verapamil has been researched along with Brain Ischemia in 46 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "High-dose IA verapamil treatment is well-tolerated in the high-risk aneurysmal subarachnoid hemorrhage population that experience severe, symptomatic CVS with good functional outcomes at follow-up." | 8.02 | The clinical impact and safety profile of high-dose intra-arterial verapamil treatment for cerebral vasospasm following aneurysmal subarachnoid hemorrhage. ( Esplin, N; Gigliotti, MJ; Mao, G; Sexton, K, 2021) |
| "To observe the protective effect of verapamil pretreatment against cerebral ischemia-reperfusion injury in gerbils." | 7.74 | [Protective effect of verapamil pretreatment against cerebral ischemia-reperfusion injury in gerbils]. ( Ding, N; Wang, DF; Wang, F; Xiao, H, 2007) |
| "We sought to determine the effects of two different calcium channel antagonists, S-emopamil and nimodipine, on hippocampal glutamate and glycine release and to compare their effects to those of mild hypothermia." | 7.68 | Effect of S-emopamil, nimodipine, and mild hypothermia on hippocampal glutamate concentrations after repeated cerebral ischemia in rabbits. ( Matsumoto, M; Scheller, MS; Strnat, MA; Zornow, MH, 1993) |
| "The effect of benidipine on experimental cerebral ischemia was investigated in rats subjected to occlusion of the bilateral common carotid arteries." | 7.68 | Effect of benidipine hydrochloride (KW-3049), on cerebral ischemia induced by bilateral occlusion of the common carotid arteries in rats. ( Karasawa, A; Kubo, K; Shirakura, S, 1993) |
| " To test the clinical usefulness of these agents in averting such damage, high-dose verapamil was administered to baboons and pigs after partial cerebral ischemia for varying periods of time." | 7.67 | Lack of efficacy of high-dose verapamil in preventing brain damage in baboons and pigs after prolonged partial cerebral ischemia. ( Barnard, CN; Cooper, DK; Lanza, RP, 1984) |
| "Digoxin treatment produced a significant decrease in cerebral infarct size and reversal of I/R induced impairment of memory and motor incoordination." | 5.35 | Studies on cerebral protection of digoxin against ischemia/reperfusion injury in mice. ( Jaggi, AS; Kaur, S; Rehni, AK; Singh, N, 2009) |
| "High-dose IA verapamil treatment is well-tolerated in the high-risk aneurysmal subarachnoid hemorrhage population that experience severe, symptomatic CVS with good functional outcomes at follow-up." | 4.02 | The clinical impact and safety profile of high-dose intra-arterial verapamil treatment for cerebral vasospasm following aneurysmal subarachnoid hemorrhage. ( Esplin, N; Gigliotti, MJ; Mao, G; Sexton, K, 2021) |
| "To observe the protective effect of verapamil pretreatment against cerebral ischemia-reperfusion injury in gerbils." | 3.74 | [Protective effect of verapamil pretreatment against cerebral ischemia-reperfusion injury in gerbils]. ( Ding, N; Wang, DF; Wang, F; Xiao, H, 2007) |
| "Levemopamil, a novel calcium channel blocker with antagonistic action on serotonin S2-receptors has been reported to be a promising compound for therapy in cerebral ischemia." | 3.69 | Failure of levemopamil to improve histological outcome following temporary occlusion of the middle cerebral artery in cats. ( Croul, S; Gomi, S; Greenberg, JH; Reivich, M, 1995) |
