verapamil and Asthma studies

Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.

Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).

Research Excerpts

Excerpt	Relevance	Reference
"Twenty patients of bronchial asthma were given 5 mg of either nifedipine or verapamil as aerosol therapy in a randomized fashion."	9.07	Effect of aerosolised verapamil and nifedipine in bronchial asthma. ( Bidani, R; Chopra, R; Gupta, S; Meena, HS, 1993)
"Methacholine challenges were performed in ten subjects with mild asthma at 2 h before and 20 min after placebo or 5, 10, 20, 40, 80, and 160 mg of inhaled verapamil given in a single-blind randomized crossover manner on different days."	9.07	Inhaled verapamil-induced bronchoconstriction in mild asthma. ( Harman, E; Hendeles, L; Hill, M; Pieper, JA, 1991)
"This article describes the immediate effect of verapamil, a calcium antagonist, on pulmonary functions in bronchial asthma."	9.06	Immediate effect of verapamil on pulmonary functions in bronchial asthma. ( Guleria, JS; Sailo, JL; Sharma, SK, 1987)
"Fifteen children with asthma underwent challenges with methacholine on separate days after double blind administration by nebuliser of either verapamil (5 mg), cromoglycate (20 mg), or saline (placebo)."	9.06	Nebulised sodium cromoglycate and verapamil in methacholine induced asthma. ( Andreoli, A; Biancotto, R; Boner, AL; Vallone, G; Warner, JO, 1987)
"The protective effect of 5 mg/2 ml and 10 mg/4 ml of the calcium antagonist verapamil on methacholine challenge and exercise were evaluated in two groups of asthmatic children."	9.06	Effects of different dosages of the calcium antagonist verapamil in exercise- and methacholine-induced bronchospasm in children with chronic asthma. ( Boner, AL; De Stefano, G; Sette, L, 1987)
"Fifteen children with exercise-induced asthma (EIA) participated in a double-blind trial comparing the protective effects of inhaled sodium cromoglycate (20 mg/2 ml), ipratropium bromide (500 micrograms/2 ml) and verapamil (5 mg/2 ml)."	9.06	Comparison of the effects of inhaled calcium antagonist verapamil, sodium cromoglycate and ipratropium bromide on exercise-induced bronchoconstriction in children with asthma. ( Andreoli, A; Antolini, I; Boner, AL; De Stefano, G; Sette, L, 1987)
"Seventeen adult patients with moderate and stable bronchial asthma and established essential hypertension (WHO I or II) were evaluated in a randomized, double-blind, crossover study of the effects of captopril (50-100 mg/day) and verapamil (160-240 mg/day) on blood pressure, orthostatic reactions, respiratory function, and asthmatic symptoms."	9.06	Effects of captopril on blood pressure and respiratory function compared to verapamil in patients with hypertension and asthma. ( Ahonen, A; Riska, H; Salorinne, Y; Sovijärvi, AR; Stenius-Aarniala, B; Sundberg, S, 1990)
"Verapamil is a useful drug with therapeutic targeting on GCH and a potential way to limit mucous production and improve bronchial inflammation."	7.78	Effect of verapamil on bronchial goblet cells of asthma: an experimental study on sensitized animals. ( Ghafarzadegan, K; Hadi, R; Khakzad, MR; Meshkat, M; Mirsadraee, M; Mohammadpour, A; Saghari, M, 2012)
"1 - 100 microM) inhibited carbachol- and high K +-induced muscle contractions in a concentration-dependent fashion, but did not affect basal muscle tension."	7.72	Inhibition of smooth muscle contraction by magnolol and honokiol in porcine trachea. ( Chan, MH; Chen, HH; Ko, CH; Lin, YR, 2003)
"A 66-year-old white woman with a 10-year history of hypertension and bronchial asthma was switched from immediate-release verapamil hydrocloride 40 mg tid to sustained-release verapamil 240 mg/d po for better hypertension control."	7.69	Acute asthma associated with sustained-release verapamil. ( Ben-Noun, L, 1997)
"A single oral dose of verapamil 80 mg was shown significantly to inhibit histamine-induced broncho-constriction in 8 out of 16 asthmatic subjects (maximum increase in PD20FEVHi 416%)."	7.68	Verapamil in the prophylaxis of bronchial asthma. Is the bronchoprotective effect related to the plasma level? ( Elsasser, S; Follath, F; Ha, HR; Imhof, E; Perruchoud, AP; Rosmus, B, 1991)
"The effect of inhaled verapamil 20 mg on pulmonary functions and arterial blood gases in 15 patients with extrinsic bronchial asthma was studied in single-blind fashion."	7.68	Effect of verapamil inhalation on bronchial asthma. ( Pande, JN; Sharma, SK, 1990)
"Inhalation histamine dose-response curves were constructed 15 minutes after inhalation of saline placebo or verapamil (4 mg) for eight patients with mild atopic asthma in a double blind, random manner."	7.67	Effects of calcium channel blockade on histamine induced bronchoconstriction in mild asthma. ( Banks, J; Davies, BH; Fennerty, A; Walters, EH, 1984)
" In the present studies the protective effect of the calcium-antagonist drug verapamil against allergen-induced asthma was assessed in eight atopic patients."	7.66	Effect of verapamil on allergen-induced asthma in patients with respiratory allergy. ( Bianchini, C; Cottini, M; Leggieri, E; Miadonna, A; Restuccia, M; Tedeschi, A, 1983)
