verapamil has been researched along with Benign Neoplasms in 97 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was designed to evaluate efficacy, toxicity, and adverse effects of combination of chemotherapy drugs and intraperitoneal perfusion of verapamil in the treatment of malignant ascites." | 9.17 | Treatment of malignant ascites with a combination of chemotherapy drugs and intraperitoneal perfusion of verapamil. ( Duan, Q; Fan, G; Fan, P; Jia, W; Liu, Y; Zhang, T; Zhu, Z, 2013) |
| "This study was designed to evaluate efficacy, toxicity, and adverse effects of combination of chemotherapy drugs and intraperitoneal perfusion of verapamil in the treatment of malignant ascites." | 5.17 | Treatment of malignant ascites with a combination of chemotherapy drugs and intraperitoneal perfusion of verapamil. ( Duan, Q; Fan, G; Fan, P; Jia, W; Liu, Y; Zhang, T; Zhu, Z, 2013) |
| "The potential for the modification of the pharmacokinetics of doxorubicin (DOX) concurrently administered with high-dose verapamil (VER) has been investigated in 17 patients with advanced neoplasms refractory to drugs belonging to the multidrug resistance spectrum." | 3.69 | Pharmacokinetics of doxorubicin co-administered with high-dose verapamil. ( Boiocchi, M; Gigante, M; Toffoli, G, 1995) |
| "Aside from its more conventional uses as a cardiovascular drug, the calcium channel blocker verapamil has recently been added to chemotherapeutic regimens to reduce drug resistance in B-cell and other neoplasms that express the P-glycoprotein." | 3.68 | Systemic toxic effects associated with high-dose verapamil infusion and chemotherapy administration. ( Appleton, CP; Dalton, WS; Miller, TP; Mosley, K; Pennock, GD; Plezia, P; Roeske, WR; Salmon, SE, 1991) |
| "The risk of cancer in users of verapamil was assessed in a long-term follow-up of 1,775 patients who were randomized to verapamil or matching placebo in the Danish Verapamil Infarction Trial-II in the years 1985 to 1987." | 2.69 | Verapamil and risk of cancer in patients with coronary artery disease. DAVIT Study Group. Danish Verapamil Infarction Trial. ( Hansen, JF; Sajadieh, A; Storm, HH, 1999) |
| "Etoposide was given daily (150 mg m-2 day-1) for three doses (each over 1 h); the first dose was given 12 h into the verapamil infusion." | 2.68 | Continuous-infusion verapamil with etoposide in relapsed or resistant paediatric cancers. ( Cowie, FJ; Dick, G; Flanagan, RJ; Judson, I; McCarthy, PT; Phillips, M; Pinkerton, CR, 1995) |
| " These differences can be attributed at least in part to the low catecholamine profile of verapamil and the marked rapid adrenergic activation with short-acting nifedipine, which could also explain the adverse effects found when this agent is given to patients with acute coronary syndromes." | 2.40 | Calcium channel blockers for hypertension: dissecting the evidence for adverse effects. ( Opie, LH, 1997) |
| "Resistance to anticancer drugs is often mediated by the overexpression of a membrane pump able to extrude many xenobiotics out of the tumour cells." | 2.40 | Multidrug resistance in oncology: diagnostic and therapeutic approaches. ( Robert, J, 1999) |
| "Chiral anticancer agents which exist as a pair of enantiomers are commonly administered as racemic (50:50) mixtures of the two isomers." | 2.38 | Stereoisomers in clinical oncology: why it is important to know what the right and left hands are doing. ( Wainer, IW, 1993) |
| " Multiple-target inhibitors of efflux transporter can be overcome the resistance and improve the oral bioavailability of chemotherapy drugs." | 1.72 | Exploration of novel phthalazinone derivatives as potential efflux transporter inhibitors for reversing multidrug resistance and improving the oral absorption of paclitaxel. ( Cai, Z; Ghaleb, H; Huang, W; Jiang, Y; Liu, Y; Qian, H; Qiu, Q; Shi, W; Yin, Z; Zhang, P; Zhou, J; Zou, F, 2022) |
