verapamil has been researched along with Cancer of Pancreas in 26 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "we observe the efficacy of verapamil and amlodipine administered simultaneously in the medical treatment of endogenous hyperinsulinemic hypoglycemia." | 7.73 | [Successful pharmacological treatment of hyperinsulinemic hypoglycemia with verapamil and amlodipine--case report]. ( Owecki, M; Sowiński, J, 2005) |
| "The efficacy of treatment with either verapamil (V), the long-acting somatostatin analogue octreotide (OCT) alone, and the combined treatment (V + OCT) were studied in a patient with a symptomatic metastasized malignant insulinoma." | 7.67 | Malignant insulinoma: is combined treatment with verapamil and the long-acting somatostatin analogue octreotide (SMS 201-995) more effective than single therapy with either drug? ( Fischer, HR; Hackeng, WH; Lems, WF; Stehouwer, CD, 1989) |
| "we observe the efficacy of verapamil and amlodipine administered simultaneously in the medical treatment of endogenous hyperinsulinemic hypoglycemia." | 3.73 | [Successful pharmacological treatment of hyperinsulinemic hypoglycemia with verapamil and amlodipine--case report]. ( Owecki, M; Sowiński, J, 2005) |
| "The efficacy of treatment with either verapamil (V), the long-acting somatostatin analogue octreotide (OCT) alone, and the combined treatment (V + OCT) were studied in a patient with a symptomatic metastasized malignant insulinoma." | 3.67 | Malignant insulinoma: is combined treatment with verapamil and the long-acting somatostatin analogue octreotide (SMS 201-995) more effective than single therapy with either drug? ( Fischer, HR; Hackeng, WH; Lems, WF; Stehouwer, CD, 1989) |
| "In an orthotopic murine model of pancreatic cancer, AES-135 prolongs survival significantly, therefore representing a candidate for further preclinical testing." | 1.51 | Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer. ( Adile, AA; Bakhshinyan, D; Berger-Becvar, A; de Araujo, ED; Deininger, MW; Fishel, ML; Gawel, JM; Geletu, M; Grimard, ML; Gunning, PT; Heaton, WL; Konieczny, SF; Luchman, HA; O'Hare, T; Raouf, YS; Shah, F; Shouksmith, AE; Singh, SK; Venugopal, C; Weiss, S, 2019) |
| "Verapamil can enhance the cytotoxic effects of chemotherapeutic drugs and multidrug resistance by targeting the transport function of the P-glycoprotein (P-gp)." | 1.43 | Verapamil inhibits tumor progression of chemotherapy-resistant pancreatic cancer side population cells. ( Bao, Q; Bruns, CJ; Camaj, P; Ellwart, JW; Guba, M; Hartig, R; Jauch, KW; Mysliwietz, J; Nelson, PJ; Schwarz, B; Zhao, L; Zhao, Y, 2016) |
| "Verapamil has been shown to reverse acquired drug resistance to Adriamycin (ADR) and vinblastine in the P388 leukemia and Ehrlich ascites carcinoma model systems." | 1.27 | Effect of verapamil on in vitro cytotoxicity of adriamycin and vinblastine in human tumor cells. ( Cox, TC; Crowley, J; Goodman, GE; Yen, YP, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (23.08) | 18.7374 |
| 1990's | 10 (38.46) | 18.2507 |
| 2000's | 5 (19.23) | 29.6817 |
| 2010's | 5 (19.23) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shouksmith, AE | 1 |
| Shah, F | 1 |
| Grimard, ML | 1 |
| Gawel, JM | 1 |
| Raouf, YS | 1 |
| Geletu, M | 1 |
| Berger-Becvar, A | 1 |
| de Araujo, ED | 1 |
| Luchman, HA | 1 |
| Heaton, WL | 1 |
| Bakhshinyan, D | 1 |
| Adile, AA | 1 |
| Venugopal, C | 1 |
| O'Hare, T | 1 |
| Deininger, MW | 1 |
| Singh, SK | 1 |
| Konieczny, SF | 1 |
| Weiss, S | 1 |
| Fishel, ML | 1 |
| Gunning, PT | 1 |
