verapamil has been researched along with Breast Cancer in 130 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Six women with breast cancer who received paclitaxel as a 3-hour infusion with and without R-verapamil were monitored with frequent plasma sampling up to 24 hours postinfusion." | 9.08 | Effect of R-verapamil on the pharmacokinetics of paclitaxel in women with breast cancer. ( Balis, FM; Berg, SL; Cowan, KH; Denicoff, AM; Noone, M; O'Shaughnessy, JA; Ognibene, FP; Tolcher, A, 1995) |
| "We conducted a phase I crossover study of escalating doses of both paclitaxel (Taxol; Bristol-Myers, Squibb, Princeton, NJ) and r-verapamil, the less cardiotoxic stereoisomer, in heavily pretreated patients with metastatic breast cancer." | 9.08 | Phase I crossover study of paclitaxel with r-verapamil in patients with metastatic breast cancer. ( Balis, FM; Barnes, CS; Berg, SL; Chang, R; Cowan, KH; Denicoff, AM; Fetsch, PA; Goldspiel, B; Gossard, MR; Noone, MH; O'Shaughnessy, JA; Ognibene, F; Solomon, D; Tolcher, AW; Venzon, DJ, 1996) |
| "The purpose of this study is to evaluate whether metastatic breast cancer that has progressed on an anthracycline-containing drug regimen will subsequently respond to that identical regimen if dexverapamil, a modulator of P-glycoprotein-mediated drug resistance, is given concomitantly." | 9.08 | Phase II study of dexverapamil plus anthracycline in patients with metastatic breast cancer who have progressed on the same anthracycline regimen. ( Andrulis, I; Blackstein, M; Franssen, E; Fraser, RA; Goss, PE; Hedley, D; Hill, W; Kates, R; Knight, S; Myers, R; Oldfield, S; Pritchard, KI; Roche, K; Trudeau, M; Warner, E; Warr, D; Webster, S, 1998) |
| "We evaluated the question of whether the chemosensitizers verapamil and quinine given orally to breast cancer patients failing combination chemotherapy alone would result in additional clinical responses." | 9.08 | Combination chemotherapy with cyclophosphamide, vincristine, adriamycin, and dexamethasone (CVAD) plus oral quinine and verapamil in patients with advanced breast cancer. ( Dalton, WS; Dorr, RT; Mosley, K; Salmon, SE; Taylor, CW, 1997) |
| " The purpose of this early phase II trial was to evaluate the effects of dexverapamil on epirubicin toxicity, activity and pharmacokinetics in patients with metastatic breast cancer." | 9.08 | Phase II trial of dexverapamil and epirubicin in patients with non-responsive metastatic breast cancer. ( Kroeger, N; Kupper, H; Lehnert, M; Mross, K; Schueller, J; Thuerlimann, B, 1998) |
| "Acquired resistance to fulvestrant and palbociclib is a new challenge to treatment of estrogen receptor positive (ER+) breast cancer." | 7.96 | Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib. ( Dubrovskyi, O; Dye, K; Gutgesell, LM; Huang, F; Li, Y; Ratia, K; Shen, Z; Thatcher, GRJ; Tonetti, DA; Xiong, R; Zhao, H; Zhao, J, 2020) |
| "The aim of this study was to investigate the synergistic effect of paclitaxel (PTX) and verapamil (VERA) on adriamycin (ADR)-resistant breast cancer (MCF-7/ADR) cells." | 7.91 | Synergistic effect of paclitaxel and verapamil to overcome multi-drug resistance in breast cancer cells. ( Gong, PY; Li, P; Zhong, D, 2019) |
| " The aim of this study was to compare the suitability of the radiolabelled Pgp inhibitors [(11)C]tariquidar and [(11)C]elacridar with the Pgp substrate radiotracer (R)-[(11)C]verapamil for discriminating tumours expressing low and high levels of Pgp using small-animal PET imaging in a murine breast cancer model." | 7.78 | A comparative small-animal PET evaluation of [11C]tariquidar, [11C]elacridar and (R)-[11C]verapamil for detection of P-glycoprotein-expressing murine breast cancer. ( Bankstahl, JP; Bankstahl, M; Erker, T; Kuntner, C; Langer, O; Löscher, W; Mairinger, S; Müller, M; Sauberer, M; Stanek, J; Strommer, S; Wacheck, V; Wanek, T, 2012) |
| " In the present study we investigated effect of hyperglycemia on cytotoxic efficacy of carboplatin and 5-fluorouracil in MCF-7 cells." | 7.77 | Hyperglycemia regulates MDR-1, drug accumulation and ROS levels causing increased toxicity of carboplatin and 5-fluorouracil in MCF-7 cells. ( Bhat, MK; Chaube, B; Pandey, V, 2011) |
| "5 degrees C) combined with two reversal agents (Interferon alpha and Verapamil) in MCF-7/ADR (ADM-resistant MCF-7 breast cancer cell line), and its relevant molecular mechanism of action." | 7.74 | Reversing adriamycin resistance of human breast cancer cells by hyperthermia combined with Interferon alpha and Verapamil. ( Hao, XS; Liu, HY; Niu, RF; Shi, YR; Wei, XY; Yang, Y; Zhang, L, 2007) |
| "Despite its intensive use in adjuvant breast cancer therapy for more than 30 years, the exact mechanisms of action of tamoxifen have not yet been fully characterized." | 7.69 | Enhancement of tamoxifen-induced E-cadherin function by Ca2+ channel antagonists in human breast cancer MCF7/6 cells. ( Bracke, M; Bruyneel, E; Castronovo, V; Charlier, C; Lechanteur, C; Mareel, M, 1996) |
| "The tumor cell growth inhibitory activity of tamoxifen was enhanced significantly by verapamil treatment in an estrogen receptor positive human breast cancer cell line, MCF-7." | 7.69 | Potentiation of tamoxifen activity by verapamil in a human breast cancer cell line. ( Gupta, V; Kamath, N; Singh, SV; Tkalcevic, GT, 1994) |
| "Pretreatment of human colon cancer LoVo-H cells and human breast cancer ZR-75 1A cells with low doses of verapamil, a Ca2+ channel blocker, for 48 h has a slight growth stimulatory effect and substantially increases cell sensitivity to lymphokine-activated killer (LAK) mediated cytotoxicity in the standard 51Cr release assay." | 7.68 | Verapamil upregulates sensitivity of human colon and breast cancer cells to LAK-cytotoxicity in vitro. ( Bianco, AR; Celio, L; Correale, P; Genua, G; Montagnani, S; Tagliaferri, P, 1991) |
| "A mitoxantrone-resistant human MCF-7 breast cancer subline (MCF/MX) which is approximately 4000-fold resistant to mitoxantrone was isolated by serial passage of the parental wild-type MCF-7 cells (MCF/WT) in stepwise increasing concentrations of drug." | 7.68 | Reduced intracellular drug accumulation in the absence of P-glycoprotein (mdr1) overexpression in mitoxantrone-resistant human MCF-7 breast cancer cells. ( Cowan, KH; Dixon, KH; Horton, J; Kelley, K; Morrow, C; Nakagawa, M; Schneider, E, 1992) |
