verapamil has been researched along with Cancer of Kidney in 16 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Toxicities included hypotension, asymptomatic bradycardia, and mild atrioventricular conduction delays, although one patient had dexverapamil discontinued for grade IV congestive heart failure." | 5.08 | Phase I/II trial of dexverapamil plus vinblastine for patients with advanced renal cell carcinoma. ( Cordon-Cardo, C; Fischer, P; Lianes, P; Lyn, P; Motzer, RJ; Ngo, RL; O'Brien, JP, 1995) |
| "Etoposide was given daily (150 mg m-2 day-1) for three doses (each over 1 h); the first dose was given 12 h into the verapamil infusion." | 2.68 | Continuous-infusion verapamil with etoposide in relapsed or resistant paediatric cancers. ( Cowie, FJ; Dick, G; Flanagan, RJ; Judson, I; McCarthy, PT; Phillips, M; Pinkerton, CR, 1995) |
| "Cells from 22 renal cell carcinomas (RCC) were established in culture." | 1.29 | Verapamil enhances doxorubicin activity in cultured human renal carcinoma cells. ( Collins, CM; Hall, P; Lai, T; Morgan, AP; Smith, PJ; Stonebridge, BR; Symes, MO, 1993) |
| "Human renal adenocarcinomas do not adequately respond to cancer chemotherapy." | 1.29 | [Enhancement of cytotoxic effect of anticancer agents of renal cell carcinoma]. ( Deguchi, T; Ehara, H; Kawada, Y; Kawamoto, S; Nezasa, S; Okano, M; Tamaki, M; Yamada, S, 1996) |
| "Multidrug resistance in human renal cell carcinoma is mainly caused by expression of the MDR1 gene and is characterized by a broad spectrum cross resistance to many natural product chemotherapeutic agents." | 1.28 | New potent verapamil derivatives that reverse multidrug resistance in human renal carcinoma cells and in transgenic mice expressing the human MDR1 gene. ( Aiken, PM; Gottesman, MM; Merlino, GT; Mickisch, GH; Pastan, I, 1991) |
| "Human renal cell carcinomas show a high degree of intrinsic multidrug resistance." | 1.28 | Mechanisms and modulation of multidrug resistance in primary human renal cell carcinoma. ( Alken, PM; Forster, S; Koessig, J; Mickisch, GH; Roehrich, K; Tschada, RK, 1990) |
| "Verapamil was more effective in potentiation of doxorubicin and this action increased in proportion to the concentration of verapamil added." | 1.28 | The effect of verapamil on the anti-tumour action of mitozantrone and doxorubicin against renal carcinoma cells in vitro. ( Lai, T; Morgan, AP; Smith, PJ; Symes, MO, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 12 (75.00) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Strobbe, G | 1 |
| Pannier, D | 1 |
| Sakji, I | 1 |
| Villain, A | 1 |
| Feutry, F | 1 |
| Marliot, G | 1 |
| Beley, S | 1 |
| Motzer, RJ | 1 |
| Lyn, P | 1 |
| Fischer, P | 1 |
| Lianes, P | 1 |
| Ngo, RL | 1 |
| Cordon-Cardo, C | 1 |
| O'Brien, JP | 1 |
| Cowie, FJ | 1 |
| Pinkerton, CR | 1 |
| Phillips, M | 1 |
| Dick, G | 1 |
| Judson, I | 1 |
| McCarthy, PT | 1 |
| Flanagan, RJ | 1 |
| Alvarez, M | 1 |
| Paull, K | 1 |
| Monks, A | 1 |
| Hose, C | 1 |
| Lee, JS | 1 |
| Weinstein, J | 1 |
| Grever, M | 1 |
| Bates, S | 1 |
| Fojo, T | 1 |
| Lai, T | 2 |
| Collins, CM | 1 |
| Hall, P | 1 |
| Morgan, AP | 2 |
| Smith, PJ | 2 |
| Stonebridge, BR | 1 |
| Symes, MO | 2 |
| Mickisch, GH | 3 |
| Noordzij, MA | 1 |
| vd Gaast, A | 1 |
| Gebreamlack, P | 1 |
| Köhrmann, KU | 1 |
| Mogler-Drautz, E | 1 |
| Kupper, H | 1 |
| Schröder, FH | 1 |
| Okano, M | 1 |
| Kawamoto, S | 1 |
| Nezasa, S | 1 |
| Tamaki, M | 1 |
| Ehara, H | 1 |
| Yamada, S | 1 |
| Deguchi, T | 1 |
| Kawada, Y | 1 |
| Yu, DS | 1 |
| Sun, GH | 1 |
| Ma, CP | 1 |
| Chang, SY | 1 |
| Merlino, GT | 1 |
| Aiken, PM | 1 |
| Gottesman, MM | 1 |
| Pastan, I | 1 |
| Moser, C | 1 |
| Risse, N | 1 |
| Langer, HJ | 1 |
| Fröhlig, G | 1 |
| Volkmer, I | 1 |
| Hinkeldey, K | 1 |
| Weinges, KF | 1 |
| Nygren, P | 2 |
| Larsson, R | 2 |
| Roehrich, K | 1 |
| Koessig, J | 1 |
| Forster, S | 1 |
| Tschada, RK | 1 |
| Alken, PM | 1 |
| Watanabe, Y | 1 |
3 trials available for verapamil and Cancer of Kidney
| Article | Year |
|---|---|
Phase I/II trial of dexverapamil plus vinblastine for patients with advanced renal cell carcinoma.
