verapamil has been researched along with B-Cell Chronic Lymphocytic Leukemia in 15 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Verapamil cytotoxicity was investigated in peripheral blood samples of 35 patients with B-cell CLL and 10 healthy control subjects." | 1.31 | Calcium antagonists potentiate P-glycoprotein-independent anticancer drugs in chronic lymphocytic leukemia cells in vitro. ( Koski, T; Vilpo, J; Vilpo, L, 2000) |
| "Vincristine (VCR) accumulation in chronic lymphatic leukemia of B-cell origin (B-CLL) has recently been shown not to be inversely correlated to P-glycoprotein (PGP) levels." | 1.29 | Beta-tubulin and P-glycoprotein: major determinants of vincristine accumulation in B-CLL cells. ( Altmayr, F; Andreesen, R; Diddens, H; Rastetter, J; Reichle, A, 1995) |
| " Thus the interpretation of results of clinical 'modulator' trials should consider the decreased bioavailability of MDR-reversing agents." | 1.29 | Decreased potency of MDR-modulators under serum conditions determined by a functional assay. ( Eisterer, W; Hilbe, W; Hofmann, J; Ludescher, C; Thaler, J, 1995) |
| "On 16 consecutive fresh B-cell chronic lymphocytic leukemia cell samples, significant T101-F(ab')2 RTA-IT and HNC-241 RTA-IT enhancement was observed with perhexiline which was comparable to that of NH4Cl and monensin." | 1.28 | Enhancement of ricin A chain immunotoxin activity by perhexiline on established and fresh leukemic cells. ( Carrière, D; Chiron, M; Grandjean, H; Jaffrézou, JP; Kuhlein, E; Laurent, G; Levade, T; Thurneyssen, O, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 12 (80.00) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wiley, JS | 1 |
| Chen, R | 1 |
| Jamieson, GP | 1 |
| Berrebi, A | 1 |
| Shtalrid, M | 1 |
| Klepfish, A | 1 |
| Bassous, L | 1 |
| Kushnir, M | 1 |
| Shulman, L | 1 |
| Vorst, E | 1 |
| Hahn, T | 1 |
| Lahmy, S | 1 |
| Lautier, D | 1 |
| Canitrot, Y | 1 |
| Laurent, G | 2 |
| Salmon, JM | 1 |
| Gruber, A | 2 |
| Larsson, R | 1 |
| Nygren, P | 1 |
| Björkholm, M | 1 |
| Peterson, C | 3 |
| Reichle, A | 2 |
| Diddens, H | 2 |
| Altmayr, F | 2 |
| Rastetter, J | 2 |
| Andreesen, R | 2 |
| Tidefelt, U | 1 |
| Juliusson, G | 1 |
| Elmhorn-Rosenborg, A | 1 |
| Paul, C | 1 |
| Ludescher, C | 1 |
| Eisterer, W | 1 |
| Hilbe, W | 1 |
| Hofmann, J | 1 |
| Thaler, J | 1 |
| Maynadié, M | 1 |
| Matutes, E | 1 |
| Catovsky, D | 1 |
| Maia, RC | 1 |
| Vasconcelos, FC | 1 |
| Harab, RC | 1 |
| Coelho, AM | 1 |
| Dobbin, JA | 1 |
| Rumjanek, VM | 1 |
| Kantharidis, P | 1 |
| El-Osta, A | 1 |
| deSilva, M | 1 |
| Wall, DM | 1 |
| Hu, XF | 1 |
| Slater, A | 1 |
| Nadalin, G | 1 |
| Parkin, JD | 1 |
| Zalcberg, JR | 1 |
| Vilpo, J | 1 |
| Koski, T | 1 |
| Vilpo, L | 1 |
| Ganeshaguru, K | 1 |
| Wickremasinghe, RG | 1 |
| Jones, DT | 1 |
| Gordon, M | 1 |
| Hart, SM | 1 |
| Virchis, AE | 1 |
| Prentice, HG | 1 |
| Hoffbrand, AV | 1 |
| Man, A | 1 |
| Champain, K | 1 |
| Csermak, K | 1 |
| Mehta, AB | 1 |
| Jaffrézou, JP | 1 |
| Levade, T | 1 |
| Kuhlein, E | 1 |
| Thurneyssen, O | 1 |
| Chiron, M | 1 |
| Grandjean, H | 1 |
| Carrière, D | 1 |
| Reizenstein, P | 1 |
| Kapoor, R | 1 |
15 other studies available for verapamil and B-Cell Chronic Lymphocytic Leukemia
| Article | Year |
|---|---|
The ATP4- receptor-operated channel (P2Z class) of human lymphocytes allows Ba2+ and ethidium+ uptake: inhibition of fluxes by suramin.
Topics: Adenosine Triphosphate; Barium; Biological Transport; Calcium; Ethidium; Flow Cytometry; Humans; Ion | 1993 |
Verapamil inhibits B-cell proliferation and tumor necrosis factor release and induces a clinical response in B-cell chronic lymphocytic leukemia.
Topics: Aged; Aged, 80 and over; B-Lymphocytes; Calcium; Cell Division; Female; Humans; Leukemia, Lymphocyti | 1994 |
Staining with Hoechst 33342 and rhodamine 123: an attempt to detect multidrug resistant phenotype cells in leukemia.
Topics: Adult; Aged; Antigens, CD; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; | 1993 |
A non-P-glycoprotein-mediated mechanism of vincristine transport which is affected by resistance modifiers and present in chemosensitive cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carrier Prot | 1994 |
Chemomodulation of drugs involved in multidrug resistance in chronic lymphatic leukemia of the B-cell type.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Da | 1994 |
Increased intracellular concentrations of doxorubicin in resistant lymphoma cells in vivo by concomitant therapy with verapamil and cyclosporin A.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cyclosporine; Doxorubicin; Drug Interactions; | 1994 |
Beta-tubulin and P-glycoprotein: major determinants of vincristine accumulation in B-CLL cells.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfam | 1995 |
Decreased potency of MDR-modulators under serum conditions determined by a functional assay.
Topics: Acute Disease; Antimetabolites, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transpor | 1995 |
Quantification of P-glycoprotein in chronic lymphocytic leukemia by flow cytometry.
Topics: Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Antibodies, Monoclonal; ATP Binding Cas | 1997 |
Comparison between anthracyclines and rhodamine-123 accumulation in chronic lymphoid leukemia: effect of cyclosporin A and verapamil.
Topics: Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfa | 1998 |
Altered methylation of the human MDR1 promoter is associated with acquired multidrug resistance.
Topics: Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azacitidin | 1997 |
Calcium antagonists potentiate P-glycoprotein-independent anticancer drugs in chronic lymphocytic leukemia cells in vitro.
Topics: Adult; Aged; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member | 2000 |
Actions of the selective protein kinase C inhibitor PKC412 on B-chronic lymphocytic leukemia cells in vitro.
Topics: 2-Chloroadenosine; Aged; Aged, 80 and over; Antineoplastic Agents; Apoptosis; ATP Binding Cassette T | 2002 |
Enhancement of ricin A chain immunotoxin activity by perhexiline on established and fresh leukemic cells.
Topics: Ammonium Chloride; Antibodies, Monoclonal; Cell Line; Humans; Immunotoxins; Kinetics; Leukemia, Lymp | 1990 |
Accumulation of vincristine and doxorubicin in malignant lymphocytes with different immunophenotypes.
Topics: Aged; Aged, 80 and over; Antibodies, Monoclonal; B-Lymphocytes; Doxorubicin; Female; Fluorescent Ant | 1989 |