| "Cardiovascular and cancer illnesses often co-exist, share pathological pathways, and complicate therapy." | 1.72 | Calcium-channel-blockers exhibit divergent regulation of cancer extravasation through the mechanical properties of cancer cells and underlying vascular endothelial cells. ( Bajpai, SK; Edwina, P; Roy, B; Sivasubramaniapandian, M; Vaibavi, SR; Vaippully, R, 2022) |
| "Evaluation of three different colon cancer PDCs with low to modest MDR1 expression verified that FCCP significantly suppressed MMP and similarly reduced 99mTc-MIBI accumulation." | 1.56 | 99mTc-MIBI uptake as a marker of mitochondrial membrane potential in cancer cells and effects of MDR1 and verapamil. ( Cho, YS; Hong, SP; Jung, KH; Lee, J; Lee, JH; Lee, KH; Moon, SH; Park, JW, 2020) |
| "Cancer is the second most common cause of death, and nanomedicine is regarded as one of the strategies that may revolutionize cancer treatments." | 1.51 | Designing nanoparticles with improved tumor penetration: surface properties from the molecular architecture viewpoint. ( Appelhans, D; Feng, S; Hao, P; Peng, B; Yang, D; Zan, X; Zhang, L; Zhang, T, 2019) |
| " Pharmacokinetic results indicate that PTX-loaded CR PMs could significantly enhance the oral bioavailability of PTX." | 1.51 | Preparation and evaluation of carboxymethyl chitosan-rhein polymeric micelles with synergistic antitumor effect for oral delivery of paclitaxel. ( Chu, K; Guo, Y; Han, L; Li, T; Ouyang, H; Qiu, L; Wang, X; Xu, W, 2019) |
| "Treatment of cancer patients with chemotherapeutic drugs is often associated with the occurrence of tumors with a multidrug resistance (MDR)." | 1.46 | Structure-activity relationship study of novel 2-aminobenzofuran derivatives as P-glycoprotein inhibitors. ( Chang, CS; Chen, CY; Huang, CF; Hung, CC; Lee, CY; Lin, CM; Lin, HC; Si Tou, TC, 2017) |
| "The issue of multidrug resistance (MDR) cancer is one of the major barriers to successful chemotherapy treatment." | 1.43 | β-carotene reverses multidrug resistant cancer cells by selectively modulating human P-glycoprotein function. ( Chiang, YC; Hsieh, YW; Hung, CC; Sheu, MJ; Teng, YN; Wang, RY, 2016) |
| "Sal sensitized radiation-treated cancer cells by inducing G2 arrest and causing DNA damage." | 1.38 | Salinomycin, a p-glycoprotein inhibitor, sensitizes radiation-treated cancer cells by increasing DNA damage and inducing G2 arrest. ( Kang, HS; Kim, JH; Kim, S; Kim, WK; Ro, J; Yoon, K; Yoon, S, 2012) |
| " Thus, a functional interplay between membrane Gb3 and MDR1 provides a more physiologically based approach to MDR1 regulation to increase the bioavailability of chemotherapeutic drugs." | 1.35 | Inhibition of multidrug resistance by adamantylgb3, a globotriaosylceramide analog. ( Ackerley, C; Clarke, DM; De Rosa, MF; Ito, S; Lingwood, C; Wang, B, 2008) |
| "Recent evidence has supported the cancer stem cell theory that cancer contains a small number of cancer stem cells (CSC) as a reservoir of cancer cells." | 1.34 | Identification of side population cells (stem-like cell population) in pediatric solid tumor cell lines. ( Hayashi, Y; Kaneko, M; Kaneko, S; Komuro, H; Saihara, R; Shinya, M; Takita, J, 2007) |
| "Verapamil was employed as a comparative agent." | 1.33 | Reversal of p-glycoprotein-mediated multidrug resistance by CJX1, an amlodipine derivative, in doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells. ( He, L; Ji, BS; Liu, GQ, 2005) |
| "Incident cancer events were gathered from a nationwide registry of hospitalisation data and from a specialised cancer centre in the Rotterdam region." | 1.32 | Verapamil is associated with an increased risk of cancer in the elderly: the Rotterdam study. ( Beiderbeck-Noll, AB; Coebergh, JW; Herings, RM; Hofman, A; Leufkens, HG; Stricker, BH; Sturkenboom, MC; van der Linden, PD, 2003) |
| "Of 246 incident cancer cases, 129 occurred among the users (2." | 1.30 | Calcium channel blocking agents and risk of cancer in patients with coronary heart disease. Benzafibrate Infarction Prevention (BIP) Study Research Group. ( Behar, S; Boyko, V; Braun, S; Goldbourt, U; Kaplinsky, E; Laniado, S; Reicher-Reiss, H, 1998) |
