluble antifolate trimetrexate to various human carcinoma cells and their doxorubicin-resistant sublines." | 7.67 | Cross-resistance to the lipid-soluble antifolate trimetrexate in human carcinoma cells with the multidrug-resistant phenotype. ( Assaraf, YG; Molina, A; Schimke, RT, 1989) |
| "A subline of human colon carcinoma cells (WiDr/R) resistant to the cytotoxic effects of mitoxantrone in vitro, was developed by continuous exposure to increasing concentrations of drug." | 7.67 | Development of resistance and characteristics of a human colon carcinoma subline resistant to mitoxantrone in vitro. ( Durr, FE; Lindh, D; Wallace, RE, 1987) |
| "The cytotoxicities of anticancer drugs with or without estramustine or verapamil toward MCF-7 breast carcinoma cells and a P-glycoprotein-overexpressing subline MCF-7/ADR were determined using the sulforhodamine-binding assay." | 3.69 | Modulation of P-glycoprotein activity by estramustine is limited by binding to plasma proteins. ( Hudes, GR; Smith, CD; Tew, KD; Zhang, X; Zilfou, JT, 1995) |
| "Human lung carcinoma A549-T27 cells were used to determine the effect of diamide on cadmium accumulation." | 3.68 | Diamide reduces cadmium accumulation by human lung carcinoma A549 cells. ( Enger, MD; Kang, YJ; Liu, MS, 1990) |
| " In the present study, the effect of two membrane-acting agents, hyperthermia and the calcium channel blocker verapamil, on the action of adriamycin (ADR) on Lewis lung carcinoma (3LL) was examined." | 3.68 | Combined effect in vitro of chemotherapy with agents acting on the cell membrane of Lewis lung carcinoma. ( Hoenig, S; Leibovici, J; Siegal, A, 1990) |
| " We determined the cytotoxicity of methotrexate and the lipid-soluble antifolate trimetrexate to various human carcinoma cells and their doxorubicin-resistant sublines." | 3.67 | Cross-resistance to the lipid-soluble antifolate trimetrexate in human carcinoma cells with the multidrug-resistant phenotype. ( Assaraf, YG; Molina, A; Schimke, RT, 1989) |
| "A subline of human colon carcinoma cells (WiDr/R) resistant to the cytotoxic effects of mitoxantrone in vitro, was developed by continuous exposure to increasing concentrations of drug." | 3.67 | Development of resistance and characteristics of a human colon carcinoma subline resistant to mitoxantrone in vitro. ( Durr, FE; Lindh, D; Wallace, RE, 1987) |
| "Gastric carcinoma is one of the most common malignant tumors and one of the most common cancer-related fatal diseases." | 1.56 | Effect of verapamil in the reversal of doxorubicin chemotherapy resistance in advanced gastric cancer. ( Fan, GF; Fan, PS; Li, Y; Sun, B; Wang, X; Zhang, TY, 2020) |
| "Verapamil/CDDP co-treatment inhibited tumor xenograft growth via the downregulation of MRP1 expression." | 1.39 | Mechanisms of verapamil-enhanced chemosensitivity of gallbladder cancer cells to platinum drugs: glutathione reduction and MRP1 downregulation. ( Chen, T; Li, H; Li, X; Liu, Q; Wang, H; Wang, J; Wang, W; Yi, J, 2013) |
| "Anaplastic thyroid cancer cell lines that consisted of 0." | 1.36 | Doxorubicin fails to eradicate cancer stem cells derived from anaplastic thyroid carcinoma cells: characterization of resistant cells. ( Brabant, G; Cui, D; Derwahl, M; Xu, S; Zheng, X, 2010) |
| "Tamoxifen did not inhibit cell-free C6-GC synthesis in the P-gp/off or P-gp/on homogenates." | 1.36 | Expression of P-glycoprotein in HeLa cells confers resistance to ceramide cytotoxicity. ( Cabot, MC; Chapman, JV; Gouazé-Andersson, V, 2010) |