| " We determined the cytotoxicity of methotrexate and the lipid-soluble antifolate trimetrexate to various human carcinoma cells and their doxorubicin-resistant sublines." | 7.67 | Cross-resistance to the lipid-soluble antifolate trimetrexate in human carcinoma cells with the multidrug-resistant phenotype. ( Assaraf, YG; Molina, A; Schimke, RT, 1989) |
| "Dexverapamil was given at 300 mg every 6 h for a total of 13 doses and commenced 2 days prior to epirubicin administration." | 6.68 | Dexverapamil to overcome epirubicin resistance in advanced breast cancer. ( Gastl, G; Greiner, J; Hartlapp, J; Kröger, N; Kupper, H; Mross, K; Schernhammer, E; Schüller, J; Schumacher, K; Thürlimann, B, 1995) |
| "Previous evidence suggests that breast cancer stem cells (BCSC) develop resistance through upregulation of stemness and chemo-evasion markers viz." | 5.72 | Deregulation of the CD44-NANOG-MDR1 associated chemoresistance pathways of breast cancer stem cells potentiates the anti-cancer effect of Kaempferol in synergism with Verapamil. ( Banerjee, N; Basu, S; Bhattacharya, R; Chatterjee, K; Chattopadhyay, S; Choudhury, P; Mukhopadhyay, A; Mukhopadhyay, S; Nandi, SK; Roychowdhury, T; Saha, P, 2022) |
| "It is suggested that thermochemotherapy combined with Verapamil could be used as a way to overcome the multidrug resistance." | 5.35 | [Experimental study on thermochemotherapy combined with verapamil for reversing the multidrug resistance responsible to breast cancer cell]. ( Hou, M; Li, SF; Liu, YY; Yan, X, 2008) |
| "Verapamil has been shown to be a competitive inhibitor of Pgp, and was one of the first multidrug-resistant reversing agents identified." | 5.31 | Verapamil decreases accumulation of 99Tcm-MIBI and 99Tcm-tetrofosmin in human breast cancer and soft tissue sarcoma cell lines. ( Kalinowska, W; Rodrigues, M; Sinzinger, H; Zielinski, C, 2001) |
| "Patients with metastatic breast cancer entered the study after hormone therapy had failed; prior treatment with cyclophosphamide, methotrexate and 5-fluorouracil (CMF) was also allowed." | 5.28 | A phase II study of intensive-dose epirubicin/verapamil as induction therapy followed by intensive-dose ifosfamide for advanced breast cancer. ( Hossfeld, DK; Jonat, W; Langenbuch, T; Mross, K, 1990) |
| "We evaluated the question of whether the chemosensitizers verapamil and quinine given orally to breast cancer patients failing combination chemotherapy alone would result in additional clinical responses." | 5.08 | Combination chemotherapy with cyclophosphamide, vincristine, adriamycin, and dexamethasone (CVAD) plus oral quinine and verapamil in patients with advanced breast cancer. ( Dalton, WS; Dorr, RT; Mosley, K; Salmon, SE; Taylor, CW, 1997) |
| "The purpose of this study is to evaluate whether metastatic breast cancer that has progressed on an anthracycline-containing drug regimen will subsequently respond to that identical regimen if dexverapamil, a modulator of P-glycoprotein-mediated drug resistance, is given concomitantly." | 5.08 | Phase II study of dexverapamil plus anthracycline in patients with metastatic breast cancer who have progressed on the same anthracycline regimen. ( Andrulis, I; Blackstein, M; Franssen, E; Fraser, RA; Goss, PE; Hedley, D; Hill, W; Kates, R; Knight, S; Myers, R; Oldfield, S; Pritchard, KI; Roche, K; Trudeau, M; Warner, E; Warr, D; Webster, S, 1998) |
| "We conducted a phase I crossover study of escalating doses of both paclitaxel (Taxol; Bristol-Myers, Squibb, Princeton, NJ) and r-verapamil, the less cardiotoxic stereoisomer, in heavily pretreated patients with metastatic breast cancer." | 5.08 | Phase I crossover study of paclitaxel with r-verapamil in patients with metastatic breast cancer. ( Balis, FM; Barnes, CS; Berg, SL; Chang, R; Cowan, KH; Denicoff, AM; Fetsch, PA; Goldspiel, B; Gossard, MR; Noone, MH; O'Shaughnessy, JA; Ognibene, F; Solomon, D; Tolcher, AW; Venzon, DJ, 1996) |
| "Six women with breast cancer who received paclitaxel as a 3-hour infusion with and without R-verapamil were monitored with frequent plasma sampling up to 24 hours postinfusion." | 5.08 | Effect of R-verapamil on the pharmacokinetics of paclitaxel in women with breast cancer. ( Balis, FM; Berg, SL; Cowan, KH; Denicoff, AM; Noone, M; O'Shaughnessy, JA; Ognibene, FP; Tolcher, A, 1995) |
| " The purpose of this early phase II trial was to evaluate the effects of dexverapamil on epirubicin toxicity, activity and pharmacokinetics in patients with metastatic breast cancer." | 5.08 | Phase II trial of dexverapamil and epirubicin in patients with non-responsive metastatic breast cancer. ( Kroeger, N; Kupper, H; Lehnert, M; Mross, K; Schueller, J; Thuerlimann, B, 1998) |
| "Acquired resistance to fulvestrant and palbociclib is a new challenge to treatment of estrogen receptor positive (ER+) breast cancer." | 3.96 | Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib. ( Dubrovskyi, O; Dye, K; Gutgesell, LM; Huang, F; Li, Y; Ratia, K; Shen, Z; Thatcher, GRJ; Tonetti, DA; Xiong, R; Zhao, H; Zhao, J, 2020) |
| "The aim of this study was to investigate the synergistic effect of paclitaxel (PTX) and verapamil (VERA) on adriamycin (ADR)-resistant breast cancer (MCF-7/ADR) cells." | 3.91 | Synergistic effect of paclitaxel and verapamil to overcome multi-drug resistance in breast cancer cells. ( Gong, PY; Li, P; Zhong, D, 2019) |
| "A promising drug, palbociclib, received accelerated approval as a first line treatment when used with the aromatase inhibitor, letrozole, for postmenopausal women with hormone receptor positive advanced or metastatic breast cancer." | 3.91 | Verapamil as a culprit of palbociclib toxicity. ( Gowarty, JL; Herrington, JD, 2019) |
| " Leptin, an adipokine overexpressed in obese patients, has been investigated in studies on breast carcinogenesis, but its effects on oxidative stress remain largely unexplored, especially in breast cancer." | 3.85 | Leptin induces ROS via NOX5 in healthy and neoplastic mammary epithelial cells. ( Der Vartanian, A; Mahbouli, S; Ortega, S; Rossary, A; Rougé, S; Vasson, MP, 2017) |
| " The aim of this study was to compare the suitability of the radiolabelled Pgp inhibitors [(11)C]tariquidar and [(11)C]elacridar with the Pgp substrate radiotracer (R)-[(11)C]verapamil for discriminating tumours expressing low and high levels of Pgp using small-animal PET imaging in a murine breast cancer model." | 3.78 | A comparative small-animal PET evaluation of [11C]tariquidar, [11C]elacridar and (R)-[11C]verapamil for detection of P-glycoprotein-expressing murine breast cancer. ( Bankstahl, JP; Bankstahl, M; Erker, T; Kuntner, C; Langer, O; Löscher, W; Mairinger, S; Müller, M; Sauberer, M; Stanek, J; Strommer, S; Wacheck, V; Wanek, T, 2012) |