Topics: Adult; Aged; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bradycardia; Carcinoma, Renal | 1995 |
Continuous-infusion verapamil with etoposide in relapsed or resistant paediatric cancers.
Topics: Adolescent; Adult; Bone Neoplasms; Child; Child, Preschool; Drug Administration Schedule; Drug Resis | 1995 |
Dexverapamil to modulate vinblastine resistance in metastatic renal cell carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfa | 1995 |
13 other studies available for verapamil and Cancer of Kidney
| Article | Year |
|---|---|
Advantages of everolimus therapeutic drug monitoring in oncology when drug-drug interaction is suspected: A case report.
Topics: Carcinoma, Renal Cell; Drug Interactions; Drug Monitoring; Everolimus; Female; Humans; Immunosuppres | 2020 |
[La Peyronie disease, erectile dysfunction, kidney tumors]].
Topics: Adult; Age Factors; Anti-Inflammatory Agents; Biopsy; Erectile Dysfunction; Follow-Up Studies; Human | 2008 |
Generation of a drug resistance profile by quantitation of mdr-1/P-glycoprotein in the cell lines of the National Cancer Institute Anticancer Drug Screen.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Cell Surv | 1995 |
Verapamil enhances doxorubicin activity in cultured human renal carcinoma cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Renal Cell; Carrier Proteins; Do | 1993 |
[Enhancement of cytotoxic effect of anticancer agents of renal cell carcinoma].
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Bloc | 1996 |
Verapamil modulation of multidrug resistance in renal cell carcinoma.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Renal Cell; Doxorubicin; Drug Re | 2000 |
New potent verapamil derivatives that reverse multidrug resistance in human renal carcinoma cells and in transgenic mice expressing the human MDR1 gene.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Renal Cell; Daunorubici | 1991 |
[Cardiac metastasis as cause of therapy-resistant heart failure].
Topics: Aged; Carcinoma, Papillary; Cardiac Glycosides; Diuretics; Echocardiography; Heart Failure; Heart Ne | 1991 |
Verapamil and cyclosporin A sensitize human kidney tumor cells to vincristine in absence of membrane P-glycoprotein and without apparent changes in the cytoplasmic free Ca2+ concentration.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium; Cell Division; Cyc | 1990 |
Mechanisms and modulation of multidrug resistance in primary human renal cell carcinoma.
Topics: Antimetabolites; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; But | 1990 |
Differential in vitro sensitivity of human tumor and normal cells to chemotherapeutic agents and resistance modulators.
Topics: Adenocarcinoma; Antineoplastic Agents; Buthionine Sulfoximine; Cell Division; Cell Line; Cell Surviv | 1991 |
The effect of verapamil on the anti-tumour action of mitozantrone and doxorubicin against renal carcinoma cells in vitro.
Topics: Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Drug Therapy, Combination; Humans; Ki | 1990 |
[Enhancement of cytotoxicity of anticancer drugs by verapamil--effects on established human renal tumor cell line].
Topics: Antineoplastic Agents; Carcinoma, Renal Cell; Cisplatin; Doxorubicin; Drug Screening Assays, Antitum | 1988 |