| "We conclude that VRACs in human prostate cancer epithelial cells are modulated via protein tyrosine phosphorylation." | 1.31 | Volume-regulated chloride conductance in the LNCaP human prostate cancer cell line. ( Kostyuk, PG; Lemonnier, L; Mauroy, B; Prevarskaya, N; Shuba, YM; Skryma, R; Van Coppenolle, F, 2000) |
| "Murine CT-26 colon cancer cells growing in continuous culture (parental cells) were harvested and injected subcutaneously into the lateral flank (to produce subcutaneous tumors) or the lateral tail vein (to produce experimental lung metastases) of 10 8-week-old syngeneic male BALB/c mice." | 1.29 | Organ-specific modulation of steady-state mdr gene expression and drug resistance in murine colon cancer cells. ( Bucana, CD; Dong, Z; Fan, D; Fidler, IJ; Radinsky, R; Tsan, R; Wilmanns, C, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (22.73) | 18.7374 |
| 1990's | 10 (45.45) | 18.2507 |
| 2000's | 3 (13.64) | 29.6817 |
| 2010's | 3 (13.64) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Jiao, W | 1 |
| Dong, W | 1 |
| Li, Z | 1 |
| Deng, M | 1 |
| Lu, R | 1 |
| Wang, X | 1 |
| Li, Y | 1 |
| Fan, GF | 1 |
| Zhang, TY | 1 |
| Sun, B | 1 |
| Fan, PS | 1 |
| Zheng, X | 1 |
| Cui, D | 1 |
| Xu, S | 1 |
| Brabant, G | 1 |
| Derwahl, M | 1 |
| Chapman, JV | 1 |
| Gouazé-Andersson, V | 1 |
| Cabot, MC | 1 |
| Wang, H | 1 |
| Li, X | 1 |
| Chen, T | 1 |
| Wang, W | 1 |
| Liu, Q | 1 |
| Li, H | 1 |
| Yi, J | 1 |
| Wang, J | 1 |
| Thews, O | 1 |
| Gassner, B | 1 |
| Kelleher, DK | 1 |
| Gekle, M | 1 |
| Smith, CD | 1 |
| Zilfou, JT | 1 |
| Zhang, X | 1 |
| Hudes, GR | 1 |
| Tew, KD | 1 |
| Seemann, O | 1 |
| Muscheck, M | 1 |
| Siegsmund, M | 1 |
| Pilch, H | 1 |
| Nebe, CT | 1 |
| Rassweiler, J | 1 |
| Alken, P | 1 |
| Dong, Z | 1 |
| Radinsky, R | 1 |
| Fan, D | 1 |
| Tsan, R | 1 |
| Bucana, CD | 1 |
| Wilmanns, C | 1 |
| Fidler, IJ | 1 |
| Toffoli, G | 1 |
| Tumiotto, L | 1 |
| Gigante, M | 1 |
| Perin, T | 1 |
| Biscontin, G | 1 |
| Boiocchi, M | 1 |
| Baldini, N | 1 |
| Scotlandi, K | 1 |
| Serra, M | 1 |
| Shikita, T | 1 |
| Zini, N | 1 |
| Ognibene, A | 1 |
| Santi, S | 1 |
| Ferracini, R | 1 |
| Maraldi, NM | 1 |
| Aherne, GW | 1 |
| Hardcastle, A | 1 |
| Valenti, M | 1 |
| Bryant, A | 1 |
| Rogers, P | 1 |
| Pettit, GR | 1 |
| Srirangam, JK | 1 |
| Kelland, LR | 1 |
| Harstrick, A | 1 |
| Vanhoefer, U | 1 |
| Schleucher, N | 1 |
| Schroeder, J | 1 |
| Baumgart, J | 1 |
| Scheulen, ME | 1 |
| Wilke, H | 1 |
| Seeber, S | 1 |
| Shuba, YM | 1 |
| Prevarskaya, N | 1 |
| Lemonnier, L | 1 |
| Van Coppenolle, F | 1 |
| Kostyuk, PG | 1 |
| Mauroy, B | 1 |
| Skryma, R | 1 |
| Coley, HM | 1 |
| Workman, P | 1 |
| Twentyman, PR | 1 |
| Kang, YJ | 1 |
| Liu, MS | 1 |
| Enger, MD | 1 |
| Siegal, A | 1 |
| Hoenig, S | 1 |
| Leibovici, J | 1 |
| Cornwell, MM | 2 |
| Pastan, I | 2 |
| Gottesman, MM | 2 |
| Urade, M | 1 |
| Sugi, M | 1 |
| Miyazaki, T | 1 |
| Assaraf, YG | 1 |
| Molina, A | 1 |
| Schimke, RT | 1 |
| Wallace, RE | 1 |
| Lindh, D | 1 |
| Durr, FE | 1 |
| Willingham, MC | 1 |
| Cardarelli, CO | 1 |
22 other studies available for verapamil and Carcinoma, Anaplastic
| Article | Year |
|---|---|
Lathyrane diterpenes from Euphorbia lathyris as modulators of multidrug resistance and their crystal structures.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Carcinoma; Cell Line, Tum | 2009 |
Effect of verapamil in the reversal of doxorubicin chemotherapy resistance in advanced gastric cancer.