| " In the present study we investigated effect of hyperglycemia on cytotoxic efficacy of carboplatin and 5-fluorouracil in MCF-7 cells." | 3.77 | Hyperglycemia regulates MDR-1, drug accumulation and ROS levels causing increased toxicity of carboplatin and 5-fluorouracil in MCF-7 cells. ( Bhat, MK; Chaube, B; Pandey, V, 2011) |
| "5 degrees C) combined with two reversal agents (Interferon alpha and Verapamil) in MCF-7/ADR (ADM-resistant MCF-7 breast cancer cell line), and its relevant molecular mechanism of action." | 3.74 | Reversing adriamycin resistance of human breast cancer cells by hyperthermia combined with Interferon alpha and Verapamil. ( Hao, XS; Liu, HY; Niu, RF; Shi, YR; Wei, XY; Yang, Y; Zhang, L, 2007) |
| "The uptake of Tc-TF was examined in the MCF7/WT cell line, a wild-type breast cancer cell line that does not exhibit MDR, and its subclonal etoposide resistant cell line MCF7/VP, which expresses high levels of MRP1, one of the multi-drug resistance associated proteins (MRPs), in the presence of increasing concentrations of verapamil, a classical MDR modulator." | 3.72 | Limitations of (99m)Tc tetrofosmin in assessing reversal effects of verapamil on the function of multi-drug resistance associated protein 1. ( Bunko, H; Kinuya, S; Li, XF; Michigishi, T; Mori, H; Shiba, K; Shuke, N; Tonami, N; Watanabe, N; Yokoyama, K, 2004) |
| " We studied daunorubicin (DNR) subcellular distribution in the presence of an H+-ATPase pump inhibitor 7-chloro-4-nitrobenz-2-oxa-1,3-diazole (NBD) and verapamil (VPL) in two human breast adenocarcinoma MCF7 etoposide-resistant and adriamycin-resistant cell lines, overexpressing respectively MRP (MCF7/VP) and Pgp (MCF7/ADR)." | 3.70 | Role of the vacuolar H+-ATPase in daunorubicin distribution in etoposide-resistant MCF7 cells overexpressing the multidrug-resistance associated protein. ( Benderra, Z; Manfait, M; Morjani, H; Trussardi, A, 1998) |
| "The cytotoxicities of anticancer drugs with or without estramustine or verapamil toward MCF-7 breast carcinoma cells and a P-glycoprotein-overexpressing subline MCF-7/ADR were determined using the sulforhodamine-binding assay." | 3.69 | Modulation of P-glycoprotein activity by estramustine is limited by binding to plasma proteins. ( Hudes, GR; Smith, CD; Tew, KD; Zhang, X; Zilfou, JT, 1995) |
| " Treatment of human MCF-7 breast cancer cells with chemosensitizers (CS), such as verapamil, trifluoperazine or BSO, for 72 hr resulted in an enhanced sensitization of cells to Adriamycin, trifluoperazine being the most potent compound in the reversion of chemoresistance." | 3.69 | Comparative study of intracellular calcium and adenosine 3',5'-cyclic monophosphate levels in human breast carcinoma cells sensitive or resistant to Adriamycin: contribution to reversion of chemoresistance. ( Hénichart, JP; Hornez, L; Mestdagh, N; Vandewalle, B, 1994) |
| "The tumor cell growth inhibitory activity of tamoxifen was enhanced significantly by verapamil treatment in an estrogen receptor positive human breast cancer cell line, MCF-7." | 3.69 | Potentiation of tamoxifen activity by verapamil in a human breast cancer cell line. ( Gupta, V; Kamath, N; Singh, SV; Tkalcevic, GT, 1994) |
| "Despite its intensive use in adjuvant breast cancer therapy for more than 30 years, the exact mechanisms of action of tamoxifen have not yet been fully characterized." | 3.69 | Enhancement of tamoxifen-induced E-cadherin function by Ca2+ channel antagonists in human breast cancer MCF7/6 cells. ( Bracke, M; Bruyneel, E; Castronovo, V; Charlier, C; Lechanteur, C; Mareel, M, 1996) |
| "Pretreatment of human colon cancer LoVo-H cells and human breast cancer ZR-75 1A cells with low doses of verapamil, a Ca2+ channel blocker, for 48 h has a slight growth stimulatory effect and substantially increases cell sensitivity to lymphokine-activated killer (LAK) mediated cytotoxicity in the standard 51Cr release assay." | 3.68 | Verapamil upregulates sensitivity of human colon and breast cancer cells to LAK-cytotoxicity in vitro. ( Bianco, AR; Celio, L; Correale, P; Genua, G; Montagnani, S; Tagliaferri, P, 1991) |
| "A mitoxantrone-resistant human MCF-7 breast cancer subline (MCF/MX) which is approximately 4000-fold resistant to mitoxantrone was isolated by serial passage of the parental wild-type MCF-7 cells (MCF/WT) in stepwise increasing concentrations of drug." | 3.68 | Reduced intracellular drug accumulation in the absence of P-glycoprotein (mdr1) overexpression in mitoxantrone-resistant human MCF-7 breast cancer cells. ( Cowan, KH; Dixon, KH; Horton, J; Kelley, K; Morrow, C; Nakagawa, M; Schneider, E, 1992) |
| "The calcium channel antagonists (CCAs) amlodipine, diltiazem, and verapamil inhibited HT-39 human breast cancer cell proliferation in a concentration-dependent manner." | 3.68 | Inhibition of cancer cell growth by calcium channel antagonists in the athymic mouse. ( Simpson, RU; Taylor, JM, 1992) |
| " We determined the cytotoxicity of methotrexate and the lipid-soluble antifolate trimetrexate to various human carcinoma cells and their doxorubicin-resistant sublines." | 3.67 | Cross-resistance to the lipid-soluble antifolate trimetrexate in human carcinoma cells with the multidrug-resistant phenotype. ( Assaraf, YG; Molina, A; Schimke, RT, 1989) |
| "Dexverapamil was given at 300 mg every 6 h for a total of 13 doses and commenced 2 days prior to epirubicin administration." | 2.68 | Dexverapamil to overcome epirubicin resistance in advanced breast cancer. ( Gastl, G; Greiner, J; Hartlapp, J; Kröger, N; Kupper, H; Mross, K; Schernhammer, E; Schüller, J; Schumacher, K; Thürlimann, B, 1995) |
| "Previous evidence suggests that breast cancer stem cells (BCSC) develop resistance through upregulation of stemness and chemo-evasion markers viz." | 1.72 | Deregulation of the CD44-NANOG-MDR1 associated chemoresistance pathways of breast cancer stem cells potentiates the anti-cancer effect of Kaempferol in synergism with Verapamil. ( Banerjee, N; Basu, S; Bhattacharya, R; Chatterjee, K; Chattopadhyay, S; Choudhury, P; Mukhopadhyay, A; Mukhopadhyay, S; Nandi, SK; Roychowdhury, T; Saha, P, 2022) |
| "Oleanolic acid (OA) is a triterpenoid, widely found in plants and possesses antitumor activity in many cancer lines." | 1.56 | P-glycoprotein modulates oleanolic acid effects in hepatocytes cancer cells and zebrafish embryos. ( Greige-Gerges, H; Hamade, A; Kayouka, M; Landy, D; Najjar, F; Saliba, E, 2020) |