| "In an in vitro model of cerebral ischemia we investigated the functional consequences of repeated hypoxias and the potential protective effect of the N-methyl-D-aspartate (NMDA) receptor antagonist D-2-amino-5-phosphonovaleric acid (D-APV) and the calcium channel blocker verapamil in preventing the expression of pathophysiological activity." | 3.68 | Role of NMDA receptors and voltage-activated calcium channels in an in vitro model of cerebral ischemia. ( Heinemann, U; Kral, T; Luhmann, HJ; Mittmann, T, 1993) |
| "We sought to determine the effects of two different calcium channel antagonists, S-emopamil and nimodipine, on hippocampal glutamate and glycine release and to compare their effects to those of mild hypothermia." | 3.68 | Effect of S-emopamil, nimodipine, and mild hypothermia on hippocampal glutamate concentrations after repeated cerebral ischemia in rabbits. ( Matsumoto, M; Scheller, MS; Strnat, MA; Zornow, MH, 1993) |
| "The effect of benidipine on experimental cerebral ischemia was investigated in rats subjected to occlusion of the bilateral common carotid arteries." | 3.68 | Effect of benidipine hydrochloride (KW-3049), on cerebral ischemia induced by bilateral occlusion of the common carotid arteries in rats. ( Karasawa, A; Kubo, K; Shirakura, S, 1993) |
| "A study was performed to examine the effects of the calcium-channel blocker levemopamil on neurologic outcome and neuropathology in a clinically relevant model of complete global cerebral ischemia (ventricular fibrillation in cats)." | 3.68 | Effects of levemopamil on neurologic and histologic outcome after cardiac arrest in cats. ( Drummond, JC; Fleischer, JE; Grafe, MR; Nakakimura, K; Scheller, MS; Shapiro, HM; Zornow, MH, 1992) |
| "To provide evidence to support the calcium hypothesis of cerebral ischemia, we examined the effects of extracellular calcium and calcium antagonists (verapamil, flunarizine, nicardipine) on in vitro 'ischemia' using guinea pig hippocampal slices." | 3.68 | Effects of calcium and calcium antagonists against deprivation of glucose and oxygen in guinea pig hippocampal slices. ( Amagasa, M; Ogawa, A; Yoshimoto, T, 1990) |
| " To test the clinical usefulness of these agents in averting such damage, high-dose verapamil was administered to baboons and pigs after partial cerebral ischemia for varying periods of time." | 3.67 | Lack of efficacy of high-dose verapamil in preventing brain damage in baboons and pigs after prolonged partial cerebral ischemia. ( Barnard, CN; Cooper, DK; Lanza, RP, 1984) |
| "(S)-Emopamil pre-treatment, 20 mg/kg i." | 2.38 | Calcium antagonists in the treatment of experimental cerebral ischemia. ( Busto, R; Dietrich, WD; Ginsberg, MD; Globus, MY; Lin, B; Morikawa, E, 1991) |
| "Delayed cerebral ischemia (DCI) is a major cause of morbidity and mortality in aneurysmal subarachnoid hemorrhage." | 1.42 | Results of an International Survey on the Investigation and Endovascular Management of Cerebral Vasospasm and Delayed Cerebral Ischemia. ( Bulsara, KR; Chen, PR; Coulthard, A; Goddard, AJ; Hollingworth, M; Söderman, M, 2015) |