| Bridges, E | 1 |
| Harris, AL | 1 |
| Wong, PP | 1 |
| Demircioglu, F | 1 |
| Ghazaly, E | 1 |
| Alrawashdeh, W | 1 |
| Stratford, MR | 1 |
| Scudamore, CL | 1 |
| Cereser, B | 1 |
| Crnogorac-Jurcevic, T | 1 |
| McDonald, S | 1 |
| Elia, G | 1 |
| Hagemann, T | 1 |
| Kocher, HM | 1 |
| Hodivala-Dilke, KM | 1 |
| Villanueva, MT | 1 |
| Zhao, L | 1 |
| Zhao, Y | 1 |
| Schwarz, B | 1 |
| Mysliwietz, J | 1 |
| Hartig, R | 1 |
| Camaj, P | 1 |
| Bao, Q | 1 |
| Jauch, KW | 1 |
| Guba, M | 1 |
| Ellwart, JW | 1 |
| Nelson, PJ | 1 |
| Bruns, CJ | 1 |
| Moreira, RO | 1 |
| Vaisman, M | 1 |
| Peixoto, PC | 1 |
| Azevedo, F | 1 |
| Owecki, M | 1 |
| Sowiński, J | 1 |
| Guo, JC | 1 |
| Zhao, YP | 1 |
| Liao, Q | 1 |
| Zhu, Y | 1 |
| De Marinis, L | 1 |
| Barbarino, A | 1 |
| Bertrand, V | 1 |
| Bastié, MJ | 1 |
| Vaysse, N | 1 |
| Pradayrol, L | 1 |
| Sato, K | 1 |
| Ishizuka, J | 2 |
| Cooper, CW | 2 |
| Chung, DH | 1 |
| Tsuchiya, T | 1 |
| Uchida, T | 1 |
| Rajaraman, S | 1 |
| Townsend, CM | 2 |
| Thompson, JC | 2 |
| Verovski, VN | 1 |
| Van den Berge, DL | 1 |
| Delvaeye, MM | 1 |
| Scheper, RJ | 1 |
| De Neve, WJ | 1 |
| Storme, GA | 1 |
| Kornek, G | 2 |
| Raderer, M | 2 |
| Schenk, T | 1 |
| Pidlich, J | 1 |
| Schulz, F | 1 |
| Globits, S | 1 |
| Tetzner, C | 2 |
| Scheithauer, W | 2 |
| Nakaizumi, A | 1 |
| Uehara, H | 1 |
| Baba, M | 1 |
| Iishi, H | 1 |
| Tatsuta, M | 1 |
| Koperna-Mach, K | 1 |
| Müller, C | 1 |
| Karner, J | 1 |
| Kastner, J | 1 |
| Weinhaus, AJ | 1 |
| Poronnik, P | 1 |
| Tuch, BE | 1 |
| Cook, DI | 1 |
| McClenaghan, NH | 1 |
| Flatt, PR | 1 |
| Liu, B | 1 |
| Staren, ED | 1 |
| Iwamura, T | 1 |
| Appert, HE | 1 |
| Howard, JM | 1 |
| Murakami, M | 1 |
| Sumi, S | 1 |
| Nickols, GA | 1 |
| Chang, BK | 1 |
| Tzanakakis, GN | 1 |
| Agarwal, KC | 1 |
| Veronikis, DK | 1 |
| Vezeridis, MP | 1 |
| Findlay, I | 1 |
| Dunne, MJ | 1 |
| Harty, RF | 1 |
| Jain, DK | 1 |
| McGuigan, JE | 1 |
| Stehouwer, CD | 1 |
| Lems, WF | 1 |
| Fischer, HR | 1 |
| Hackeng, WH | 1 |
| Imanaka, S | 1 |
| Matsuda, S | 1 |
| Ito, K | 1 |
| Matsuoka, T | 1 |
| Okada, Y | 1 |
| Goodman, GE | 1 |
| Yen, YP | 1 |
| Cox, TC | 1 |
| Crowley, J | 1 |
2 trials available for verapamil and Cancer of Pancreas
| Article | Year |
|---|---|
Phase I/II trial of dexverapamil, epirubicin, and granulocyte-macrophage-colony stimulating factor in patients with advanced pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; | 1995 |
Phase I/II trial of dexverapamil, epirubicin and granulocyte/macrophage-colony-stimulating factor in patients with advanced pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Calcium Channel Blockers; Drug | 1995 |
24 other studies available for verapamil and Cancer of Pancreas
| Article | Year |
|---|---|
Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer.
Topics: Animals; Apoptosis; Benzamides; Cell Line, Tumor; Cell Proliferation; Coculture Techniques; Disease | 2019 |
Vascular-promoting therapy reduced tumor growth and progression by improving chemotherapy efficacy.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Lewis Lung; Deoxycytidine; Gemcitabine; Humans; | 2015 |
Dual-action combination therapy enhances angiogenesis while reducing tumor growth and spread.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, | 2015 |
Angiogenesis: a sudden rush of blood to the tumour.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Lewis Lung; Deoxycytidine; Humans; Pancreatic N | 2015 |
Verapamil inhibits tumor progression of chemotherapy-resistant pancreatic cancer side population cells.
