verapamil has been researched along with B16 Melanoma in 17 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of the antibiotic agent novobiocin on the sensitivity of melanoma cells to colchicine and vinblastine was examined in drug-sensitive and drug-resistant B16 melanoma cells." | 7.69 | Novobiocin modulates colchicine sensitivity in parental and multidrug-resistant B16 melanoma cells. ( Beery, E; Halabe, E; Kornfeld, J; Landau, O; Nordenberg, J; Novogrodsky, A; Shafran, M; Sidi, Y; Wasserman, L, 1994) |
| " The resulting dose-survival curve was identical to the dose-response curve of RS cells treated with R123 alone." | 5.28 | Relationship between cellular accumulation of rhodamine 123 (R123) and cytotoxicity in B16 melanoma cells. ( Gan, L; Krag, DN; Tao, SZ; Theon, AP; Wardell, J, 1989) |
| "The effect of the antibiotic agent novobiocin on the sensitivity of melanoma cells to colchicine and vinblastine was examined in drug-sensitive and drug-resistant B16 melanoma cells." | 3.69 | Novobiocin modulates colchicine sensitivity in parental and multidrug-resistant B16 melanoma cells. ( Beery, E; Halabe, E; Kornfeld, J; Landau, O; Nordenberg, J; Novogrodsky, A; Shafran, M; Sidi, Y; Wasserman, L, 1994) |
| "Malignant melanomas are intrinsically resistant to many conventional treatments, such as radiation and chemotherapy, for reasons that are poorly understood." | 1.35 | Influence of melanosome dynamics on melanoma drug sensitivity. ( Cardarelli, CO; Chen, KG; Gottesman, MM; Hearing, VJ; Lai, B; Leapman, RD; Valencia, JC; Vieira, WD; Zhang, G, 2009) |
| "Highly metastatic B16 melanoma (B16M)-F10 cells, as compared with the low metastatic B16M-F1 line, have higher GSH content and preferentially overexpress BCL-2." | 1.33 | Acceleration of glutathione efflux and inhibition of gamma-glutamyltranspeptidase sensitize metastatic B16 melanoma cells to endothelium-induced cytotoxicity. ( Asensi, M; Benlloch, M; Carretero, J; Estrela, JM; Ferrer, P; Obrador, E; Ortega, A; Segarra, R, 2005) |
| "MTS1 is a metastasis-associated gene highly expressed in highly metastatic tumours." | 1.28 | Modulators of intracellular Ca2+ and the calmodulin inhibitor W-7 alter the expression of metastasis-associated genes MTS1 and NM23 in metastatic variants of the B16 murine melanoma. ( Parker, C; Sherbet, GV, 1992) |
| " Dose-response studies indicated that exceedingly high doses of DTIC were necessary to produce antimetastatic effects even when drug treatment was combined with the calcium channel blocker verapamil." | 1.28 | Efficacy of dacarbazine (DTIC) in preventing metastases arising from intraocular melanomas in mice. ( Gamel, JW; Niederkorn, JY; Sanborn, GE, 1992) |
| " The resulting dose-survival curve was identical to the dose-response curve of RS cells treated with R123 alone." | 1.28 | Relationship between cellular accumulation of rhodamine 123 (R123) and cytotoxicity in B16 melanoma cells. ( Gan, L; Krag, DN; Tao, SZ; Theon, AP; Wardell, J, 1989) |
| "Nifedipine was included as the standard or reference compound." | 1.28 | In vivo characterization of combination antitumor chemotherapy with calcium channel blockers and cis-diamminedichloroplatinum(II). ( Honn, KV; Nelson, KK; Onoda, JM; Taylor, JD, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (23.53) | 18.7374 |
| 1990's | 10 (58.82) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, KG | 1 |
| Leapman, RD | 1 |
| Zhang, G | 1 |
| Lai, B | 1 |
| Valencia, JC | 1 |
| Cardarelli, CO | 1 |
| Vieira, WD | 1 |
| Hearing, VJ | 1 |
| Gottesman, MM | 1 |
| Benlloch, M | 1 |
| Ortega, A | 1 |
| Ferrer, P | 1 |
| Segarra, R | 1 |
| Obrador, E | 1 |
| Asensi, M | 1 |
| Carretero, J | 1 |
| Estrela, JM | 1 |
| Hunt, G | 1 |
| Thody, AJ | 1 |
| Nordenberg, J | 1 |
| Kornfeld, J | 1 |
| Wasserman, L | 1 |
| Shafran, M | 1 |
| Halabe, E | 1 |
| Beery, E | 1 |
| Landau, O | 1 |
| Novogrodsky, A | 1 |
| Sidi, Y | 1 |
| Fink-Puches, R | 2 |
| Helige, C | 2 |
| Kerl, H | 2 |
| Smolle, J | 2 |
| Tritthart, HA | 2 |
| Parker, C | 2 |
| Sherbet, GV | 2 |
| Hofmann-Wellenhof, R | 1 |
| Elstad, CA | 1 |
| Thrall, BD | 1 |
| Raha, G | 1 |
| Meadows, GG | 1 |
| Kozłowska, K | 1 |
| Witkowski, JM | 1 |
| Zarzeczna, M | 1 |
| Cichorek, M | 1 |
| Madeja, Z | 1 |
| Szymkiewicz, I | 1 |
| Zaczek, A | 1 |
| Sroka, J | 1 |
| Miekus, K | 1 |
| Korohoda, W | 1 |
| D'Ancona, S | 1 |
| Mazzo, M | 1 |
| Pea, F | 1 |
| Sanborn, GE | 1 |
| Niederkorn, JY | 1 |
| Gamel, JW | 1 |
| Krag, DN | 1 |
| Theon, AP | 1 |
| Gan, L | 1 |
| Wardell, J | 1 |
| Tao, SZ | 1 |
| Onoda, JM | 1 |
| Nelson, KK | 1 |
| Taylor, JD | 1 |
| Honn, KV | 1 |
| Huber, KR | 1 |
| Schmidt, WF | 1 |
| Thompson, EA | 1 |
| Forsthoefel, AM | 1 |
| Neuberg, RW | 1 |
| Ettinger, RS | 1 |
| Morrow, M | 1 |
| Wait, RB | 1 |
| Rosenthal, RA | 1 |
| Gamelli, RL | 1 |
17 other studies available for verapamil and B16 Melanoma
| Article | Year |
|---|---|
Influence of melanosome dynamics on melanoma drug sensitivity.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Death; Cell Line, Tumor; Cisplatin; Cy | 2009 |
Acceleration of glutathione efflux and inhibition of gamma-glutamyltranspeptidase sensitize metastatic B16 melanoma cells to endothelium-induced cytotoxicity.