| "These data suggest that acute cerebral ischemia may specifically disturb cardiac function and calcium homeostasis, which are related to increase of Ca(v)1." | 1.36 | Cerebral ischemia elicits aberration in myocardium contractile function and intracellular calcium handling. ( Ai, J; Hang, P; Li, J; Lu, Y; Sun, L; Wang, N; Wu, W; Yang, B; Zhang, R; Zhang, T, 2010) |
| "Cerebral ischemic model was made by middle cerebral artery occlusion (MCAO)." | 1.35 | Aberration of L-type calcium channel in cardiac myocytes is one of the mechanisms of arrhythmia induced by cerebral ischemia. ( Du, J; Pan, G; Sun, L; Wang, L; Yang, B; Zhang, G; Zhang, Y, 2008) |
| "Digoxin treatment produced a significant decrease in cerebral infarct size and reversal of I/R induced impairment of memory and motor incoordination." | 1.35 | Studies on cerebral protection of digoxin against ischemia/reperfusion injury in mice. ( Jaggi, AS; Kaur, S; Rehni, AK; Singh, N, 2009) |
| "It is known that exertion can aggravate migraine headache." | 1.31 | Hemiplegic migraine induced by exertion. ( Adams, HP; Afifi, A; Fattal, D; Razavi, B; Razavi, M, 2000) |
| "Treatment with dextromethorphan or levemopamil reduced the deficit in spatial learning by limiting the increase in swim distance due to ischemia." | 1.30 | Global ischemic neuronal damage relates to behavioural deficits: a pharmacological approach. ( Block, F; Schwarz, M, 1998) |
| "(S)-Emopamil is a novel calcium channel blocker of the phenylalkylamine class, with potent serotonin S2 antagonist activity." | 1.28 | (S)-emopamil protects against global ischemic brain injury in rats. ( Busto, R; Dietrich, WD; Ginsberg, MD; Lin, BW, 1990) |
| "Forebrain ischemia was induced and maintained for 20 min by lowering arterial blood pressure to approximately 40 mmHg and clamping both carotid arteries." | 1.28 | (S)-emopamil, a novel calcium and serotonin antagonist for the treatment of cerebrovascular disorders. 3rd communication: effect on postischemic cerebral blood flow and metabolism, and ischemic neuronal cell death. ( Hofmann, HP; Szabo, L, 1989) |
| "Verapamil was most active as a vasodilator in muscular microvasculature." | 1.27 | Pharmacologic inhibition of cerebral vasospasm in ischemia, hallucinogen ingestion, and hypomagnesemia: barbiturates, calcium antagonists, and magnesium. ( Altura, BM; Altura, BT, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (34.78) | 18.7374 |
| 1990's | 15 (32.61) | 18.2507 |
| 2000's | 6 (13.04) | 29.6817 |
| 2010's | 8 (17.39) | 24.3611 |
| 2020's | 1 (2.17) | 2.80 |
| Authors | Studies |
|---|---|
| Monjas, L | 1 |
| Arce, MP | 1 |
| León, R | 1 |
| Egea, J | 1 |
| Pérez, C | 1 |
| Villarroya, M | 1 |
| López, MG | 1 |
| Gil, C | 1 |
| Conde, S | 1 |
| Rodríguez-Franco, MI | 1 |
| Mao, G | 1 |
| Gigliotti, MJ | 1 |
| Esplin, N | 1 |
| Sexton, K | 1 |
| Fraser, JF | 2 |
| Maniskas, M | 1 |
| Trout, A | 1 |
| Lukins, D | 1 |
| Parker, L | 1 |
| Stafford, WL | 1 |
| Alhajeri, A | 1 |
| Roberts, J | 1 |
| Bix, GJ | 2 |
| Hollingworth, M | 1 |
| Chen, PR | 1 |
| Goddard, AJ | 1 |
| Coulthard, A | 1 |
| Söderman, M | 1 |
| Bulsara, KR | 1 |
| Maniskas, ME | 1 |
| Roberts, JM | 1 |
| Aron, I | 1 |
| Sun, L | 2 |
| Du, J | 1 |
