verapamil has been researched along with Brain Vascular Disorders in 27 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "(S)-Emopamil has a less potent calcium antagonistic effect (EC50 = 270 nmol/l) on the aorta than verapamil and gallopamil (EC50 = 35 and 14 nmol/l, respectively)." | 5.28 | (S)-emopamil, a novel calcium and serotonin antagonist for the treatment of cerebrovascular disorders. 1st communication: pharmacological profile. ( Hofmann, HP; Raschack, M; Unger, L, 1989) |
| "A 20-year-old female with hemiplegic migraine was treated during an acute attack with intravenous verapamil, which reproducibly resolved the headache within 20 min but did not affect her hemiplegia." | 3.74 | Hemiplegic migraine: hyperperfusion and abortive therapy with intravenous verapamil. ( Dulli, DA; Hsu, DA; Kiff, JE; Rowley, HA; Stafstrom, CE, 2008) |
| "In stroke-prone spontaneously hypertensive rats, oral long-term treatment with verapamil, propranolol, hydrochlorothiazide, and dihydralazine attenuated the development of hypertension." | 3.67 | Development of hypertension and life span in stroke-prone spontaneously hypertensive rats during oral long-term treatment with various antihypertensive drugs. ( Gries, J; Kretzschmar, R; Neumann, BW, 1989) |
| " However, 4-hourly dosing is a practical limitation and verapamil has been proposed as an alternative." | 3.01 | Verapamil in the treatment of reversible cerebral vasoconstriction syndrome: A systematic review. ( Bacchi, S; Bagster, M; Collins, L; Goh, R; Gupta, A; Kleinig, O; Kleinig, T; Kovoor, J; Lam, L; Proudman, W; Schultz, D; Zhang, R, 2023) |
| " These differences can be attributed at least in part to the low catecholamine profile of verapamil and the marked rapid adrenergic activation with short-acting nifedipine, which could also explain the adverse effects found when this agent is given to patients with acute coronary syndromes." | 2.40 | Calcium channel blockers for hypertension: dissecting the evidence for adverse effects. ( Opie, LH, 1997) |
| "(S)-Emopamil has a less potent calcium antagonistic effect (EC50 = 270 nmol/l) on the aorta than verapamil and gallopamil (EC50 = 35 and 14 nmol/l, respectively)." | 1.28 | (S)-emopamil, a novel calcium and serotonin antagonist for the treatment of cerebrovascular disorders. 1st communication: pharmacological profile. ( Hofmann, HP; Raschack, M; Unger, L, 1989) |
| "Diltiazem-treated animals had decreased cerebral H2O content, but had a marked increase in the area of nonperfused brain, a finding associated with the high incidence of transtentorial herniation in the diltiazem-treated animals." | 1.27 | Effects of verapamil and diltiazem on acute stroke in cats. ( Dempsey, RJ; Donaldson, DL; Meyer, KL; Roy, MW; Tibbs, PA; Young, AB, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (29.63) | 18.7374 |
| 1990's | 12 (44.44) | 18.2507 |
| 2000's | 3 (11.11) | 29.6817 |
| 2010's | 2 (7.41) | 24.3611 |
| 2020's | 2 (7.41) | 2.80 |
| Authors | Studies |
|---|---|
| Collins, L | 1 |
| Lam, L | 1 |
| Kleinig, O | 1 |
| Proudman, W | 1 |
| Zhang, R | 1 |
| Bagster, M | 1 |
| Kovoor, J | 1 |
| Gupta, A | 1 |
| Goh, R | 1 |
| Bacchi, S | 1 |
| Schultz, D | 1 |
| Kleinig, T | 1 |
| Ospel, JM | 1 |
| Wright, CH | 1 |
| Jung, R | 1 |
| Vidal, LLM | 1 |
| Manjila, S | 1 |
| Singh, G | 1 |
| Heck, DV | 1 |
| Ray, A | 1 |
| Blackham, KA | 1 |
| Fletcher, JJ | 1 |
| Kramer, AH | 1 |
| Bleck, TP | 1 |
| Solenski, NJ | 1 |