| " Using drugs with potential to be repurposed, combined with 5-fluorouracil, the aim of this project was to investigate whether this combination led to therapeutic benefits, comparing with the isolated drugs." | 1.48 | Study of New Therapeutic Strategies to Combat Breast Cancer Using Drug Combinations. ( Correia, A; Gärtner, F; Silva, D; Vale, N; Vilanova, M, 2018) |
| "Multidrug-resistant breast cancers have limited and ineffective clinical treatment options." | 1.40 | Dual agent loaded PLGA nanoparticles enhanced antitumor activity in a multidrug-resistant breast tumor eenograft model. ( Chen, Y; Fang, DL; Lei, Y; Li, HL; Ren, K; Song, XR; Xu, B; Yang, Y; Zhang, JK; Zheng, XL, 2014) |
| "Human MDA-MB-231-Luc or MCF7-Luc breast cancer cells were orthotopically grown in NOD/SCID mice to a minimum mass of 5 mm." | 1.38 | In vivo imaging of human breast cancer mouse model with high level expression of calcium sensing receptor at 3T. ( Baio, G; Carbotti, G; Cilli, M; Emionite, L; Fabbi, M; Ghedin, P; Neumaier, CE; Prato, S; Salvi, S; Tagliafico, A; Truini, M, 2012) |
| "Phytosterols have been proposed to act as potent anticancer agents." | 1.36 | Phytosterols in physiological concentrations target multidrug resistant cancer cells. ( Kaczmarek, M; Knula, H; Polrolniczak, A; Potapinska, O; Rubis, B; Rybczynska, M, 2010) |
| "Breast carcinoma is the most common malignancy in women." | 1.36 | Survivin transcription is associated with P-glycoprotein/MDR1 overexpression in the multidrug resistance of MCF-7 breast cancer cells. ( He, S; Jiang, Y; Liu, F; Liu, S; Xie, Z; Zu, X, 2010) |
| "It is suggested that thermochemotherapy combined with Verapamil could be used as a way to overcome the multidrug resistance." | 1.35 | [Experimental study on thermochemotherapy combined with verapamil for reversing the multidrug resistance responsible to breast cancer cell]. ( Hou, M; Li, SF; Liu, YY; Yan, X, 2008) |
| "MDA-MB-468 breast carcinoma cells respond to non-volatile anaesthetics such as propofol with an increased migration." | 1.33 | Propofol-induced calcium signalling and actin reorganization within breast carcinoma cells. ( Brandt, L; Dittmar, T; Garib, V; Lang, K; Niggemann, B; Zänker, KS, 2005) |
| "Pretreatment with verapamil reversed the MDR phenotype." | 1.31 | Increased resistance to anticancer therapy of mouse cells lacking the poly(ADP-ribose) polymerase attributable to up-regulation of the multidrug resistance gene product P-glycoprotein. ( Herceg, Z; Wesierska-Gadek, J; Wurzer, G, 2000) |
| "Verapamil has been shown to be a competitive inhibitor of Pgp, and was one of the first multidrug-resistant reversing agents identified." | 1.31 | Verapamil decreases accumulation of 99Tcm-MIBI and 99Tcm-tetrofosmin in human breast cancer and soft tissue sarcoma cell lines. ( Kalinowska, W; Rodrigues, M; Sinzinger, H; Zielinski, C, 2001) |
| "Biopsy specimens of human breast tumors were investigated with the new method and functional activity of various efflux transporters was revealed: (1) only P-gp, (2) both P-gp and other ABC transporters, (3) only transporters different from P-gp, (4) no functional activity of efflux transporters." | 1.30 | [A new method for the intravital assessment of the functional activity of the membrane transporters performing the efflux of antitumor preparations from the cells of solid tumor specimens]. ( Bogush, EA; Bogush, TA; Robert, J; Smirnova, GB, 1999) |
| "Induction of CYP1A1 by TCDD in human breast cancer cells has been reported and results of several studies suggest that the estrogen receptor (ER) may be required for Ah responsiveness." | 1.30 | Studies on the relationship between estrogen receptor content, glutathione S-transferase pi expression, and induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and drug resistance in human breast cancer cells. ( Barhoumi, R; Burghardt, R; Hoivik, D; Safe, S; Wang, W; Willett, K; Wilson, C, 1997) |
| "Mitomycin C pretreatment also significantly increased the sensitivity of cancer cells to subsequent killing by the P-glycoprotein substrate doxorubicin, decreasing the ED50 by 5- to 10-fold." | 1.30 | Suppression of P-glycoprotein expression and multidrug resistance by DNA cross-linking agents. ( Blaxall, JR; Hamilton, JW; Ihnat, MA; La Ronde, N; Lariviere, JP; Pierre, KM; Turpie, BW; Warren, AJ, 1997) |
| "In particular, in resistant human breast carcinoma cells (MCF-7), adriamycin appeared to be exclusively located within the cytoplasm whereas the nuclei were shown to be completely negative." | 1.29 | Intracellular localization of the antitumour drug adriamycin in living cultured cells: a confocal microscopy study. ( Arancia, G; Calcabrini, A; Citro, G; Meschini, S; Molinari, A, 1994) |
| "Etoposide efflux may have been inhibited, not because of (competitive) inhibition by BSO or disturbance of the energy required for this process, but probably because of plasma membrane alterations." | 1.28 | Modulation by D,L-buthionine-S,R-sulphoximine of etoposide cytotoxicity on human non-small cell lung, ovarian and breast carcinoma cell lines. ( Lafleur, MV; Lankelma, J; Mans, DR; Pinedo, HM; Retèl, J; Schuurhuis, GJ; Treskes, M, 1992) |
| "We have previously observed that breast cancer cell lines could exhibit either epithelial or fibroblastic phenotypes as reflected by their morphologies and intermediate filament protein expression (C." | 1.28 | Loss of epithelial markers and acquisition of vimentin expression in adriamycin- and vinblastine-resistant human breast cancer cell lines. ( Byers, SW; Gelmann, EP; Heckford, SE; Skerker, JM; Sommers, CL; Thompson, EW; Torri, JA; Worland, P, 1992) |
| "The effects of GSH depletion in a human breast cancer cell line and a multi-drug resistant subline (ADRr) were determined in a number of experimental conditions." | 1.28 | Glutathione depletion in human and in rat multi-drug resistant breast cancer cell lines. ( Batist, G; Greene, D; Lehnert, S; Schecter, R; Woo, A, 1991) |
| "Patients with metastatic breast cancer entered the study after hormone therapy had failed; prior treatment with cyclophosphamide, methotrexate and 5-fluorouracil (CMF) was also allowed." | 1.28 | A phase II study of intensive-dose epirubicin/verapamil as induction therapy followed by intensive-dose ifosfamide for advanced breast cancer. ( Hossfeld, DK; Jonat, W; Langenbuch, T; Mross, K, 1990) |
