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verapamil and Brain Edema

verapamil has been researched along with Brain Edema in 8 studies

Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.

Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)

Research Excerpts

ExcerptRelevanceReference
"The authors sought to determine whether amiloride or emopamil could reduce intracranial pressure in experimental brain edema of the rat."3.69Effect of amiloride and emopamil on intracranial pressure. ( Plangger, C; Völkl, H, 1995)
"Three children with familial hemiplegic migraine presented with right-sided weakness, speech difficulty, altered mental status, and gait abnormalities."1.38Variable manifestations of familial hemiplegic migraine associated with reversible cerebral edema in children. ( Asghar, SJ; Glasier, C; Kaushik, C; Milesi-Hallé, A; Sharp, GB, 2012)
"Diltiazem-treated animals had decreased cerebral H2O content, but had a marked increase in the area of nonperfused brain, a finding associated with the high incidence of transtentorial herniation in the diltiazem-treated animals."1.27Effects of verapamil and diltiazem on acute stroke in cats. ( Dempsey, RJ; Donaldson, DL; Meyer, KL; Roy, MW; Tibbs, PA; Young, AB, 1985)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19902 (25.00)18.7374
1990's5 (62.50)18.2507
2000's0 (0.00)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Asghar, SJ1
Milesi-Hallé, A1
Kaushik, C1
Glasier, C1
Sharp, GB1
Rosenberg, GA1
Navratil, MJ1
Elger, B2
Seega, J2
Raschack, M1
Plangger, C1
Völkl, H1
Okiyama, K1
Smith, DH1
Thomas, MJ1
McIntosh, TK1
Roy, MW1
Dempsey, RJ1
Meyer, KL1
Donaldson, DL1
Tibbs, PA1
Young, AB1
Philipp, T1
Nast, HP1

Other Studies

8 other studies available for verapamil and Brain Edema

ArticleYear
Variable manifestations of familial hemiplegic migraine associated with reversible cerebral edema in children.
    Pediatric neurology, 2012, Volume: 47, Issue:3

    Topics: Adolescent; Anti-Inflammatory Agents; Brain Edema; Calcium Channel Blockers; Calcium Channels; Child

2012
(S)-emopamil reduces brain edema from collagenase-induced hemorrhage in rats.
    Stroke, 1994, Volume: 25, Issue:10

    Topics: Animals; Body Water; Brain Chemistry; Brain Edema; Calcium Channel Blockers; Cerebral Hemorrhage; Co

1994
Oedema reduction by levemopamil in focal cerebral ischaemia of spontaneously hypertensive rats studied by magnetic resonance imaging.
    European journal of pharmacology, 1994, Mar-11, Volume: 254, Issue:1-2

    Topics: Animals; Body Temperature; Brain Edema; Calcium Channel Blockers; Cerebral Infarction; Dose-Response

1994
Diffusion- and T2-weighted imaging: evaluation of oedema reduction in focal cerebral ischaemia by the calcium and serotonin antagonist levemopamil.
    Magnetic resonance imaging, 1993, Volume: 11, Issue:3

    Topics: Animals; Brain; Brain Edema; Calcium Channel Blockers; Ischemic Attack, Transient; Magnetic Resonanc

1993
Effect of amiloride and emopamil on intracranial pressure.
    Acta neurologica Scandinavica, 1995, Volume: 92, Issue:5

    Topics: Amiloride; Animals; Brain Edema; Calcium Channel Blockers; Diuretics; Intracranial Pressure; Male; R

1995
Evaluation of a novel calcium channel blocker, (S)-emopamil, on regional cerebral edema and neurobehavioral function after experimental brain injury.
    Journal of neurosurgery, 1992, Volume: 77, Issue:4

    Topics: Animals; Blood Pressure; Brain Edema; Brain Injuries; Calcium Channel Blockers; Male; Memory; Psycho

1992
Effects of verapamil and diltiazem on acute stroke in cats.
    Journal of neurosurgery, 1985, Volume: 63, Issue:6

    Topics: Animals; Benzazepines; Blood Volume; Brain; Brain Edema; Cats; Cerebrovascular Circulation; Cerebrov

1985
[Hypertensive emergencies].
    Der Internist, 1974, Volume: 15, Issue:3

    Topics: Brain Edema; Clonidine; Diazoxide; Digitalis Glycosides; Diuretics; Drug Combinations; Emergencies;

1974