| Chatterjee, N | 1 |
| Domoto-Reilly, K | 1 |
| Fecci, PE | 1 |
| Schwamm, LH | 1 |
| Singhal, AB | 1 |
| French, KF | 1 |
| Hoesch, RE | 1 |
| Allred, J | 1 |
| Wilder, M | 1 |
| Smith, AG | 1 |
| Digre, KB | 1 |
| La Barge, DV | 1 |
| Ducros, A | 1 |
| Hsu, DA | 1 |
| Stafstrom, CE | 1 |
| Rowley, HA | 1 |
| Kiff, JE | 1 |
| Dulli, DA | 1 |
| Hansen, JF | 1 |
| Novosel, D | 1 |
| Lang, MG | 1 |
| Noll, G | 1 |
| Lüscher, TF | 1 |
| Salerno, SM | 1 |
| Zugibe, FT | 1 |
| Blackshear, JL | 1 |
| Kopecky, SL | 1 |
| Litin, SC | 1 |
| Safford, RE | 1 |
| Hammill, SC | 1 |
| Münter, K | 1 |
| Hergenröder, S | 1 |
| Jochims, K | 1 |
| Kirchengast, M | 1 |
| Hunter, AJ | 1 |
| Opie, LH | 1 |
| Black, HR | 1 |
| Elliott, WJ | 1 |
| Neaton, JD | 1 |
| Grandits, G | 1 |
| Grambsch, P | 1 |
| Grimm, RH | 1 |
| Hansson, L | 1 |
| Lacoucière, Y | 1 |
| Muller, J | 1 |
| Sleight, P | 1 |
| Weber, MA | 1 |
| White, WB | 1 |
| Williams, G | 1 |
| Wittes, J | 1 |
| Zanchetti, A | 1 |
| Fakouhi, TD | 1 |
| Shah, AR | 1 |
| Passalacqua, BR | 1 |
| Smeda, JS | 1 |
| Burtsev, EM | 3 |
| Shprakh, VV | 1 |
| Savkov, VS | 3 |
| Ishchenko, MM | 1 |
| Dorogiĭ, AN | 1 |
| Nechaĭ, EE | 1 |
| Shkrobot, SI | 1 |
| Gries, J | 1 |
| Kretzschmar, R | 1 |
| Neumann, BW | 1 |
| Hofmann, HP | 1 |
| Raschack, M | 1 |
| Unger, L | 1 |
| Zhuravlev, AK | 1 |
| Murashko, VV | 1 |
| Kamchatnov, PR | 1 |
| Stern, WE | 1 |
| Hakim, AM | 1 |
| Roy, MW | 1 |
| Dempsey, RJ | 1 |
| Meyer, KL | 1 |
| Donaldson, DL | 1 |
| Tibbs, PA | 1 |
| Young, AB | 1 |
5 reviews available for verapamil and Brain Vascular Disorders
| Article | Year |
|---|---|
Verapamil in the treatment of reversible cerebral vasoconstriction syndrome: A systematic review.
Topics: Cerebrovascular Disorders; Humans; Nimodipine; Vasoconstriction; Vasospasm, Intracranial; Verapamil | 2023 |
[Acute and chronic headaches].
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspir | 2006 |
Management of atrial fibrillation in adults: prevention of thromboembolism and symptomatic treatment.
Topics: Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Anti-Arrhythmia Agents; Aspirin; Atrial Fibri | 1996 |
Calcium antagonists: their role in neuroprotection.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Calcium Channels; Cerebrovascular Disorders; Dihy | 1997 |
Calcium channel blockers for hypertension: dissecting the evidence for adverse effects.
Topics: Calcium Channel Blockers; Catecholamines; Cerebrovascular Disorders; Drug Evaluation; Gastrointestin | 1997 |
2 trials available for verapamil and Brain Vascular Disorders
| Article | Year |
|---|---|
Postinfarct treatment with verapamil. Effect of verapamil in patients with hypertension.
Topics: Cerebrovascular Disorders; Death, Sudden, Cardiac; Denmark; Double-Blind Method; Follow-Up Studies; | 1993 |
Rationale and design for the Controlled ONset Verapamil INvestigation of Cardiovascular Endpoints (CONVINCE) Trial.
Topics: Aged; Antihypertensive Agents; Atenolol; Cardiovascular Diseases; Cerebrovascular Disorders; Double- | 1998 |
20 other studies available for verapamil and Brain Vascular Disorders
| Article | Year |
|---|---|
Intra-Arterial Verapamil Treatment in Oral Therapy-Refractory Reversible Cerebral Vasoconstriction Syndrome.
Topics: Adult; Aged; Cerebrovascular Disorders; Female; Humans; Infusions, Intra-Arterial; Male; Middle Aged | 2020 |
Overlapping features of eclampsia and postpartum angiopathy.