| "Verapamil has been shown to reverse acquired drug resistance to Adriamycin (ADR) and vinblastine in the P388 leukemia and Ehrlich ascites carcinoma model systems." | 1.27 | Effect of verapamil on in vitro cytotoxicity of adriamycin and vinblastine in human tumor cells. ( Cox, TC; Crowley, J; Goodman, GE; Yen, YP, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (3.85) | 18.7374 |
| 1990's | 57 (43.85) | 18.2507 |
| 2000's | 31 (23.85) | 29.6817 |
| 2010's | 30 (23.08) | 24.3611 |
| 2020's | 7 (5.38) | 2.80 |
| Authors | Studies |
|---|---|
| Colabufo, NA | 1 |
| Berardi, F | 1 |
| Cantore, M | 1 |
| Perrone, MG | 1 |
| Contino, M | 1 |
| Inglese, C | 1 |
| Niso, M | 1 |
| Perrone, R | 1 |
| Azzariti, A | 1 |
| Simone, GM | 1 |
| Porcelli, L | 1 |
| Paradiso, A | 1 |
| Pick, A | 2 |
| Müller, H | 2 |
| Wiese, M | 3 |
| Jiao, W | 1 |
| Dong, W | 1 |
| Li, Z | 2 |
| Deng, M | 1 |
| Lu, R | 1 |
| Reddy, KP | 1 |
| Bid, HK | 1 |
| Nayak, VL | 1 |
| Chaudhary, P | 1 |
| Chaturvedi, JP | 1 |
| Arya, KR | 1 |
| Konwar, R | 1 |
| Narender, T | 1 |
| Mayer, R | 1 |
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1 review available for verapamil and Breast Cancer
| Article | Year |
|---|---|
[A negative first-line work-up of Raynaud's phenomenon: And what if it were cancer?].
Topics: Adenocarcinoma, Mucinous; Aged, 80 and over; Anastrozole; Antineoplastic Agents, Hormonal; Breast Ne | 2010 |
10 trials available for verapamil and Breast Cancer
| Article | Year |
|---|---|
Effect of R-verapamil on the pharmacokinetics of paclitaxel in women with breast cancer.
Topics: Breast Neoplasms; Chromatography, High Pressure Liquid; Cross-Over Studies; Drug Therapy, Combinatio | 1995 |
Randomized phase II study of single-agent epirubicin +/- verapamil in patients with advanced metastatic breast cancer. An AIO clinical trial. Arbeitsgemeinschaft Internistische Onkologie of the German Cancer Society.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Epirubicin; Female; H | 1993 |
Phase I crossover study of paclitaxel with r-verapamil in patients with metastatic breast cancer.
Topics: Adult; Aged; Antibodies, Monoclonal; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transpo | 1996 |
Dexverapamil to overcome epirubicin resistance in advanced breast cancer.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Calcium Channel Blockers; D | 1995 |
Does verapamil help overcome multidrug resistance in tumor cell lines and cancer patients?
Topics: Adult; Aged; Antibiotics, Antineoplastic; Breast Neoplasms; Calcium Channel Blockers; Cell Division; | 1996 |
Combination chemotherapy with cyclophosphamide, vincristine, adriamycin, and dexamethasone (CVAD) plus oral quinine and verapamil in patients with advanced breast cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Dex | 1997 |
Phase II trial of dexverapamil and epirubicin in patients with non-responsive metastatic breast cancer.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Blood Pressure; Breast Neoplasms; Calcium Channel Blockers | 1998 |
Phase II study of dexverapamil plus anthracycline in patients with metastatic breast cancer who have progressed on the same anthracycline regimen.
Topics: Adult; Aged; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; B | 1998 |
Verapamil increases the survival of patients with anthracycline-resistant metastatic breast carcinoma.
Topics: Administration, Oral; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protoc | 2000 |
Treatment of advanced and refractory breast cancer with doxorubicin, vincristine and continuous infusion of verapamil. A phase I-II clinical trial.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Doxorubicin; Drug Eva | 1991 |
119 other studies available for verapamil and Breast Cancer
| Article | Year |
|---|---|
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives.
Topics: Acridines; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Ne | 2008 |
Structure-activity relationships of new inhibitors of breast cancer resistance protein (ABCG2).
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member | 2008 |
Lathyrane diterpenes from Euphorbia lathyris as modulators of multidrug resistance and their crystal structures.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Carcinoma; Cell Line, Tum | 2009 |
In vitro and in vivo anticancer activity of 2-deacetoxytaxinine J and synthesis of novel taxoids and their in vitro anticancer activity.
Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line; Cell Line, Tumor; Epithelia | 2009 |
Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP).
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette | 2011 |
4,5-Di-substituted benzyl-imidazol-2-substituted amines as the structure template for the design and synthesis of reversal agents against P-gp-mediated multidrug resistance breast cancer cells.
Topics: Amines; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bre | 2014 |
Synthesis and biological evaluation of 2,5-disubstituted furan derivatives as P-glycoprotein inhibitors for Doxorubicin resistance in MCF-7/ADR cell.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplas | 2018 |
The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dictamnus | 2018 |
Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib.
Topics: Animals; Breast Neoplasms; Drug Resistance, Neoplasm; Fulvestrant; Humans; MCF-7 Cells; Mice; Models | 2020 |
Development of oxoisoaporphine derivatives with topoisomerase I inhibition and reversal of multidrug resistance in breast cancer MCF-7/ADR cells.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; DN | 2022 |
Deregulation of the CD44-NANOG-MDR1 associated chemoresistance pathways of breast cancer stem cells potentiates the anti-cancer effect of Kaempferol in synergism with Verapamil.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Breast Neoplasms; Cell Line, T | 2022 |
Down-regulation of ABCB1 by collateral sensitivity drugs reverses multidrug resistance and up-regulates enolase I.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Breast Neoplasms; Cell Line, T | 2022 |
5-FU and the dietary flavonoid carvacrol: a synergistic combination that induces apoptosis in MCF-7 breast cancer cells.
Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Line, Tum | 2022 |
Kaempferol with Verapamil impeded panoramic chemoevasion pathways in breast cancer through ROS overproduction and disruption of lysosomal biogenesis.
