verapamil has been researched along with Brain Injuries in 12 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with verapamil (1." | 1.33 | Verapamil prevents, in a dose-dependent way, the loss of ChAT-immunoreactive neurons in the cerebral cortex following lesions of the rat nucleus basalis magnocellularis. ( Caballero-Bleda, M; Popović, M; Popović, N; Puelles, L; van Groen, T; Witter, MP, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, YY | 1 |
| Gao, YX | 1 |
| Gao, W | 1 |
| Xu, Y | 1 |
| Xu, YZ | 1 |
| Wang, YJ | 1 |
| Chang, S | 1 |
| Yu, LG | 1 |
| Zhang, LY | 1 |
| Liao, H | 1 |
| Yang, LF | 1 |
| Pang, T | 1 |
| Qiu, WW | 1 |
| Hwang, JJ | 1 |
| Sherwin, RS | 1 |
| Shahlaie, K | 1 |
| Boggan, JE | 1 |
| Latchaw, RE | 1 |
| Ji, C | 1 |
| Muizelaar, JP | 1 |
| Lee, DJ | 1 |
| Moftakhar, P | 1 |
| Glenn, TC | 1 |
| Vespa, PM | 1 |
| Martin, NA | 1 |
| Maeda, T | 1 |
| Lee, SM | 1 |
| Hovda, DA | 1 |
| Popović, M | 1 |
| Caballero-Bleda, M | 1 |
| Popović, N | 1 |
| Puelles, L | 1 |
| van Groen, T | 1 |
| Witter, MP | 1 |
| Okiyama, K | 2 |
| Rosenkrantz, TS | 1 |
| Smith, DH | 2 |
| Gennarelli, TA | 1 |
| McIntosh, TK | 2 |
| Matyja, E | 1 |
| Kida, E | 1 |
| Ciani, E | 1 |
| Baldinotti, I | 1 |
| Contestabile, A | 1 |
| Thomas, MJ | 1 |
| Damron, DS | 1 |
| Dorman, RV | 1 |
| Koenig, H | 1 |
| Goldstone, AD | 1 |
| Lu, CY | 1 |
1 review available for verapamil and Brain Injuries
| Article | Year |
|---|---|
Posttraumatic vasospasm detected by continuous brain tissue oxygen monitoring: treatment with intraarterial verapamil and balloon angioplasty.
Topics: Adult; Angioplasty, Balloon; Brain Injuries; Female; Humans; Monitoring, Physiologic; Oxygen Consump | 2009 |
11 other studies available for verapamil and Brain Injuries
| Article | Year |
|---|---|
Design, synthesis and biological evaluation of tricyclic diterpene derivatives as novel neuroprotective agents against ischemic brain injury.
Topics: Animals; Brain Injuries; Cell Survival; Diterpenes; Dose-Response Relationship, Drug; Drug Design; G | 2015 |
Verapamil is a potential therapy for hypoglycaemic brain injury.
Topics: Brain; Brain Injuries; Cognitive Dysfunction; Humans; Hypoglycemia; Hypoglycemic Agents; Verapamil | 2018 |
Intra-arterial calcium channel blocker infusion for treatment of severe vasospasm in traumatic brain injury: case report.
Topics: Accidents, Traffic; Adult; Brain Injuries; Calcium Channel Blockers; Cerebral Angiography; Cerebral | 2008 |
Restoration of cerebral vasoreactivity by an L-type calcium channel blocker following fluid percussion brain injury.
Topics: Animals; Antipyrine; Blood Pressure; Brain Injuries; Calcium; Calcium Channel Blockers; Calcium Chan | 2005 |
Verapamil prevents, in a dose-dependent way, the loss of ChAT-immunoreactive neurons in the cerebral cortex following lesions of the rat nucleus basalis magnocellularis.
Topics: Analysis of Variance; Animals; Basal Nucleus of Meynert; Brain Injuries; Calcium Channel Blockers; C | 2006 |
(S)-emopamil attenuates acute reduction in regional cerebral blood flow following experimental brain injury.
Topics: Animals; Brain Injuries; Brain Stem; Calcium Channel Blockers; Cerebellum; Cerebrovascular Circulati | 1994 |
Verapamil reduces quinolinic acid-induced neuronal damage in rat hippocampus in vitro.
Topics: Animals; Brain Injuries; Dendritic Cells; Hippocampus; In Vitro Techniques; Microscopy, Electron; Ne | 1993 |
Sustained, long-lasting inhibition of nitric oxide synthase aggravates the neural damage in some models of excitotoxic brain injury.
Topics: Animals; Basal Nucleus of Meynert; Brain; Brain Injuries; Calcium Channel Blockers; Choline O-Acetyl | 2001 |
Evaluation of a novel calcium channel blocker, (S)-emopamil, on regional cerebral edema and neurobehavioral function after experimental brain injury.
Topics: Animals; Blood Pressure; Brain Edema; Brain Injuries; Calcium Channel Blockers; Male; Memory; Psycho | 1992 |
Calcium-dependent phospholipid catabolism and arachidonic acid mobilization in cerebral minces.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Brain; Brain Injuries; Calcium; Egtazic Acid; Kinetics | 1990 |
Blood-brain barrier breakdown in cold-injured brain is linked to a biphasic stimulation of ornithine decarboxylase activity and polyamine synthesis: both are coordinately inhibited by verapamil, dexamethasone, and aspirin.
Topics: Animals; Aspirin; Blood-Brain Barrier; Brain; Brain Injuries; Cold Temperature; Cycloheximide; Dacti | 1989 |