| "Prospective clinical and pharmacokinetic study." | 1.30 | Pharmacokinetic and pharmacodynamic effects of high-dose continuous intravenous verapamil infusion: clinical experience in the intensive care unit. ( Boiocchi, M; De Cicco, M; Fabiani, F; Fantin, D; Fracasso, A; Lestuzzi, C; Macor, F; Matovic, M; Nicolosi, G; Robieux, I; Santantonio, C; Toffoli, G; Zanette, G, 1999) |
| "Studies were performed in rats bearing tumors bilaterally, a P-gp-negative small cell lung carcinoma (GLC4) and its P-gp-overexpressing subline (GLC4/P-gp)." | 1.30 | A new in vivo method to study P-glycoprotein transport in tumors and the blood-brain barrier. ( de Vries, EG; Eriks-Fluks, L; Franssen, EJ; Hendrikse, NH; Hospers, GA; Vaalburg, W; van der Graaf, WT; Willemsen, AT, 1999) |
| " The dosage of adriamycin was 50 mg/M2 every 3 weeks." | 1.27 | Verapamil reversal of clinical doxorubicin resistance in human cancer. A Wilshire Oncology Medical Group pilot phase I-II study. ( Bouzaglou, A; Gala, K; Kennedy, PS; Naessig, V; Presant, CA; Wiseman, C; Wyres, M, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (5.15) | 18.7374 |
| 1990's | 35 (36.08) | 18.2507 |
| 2000's | 18 (18.56) | 29.6817 |
| 2010's | 32 (32.99) | 24.3611 |
| 2020's | 7 (7.22) | 2.80 |
| Authors | Studies |
|---|---|
| Richter, M | 1 |
| Molnár, J | 4 |
| Hilgeroth, A | 4 |
| Fong, WF | 1 |
| Shen, XL | 1 |
| Globisch, C | 1 |
| Wiese, M | 1 |
| Chen, GY | 1 |
| Zhu, GY | 1 |
| Yu, ZL | 1 |
| Tse, AK | 1 |
| Hu, YJ | 1 |
| Li, Y | 2 |
| Zhang, HB | 1 |
| Huang, WL | 1 |
| Li, YM | 1 |
| Das, U | 1 |
| Pati, HN | 1 |
| Panda, AK | 1 |
| De Clercq, E | 1 |
| Balzarini, J | 1 |
| Baráth, Z | 1 |
| Ocsovszki, I | 1 |
| Kawase, M | 1 |
| Zhou, L | 1 |
| Sakagami, H | 1 |
| Dimmock, JR | 1 |
| Krug, M | 1 |
| Voigt, B | 1 |
| Baumert, C | 2 |
| Lüpken, R | 1 |
| Huang, M | 1 |
| Zhao, X | 1 |
| Zhang, M | 1 |
| Gu, J | 1 |
| Chen, X | 1 |
| Yin, D | 1 |
| Günthel, M | 1 |
| Krawczyk, S | 2 |
| Hemmer, M | 2 |
| Wersig, T | 1 |
| Langner, A | 1 |
| Lage, H | 1 |
| Liu, J | 1 |
| Wang, X | 5 |
| Liu, P | 1 |
| Deng, R | 1 |
| Lei, M | 1 |
| Chen, W | 1 |
| Hu, L | 1 |
| Wong, IL | 1 |
| Wang, BC | 1 |
| Yuan, J | 1 |
| Duan, LX | 1 |
| Liu, Z | 1 |
| Liu, T | 1 |
| Li, XM | 1 |
| Hu, X | 1 |
| Zhang, XY | 1 |
| Jiang, T | 1 |
| Wan, SB | 1 |
| Chow, LM | 1 |
| Simon, I | 1 |
| Unzue, A | 1 |
| Lafleur, K | 1 |
| Zhao, H | 1 |
| Zhou, T | 1 |
| Dong, J | 1 |
| Kolb, P | 1 |
| Liebl, J | 1 |
| Zahler, S | 1 |
| Caflisch, A | 1 |
| Nevado, C | 1 |
| Wu, Y | 1 |
| Pan, M | 2 |
| Dai, Y | 2 |
| Liu, B | 1 |
| Cui, J | 2 |
| Shi, W | 3 |
| Qiu, Q | 3 |
| Huang, W | 4 |
| Qian, H | 3 |
| Chen, CY | 1 |
| Lin, CM | 1 |
| Lin, HC | 1 |
| Huang, CF | 1 |
| Lee, CY | 1 |
| Si Tou, TC | 1 |
| Hung, CC | 2 |
| Chang, CS | 1 |
| Li, Z | 2 |
| Zhang, B | 1 |
| Joshi, P | 1 |
| Vishwakarma, RA | 1 |
| Bharate, SB | 1 |
| Gu, X | 1 |
| Jiang, Y | 2 |
| Qu, Y | 1 |
| Chen, J | 1 |
| Feng, D | 1 |
| Li, C | 1 |
| Yin, X | 1 |
| Lin, MS | 1 |
| Hong, TM | 1 |
| Chou, TH | 1 |
| Yang, SC | 1 |
| Chung, WC | 1 |
| Weng, CW | 1 |
| Tsai, ML | 1 |
| Cheng, TR | 1 |
| Chen, JJW | 1 |
| Lee, TC | 1 |
| Wong, CH | 1 |
| Chein, RJ | 1 |
| Yang, PC | 1 |
| Zhang, P | 1 |
| Zou, F | 1 |
| Zhou, J | 1 |
| Yin, Z | 1 |
| Cai, Z | 1 |
| Ghaleb, H | 1 |
| Liu, Y | 2 |
| Vaibavi, SR | 1 |
| Sivasubramaniapandian, M | 1 |
| Vaippully, R | 1 |
| Edwina, P | 1 |
| Roy, B | 1 |
| Bajpai, SK | 1 |
| Wada, K | 1 |
| Goto, M | 1 |
| Ohkoshi, E | 1 |
| Lee, KH | 2 |
| Yamashita, H | 1 |
| Żesławska, E | 1 |
| Tejchman, W | 1 |
| Kincses, A | 1 |
| Spengler, G | 1 |
| Nitek, W | 1 |
| Żuchowski, G | 1 |
| Szymańska, E | 1 |
| Qiu, L | 2 |
| Ouyang, H | 2 |
| Li, T | 2 |
| Han, L | 2 |
| Zhang, X | 1 |
| Xu, W | 2 |
| Chu, K | 2 |
| Park, JW | 1 |
| Hong, SP | 1 |
| Lee, JH | 1 |
| Moon, SH | 1 |
| Cho, YS | 1 |
| Jung, KH | 1 |
| Lee, J | 1 |
| Zhang, L | 1 |
| Hao, P | 1 |
| Yang, D | 1 |