| Zhang, G | 1 |
| Zhang, Y | 1 |
| Pan, G | 1 |
| Wang, L | 1 |
| Yang, B | 2 |
| Kaur, S | 1 |
| Rehni, AK | 1 |
| Singh, N | 1 |
| Jaggi, AS | 1 |
| Yui, J | 1 |
| Hatori, A | 1 |
| Kawamura, K | 1 |
| Yanamoto, K | 1 |
| Yamasaki, T | 1 |
| Ogawa, M | 1 |
| Yoshida, Y | 1 |
| Kumata, K | 1 |
| Fujinaga, M | 1 |
| Nengaki, N | 1 |
| Fukumura, T | 1 |
| Suzuki, K | 1 |
| Zhang, MR | 1 |
| Ai, J | 1 |
| Wang, N | 1 |
| Zhang, R | 1 |
| Li, J | 1 |
| Zhang, T | 1 |
| Wu, W | 1 |
| Hang, P | 1 |
| Lu, Y | 1 |
| El-Zammar, ZM | 1 |
| Latorre, JG | 1 |
| Wang, D | 1 |
| Satyan, S | 1 |
| Elnour, E | 1 |
| Kamel, A | 1 |
| Devasenapathy, A | 1 |
| Lodi, YM | 1 |
| Fang, W | 1 |
| Lv, P | 1 |
| Geng, X | 1 |
| Shang, E | 1 |
| Yang, Q | 1 |
| Sha, L | 1 |
| Li, Y | 1 |
| Ding, N | 1 |
| Wang, F | 1 |
| Xiao, H | 1 |
| Wang, DF | 1 |
| Omura, Y | 1 |
| Lanza, RP | 1 |
| Cooper, DK | 1 |
| Barnard, CN | 1 |
| Altura, BM | 1 |
| Altura, BT | 1 |
| Hagberg, H | 1 |
| Lehmann, A | 1 |
| Hamberger, A | 1 |
| Reedy, DP | 1 |
| Little, JR | 1 |
| Capraro, JA | 1 |
| Slugg, RM | 1 |
| Lesser, RP | 1 |
| Kim, KW | 1 |
| Kim, DC | 1 |
| Kim, YH | 1 |
| Eun, YA | 1 |
| Kim, HI | 1 |
| Cho, KP | 1 |
| Sorrenti, V | 1 |
| Di Giacomo, C | 1 |
| Renis, M | 1 |
| Russo, A | 1 |
| La Delfa, C | 1 |
| Perez-Polo, JR | 1 |
| Vanella, A | 1 |
| Kral, T | 1 |
| Luhmann, HJ | 1 |
| Mittmann, T | 1 |
| Heinemann, U | 1 |
| Matsumoto, M | 1 |
| Scheller, MS | 2 |
| Zornow, MH | 2 |
| Strnat, MA | 1 |
| Shirakura, S | 1 |
| Karasawa, A | 1 |
| Kubo, K | 1 |
| Gomi, S | 1 |
| Greenberg, JH | 1 |
| Croul, S | 1 |
| Reivich, M | 1 |
| Hunter, AJ | 1 |
| Leira, EC | 1 |
| Ajax, T | 1 |
| Adams, HP | 2 |
| Block, F | 1 |
| Schwarz, M | 1 |
| Razavi, M | 1 |
| Razavi, B | 1 |
| Fattal, D | 1 |
| Afifi, A | 1 |
| Bogaert, L | 1 |
| O'Neill, MJ | 1 |
| Moonen, J | 1 |
| Sarre, S | 1 |
| Smolders, I | 1 |
| Ebinger, G | 1 |
| Michotte, Y | 1 |
| Dan, Y | 1 |
| Murakami, H | 1 |
| Koyabu, N | 1 |
| Ohtani, H | 1 |
| Sawada, Y | 1 |
| Shimauchi, M | 1 |
| Yamamoto, YL | 2 |
| Fleischer, JE | 1 |
| Nakakimura, K | 1 |
| Drummond, JC | 1 |
| Grafe, MR | 1 |
| Shapiro, HM | 1 |
| Ginsberg, MD | 2 |
| Lin, B | 1 |
| Morikawa, E | 1 |
| Dietrich, WD | 2 |
| Busto, R | 2 |
| Globus, MY | 1 |
| Amagasa, M | 1 |
| Ogawa, A | 1 |
| Yoshimoto, T | 1 |
| Lin, BW | 1 |
| Ishchenko, MM | 2 |
| Shkrobot, SI | 1 |
| Weber, J | 1 |
| Bielenberg, GW | 3 |
| Krieglstein, J | 3 |
| Defeudis, FV | 1 |
| Lobas, VA | 1 |
| Weintraub, MI | 1 |
| Szabo, L | 1 |
| Hofmann, HP | 1 |
| Ueda, T | 1 |
| Diksic, M | 1 |
| Berger, L | 1 |
| Hakim, AM | 2 |
| Haubruck, H | 1 |
| Beck, T | 1 |
| Sauer, D | 1 |
| Burniol, M | 1 |
| Wendling, WW | 1 |
| Harakal, C | 1 |
3 reviews available for verapamil and Brain Ischemia
| Article | Year |
|---|---|
Calcium antagonists: their role in neuroprotection.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Calcium Channels; Cerebrovascular Disorders; Dihy | 1997 |
Calcium antagonists in the treatment of experimental cerebral ischemia.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Humans; Verapamil | 1991 |
The Ca2+ channel and 5-HT2 receptor antagonist (s)-emopamil in cerebral ischaemia.