Topics: Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Proliferation; Dru | 2016 |
Is long-term use of a calcium channel blocker associated with an exacerbated response of an insulinoma during selective intraarterial calcium stimulation?
Topics: Adult; Calcium Channel Blockers; Calcium Gluconate; Female; Humans; Hypoglycemia; Insulinoma; Pancre | 2003 |
[Successful pharmacological treatment of hyperinsulinemic hypoglycemia with verapamil and amlodipine--case report].
Topics: Aged, 80 and over; Amlodipine; Calcium Channel Blockers; Female; Humans; Hyperinsulinism; Hypertensi | 2005 |
[Significance and reversal of MDR1/P-gp in pancreatic cancer chemotherapy].
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transport | 2007 |
Calcium antagonists and hormone release. I. Effects of verapamil on insulin release in normal subjects and patients with islet-cell tumor.
Topics: Adenoma, Islet Cell; Adolescent; Adult; Blood Glucose; Female; Glucagon; Glucose Tolerance Test; Gly | 1980 |
Inhibition of gastrin-induced proliferation of AR4-2J cells by calcium channel antagonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1994 |
Inhibitory effect of calcium channel blockers on growth of pancreatic cancer cells.
Topics: Calcium Channel Blockers; Cell Division; Humans; Pancreatic Neoplasms; Phenytoin; Tumor Cells, Cultu | 1994 |
Low-level doxorubicin resistance in P-glycoprotein-negative human pancreatic tumour PSN1/ADR cells implicates a brefeldin A-sensitive mechanism of drug extrusion.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Tra | 1996 |
Inhibition by verapamil of cholecystokinin-enhancement of pancreatic carcinogenesis induced by azaserine in Wistar rats.
Topics: Animals; Azaserine; Calcium Channel Blockers; Cholecystokinin; Drug Synergism; Glutathione Transfera | 1996 |
Mechanisms of arginine-induced increase in cytosolic calcium concentration in the beta-cell line NIT-1.
Topics: Animals; Arginine; Calcium; Cell Line; Cytosol; Diazoxide; Homoarginine; Insulin; Insulin Secretion; | 1997 |
Metabolic and K(ATP) channel-independent actions of keto acid initiators of insulin secretion.
Topics: Animals; Arginine; Butyrates; Calcium; Calcium Channel Blockers; Calcium Channels; Coumaric Acids; D | 2000 |
Mechanisms of taxotere-related drug resistance in pancreatic carcinoma.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Antineopla | 2001 |
Role of extracellular magnesium in insulin secretion from rat insulinoma cells.
Topics: Animals; Calcium; Cell Line; Colforsin; Glyburide; Glyceraldehyde; Insulin; Insulin Secretion; Insul | 1992 |
Inhibitory effects of a calcium antagonist on ornithine decarboxylase induction in pancreatic cancer cell lines.
Topics: Animals; Calcium; Eflornithine; Enzyme Induction; Ornithine Decarboxylase; Ornithine Decarboxylase I | 1991 |
Effects of antiplatelet agents alone or in combinations on platelet aggregation and on liver metastases from a human pancreatic adenocarcinoma in the nude mouse.
Topics: Adenocarcinoma; Animals; Colforsin; Drug Interactions; Humans; Indomethacin; Ketoconazole; Liver Neo | 1991 |
Voltage-activated Ca2+ and K+ currents in an insulin-secreting cell line (RINm5F).
Topics: Animals; Calcium; Cell Line; Cell Membrane; Egtazic Acid; Insulin; Insulin Secretion; Insulinoma; Io | 1986 |
Mechanisms of vasoactive intestinal peptide release in short-term culture of vasoactive intestinal peptide-producing tumor.
Topics: 1-Methyl-3-isobutylxanthine; Adenoma, Islet Cell; Calcimycin; Calcium; Cells, Cultured; Cyclic AMP; | 1988 |
Malignant insulinoma: is combined treatment with verapamil and the long-acting somatostatin analogue octreotide (SMS 201-995) more effective than single therapy with either drug?
Topics: Adenoma, Islet Cell; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Insulinom | 1989 |
Medical treatment for inoperable insulinoma: clinical usefulness of diphenylhydantoin and diltiazem.
Topics: Adenoma, Islet Cell; Aged; Benzazepines; Blood Glucose; C-Peptide; Celiac Artery; Diltiazem; Female; | 1986 |
Effect of verapamil on in vitro cytotoxicity of adriamycin and vinblastine in human tumor cells.
Topics: Breast Neoplasms; Cell Survival; Clone Cells; Colonic Neoplasms; Doxorubicin; Drug Resistance; Esoph | 1987 |