| Feng, S | 1 |
| Peng, B | 1 |
| Appelhans, D | 1 |
| Zhang, T | 2 |
| Zan, X | 1 |
| Shiozaki, A | 1 |
| Katsurahara, K | 1 |
| Otsuji, E | 1 |
| Kania, E | 1 |
| Pająk, B | 1 |
| O'Prey, J | 1 |
| Sierra Gonzalez, P | 1 |
| Litwiniuk, A | 1 |
| Urbańska, K | 1 |
| Ryan, KM | 1 |
| Orzechowski, A | 1 |
| Zhang, H | 1 |
| Jiang, W | 1 |
| Liu, R | 1 |
| Zhang, J | 1 |
| Zhang, D | 1 |
| Luan, Y | 2 |
| Kryczka, J | 1 |
| Boncela, J | 1 |
| Kobayashi, M | 1 |
| Tsujiuchi, T | 1 |
| Okui, Y | 1 |
| Mizutani, A | 1 |
| Nishi, K | 1 |
| Nakanishi, T | 1 |
| Nishii, R | 1 |
| Fukuchi, K | 1 |
| Tamai, I | 1 |
| Kawai, K | 1 |
| Guo, Y | 1 |
| Jia, W | 1 |
| Zhu, Z | 1 |
| Fan, G | 1 |
| Fan, P | 1 |
| Duan, Q | 1 |
| Qin, M | 1 |
| Lee, YE | 1 |
| Ray, A | 1 |
| Kopelman, R | 1 |
| Singh, MS | 1 |
| Lamprecht, A | 1 |
| Hu, Z | 1 |
| Zhou, Z | 1 |
| Hu, Y | 2 |
| Wu, J | 2 |
| Teng, YN | 1 |
| Sheu, MJ | 1 |
| Hsieh, YW | 1 |
| Wang, RY | 1 |
| Chiang, YC | 1 |
| Li, N | 1 |
| Huang, C | 1 |
| Song, A | 1 |
| Song, Y | 1 |
| Garg, S | 1 |
| Ogawara, K | 1 |
| Un, K | 1 |
| Tanaka, K | 1 |
| Higaki, K | 1 |
| Kimura, T | 1 |
| Kortylewicz, ZP | 1 |
| Augustine, AM | 1 |
| Nearman, J | 1 |
| McGarry, J | 1 |
| Baranowska-Kortylewicz, J | 1 |
| Rund, D | 1 |
| Gros, A | 1 |
| Puig, C | 1 |
| Guedan, S | 1 |
| Rojas, JJ | 1 |
| Alemany, R | 2 |
| Cascallo, M | 1 |
| Kim, WK | 1 |
| Kim, JH | 1 |
| Yoon, K | 1 |
| Kim, S | 1 |
| Ro, J | 1 |
| Kang, HS | 1 |
| Yoon, S | 1 |
| Genoux-Bastide, E | 1 |
| Lorendeau, D | 1 |
| Nicolle, E | 1 |
| Yahiaoui, S | 1 |
| Magnard, S | 1 |
| Di Pietro, A | 1 |
| Baubichon-Cortay, H | 1 |
| Boumendjel, A | 1 |
| Fetisova, EK | 1 |
| Avetisian, AV | 1 |
| Iziumov, DS | 1 |
| Korotetskaia, MV | 1 |
| Tashlitskiĭ, VN | 1 |
| Skulachev, VP | 1 |
| Cherniak, BV | 1 |
| Koski, A | 1 |
| Raki, M | 1 |
| Nokisalmi, P | 1 |
| Liikanen, I | 1 |
| Kangasniemi, L | 1 |
| Joensuu, T | 1 |
| Kanerva, A | 1 |
| Pesonen, S | 1 |
| Hemminki, A | 1 |
| Xu, Y | 1 |
| Zhi, F | 1 |
| Xu, G | 1 |
| Tang, X | 1 |
| Lu, S | 1 |
| Covell, DG | 1 |
| Choudhuri, SK | 1 |
| La Vecchia, C | 1 |
| Bosetti, C | 1 |
| Beiderbeck-Noll, AB | 1 |
| Sturkenboom, MC | 1 |
| van der Linden, PD | 1 |
| Herings, RM | 1 |
| Hofman, A | 1 |
| Coebergh, JW | 1 |
| Leufkens, HG | 1 |
| Stricker, BH | 1 |
| de Geus-Oei, LF | 1 |
| van Eerd-Vismale, J | 1 |
| Molthoff, C | 1 |
| Corstens, F | 1 |
| Oyen, W | 1 |
| Boerman, O | 1 |
| Ji, BS | 1 |
| He, L | 1 |
| Liu, GQ | 1 |
| Krishna, CM | 1 |
| Kegelaer, G | 1 |
| Adt, I | 1 |
| Rubin, S | 1 |
| Kartha, VB | 1 |
| Manfait, M | 2 |
| Sockalingum, GD | 1 |
| Limtrakul, P | 1 |
| Siwanon, S | 1 |
| Yodkeeree, S | 1 |
| Duangrat, C | 1 |
| De Rosa, MF | 1 |
| Ackerley, C | 1 |
| Wang, B | 1 |
| Ito, S | 1 |
| Clarke, DM | 1 |
| Lingwood, C | 1 |
| Komuro, H | 1 |
| Saihara, R | 1 |
| Shinya, M | 1 |
| Takita, J | 1 |
| Kaneko, S | 1 |
| Kaneko, M | 1 |
| Hayashi, Y | 1 |
| Robey, RW | 2 |
| Shukla, S | 1 |
| Finley, EM | 1 |
| Oldham, RK | 2 |
| Barnett, D | 1 |
| Ambudkar, SV | 1 |
| Fojo, T | 1 |
| Bates, SE | 3 |
| Müllerleile, U | 1 |
| Garbrecht, M | 1 |
| Hanrath, P | 1 |
| Langenstein, BA | 1 |
| Bieber, K | 1 |
| Bleifeld, W | 1 |
| Hossfeld, DK | 1 |
| Lizard, G | 1 |
| Chignol, MC | 1 |
| Chardonnet, Y | 1 |
| Schmitt, D | 1 |
| Sikic, BI | 1 |
| Fisher, GA | 1 |
| Lum, BL | 1 |
| Brophy, NA | 1 |
| Yahanda, AM | 1 |
| Adler, KM | 1 |
| Halsey, J | 1 |
| O'Brian, CA | 1 |
| Ward, NE | 1 |
| Gravitt, KR | 1 |
| Fan, D | 1 |
| Cowie, FJ | 1 |
| Pinkerton, CR | 2 |
| Phillips, M | 1 |
| Dick, G | 1 |
| Judson, I | 1 |
| McCarthy, PT | 1 |
| Flanagan, RJ | 1 |
| Regis, JI | 1 |
| Zhan, Z | 2 |
| Scala, S | 2 |
| Meadows, BJ | 1 |
| Soudon, J | 1 |
| Berlion, M | 1 |
| Lucas, C | 1 |
| Haddad, P | 1 |
| Bizzari, JP | 1 |
| Calvo, F | 1 |
| Miniero, R | 1 |
| Massara, FM | 1 |
| Saroglia, EM | 1 |
| Soldano, S | 1 |
| Barisone, E | 1 |
| Leone, L | 1 |
| Arrighini, A | 1 |
| Andolina, M | 1 |