Topics: Adult; Cerebrovascular Disorders; Eclampsia; Female; Headache; Humans; Methylprednisolone; Nicardipi | 2009 |
Licorice-associated reversible cerebral vasoconstriction with PRES.
Topics: Administration, Oral; Brain; Cerebral Angiography; Cerebrovascular Circulation; Cerebrovascular Diso | 2010 |
Repetitive use of intra-arterial verapamil in the treatment of reversible cerebral vasoconstriction syndrome.
Topics: Adult; Aged, 80 and over; Cerebral Arteries; Cerebrovascular Disorders; Female; Humans; Radiography; | 2012 |
Hemiplegic migraine: hyperperfusion and abortive therapy with intravenous verapamil.
Topics: Adult; Brain; Cerebral Angiography; Cerebral Arteries; Cerebrovascular Circulation; Cerebrovascular | 2008 |
Endothelial dysfunction in aorta of the spontaneously hypertensive, stroke-prone rat: effects of therapy with verapamil and trandolapril alone and in combination.
Topics: Administration, Oral; Angiotensin-Converting Enzyme Inhibitors; Animals; Body Weight; Cerebrovascula | 1994 |
Calcium channel antagonists. What do the second-generation agents have to offer?
Topics: Arteriosclerosis; Calcium Channel Blockers; Cardiovascular Diseases; Cerebrovascular Disorders; Dihy | 1994 |
Individual and combined effects of verapamil or trandolapril on attenuating hypertensive glomerulopathic changes in the stroke-prone rat.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Calcium | 1996 |
Case report: sustained-release verapamil overdose causing stroke: an unusual complication.
Topics: Cerebrovascular Disorders; Delayed-Action Preparations; Drug Overdose; Female; Humans; Middle Aged; | 1992 |
Cerebral vascular changes associated with hemorrhagic stroke in hypertension.
Topics: Aging; Animals; Cerebral Arteries; Cerebral Hemorrhage; Cerebrovascular Circulation; Cerebrovascular | 1992 |
[A differential approach to cavinton and finoptin treatment of patients with circulatory encephalopathies].
Topics: Aged; Cerebrovascular Circulation; Cerebrovascular Disorders; Humans; Middle Aged; Phosphodiesterase | 1992 |
[Vasoactive and cardiotonic drugs in the treatment of initial manifestations of cerebrovascular insufficiency in occlusive diseases of major blood vessels of the head].
Topics: Adult; Aged; Aminophylline; Arterial Occlusive Diseases; Carotid Artery Diseases; Cerebrovascular Di | 1991 |
Development of hypertension and life span in stroke-prone spontaneously hypertensive rats during oral long-term treatment with various antihypertensive drugs.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cerebrovascular Disorders; Dihydralazine; Heart; H | 1989 |
[Calcium antagonists (finoptin and senzit) in the treatment of cerebrovascular disorders].
Topics: Adult; Age Factors; Arteriosclerosis; Cerebrovascular Disorders; Drug Evaluation; Fendiline; Humans; | 1989 |
[Experience in the use of finoptin (verapamil) in cerebrovascular diseases].
Topics: Cerebrovascular Disorders; Electrocardiography; Hemodynamics; Humans; Middle Aged; Plethysmography, | 1989 |
(S)-emopamil, a novel calcium and serotonin antagonist for the treatment of cerebrovascular disorders. 1st communication: pharmacological profile.
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Cerebrovascular Disorders; Female; Guinea P | 1989 |
[Effect of corinfar and finoptin on lipid peroxidation].
Topics: Adult; Calcium Channel Blockers; Cerebrovascular Disorders; Humans; Lipid Peroxides; Middle Aged; My | 1988 |
Effects of verapamil and diltiazem: correction.
Topics: Animals; Benzazepines; Cats; Cerebrovascular Disorders; Diltiazem; Verapamil | 1986 |
Cerebral acidosis in focal ischemia: II. Nimodipine and verapamil normalize cerebral pH following middle cerebral artery occlusion in the rat.
Topics: Acidosis; Animals; Arterial Occlusive Diseases; Brain; Brain Diseases; Brain Ischemia; Calcium Chann | 1986 |
Effects of verapamil and diltiazem on acute stroke in cats.
Topics: Animals; Benzazepines; Blood Volume; Brain; Brain Edema; Cats; Cerebrovascular Circulation; Cerebrov | 1985 |