verapamil has been researched along with Blast Phase in 7 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dipyridamole strongly inhibited spontaneous in vitro proliferation of peripheral blood mononuclear cells from patients with acute myelogenous leukaemia (n = 9), chronic myelogenous leukaemia in first chronic phase (n = 4) and blast phase (n = 1)." | 3.68 | Effect of dipyridamole, theophyllamine and verapamil on spontaneous in vitro proliferation of myelogenous leukaemia cells. ( Bruserud, O, 1992) |
| "Also in acute myeloid leukemia (AML), the proliferation rate (percentage S/G(2)+M and Iododeoxyuridine labelings index) was significantly less in the RhoD blasts (P | 1.30 | Triggering noncycling hematopoietic progenitors and leukemic blasts to proliferate increases anthracycline retention and toxicity by downregulating multidrug resistance. ( de Witte, T; Pennings, AH; Raymakers, RA; Smeets, ME; Vierwinden, G; Wessels, H, 1999) |
| "Pgp was positive in 75% of acute nonlymphoblastic leukemia (ANLL) and 50% of acute lymphoblastic leukemia (ALL)." | 1.28 | P-glycoprotein expression in refractory hematological neoplasms and circumvention of resistance with verapamil or cyclosporine A containing protocols. ( Akan, H; Beksaç, M; Ertürk, S; Güneyli, A; Ikizünal, Y; Ilhan, O; Koç, H; Sardaş, OS, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (85.71) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bruserud, O | 2 |
| Pawelec, G | 1 |
| Maslak, P | 1 |
| Hegewisch-Becker, S | 1 |
| Godfrey, L | 1 |
| Andreeff, M | 1 |
| Galimberti, S | 1 |
| Bianchi, F | 1 |
| Bernardini, N | 1 |
| Mattii, L | 1 |
| Dolfi, A | 1 |
| Lupetti, M | 1 |
| Petrini, M | 1 |
| Smeets, ME | 1 |
| Raymakers, RA | 1 |
| Vierwinden, G | 1 |
| Pennings, AH | 1 |
| Wessels, H | 1 |
| de Witte, T | 1 |
| Schröder, JK | 1 |
| Kasimir-Bauer, S | 1 |
| Seeber, S | 1 |
| Scheulen, ME | 1 |
| Beksaç, M | 1 |
| Akan, H | 1 |
| Koç, H | 1 |
| Ilhan, O | 1 |
| Ertürk, S | 1 |
| Güneyli, A | 1 |
| Ikizünal, Y | 1 |
| Sardaş, OS | 1 |
7 other studies available for verapamil and Blast Phase
| Article | Year |
|---|---|
Effects of dipyridamole and R-verapamil on in vitro proliferation of blast cells from patients with acute myelogenous leukaemia.
Topics: Adult; Aged; Blast Crisis; Cell Division; Dipyridamole; Dose-Response Relationship, Drug; Female; Gr | 1993 |
Flow cytometric determination of the multidrug-resistant phenotype in acute leukemia.
Topics: Acute Disease; Adolescent; Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemoth | 1994 |
Scanning electron microscopy of multidrug resistant cells in haematological and mammary malignancies.
Topics: Acute Disease; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blast Crisis; Breas | 1993 |
Triggering noncycling hematopoietic progenitors and leukemic blasts to proliferate increases anthracycline retention and toxicity by downregulating multidrug resistance.
Topics: Antibiotics, Antineoplastic; Antigens, CD34; ATP Binding Cassette Transporter, Subfamily B, Member 1 | 1999 |
In vitro effect of multidrug resistance modifiers on idarubicinol efflux in blasts of acute myeloid leukemia.
Topics: Antineoplastic Agents; Blast Crisis; Calcium Channel Blockers; Daunorubicin; Dihydropyridines; Drug | 2000 |
P-glycoprotein expression in refractory hematological neoplasms and circumvention of resistance with verapamil or cyclosporine A containing protocols.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, | 1992 |
Effect of dipyridamole, theophyllamine and verapamil on spontaneous in vitro proliferation of myelogenous leukaemia cells.
Topics: Aminophylline; Blast Crisis; Cell Division; Dipyridamole; Dose-Response Relationship, Drug; Drug Scr | 1992 |