| Brach del Prever, A | 1 |
| Madon, E | 1 |
| Gigante, M | 1 |
| Toffoli, G | 2 |
| Boiocchi, M | 2 |
| Dickstein, B | 1 |
| Lee, JS | 1 |
| Fojo, AT | 1 |
| Paull, K | 1 |
| Wilson, W | 1 |
| Hill, BT | 1 |
| van der Graaf, WT | 2 |
| Hosking, LK | 1 |
| de Vries, EG | 2 |
| Mulder, NH | 1 |
| Whelan, RD | 1 |
| Pérez, V | 1 |
| Pierré, A | 1 |
| Léonce, S | 1 |
| Anstett, M | 1 |
| Prost, JF | 1 |
| Atassi, G | 1 |
| Wainer, IW | 1 |
| Ferry, DR | 1 |
| Traunecker, H | 1 |
| Kerr, DJ | 1 |
| Tagliaferri, P | 1 |
| Correale, P | 1 |
| Mottola, M | 1 |
| de Simone, G | 1 |
| Montesarchio, V | 1 |
| Matano, E | 1 |
| Rea, A | 1 |
| Morabito, A | 1 |
| Famiani, M | 1 |
| Ciardiello, F | 1 |
| Tortora, G | 1 |
| Caraglia, M | 1 |
| Barile, C | 1 |
| Palmieri, G | 1 |
| Bianco, AR | 1 |
| Riffkin, CD | 1 |
| Chung, R | 1 |
| Wall, DM | 1 |
| Zalcberg, JR | 1 |
| Cowman, AF | 1 |
| Foley, M | 1 |
| Tilley, L | 1 |
| Storozhenko, IV | 1 |
| Sergeeva, NS | 1 |
| Chissov, VI | 1 |
| Skotnikova, OI | 1 |
| Opie, LH | 1 |
| Millot, C | 1 |
| Millot, JM | 1 |
| Morjani, H | 1 |
| Desplaces, A | 1 |
| Tsuruo, T | 1 |
| Braun, S | 1 |
| Boyko, V | 1 |
| Behar, S | 1 |
| Reicher-Reiss, H | 1 |
| Laniado, S | 1 |
| Kaplinsky, E | 1 |
| Goldbourt, U | 1 |
| Szakács, G | 1 |
| Jakab, K | 1 |
| Antal, F | 1 |
| Sarkadi, B | 1 |
| De Cicco, M | 1 |
| Macor, F | 1 |
| Robieux, I | 1 |
| Zanette, G | 1 |
| Fantin, D | 1 |
| Fabiani, F | 1 |
| Nicolosi, G | 1 |
| Fracasso, A | 1 |
| Santantonio, C | 1 |
| Lestuzzi, C | 1 |
| Matovic, M | 1 |
| Sajadieh, A | 1 |
| Storm, HH | 1 |
| Hansen, JF | 1 |
| Hendrikse, NH | 1 |
| Eriks-Fluks, L | 1 |
| Hospers, GA | 1 |
| Willemsen, AT | 1 |
| Vaalburg, W | 1 |
| Franssen, EJ | 1 |
| Robert, J | 1 |
| Pertusini, E | 1 |
| Ratajczak, J | 1 |
| Majka, M | 1 |
| Vaughn, D | 1 |
| Ratajczak, MZ | 1 |
| Gewirtz, AM | 1 |
| Goldstein, LJ | 1 |
| Pastan, I | 2 |
| Gottesman, MM | 2 |
| Stuart, NS | 1 |
| Philip, P | 1 |
| Harris, AL | 1 |
| Tonkin, K | 1 |
| Houlbrook, S | 1 |
| Kirk, J | 1 |
| Lien, EA | 1 |
| Carmichael, J | 1 |
| Carpentier, Y | 1 |
| Gorisse, MC | 1 |
| Desoize, B | 1 |
| Beck, WT | 1 |
| Plumb, JA | 1 |
| Milroy, R | 1 |
| Kaye, SB | 2 |
| Pennock, GD | 1 |
| Dalton, WS | 1 |
| Roeske, WR | 1 |
| Appleton, CP | 1 |
| Mosley, K | 1 |
| Plezia, P | 1 |
| Miller, TP | 1 |
| Salmon, SE | 1 |
| Eliason, JF | 1 |
| Ramuz, H | 1 |
| Kaufmann, F | 1 |
| Presant, CA | 1 |
| Kennedy, PS | 1 |
| Wiseman, C | 1 |
| Gala, K | 1 |
| Bouzaglou, A | 1 |
| Wyres, M | 1 |
| Naessig, V | 1 |
| Fine, RL | 1 |
| Koizumi, S | 1 |
| Curt, GA | 1 |
| Chabner, BA | 1 |
| Minors, DS | 1 |
| Fojo, A | 1 |
| Akiyama, S | 1 |
18 reviews available for verapamil and Benign Neoplasms
| Article | Year |
|---|---|
Three stories on Eph kinase inhibitors: From in silico discovery to in vivo validation.
Topics: Animals; Computer Simulation; Drug Design; Humans; Isoquinolines; Neoplasms; Protein Kinase Inhibito | 2016 |
Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member | 2017 |
Cell Migration Related to MDR-Another Impediment to Effective Chemotherapy?
Topics: Antibodies, Monoclonal; Antineoplastic Agents; ATP-Binding Cassette Transporters; Cancer-Associated | 2018 |
Clinical reversal of multidrug resistance.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport | 1994 |
The role of protein kinase C in multidrug resistance.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological | 1994 |
Chemoresistance in the clinic: overview 1994.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Dipyridamole; Drug Resistance | 1994 |
Reversal of multidrug resistance.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; Clini | 1994 |
Stereoisomers in clinical oncology: why it is important to know what the right and left hands are doing.
Topics: Antineoplastic Agents; Humans; Ifosfamide; Leucovorin; Neoplasms; Stereoisomerism; Verapamil | 1993 |
Multidrug resistance reversal in childhood malignancies--potential for a real step forward?