"Verapamil was chosen because of its aqueous solubility and hence suitability for aerosol administration in higher doses than previously given."	6.66	Effects of the calcium channel blocker, verapamil, on asthmatic airway responses to muscarinic, histaminergic, and allergenic stimuli. ( Fish, JE; Norman, PS, 1986)
"The study was conducted to characterize the action of NaF, which had relaxing property in carbachol precontracted isolated bovine bronchus, on airway responsiveness challenged by acetylcholine receptor agonists in rats and asthmatic humans."	5.10	Inhaled sodium fluoride decreases airway responsiveness to acetylcholine analogs in vivo. ( Guénard, H; Rouatbi, S; Tabka, Z; Zhao, W, 2002)
"Twenty patients of bronchial asthma were given 5 mg of either nifedipine or verapamil as aerosol therapy in a randomized fashion."	5.07	Effect of aerosolised verapamil and nifedipine in bronchial asthma. ( Bidani, R; Chopra, R; Gupta, S; Meena, HS, 1993)
"Methacholine challenges were performed in ten subjects with mild asthma at 2 h before and 20 min after placebo or 5, 10, 20, 40, 80, and 160 mg of inhaled verapamil given in a single-blind randomized crossover manner on different days."	5.07	Inhaled verapamil-induced bronchoconstriction in mild asthma. ( Harman, E; Hendeles, L; Hill, M; Pieper, JA, 1991)
"A series of 8 adult patients with stable bronchial asthma and an established diagnois of essential hypertension (WHO I and II) was studied in a randomized double-blind cross-over study to assess the effect of captopril (50-100 mg/day) and verapamil (160-240 mg/day) on blood pressure, lung function and asthmatic symptoms."	5.06	Comparison of the efficacy of an ACE-inhibitor and a calcium channel blocker in hypertensive asthmatics. A preliminiary report. ( Riska, H; Sovijärvi, AR; Stenius-Aaniala, B, 1986)
"The protective effect of 5 mg/2 ml and 10 mg/4 ml of the calcium antagonist verapamil on methacholine challenge and exercise were evaluated in two groups of asthmatic children."	5.06	Effects of different dosages of the calcium antagonist verapamil in exercise- and methacholine-induced bronchospasm in children with chronic asthma. ( Boner, AL; De Stefano, G; Sette, L, 1987)
"This article describes the immediate effect of verapamil, a calcium antagonist, on pulmonary functions in bronchial asthma."	5.06	Immediate effect of verapamil on pulmonary functions in bronchial asthma. ( Guleria, JS; Sailo, JL; Sharma, SK, 1987)
"Seventeen adult patients with moderate and stable bronchial asthma and established essential hypertension (WHO I or II) were evaluated in a randomized, double-blind, crossover study of the effects of captopril (50-100 mg/day) and verapamil (160-240 mg/day) on blood pressure, orthostatic reactions, respiratory function, and asthmatic symptoms."	5.06	Effects of captopril on blood pressure and respiratory function compared to verapamil in patients with hypertension and asthma. ( Ahonen, A; Riska, H; Salorinne, Y; Sovijärvi, AR; Stenius-Aarniala, B; Sundberg, S, 1990)
"Fifteen children with asthma underwent challenges with methacholine on separate days after double blind administration by nebuliser of either verapamil (5 mg), cromoglycate (20 mg), or saline (placebo)."	5.06	Nebulised sodium cromoglycate and verapamil in methacholine induced asthma. ( Andreoli, A; Biancotto, R; Boner, AL; Vallone, G; Warner, JO, 1987)
"A series of 12 adult patients with stable bronchial asthma and an established diagnosis of essential hypertension (WHO I or II) were studied in a randomized double-blind crossover study to assess the effect of captopril (50-100 mg/day) and verapamil (160-240 mg/day) on blood pressure, lung function, and asthmatic symptoms."	5.06	Comparison of the effects of an angiotensin converting enzyme inhibitor and a calcium channel blocker on blood pressure and respiratory function in patients with hypertension and asthma. ( Riska, H; Sovijärvi, AR; Stenius-Aarniala, B, 1987)
"Fifteen children with exercise-induced asthma (EIA) participated in a double-blind trial comparing the protective effects of inhaled sodium cromoglycate (20 mg/2 ml), ipratropium bromide (500 micrograms/2 ml) and verapamil (5 mg/2 ml)."	5.06	Comparison of the effects of inhaled calcium antagonist verapamil, sodium cromoglycate and ipratropium bromide on exercise-induced bronchoconstriction in children with asthma. ( Andreoli, A; Antolini, I; Boner, AL; De Stefano, G; Sette, L, 1987)
"Ten patients with exercise-induced asthma participated in a single-blind trial comparing the protective effects of inhaled verapamil (estimated dose 3 mg) and sodium cromoglycate (estimated dose 12 mg)."	5.05	Calcium antagonists in exercise-induced asthma. ( Patel, KR, 1981)
"Verapamil is a useful drug with therapeutic targeting on GCH and a potential way to limit mucous production and improve bronchial inflammation."	3.78	Effect of verapamil on bronchial goblet cells of asthma: an experimental study on sensitized animals. ( Ghafarzadegan, K; Hadi, R; Khakzad, MR; Meshkat, M; Mirsadraee, M; Mohammadpour, A; Saghari, M, 2012)
"1 - 100 microM) inhibited carbachol- and high K +-induced muscle contractions in a concentration-dependent fashion, but did not affect basal muscle tension."	3.72	Inhibition of smooth muscle contraction by magnolol and honokiol in porcine trachea. ( Chan, MH; Chen, HH; Ko, CH; Lin, YR, 2003)