Topics: Autophagy; Breast Neoplasms; Calcium; Female; Glucose; Humans; Kaempferols; Lysosomes; Molecular Doc | 2023 |
P-glycoprotein modulates oleanolic acid effects in hepatocytes cancer cells and zebrafish embryos.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neop | 2020 |
Incorporation of drug efflux inhibitor and chemotherapeutic agent into an inorganic/organic platform for the effective treatment of multidrug resistant breast cancer.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Calcium Phosphates; Cell Line, Tumor; Cell Membran | 2019 |
Effects of a novel photoactivated photosensitizer on MDR1 over-expressing human breast cancer cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Survival; Doxorubici | 2017 |
Leptin induces ROS via NOX5 in healthy and neoplastic mammary epithelial cells.
Topics: Breast Neoplasms; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; Humans; Leptin; | 2017 |
Polysaccharide-based nanoparticles for co-loading mitoxantrone and verapamil to overcome multidrug resistance in breast tumor.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Chitosan; Drug D | 2017 |
Verapamil as a culprit of palbociclib toxicity.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Humans; Letrozole; P | 2019 |
Enhanced anticancer activity and intracellular uptake of paclitaxel-containing solid lipid nanoparticles in multidrug-resistant breast cancer cells.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neop | 2018 |
Study of New Therapeutic Strategies to Combat Breast Cancer Using Drug Combinations.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Resistance, Neoplasm; Epithel | 2018 |
Synergistic effect of paclitaxel and verapamil to overcome multi-drug resistance in breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Doxorubici | 2019 |
Novel peptide-doxorubucin conjugates for targeting breast cancer cells including the multidrug resistant cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line; Cell Line, Tumor; Doxorubicin; Drug Resistance, | 2013 |
Dual agent loaded PLGA nanoparticles enhanced antitumor activity in a multidrug-resistant breast tumor eenograft model.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Drug Carriers; Drug Resistance, Neoplas | 2014 |
Nifedipine promotes the proliferation and migration of breast cancer cells.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Gene Express | 2014 |
Targeting microparticle biogenesis: a novel approach to the circumvention of cancer multidrug resistance.
Topics: Acrylates; Amides; Antineoplastic Agents; Breast Neoplasms; Calcimycin; Cell Line, Tumor; Cell-Deriv | 2015 |
Co-delivery of docetaxel and verapamil by reduction-sensitive PEG-PLGA-SS-DTX conjugate micelles to reverse the multi-drug resistance of breast cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; ATP Binding Cassette Transporter | 2017 |
[Experimental study on thermochemotherapy combined with verapamil for reversing the multidrug resistance responsible to breast cancer cell].
Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Dose-Response Relationship, Drug; Doxorubicin; Drug R | 2008 |
Inhibition of P-glycoprotein-mediated paclitaxel resistance by reversibly linked quinine homodimers.
Topics: Adenocarcinoma; Adenosine Triphosphatases; Affinity Labels; ATP Binding Cassette Transporter, Subfam | 2009 |
Dual potency anti-HER2/neu and anti-EGFR anthracycline immunoconjugates in chemotherapeutic-resistant mammary carcinoma combined with cyclosporin A and verapamil P-glycoprotein inhibition.
Topics: Antibiotics, Antineoplastic; Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, | 2009 |
Chemosensitivity of radioresistant cells in the multicellular spheroids of A549 lung adenocarcinoma.
Topics: Adenocarcinoma; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Ca | 2009 |
Ethidium bromide as a vital probe of mitochondrial DNA in carcinoma cells.
Topics: Breast; Breast Neoplasms; Calcium Channel Blockers; Cell Line, Tumor; DNA, Mitochondrial; Drug Resis | 2009 |
The influence of P-glycoprotein expression and its inhibitors on the distribution of doxorubicin in breast tumors.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Vesse | 2009 |
Survivin transcription is associated with P-glycoprotein/MDR1 overexpression in the multidrug resistance of MCF-7 breast cancer cells.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Tra | 2010 |
Effect of MDR modulators verapamil and promethazine on gene expression levels of MDR1 and MRP1 in doxorubicin-resistant MCF-7 cells.
Topics: Antibiotics, Antineoplastic; Biological Transport; Breast Neoplasms; Cell Line, Tumor; Doxorubicin; | 2011 |
Phytosterols in physiological concentrations target multidrug resistant cancer cells.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Ce | 2010 |
The transport of gastrodin in Caco-2 cells and uptake in Bcap37 and Bcap37/MDR1 cells.
Topics: Acridines; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzyl Alcohols; Biological Tran | 2010 |
Reversal of doxorubicin-resistance by multifunctional nanoparticles in MCF-7/ADR cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Line, Tumor; Cell Nu | 2011 |
Hyperglycemia regulates MDR-1, drug accumulation and ROS levels causing increased toxicity of carboplatin and 5-fluorouracil in MCF-7 cells.
Topics: Acetylcysteine; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Carboplat | 2011 |
In vivo imaging of human breast cancer mouse model with high level expression of calcium sensing receptor at 3T.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Chlorides; Contrast Media; Disease Models, Animal; Fema | 2012 |
A comparative small-animal PET evaluation of [11C]tariquidar, [11C]elacridar and (R)-[11C]verapamil for detection of P-glycoprotein-expressing murine breast cancer.
Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; B | 2012 |
Evaluation of the relationship between [18F]FDG and P-glycoprotein expression: an experimental study.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Breast Neopl | 2012 |
Reversion of multidrug resistance in a chemoresistant human breast cancer cell line by β-elemene.
Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Ne | 2012 |
BBA, a derivative of 23-hydroxybetulinic acid, potently reverses ABCB1-mediated drug resistance in vitro and in vivo.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apop | 2012 |
2-Hydroxypropyl-β-cyclodextrin-modified SLN of paclitaxel for overcoming p-glycoprotein function in multidrug-resistant breast cancer cells.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transport | 2013 |
The expression of growth hormone-releasing hormone (GHRH) and its receptor splice variants in human breast cancer lines; the evaluation of signaling mechanisms in the stimulation of cell proliferation.
Topics: Alternative Splicing; Breast Neoplasms; Cell Division; Cyclic AMP; DNA Primers; Female; Growth Hormo | 2003 |
Protein kinase Calpha regulates Ets1 transcriptional activity in invasive breast cancer cells.
Topics: Blotting, Western; Breast Neoplasms; Calcium; Calcium Channel Blockers; Cell Line; Cell Line, Tumor; | 2003 |
Particular sensitivity to calcium channel blockers of the fast inward voltage-dependent sodium current involved in the invasive properties of a metastastic breast cancer cell line.
Topics: Breast Neoplasms; Calcium Channel Blockers; Cell Division; Cell Line, Tumor; Cell Survival; Diltiaze | 2004 |
Using 99mTc-sestamibi to evaluate the effects of a chemosensitizer on P-glycoprotein in multidrug-resistant carcinoma cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Line, Tumor; Data In | 2004 |
Limitations of (99m)Tc tetrofosmin in assessing reversal effects of verapamil on the function of multi-drug resistance associated protein 1.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Ce | 2004 |
[Effects of functional inhibition of p-glycoprotein on radiosensitivity of drug-resistant MCF-7/Adr tumor cells].
Topics: Antibiotics, Antineoplastic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bre | 2004 |
Genomic changes identified by comparative genomic hybridisation in docetaxel-resistant breast cancer cell lines.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast N | 2005 |
Modulation of sensitivity to doxorubicin by the histone deacetylase inhibitor sodium butyrate in breast cancer cells.