Topics: Adult; Aged; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Carcin | 2020 |
Doxorubicin fails to eradicate cancer stem cells derived from anaplastic thyroid carcinoma cells: characterization of resistant cells.
Topics: Antibiotics, Antineoplastic; ATP-Binding Cassette Transporters; Biomarkers, Tumor; Carcinoma; Cell L | 2010 |
Expression of P-glycoprotein in HeLa cells confers resistance to ceramide cytotoxicity.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma; Cell Surv | 2010 |
Mechanisms of verapamil-enhanced chemosensitivity of gallbladder cancer cells to platinum drugs: glutathione reduction and MRP1 downregulation.
Topics: Animals; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; | 2013 |
Activity of drug efflux transporters in tumor cells under hypoxic conditions.
Topics: Acidosis; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Ca | 2008 |
Modulation of P-glycoprotein activity by estramustine is limited by binding to plasma proteins.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Proteins; Breast Neoplasms; Carcinoma | 1995 |
Establishment and characterization of a multidrug-resistant human bladder carcinoma cell line RT112/D21.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma; Cell Divi | 1995 |
Organ-specific modulation of steady-state mdr gene expression and drug resistance in murine colon cancer cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma; Carrier Proteins; Colon | 1994 |
Doxorubicin, vincristine, and actinomycin-D, but not teniposide, require long-lasting uninterrupted verapamil pressure to overcome drug resistance in multidrug-resistant cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Colonic Neoplasms; Dactinomycin; Doxorubi | 1993 |
Nuclear immunolocalization of P-glycoprotein in multidrug-resistant cell lines showing similar mechanisms of doxorubicin distribution.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma; Cel | 1995 |
Antitumour evaluation of dolastatins 10 and 15 and their measurement in plasma by radioimmunoassay.
Topics: Animals; Antineoplastic Agents; Carcinoma; Cell Division; Colonic Neoplasms; Cross Reactions; Depsip | 1996 |
Activity of N-benzyl-adriamycin-14-valerate (AD198), a new anthracycline derivate, in multidrug resistant human ovarian and breast carcinoma cell lines.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplas | 1995 |
Volume-regulated chloride conductance in the LNCaP human prostate cancer cell line.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine | 2000 |
Retention of activity by selected anthracyclines in a multidrug resistant human large cell lung carcinoma line without P-glycoprotein hyperexpression.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma; Dau | 1991 |
Diamide reduces cadmium accumulation by human lung carcinoma A549 cells.
Topics: Azo Compounds; Cadmium; Calcium Channels; Carcinoma; Cell Line; Diamide; Glutathione; Humans; Lung N | 1990 |
Combined effect in vitro of chemotherapy with agents acting on the cell membrane of Lewis lung carcinoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cell Membrane; Cell Membrane Per | 1990 |
Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1987 |
Establishment of three bleomycin-resistant human carcinoma cell lines and their cross-resistance to other antitumor agents.
Topics: Aged; Antineoplastic Agents; Bleomycin; Carcinoma; Drug Resistance; Filipin; HeLa Cells; Humans; KB | 1988 |
Cross-resistance to the lipid-soluble antifolate trimetrexate in human carcinoma cells with the multidrug-resistant phenotype.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carcinoma; Cell Line; Drug Resistance; Female; Gen | 1989 |
Development of resistance and characteristics of a human colon carcinoma subline resistant to mitoxantrone in vitro.
Topics: 2,4-Dinitrophenol; Carcinoma; Cell Nucleus; Colonic Neoplasms; Dinitrophenols; DNA, Neoplasm; Drug R | 1987 |
Single cell analysis of daunomycin uptake and efflux in multidrug-resistant and -sensitive KB cells: effects of verapamil and other drugs.
Topics: Biological Transport; Carcinoma; Cell Nucleus; Daunorubicin; Drug Resistance; Humans; KB Cells; Quin | 1986 |