"A 66-year-old white woman with a 10-year history of hypertension and bronchial asthma was switched from immediate-release verapamil hydrocloride 40 mg tid to sustained-release verapamil 240 mg/d po for better hypertension control."	3.69	Acute asthma associated with sustained-release verapamil. ( Ben-Noun, L, 1997)
"A single oral dose of verapamil 80 mg was shown significantly to inhibit histamine-induced broncho-constriction in 8 out of 16 asthmatic subjects (maximum increase in PD20FEVHi 416%)."	3.68	Verapamil in the prophylaxis of bronchial asthma. Is the bronchoprotective effect related to the plasma level? ( Elsasser, S; Follath, F; Ha, HR; Imhof, E; Perruchoud, AP; Rosmus, B, 1991)
"The effect of inhaled verapamil 20 mg on pulmonary functions and arterial blood gases in 15 patients with extrinsic bronchial asthma was studied in single-blind fashion."	3.68	Effect of verapamil inhalation on bronchial asthma. ( Pande, JN; Sharma, SK, 1990)
"The aim of the study was to investigate the influence of verapamil on anti-IgE induced histamine release from basophils isolated from the blood of 10 atopic asthma patients."	3.67	The influence of the calcium channel antagonist verapamil on histamine release from target cells. ( Chyrek-Borowska, S; Hofman, J; Siergiejko, Z, 1989)
"The induction of allergic pulmonary distress (APD) in ovalbumin sensitive rats can be used as a model of human allergic asthma."	3.67	The effect of calcium antagonists on allergic pulmonary distress in actively sensitized rats. ( Aspinall, RL; Carnathan, GW; Korach, ES, 1987)
"Inhalation histamine dose-response curves were constructed 15 minutes after inhalation of saline placebo or verapamil (4 mg) for eight patients with mild atopic asthma in a double blind, random manner."	3.67	Effects of calcium channel blockade on histamine induced bronchoconstriction in mild asthma. ( Banks, J; Davies, BH; Fennerty, A; Walters, EH, 1984)
" Certain drugs such as antihistamines and ketotifen may be more effective administered by inhalation since high concentrations with reduced unwanted effects can be achieved on the bronchial surface where, in allergic asthma, the critical initial interaction between sensitized mast cells (mucosal?) and allergen with subsequent mediator release occurs."	3.67	Use of inhaled calcium channel blocking agents in the treatment of asthma. ( Bennett, J; Davies, RJ; Osman, J, 1984)
" verapamil administration on some indices of the hemodynamics of the greater and lesser circulation was studied in 19 patients with bronchial asthma by a multiple approach using noninvasive methods (rheopulmonography, polycardiography, tetrapolar chest rheography)."	3.67	[Acute hemodynamic effects of finoptin in patients with bronchial asthma complicated by pulmonary hypertension]. ( Brimkulov, NN, 1987)
"Verapamil was found to be an effective inhibitor of isometric tension in in vitro, experimental anaphylaxis in guinea pig trachealis smooth muscle."	3.66	Effect of calcium antagonists in experimental asthma. ( Barbero, L; Markowicz, J; Weiss, EB, 1982)
" 4 mg) and sub-lingual nifedipine (20 mg) against allergen-induced asthma were each assessed by the administration of calcium antagonists 30 min before bronchial provocation tests using Dermatophagoides pteronyssinus extracts on eight young perennial asthmatics."	3.66	Effect of calcium antagonists on allergen-induced asthma. ( Lam, WK; So, SY; Yu, DY, 1982)
" In the present studies the protective effect of the calcium-antagonist drug verapamil against allergen-induced asthma was assessed in eight atopic patients."	3.66	Effect of verapamil on allergen-induced asthma in patients with respiratory allergy. ( Bianchini, C; Cottini, M; Leggieri, E; Miadonna, A; Restuccia, M; Tedeschi, A, 1983)
"In eight patients with extrinsic bronchial asthma the effect of inhaled verapamil (3 and 6 mg) was compared with saline on bronchial challenge with extracts of Dermatophagoides pteronyssinus."	3.66	The effect of inhaled verapamil on allergen-induced bronchoconstriction. ( Al Shama, MR; Kerr, JW; Patel, KR, 1983)
"Calcium antagonist, verapamil given by inhalation did not alter histamine bronchial hyper-reactivity in ten patients with extrinsic bronchial asthma and similarly did not modify methacholine-induced bronchoconstriction in further five patients."	3.66	The effect of verapamil on histamine and methacholine-induced bronchoconstriction. ( Patel, KR, 1981)
"Verapamil was chosen because of its aqueous solubility and hence suitability for aerosol administration in higher doses than previously given."	2.66	Effects of the calcium channel blocker, verapamil, on asthmatic airway responses to muscarinic, histaminergic, and allergenic stimuli. ( Fish, JE; Norman, PS, 1986)
"webbiana for treating diarrhea and asthma."	1.91	Ethnopharmacological basis and pharmacodynamics prospectives for folkloric claims of Rosa webbiana wall. Ex. Royle in diarrhea and asthma via In vitro, In vivo and In silico techniques. ( Ali, A; Saqib, F, 2023)
"Trifluoperazine was less effective against acetylcholine-induced tone in sensitized, as compared to untreated, trachea."	1.29	Effects of two Ca2+ modulators in normal and albumin-sensitized guinea-pig trachea. ( De Jonckheere, S; McCaig, D, 1993)