Topics: Breast Neoplasms; Butyrates; Cell Line, Tumor; Doxorubicin; Drug Synergism; Enzyme Inhibitors; Femal | 2005 |
Inhibition of P-glycoprotein-mediated multidrug resistance by unfractionated heparin: a new potential chemosensitizer for cancer therapy.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Breast Neoplasms; Cel | 2005 |
Transport and cytotoxicity of paclitaxel, docetaxel, and novel taxanes in human breast cancer cells.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Su | 2005 |
Propofol-induced calcium signalling and actin reorganization within breast carcinoma cells.
Topics: Actins; Anesthetics, Intravenous; Blotting, Western; Breast Neoplasms; Calcium Channel Blockers; Cal | 2005 |
Quantitative study of the drug efflux kinetics from sensitive and MDR human breast cancer cells.
Topics: Antibiotics, Antineoplastic; Biological Transport; Breast Neoplasms; Calcium Channel Blockers; Cell | 2007 |
Reversing adriamycin resistance of human breast cancer cells by hyperthermia combined with Interferon alpha and Verapamil.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Ce | 2007 |
Levistolide A overcomes P-glycoprotein-mediated drug resistance in human breast carcinoma cells.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Su | 2008 |
Influence of S9788, a new modulator of multidrug resistance, on the cellular accumulation and subcellular distribution of daunorubicin in P-glycoprotein-expressing MCF7 human breast adenocarcinoma cells.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Nucl | 1995 |
Partial inhibition of multidrug resistance by safingol is independent of modulation of P-glycoprotein substrate activities and correlated with inhibition of protein kinase C.
Topics: Affinity Labels; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Memb | 1995 |
[Difference between the effects of S9788, verapamil and quinine on the reversion of multidrug resistance in two human tumor cell lines].
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Death; Doxorubicin; Drug Resistance, Multiple; Humans; | 1994 |
[Effect of the modality of exposure on the action of S9788 on the modulation of multidrug resistance of human tumor cell lines].
Topics: Adenocarcinoma; Antineoplastic Agents; Breast Neoplasms; Cyclosporine; Daunorubicin; Drug Resistance | 1994 |
Modulation of P-glycoprotein activity by estramustine is limited by binding to plasma proteins.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Proteins; Breast Neoplasms; Carcinoma | 1995 |
Intracellular localization of the antitumour drug adriamycin in living cultured cells: a confocal microscopy study.
Topics: Breast Neoplasms; Cell Nucleus; Cytoplasm; Doxorubicin; Drug Resistance, Multiple; Fluorescence; Hum | 1994 |
Induction of multidrug resistance (MDR) by transfection of MCF-10A cell line with c-Ha-ras and c-erbB-2 oncogenes.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Breast Neoplasms; Doxorubici | 1994 |
Free radical formation by ansamycin benzoquinone in human breast tumor cells: implications for cytotoxicity and resistance.
Topics: Adenocarcinoma; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1 | 1994 |
Modulation of adriamycin resistance in human breast carcinoma MCF-7 cells in vitro and in vivo by medroxyprogesterone acetate.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Doxorubicin; Drug Resista | 1994 |
Comparative study of intracellular calcium and adenosine 3',5'-cyclic monophosphate levels in human breast carcinoma cells sensitive or resistant to Adriamycin: contribution to reversion of chemoresistance.
Topics: Binding Sites; Breast Neoplasms; Calcium; Cell Line; Cyclic AMP; Doxorubicin; Drug Resistance; Gluta | 1994 |
Scanning electron microscopy of multidrug resistant cells in haematological and mammary malignancies.
Topics: Acute Disease; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blast Crisis; Breas | 1993 |
Changes in subcellular doxorubicin distribution and cellular accumulation alone can largely account for doxorubicin resistance in SW-1573 lung cancer and MCF-7 breast cancer multidrug resistant tumour cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Carrier Proteins; Cell Nu | 1993 |
Multidrug resistance circumvention by a new triazinoaminopiperidine derivative S9788 in vitro: definition of the optimal schedule and comparison with verapamil.
Topics: Antineoplastic Agents; Breast Neoplasms; Doxorubicin; Drug Resistance; Female; Humans; Piperidines; | 1994 |
Potentiation of tamoxifen activity by verapamil in a human breast cancer cell line.
Topics: Breast Neoplasms; Cell Division; Cell Survival; Drug Synergism; Female; Humans; Protein Kinase C; Re | 1994 |
Selective toxicity of TGF-alpha-PE40 to EGFR-positive cell lines: selective protection of low EGFR-expressing cell lines by EGF.
Topics: Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Division; Cell Line; C | 1994 |
Heterogeneity of anthracycline retention and response to efflux blockers in human tumors.
Topics: Anthracyclines; Ascites; Breast Neoplasms; Daunorubicin; Doxorubicin; Drug Resistance, Multiple; Fem | 1995 |
Membrane interactions of some catamphiphilic drugs and relation to their multidrug-resistance-reversing ability.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Breast Neoplasms; Calorimetry, Differential Scanning; D | 1996 |
Technetium-99m-sestamibi uptake by human benign and malignant breast tumor cells: correlation with mdr gene expression.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Breast Neoplasms; Drug R | 1996 |
Down-regulation of apoptosis-related bcl-2 but not bcl-xL or bax proteins in multidrug-resistant MCF-7/Adr human breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Base Sequence; bcl-2-Associated X Protein; bcl-X Protein; Breast N | 1996 |
Comparative in vitro evaluation of dithiane analogs of tiapamil, Ro 11-2933, Ro 44-5911 and Ro 44-5912 as multidrug resistance modulators.
Topics: Adenocarcinoma; Breast Neoplasms; Calcium Channel Blockers; Daunorubicin; Drug Resistance, Multiple; | 1996 |
Activity of N-benzyl-adriamycin-14-valerate (AD198), a new anthracycline derivate, in multidrug resistant human ovarian and breast carcinoma cell lines.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplas | 1995 |
The effects of terbium on the cellular accumulation of cisplatin in MDA-MB-231 human breast tumor cells.
Topics: Analysis of Variance; Antineoplastic Agents; Breast Neoplasms; Calcium Channel Blockers; Cisplatin; | 1997 |
Enhancement of tamoxifen-induced E-cadherin function by Ca2+ channel antagonists in human breast cancer MCF7/6 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1996 |
Functional modulation of ATPase of P-glycoprotein by C219, a monoclonal antibody against P-glycoprotein.
Topics: Adenocarcinoma; Adenosine Triphosphatases; Adenosine Triphosphate; Antibodies, Monoclonal; ATP Bindi | 1997 |
Expression of the multidrug resistance-associated protein gene in refractory lymphoma: quantitation by a validated polymerase chain reaction assay.
Topics: Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Membe | 1997 |
Studies on the relationship between estrogen receptor content, glutathione S-transferase pi expression, and induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and drug resistance in human breast cancer cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Chloramphenicol | 1997 |
Role of the vacuolar H+-ATPase in daunorubicin distribution in etoposide-resistant MCF7 cells overexpressing the multidrug-resistance associated protein.