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Child; Child, Presch | 1996 |
Clinical trials of P-glycoprotein reversal in solid tumours.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Clinical Trials as Topic; Cyclosporine; Dru | 1996 |
Calcium channel blockers for hypertension: dissecting the evidence for adverse effects.
Topics: Calcium Channel Blockers; Catecholamines; Cerebrovascular Disorders; Drug Evaluation; Gastrointestin | 1997 |
[Mechanism of multidrug resistant tumors and chemotherapeutic approaches against the resistant tumors].
Topics: Animals; Antibodies, Monoclonal; Antibody-Dependent Cell Cytotoxicity; ATP Binding Cassette Transpor | 1997 |
Diagnostics of multidrug resistance in cancer.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biologic | 1998 |
Multidrug resistance in oncology: diagnostic and therapeutic approaches.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Doxorubicin; Drug Resistance, Multiple; Fem | 1999 |
Multidrug resistance in human cancer.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Pro | 1992 |
Modulators of P-glycoprotein-associated multidrug resistance.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily | 1991 |
Reversal of multidrug resistance.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; DNA Topoisomerases, | 1990 |
Chronobiology: its importance in clinical medicine.
Topics: Airway Resistance; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Asthma; Biological Cloc | 1985 |
10 trials available for verapamil and Benign Neoplasms
| Article | Year |
|---|---|
Treatment of malignant ascites with a combination of chemotherapy drugs and intraperitoneal perfusion of verapamil.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Ascites; Disease-Free Survival; Drug Re | 2013 |
Inhibition of P-glycoprotein (ABCB1)- and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1((R)).
Topics: Adenosine Triphosphatases; Alkaloids; Animals; Antineoplastic Agents; ATP Binding Cassette Transport | 2008 |
[Possible prevention of adriamycin-induced cardiomyopathy by verapamil. Results of a pilot study].
Topics: Cardiomyopathies; Doxorubicin; Female; Hemodynamics; Humans; Male; Middle Aged; Myocardial Contracti | 1984 |
Clinical reversal of multidrug resistance.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport | 1994 |
Continuous-infusion verapamil with etoposide in relapsed or resistant paediatric cancers.
Topics: Adolescent; Adult; Bone Neoplasms; Child; Child, Preschool; Drug Administration Schedule; Drug Resis | 1995 |
Chemoresistance in the clinic: overview 1994.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Dipyridamole; Drug Resistance | 1994 |
In vitro activity of S 9788 on a multidrug-resistant leukemic cell line and on normal hematopoietic cells-reversal of multidrug resistance by sera from phase I-treated patients.
Topics: Antineoplastic Agents; Bone Marrow Cells; Cell Division; Cell Line; Cell Survival; Culture Media; Do | 1995 |
High-dose recombinant interleukin-2/verapamil combination in advanced cancer.
Topics: Adult; Aged; Antineoplastic Agents; Calcium Channel Blockers; Female; Humans; Interleukin-2; Male; M | 1996 |
Verapamil and risk of cancer in patients with coronary artery disease. DAVIT Study Group. Danish Verapamil Infarction Trial.
Topics: Aged; Calcium Channel Blockers; Coronary Disease; Female; Humans; Male; Middle Aged; Neoplasms; Rand | 1999 |
High-dose tamoxifen as an enhancer of etoposide cytotoxicity. Clinical effects and in vitro assessment in p-glycoprotein expressing cell lines.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Casse | 1992 |
71 other studies available for verapamil and Benign Neoplasms
| Article | Year |
|---|---|
Biological evaluation of bishydroxymethyl-substituted cage dimeric 1,4-dihydropyridines as a novel class of p-glycoprotein modulating agents in cancer cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Cell Proliferation; Dihydr | 2006 |
Methoxylation of 3',4'-aromatic side chains improves P-glycoprotein inhibitory and multidrug resistance reversal activities of 7,8-pyranocoumarin against cancer cells.
Topics: Adenosine Triphosphatases; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Mem | 2008 |
Design and synthesis of tetrahydroisoquinoline derivatives as potential multidrug resistance reversal agents in cancer.
Topics: Amidines; Animals; Anti-Arrhythmia Agents; Antineoplastic Agents; Arrhythmias, Cardiac; Cell Line, T | 2008 |
2-(3-Aryl-2-propenoyl)-3-methylquinoxaline-1,4-dioxides: a novel cluster of tumor-specific cytotoxins which reverse multidrug resistance.
Topics: Animals; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assa | 2009 |
First biological evaluation of developed 3-benzyloxyfluorenes as novel class of MDR modulators.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Drug Discovery; Drug Resis | 2010 |
Synthesis and structure-activity relationships of sinenxan A derivatives as multidrug resistance reversal agents.
Topics: Acetates; Calcium Channel Blockers; Diterpenes; Drug Resistance, Multiple; Humans; Neoplasms; Struct | 2010 |
Development of small-molecule P-gp inhibitors of the N-benzyl 1,4-dihydropyridine type: novel aspects in SAR and bioanalytical evaluation of multidrug resistance (MDR) reversal properties.
Topics: Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell | 2013 |
20(S)-Protopanaxadiol (PPD) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Do | 2013 |
Potent and Nontoxic Chemosensitizer of P-Glycoprotein-Mediated Multidrug Resistance in Cancer: Synthesis and Evaluation of Methylated Epigallocatechin, Gallocatechin, and Dihydromyricetin Derivatives.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transport | 2015 |
Discovery of substituted 1,4-dihydroquinolines as novel promising class of P-glycoprotein inhibitors: First structure-activity relationships and bioanalytical studies.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Drug Resistance, Multiple; | 2015 |
Design, synthesis and biological evaluation of LBM-A5 derivatives as potent P-glycoprotein-mediated multidrug resistance inhibitors.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzamides; Cl | 2016 |
Structure-activity relationship study of novel 2-aminobenzofuran derivatives as P-glycoprotein inhibitors.