Topics: Brain Ischemia; Calcium Channel Blockers; Humans; Serotonin Antagonists; Verapamil | 1989 |
2 trials available for verapamil and Brain Ischemia
| Article | Year |
|---|---|
Intra-arterial verapamil post-thrombectomy is feasible, safe, and neuroprotective in stroke.
Topics: Adult; Aged; Aged, 80 and over; Animals; Anti-Arrhythmia Agents; Brain Ischemia; Cell Death; Cells, | 2017 |
[Effect of calcium antagonists on cerebral and systemic hemodynamics in patients with ischemic disorders of cerebrovascular circulation].
Topics: Adult; Aged; Brain Ischemia; Carotid Artery Diseases; Carotid Artery, Internal; Cerebrovascular Circ | 1989 |
41 other studies available for verapamil and Brain Ischemia
| Article | Year |
|---|---|
Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia.
Topics: Alzheimer Disease; Animals; Brain Ischemia; Calcium Channel Blockers; Cholinesterase Inhibitors; Don | 2017 |
The clinical impact and safety profile of high-dose intra-arterial verapamil treatment for cerebral vasospasm following aneurysmal subarachnoid hemorrhage.
Topics: Aneurysm, Ruptured; Anticonvulsants; Brain Ischemia; Dose-Response Relationship, Drug; Female; Funct | 2021 |
Results of an International Survey on the Investigation and Endovascular Management of Cerebral Vasospasm and Delayed Cerebral Ischemia.
Topics: Adult; Australasia; Brain Ischemia; Disease Management; Endovascular Procedures; Europe; Female; Hea | 2015 |
Stroke neuroprotection revisited: Intra-arterial verapamil is profoundly neuroprotective in experimental acute ischemic stroke.
Topics: Acute Disease; Animals; Apoptosis; Behavior, Animal; Brain Ischemia; Calcium Channel Blockers; Cell | 2016 |
Aberration of L-type calcium channel in cardiac myocytes is one of the mechanisms of arrhythmia induced by cerebral ischemia.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Brain Ischemia; Caffeine; Calcium; Calcium Channel | 2008 |
Studies on cerebral protection of digoxin against ischemia/reperfusion injury in mice.
Topics: Amiloride; Animals; Brain; Brain Ischemia; Calcium; Calcium Signaling; Digoxin; Male; Memory; Mice; | 2009 |
Visualization of early infarction in rat brain after ischemia using a translocator protein (18 kDa) PET ligand [11C]DAC with ultra-high specific activity.
Topics: Acetamides; Animals; Autoradiography; Blood-Brain Barrier; Brain; Brain Ischemia; Carbon Radioisotop | 2011 |
Cerebral ischemia elicits aberration in myocardium contractile function and intracellular calcium handling.
Topics: Aniline Compounds; Animals; Brain Ischemia; Calcium; Calcium Channel Blockers; Calcium Channels, L-T | 2010 |
Intra-arterial vasodilator use during endovascular therapy for acute ischemic stroke might improve reperfusion rate.
Topics: Acute Disease; Adult; Aged; Brain Ischemia; Calcium Channel Blockers; Cerebrovascular Circulation; C | 2012 |
Penetration of verapamil across blood brain barrier following cerebral ischemia depending on both paracellular pathway and P-glycoprotein transportation.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Bloo | 2013 |
[Protective effect of verapamil pretreatment against cerebral ischemia-reperfusion injury in gerbils].