Topics: Animals; Apoptosis; Cell Adhesion; Cystic Fibrosis Transmembrane Conductance Regulator; Endothelium; | 2005 |
Agouti protein can act independently of melanocyte-stimulating hormone to inhibit melanogenesis.
Topics: Agouti Signaling Protein; alpha-MSH; Animals; Calcium Channel Blockers; Depression, Chemical; Dose-R | 1995 |
Novobiocin modulates colchicine sensitivity in parental and multidrug-resistant B16 melanoma cells.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Cell Line; Clone Cells; Colchicine; Dose-Re | 1994 |
Inhibition of melanoma cell directional migration in vitro via different cellular targets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aminoimidazole Carboxamide; Animals; Calcium Channel | 1993 |
The Ca2+ channel blocker verapamil enhances melanogenesis without altering metastatic potential in the B16 murine melanoma.
Topics: alpha-MSH; Animals; Cell Differentiation; Female; Lung Neoplasms; Melanocytes; Melanoma, Experimenta | 1993 |
Correlation of melanoma cell motility and invasion in vitro.
Topics: Animals; Calcium Channel Blockers; Cell Movement; Cells, Cultured; Chick Embryo; Cytochalasins; Dequ | 1995 |
Tyrosine and phenylalanine restriction sensitizes adriamycin-resistant P388 leukemia cells to adriamycin.
Topics: Animals; Antineoplastic Agents; Buthionine Sulfoximine; Doxorubicin; Drug Resistance, Neoplasm; Leuk | 1996 |
Diversity of the plasma membrane properties of transplantable hamster melanomas with regard to the expression of P-glycoprotein.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Membran | 1999 |
Contact-activated migration of melanoma B16 and sarcoma XC cells.
Topics: Animals; Cell Communication; Cell Movement; Cells, Cultured; Gadolinium; Humans; Melanoma, Experimen | 2001 |
Modulators of intracellular Ca2+ and the calmodulin inhibitor W-7 alter the expression of metastasis-associated genes MTS1 and NM23 in metastatic variants of the B16 murine melanoma.
Topics: Animals; Blotting, Northern; Calcium; Calmodulin; Female; Gene Expression; Genetic Variation; Lung N | 1992 |
Increased spontaneous cell detachment of F10 cells induced in vitro by some calcium-channel blockers.
Topics: Animals; Calcium Channel Blockers; Cell Adhesion; Culture Media; Flunarizine; Growth Inhibitors; Mel | 1992 |
Efficacy of dacarbazine (DTIC) in preventing metastases arising from intraocular melanomas in mice.
Topics: Animals; Anterior Eye Segment; Dacarbazine; Eye Enucleation; Eye Neoplasms; Female; Lung Neoplasms; | 1992 |
Relationship between cellular accumulation of rhodamine 123 (R123) and cytotoxicity in B16 melanoma cells.
Topics: Animals; Antineoplastic Agents; Cell Survival; Drug Resistance; Melanoma, Experimental; Mitochondria | 1989 |
In vivo characterization of combination antitumor chemotherapy with calcium channel blockers and cis-diamminedichloroplatinum(II).
Topics: Animals; Calcium Channel Blockers; Cisplatin; Diltiazem; Drug Evaluation, Preclinical; Drug Resistan | 1989 |
Effect of verapamil on cell cycle transit and c-myc gene expression in normal and malignant murine cells.
Topics: Animals; Cell Division; Cell Line; Melanocytes; Melanoma, Experimental; Mice; Proto-Oncogenes; Verap | 1989 |
Verapamil enhances antitumor activity without increasing myeloid toxicity.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Drug Synergism; Drug Therapy, Combination; Female; Fluo | 1987 |