Topics: Amination; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Benzofurans; Cell L | 2017 |
Exploration of 2-((Pyridin-4-ylmethyl)amino)nicotinamide Derivatives as Potent Reversal Agents against P-Glycoprotein-Mediated Multidrug Resistance.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-4 | 2017 |
Synthesis and biological evaluation of bifendate derivatives bearing 6,7-dihydro-dibenzo[c,e]azepine scaffold as potential P-glycoprotein and tumor metastasis inhibitors.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azepines; Biphenyl C | 2018 |
4(1H)-quinolone derivatives overcome acquired resistance to anti-microtubule agents by targeting the colchicine site of β-tubulin.
Topics: Antineoplastic Agents; Apoptosis; Binding Sites; Cell Proliferation; Colchicine; Drug Resistance, Ne | 2019 |
Exploration of novel phthalazinone derivatives as potential efflux transporter inhibitors for reversing multidrug resistance and improving the oral absorption of paclitaxel.
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; Drug Resistance, Multiple; Drug Resistance, | 2022 |
Calcium-channel-blockers exhibit divergent regulation of cancer extravasation through the mechanical properties of cancer cells and underlying vascular endothelial cells.
Topics: Calcium; Calcium Channel Blockers; Diltiazem; Endothelial Cells; Neoplasms; Nifedipine; Verapamil | 2022 |
Bioactivity inspired C
Topics: Alkaloids; Diterpenes; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Neoplasms; Pacl | 2022 |
5-Arylidenerhodanines as P-gp Modulators: An Interesting Effect of the Carboxyl Group on ABCB1 Function in Multidrug-Resistant Cancer Cells.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cell Line, Tumor; Drug Resistance, Multiple; Drug | 2022 |
Evaluation of intestinal permeation enhancement with carboxymethyl chitosan-rhein polymeric micelles for oral delivery of paclitaxel.
Topics: Administration, Oral; Animals; Anthraquinones; Antineoplastic Agents, Phytogenic; ATP Binding Casset | 2020 |
99mTc-MIBI uptake as a marker of mitochondrial membrane potential in cancer cells and effects of MDR1 and verapamil.
Topics: ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Cell Membrane; Drug Resistance, | 2020 |
Designing nanoparticles with improved tumor penetration: surface properties from the molecular architecture viewpoint.
Topics: Animals; Cell Line, Tumor; Cell Survival; Dendrimers; Disease Models, Animal; Drug Resistance, Neopl | 2019 |
ASO Author Reflections: Amlodipine and Verapamil, Voltage-Gated Ca
Topics: Amlodipine; Humans; Neoplasms; Neoplastic Stem Cells; Stomach; Verapamil | 2021 |
Verapamil treatment induces cytoprotective autophagy by modulating cellular metabolism.
Topics: Antimalarials; Antineoplastic Agents; Autophagosomes; Autophagy; Autophagy-Related Protein 5; Autoph | 2017 |
Rational Design of Metal Organic Framework Nanocarrier-Based Codelivery System of Doxorubicin Hydrochloride/Verapamil Hydrochloride for Overcoming Multidrug Resistance with Efficient Targeted Cancer Therapy.
Topics: Doxorubicin; Drug Resistance, Multiple; Humans; Metal-Organic Frameworks; Neoplasms; Verapamil | 2017 |
Different Efflux Transporter Affinity and Metabolism of
Topics: Animals; Cell Line, Tumor; Drug Monitoring; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Dr | 2018 |
Preparation and evaluation of carboxymethyl chitosan-rhein polymeric micelles with synergistic antitumor effect for oral delivery of paclitaxel.
Topics: Administration, Oral; Animals; Anthraquinones; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; | 2019 |
Overcoming cancer multidrug resistance by codelivery of doxorubicin and verapamil with hydrogel nanoparticles.
Topics: Analysis of Variance; Antineoplastic Agents; Cell Line, Tumor; Doxorubicin; Drug Delivery Systems; D | 2014 |
Cargoing P-gp inhibitors via nanoparticle sensitizes tumor cells against doxorubicin.
Topics: Acridines; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cel | 2015 |
HZ08 reverse P-glycoprotein mediated multidrug resistance in vitro and in vivo.
Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; D | 2015 |
β-carotene reverses multidrug resistant cancer cells by selectively modulating human P-glycoprotein function.
Topics: Adenosine Triphosphatases; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP | 2016 |
Active targeting co-delivery system based on pH-sensitive methoxy-poly(ethylene glycol)2K-poly(ε-caprolactone)4K-poly(glutamic acid)1K for enhanced cancer therapy.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Delayed-Action | 2016 |
In vivo anti-tumor effect of PEG liposomal doxorubicin (DOX) in DOX-resistant tumor-bearing mice: Involvement of cytotoxic effect on vascular endothelial cells.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Memb | 2009 |
Radioiodinated agents for imaging multidrug resistant tumors.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neopla | 2009 |
'Rapping' on the door of drug resistance.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette | 2009 |
Verapamil enhances the antitumoral efficacy of oncolytic adenoviruses.
Topics: Adenoviridae; Animals; Blotting, Western; Cell Line; Cell Line, Tumor; Genetic Vectors; Humans; Male | 2010 |
Salinomycin, a p-glycoprotein inhibitor, sensitizes radiation-treated cancer cells by increasing DNA damage and inducing G2 arrest.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Combined Modality Therapy | 2012 |
Identification of xanthones as selective killers of cancer cells overexpressing the ABC transporter MRP1.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line; Cricetinae; Glutathione; Humans; Multidrug Res | 2011 |
[Multidrug resistance P-glycoprotein inhibits the antiapoptotic action of mitochondria-targeted antioxidant SkQR1].
Topics: Antioxidants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Dru | 2011 |
Verapamil results in increased blood levels of oncolytic adenovirus in treatment of patients with advanced cancer.