Topics: Animals; Brain; Brain Ischemia; Endothelins; Gerbillinae; Glutathione; Malondialdehyde; Receptors, C | 2007 |
Effects of an electrical field and its polarity on an abnormal part of the body or organ representation point associated with a diseased internal organ, and its influence on the Bi-Digital O-Ring Test (simple, non-invasive dysfunction localization method)
Topics: Acupuncture Therapy; Adult; Aspirin; Brain Ischemia; Child; Coronary Disease; Electric Stimulation T | 1982 |
Lack of efficacy of high-dose verapamil in preventing brain damage in baboons and pigs after prolonged partial cerebral ischemia.
Topics: Animals; Blood Pressure; Brain Damage, Chronic; Brain Ischemia; Drug Evaluation, Preclinical; Infusi | 1984 |
Pharmacologic inhibition of cerebral vasospasm in ischemia, hallucinogen ingestion, and hypomagnesemia: barbiturates, calcium antagonists, and magnesium.
Topics: Animals; Barbiturates; Brain Ischemia; Calcium Channel Blockers; Cerebral Arteries; Magnesium; Metab | 1983 |
Inhibition by verapamil of ischemic Ca2+ uptake in the rabbit hippocampus.
Topics: Animals; Brain; Brain Ischemia; Calcium; Hippocampus; Humans; Male; Rabbits; Verapamil | 1984 |
Effects of verapamil on acute focal cerebral ischemia.
Topics: Animals; Brain; Brain Ischemia; Calcium; Cats; Cerebrovascular Circulation; Electroencephalography; | 1983 |
Ca2+-dependent and -independent mechanisms of ischaemia-evoked release of [3H]-dopamine from rat striatal slices.
Topics: Animals; Brain Ischemia; Calcium; Calcium Channel Blockers; Corpus Striatum; Culture Techniques; Cyc | 1995 |
Lipid peroxidation and survival in rats following cerebral post-ischaemic reperfusion: effect of drugs with different molecular mechanisms.
Topics: Allopurinol; Animals; Antioxidants; Brain Ischemia; Deferoxamine; Diltiazem; Lipid Peroxidation; Mal | 1994 |
Role of NMDA receptors and voltage-activated calcium channels in an in vitro model of cerebral ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Ischemia; Calcium; Calcium Channels; Electrophysiology; | 1993 |
Effect of S-emopamil, nimodipine, and mild hypothermia on hippocampal glutamate concentrations after repeated cerebral ischemia in rabbits.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Glutamates; Glutamic Acid; Hippocampus; Hypotherm | 1993 |
Effect of benidipine hydrochloride (KW-3049), on cerebral ischemia induced by bilateral occlusion of the common carotid arteries in rats.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Brain; Brain Chemistry; Brain Ischemia; Calcium C | 1993 |
Failure of levemopamil to improve histological outcome following temporary occlusion of the middle cerebral artery in cats.
Topics: Animals; Brain; Brain Ischemia; Calcium Channel Blockers; Cats; Cerebral Arteries; Cerebral Infarcti | 1995 |
Limb-shaking carotid transient ischemic attacks successfully treated with modification of the antihypertensive regimen.
Topics: Adult; Antihypertensive Agents; Brain Ischemia; Carotid Artery Diseases; Doxazosin; Humans; Male; Mo | 1997 |
Global ischemic neuronal damage relates to behavioural deficits: a pharmacological approach.
Topics: Animals; Antioxidants; Ascorbic Acid; Behavior, Animal; Brain Ischemia; Calcium Channel Blockers; De | 1998 |
Hemiplegic migraine induced by exertion.
Topics: Aged; Brain Ischemia; Calcium Channel Blockers; Diagnosis, Differential; Exercise; Hemiplegia; Human | 2000 |
The effects of LY393613, nimodipine and verapamil, in focal cerebral ischaemia.