Topics: 4-Chloro-7-nitrobenzofurazan; Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member | 1998 |
Swelling-activated chloride currents in a drug-sensitive cell line and a P glycoprotein-expressing derivative are underlied by channels with the same pharmacological properties.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; ATP Binding Cassette Transporter, Subfamily B, Mem | 1998 |
Alpha-fetoprotein-mediated targeting--a new strategy to overcome multidrug resistance of tumour cells in vitro.
Topics: alpha-Fetoproteins; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Memb | 1997 |
Suppression of P-glycoprotein expression and multidrug resistance by DNA cross-linking agents.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; ATP Binding Cassette Transporter, | 1997 |
Sensitive and rapid bioassay for analysis of P-glycoprotein-inhibiting activity of chemosensitizers in patient serum.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Assay; Breast Neoplasms; Cyclosp | 1996 |
Doxorubicin cellular pharmacokinetics plays no role in chemosensitizing effect of verapamil on Swiss-3T3 cells.
Topics: 3T3 Cells; Animals; Antibiotics, Antineoplastic; Breast Neoplasms; Doxorubicin; Drug Interactions; G | 1996 |
[A new method for the intravital assessment of the functional activity of the membrane transporters performing the efflux of antitumor preparations from the cells of solid tumor specimens].
Topics: Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Tr | 1999 |
Modulation of multidrug resistance by three bisbenzyl-isoquinolines in comparison with verapamil.
Topics: Alkaloids; Antihypertensive Agents; Breast Neoplasms; Doxorubicin; Drug Resistance, Multiple; Drugs, | 1997 |
Discovery of differentially expressed genes associated with paclitaxel resistance using cDNA array technology: analysis of interleukin (IL) 6, IL-8, and monocyte chemotactic protein 1 in the paclitaxel-resistant phenotype.
Topics: Breast Neoplasms; Chemokine CCL2; DNA, Complementary; Doxorubicin; Drug Resistance, Multiple; Female | 1999 |
The influence of expression of P-glycoprotein on the penetration of anticancer drugs through multicellular layers.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neop | 2000 |
Increased resistance to anticancer therapy of mouse cells lacking the poly(ADP-ribose) polymerase attributable to up-regulation of the multidrug resistance gene product P-glycoprotein.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neop | 2000 |
Verapamil decreases accumulation of 99Tcm-MIBI and 99Tcm-tetrofosmin in human breast cancer and soft tissue sarcoma cell lines.
Topics: Adenocarcinoma; Breast Neoplasms; Calcium Channel Blockers; Cell Line; Cell Survival; Female; Humans | 2001 |
A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).
Topics: Adenosine Triphosphatases; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cass | 2001 |
[A comparative study on effect of two bisbenzylisoquinolines, tetrandrine and berbamine, on reversal of multidrug resistance].
Topics: Alkaloids; Animals; Benzylisoquinolines; Breast Neoplasms; Calcium Channel Blockers; Doxorubicin; Dr | 1997 |
[Compared study on Fura-2/AM assay and MTT assay for screening multidrug resistant modulators].
Topics: Bepridil; Breast Neoplasms; Calcium Channel Blockers; Drug Resistance, Multiple; Drug Resistance, Ne | 1997 |
Doxycycline induces expression of P glycoprotein in MCF-7 breast carcinoma cells.
Topics: Anti-Bacterial Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Northern; | 2002 |
[Reversal of nomegestrol acetate on multidrug resistance in drug-resistant human breast cancer cell line MCF7/ADR].
Topics: Antigens, Neoplasm; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell | 2002 |
Modulation by D,L-buthionine-S,R-sulphoximine of etoposide cytotoxicity on human non-small cell lung, ovarian and breast carcinoma cell lines.
Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Buthionine Sulfoximine; Carcinoma, Non-Small-Cell | 1992 |
Reduced intracellular drug accumulation in the absence of P-glycoprotein (mdr1) overexpression in mitoxantrone-resistant human MCF-7 breast cancer cells.
Topics: Adenosine Triphosphate; Antibodies; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blottin | 1992 |
A new functional role for P-glycoprotein: efflux pump for benzo(alpha)pyrene in human breast cancer MCF-7 cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzo(a)pyrene; Breast Neoplasms; Doxorubic | 1992 |
Evaluation of a method for detection of cells with reduced drug retention in solid tumours.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Breast Neopl | 1992 |
Loss of epithelial markers and acquisition of vimentin expression in adriamycin- and vinblastine-resistant human breast cancer cell lines.
Topics: Antibodies; Biomarkers, Tumor; Breast Neoplasms; Cell Adhesion Molecules; Cytoskeletal Proteins; Des | 1992 |
Inhibition of cancer cell growth by calcium channel antagonists in the athymic mouse.
Topics: Amlodipine; Animals; Breast Neoplasms; Calcium; Calcium Channel Blockers; Cell Division; Culture Med | 1992 |
Verapamil upregulates sensitivity of human colon and breast cancer cells to LAK-cytotoxicity in vitro.
Topics: Breast Neoplasms; Calcimycin; Calcium; Colonic Neoplasms; Cytotoxicity, Immunologic; Female; Humans; | 1991 |
The activity of verapamil as a resistance modifier in vitro in drug resistant human tumour cell lines is not stereospecific.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Doxorubicin; Drug Resista | 1990 |
P-glycoprotein-independent mechanism of resistance to VP-16 in multidrug-resistant tumor cell lines: pharmacokinetic and photoaffinity labeling studies.
Topics: Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding, | 1990 |
Glutathione depletion in human and in rat multi-drug resistant breast cancer cell lines.
Topics: Animals; Breast Neoplasms; Buthionine Sulfoximine; Doxorubicin; Drug Resistance; Female; Glutathione | 1991 |
A phase II study of intensive-dose epirubicin/verapamil as induction therapy followed by intensive-dose ifosfamide for advanced breast cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Evaluation; Epir | 1990 |
Cross-resistance to the lipid-soluble antifolate trimetrexate in human carcinoma cells with the multidrug-resistant phenotype.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carcinoma; Cell Line; Drug Resistance; Female; Gen | 1989 |
4'epidoxorubicin plus verapamil in anthracycline--refractory cancer patients.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Resistance; Epir | 1989 |
Anti-transferrin receptor antibody linked to Pseudomonas exotoxin as a model immunotoxin in human ovarian carcinoma cell lines.
Topics: ADP Ribose Transferases; Bacterial Toxins; Breast Neoplasms; Cell Line; Cell Survival; Colony-Formin | 1985 |
Effect of verapamil on in vitro cytotoxicity of adriamycin and vinblastine in human tumor cells.
Topics: Breast Neoplasms; Cell Survival; Clone Cells; Colonic Neoplasms; Doxorubicin; Drug Resistance; Esoph | 1987 |
[Verapamil inhibits DNA synthesis in vitro. II. Study of the MCF7 and Jurkat neoplastic cell lines].
Topics: Breast Neoplasms; Calcium; Cell Line; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Female | 1985 |