Topics: Adenoviridae; Adolescent; Adult; Aged; Antibodies, Neutralizing; Antibodies, Viral; Calcium Channel | 2012 |
Overcoming multidrug-resistance in vitro and in vivo using the novel P-glycoprotein inhibitor 1416.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Surviv | 2012 |
Integrating constitutive gene expression and chemoactivity: mining the NCI60 anticancer screen.
Topics: Algorithms; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Proliferation; Cell Survival | 2012 |
Deactivation of P-glycoprotein by a novel compound, oxalyl bis (N-phenyl) hydroxamic acid.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzeneacetamides; Blotting, Western; Cell | 2002 |
Calcium channel blockers, verapamil and cancer risk.
Topics: Aged; Calcium Channel Blockers; Humans; Neoplasms; Prospective Studies; Risk Factors; Verapamil | 2003 |
Verapamil is associated with an increased risk of cancer in the elderly: the Rotterdam study.
Topics: Aged; Calcium Channel Blockers; Cardiovascular Diseases; Cohort Studies; Cross-Sectional Studies; Fe | 2003 |
Tracers to monitor the response to chemotherapy: in vitro screening of four radiopharmaceuticals.
Topics: DNA; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorodeoxyglucose F18; Huma | 2004 |
Reversal of p-glycoprotein-mediated multidrug resistance by CJX1, an amlodipine derivative, in doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells.
Topics: Amlodipine; Analysis of Variance; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1 | 2005 |
Combined Fourier transform infrared and Raman spectroscopic approach for identification of multidrug resistance phenotype in cancer cell lines.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tum | 2006 |
Effect of Stemona curtisii root extract on P-glycoprotein and MRP-1 function in multidrug-resistant cancer cells.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Ce | 2007 |
Inhibition of multidrug resistance by adamantylgb3, a globotriaosylceramide analog.
Topics: Adamantane; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily | 2008 |
Identification of side population cells (stem-like cell population) in pediatric solid tumor cell lines.
Topics: Cell Division; Cell Line, Tumor; Cell Separation; Child; Child, Preschool; Drug Resistance, Neoplasm | 2007 |
Active cell membrane mechanisms involved in the exclusion of Rh 123 allow distinction between normal and tumoral cells.
Topics: Cell Membrane; Cells, Cultured; Drug Resistance, Multiple; Fibroblasts; Flow Cytometry; Humans; Neop | 1994 |
[Use of cyclosporin and verapamil in association with chemotherapy in the treatment of pediatric patients with advanced-stage neoplasms. A pilot study].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cerebellar Neoplasms; Ch | 1994 |
Pharmacokinetics of doxorubicin co-administered with high-dose verapamil.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Drug Resistance, Multiple; | 1995 |
Evaluation of S9788 as a potential modulator of drug resistance against human tumour sublines expressing differing resistance mechanisms in vitro.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Do | 1993 |
[In vitro characterization of S9788, a new modulator of multidrug resistance].
Topics: Animals; Antineoplastic Agents; Cell Cycle; Drug Resistance; Drug Screening Assays, Antitumor; Human | 1993 |
Modulation of the function of human MDR1 P-glycoprotein by the antimalarial drug mefloquine.
Topics: Affinity Labels; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sit | 1996 |
[The effect of verapamil on the growth and sensitivity to vincristine of human tumor transplanted into kidney capsule of mice].
Topics: Animals; Antineoplastic Agents, Phytogenic; Calcium Channel Blockers; Cell Division; Drug Resistance | 1996 |
Characterization of acidic vesicles in multidrug-resistant and sensitive cancer cells by acridine orange staining and confocal microspectrofluorometry.
Topics: Acridine Orange; Ammonium Chloride; Cell Nucleus; Cytosol; Dose-Response Relationship, Drug; Doxorub | 1997 |
Calcium channel blocking agents and risk of cancer in patients with coronary heart disease. Benzafibrate Infarction Prevention (BIP) Study Research Group.
Topics: Aged; Calcium Channel Blockers; Cause of Death; Confidence Intervals; Coronary Disease; Diltiazem; F | 1998 |
Pharmacokinetic and pharmacodynamic effects of high-dose continuous intravenous verapamil infusion: clinical experience in the intensive care unit.
Topics: Adult; Analysis of Variance; Antineoplastic Agents; Calcium Channel Blockers; Critical Care; Doxorub | 1999 |
A new in vivo method to study P-glycoprotein transport in tumors and the blood-brain barrier.
Topics: Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood | 1999 |
Treatment of drug resistance: biotherapy or chemotherapy?
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporins; Drug R | 1998 |
Investigating the platelet-sparing mechanism of paclitaxel/carboplatin combination chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Membe | 2001 |
Evaluation of a method for detection of cells with reduced drug retention in solid tumours.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Breast Neopl | 1992 |
The activity of verapamil as a resistance modifier in vitro in drug resistant human tumour cell lines is not stereospecific.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Doxorubicin; Drug Resista | 1990 |
Systemic toxic effects associated with high-dose verapamil infusion and chemotherapy administration.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Blood Pressure; Drug Resistance; Heart | 1991 |
Human multi-drug-resistant cancer cells exhibit a high degree of selectivity for stereoisomers of verapamil and quinidine.
Topics: Cell Line; Cell Survival; Coloring Agents; Dose-Response Relationship, Drug; Drug Resistance; Drug S | 1990 |
Verapamil reversal of clinical doxorubicin resistance in human cancer. A Wilshire Oncology Medical Group pilot phase I-II study.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Doxorubicin; Drug Evaluation; Dru | 1986 |
Effect of calcium channel blockers on human CFU-GM with cytotoxic drugs.
Topics: Adolescent; Adult; Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Bone Marrow | 1987 |
Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines.
Topics: Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Resistance; Humans; KB Cells; Neoplasm | 1985 |