Topics: Amines; Animals; Brain Ischemia; Butanes; Calcium Channel Blockers; Corpus Striatum; Dopamine; Endot | 2001 |
Distribution of domperidone into the rat brain is increased by brain ischaemia or treatment with the P-glycoprotein inhibitor verapamil.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain | 2002 |
Effects of retrograde perfusion of the brain with combined drug therapy after focal ischemia in rat brain.
Topics: Analysis of Variance; Animals; Autoradiography; Blood-Brain Barrier; Brain Ischemia; Capillary Perme | 1992 |
Effects of levemopamil on neurologic and histologic outcome after cardiac arrest in cats.
Topics: Animals; Blood Gas Analysis; Brain Ischemia; Cardiopulmonary Resuscitation; Cats; Disease Models, An | 1992 |
Effects of calcium and calcium antagonists against deprivation of glucose and oxygen in guinea pig hippocampal slices.
Topics: Action Potentials; Animals; Brain Ischemia; Calcium; Calcium Channel Blockers; Disease Models, Anima | 1990 |
(S)-emopamil protects against global ischemic brain injury in rats.
Topics: Animals; Blood Pressure; Brain; Brain Ischemia; Cell Count; Cerebral Cortex; Hippocampus; Male; Neur | 1990 |
[Effect of finoptin on systemic and cerebral hemodynamics in patients with early cerebrovascular disorders in arteriosclerotic stenosis of major arteries of the head].
Topics: Adult; Aged; Arteriosclerosis; Brain Ischemia; Carotid Artery Diseases; Cerebrovascular Circulation; | 1990 |
Effects of phenylalkylamine calcium entry blockers on postischemic energy metabolism in the isolated perfused rat brain: stereoselective action of emopamil.
Topics: Animals; Brain; Brain Ischemia; Calcium Channel Blockers; Energy Metabolism; Gallopamil; In Vitro Te | 1988 |
Treatment of focal ischemia.
Topics: Animals; Brain Ischemia; Rats; Rats, Inbred Strains; Species Specificity; Verapamil | 1989 |
(S)-emopamil, a novel calcium and serotonin antagonist for the treatment of cerebrovascular disorders. 3rd communication: effect on postischemic cerebral blood flow and metabolism, and ischemic neuronal cell death.
Topics: Animals; Brain Chemistry; Brain Ischemia; Calcium Channel Blockers; Cell Survival; Cerebrovascular C | 1989 |
Transvenous perfusion of the brain with verapamil during focal cerebral ischemia in rats.
Topics: Acute Disease; Animals; Autoradiography; Blood Gas Analysis; Blood Pressure; Brain Ischemia; Cerebra | 1989 |
Calcium channel blockers correct acidosis in ischemic rat brain without altering cerebral blood flow.
Topics: Acidosis; Animals; Brain; Brain Ischemia; Calcium Channel Blockers; Cerebrovascular Circulation; Epo | 1988 |
Effects of calcium entry blocker emopamil on postischemic energy metabolism of the isolated perfused rat brain.
Topics: Animals; Brain; Brain Ischemia; Electroencephalography; Energy Metabolism; In Vitro Techniques; Male | 1987 |
Effects of cerebroprotective agents on cerebral blood flow and on postischemic energy metabolism in the rat brain.
Topics: Animals; Brain; Brain Ischemia; Calcium Channel Blockers; Cerebrovascular Circulation; Energy Metabo | 1987 |
Cerebral acidosis in focal ischemia: II. Nimodipine and verapamil normalize cerebral pH following middle cerebral artery occlusion in the rat.
Topics: Acidosis; Animals; Arterial Occlusive Diseases; Brain; Brain Diseases; Brain Ischemia; Calcium Chann | 1986 |
Comparative actions of pentobarbital and verapamil on canine cerebral and peripheral arteries in vitro.
Topics: Animals; Arteries; Brain Ischemia; Calcium; Cerebral Arteries; Dinoprost; Dogs; Female; In Vitro Tec | 1985 |