Research

Studies (73)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Number of Participants With Dose Limiting Toxicity

Timeframe	Studies, this research(%)	All Research%
pre-1990	46 (63.01)	18.7374
1990's	16 (21.92)	18.2507
2000's	4 (5.48)	29.6817
2010's	6 (8.22)	24.3611
2020's	1 (1.37)	2.80

Authors	Studies
Ali, A	1
Saqib, F	1
Ribeiro-Filho, J	1
Calheiros, AS	1
Vieira-de-Abreu, A	1
de Carvalho, KI	1
da Silva Mendes, D	1
Melo, CB	1
Martins, MA	1
da Silva Dias, C	1
Piuvezam, MR	1
Bozza, PT	1
Sweeney, D	1
Hollins, F	1
Gomez, E	1
Saunders, R	1
Challiss, RA	1
Brightling, CE	1
Shareef, H	1
Rizwani, GH	1
Mandukhail, SR	1
Watanabe, N	1
Gilani, AH	2
Daveluy, A	1
Raignoux, C	1
Miremont-Salamé, G	1
Girodet, PO	1
Moore, N	1
Haramburu, F	1
Molimard, M	1
Richards, IS	1
Bourgeois, M	1
Khakzad, MR	1
Mirsadraee, M	1
Mohammadpour, A	1
Ghafarzadegan, K	1
Hadi, R	1
Saghari, M	1
Meshkat, M	1
Shah, AJ	1
Zhao, W	1
Rouatbi, S	1
Tabka, Z	1
Guénard, H	1
Ko, CH	1
Chen, HH	1
Lin, YR	1
Chan, MH	1
Townley, RG	1
Weiss, EB	1
Markowicz, J	1
Barbero, L	1
Solway, J	1
Patel, KR	5
König, P	1
Davies, RJ	1
Bennett, J	1
Osman, J	1
Walters, EH	1
Banks, J	1
Fennerty, A	1
Davies, BH	1
Zawar, PB	1
Amrapurkar, DN	1
Chawhan, RN	1
Kulkarni, PM	1
Chandorkar, AG	1
Fish, JE	2
Hahn, HL	1
Al Shama, MR	1
Kerr, JW	2
Miadonna, A	1
Tedeschi, A	1
Leggieri, E	1
Cottini, M	1
Restuccia, M	1
Bianchini, C	1
So, SY	2
Lam, WK	2
Yu, DY	1
Rossetti, M	1
Savineau, JP	2
Crevel, H	1
Marthan, R	2
Gan, LP	1
Ling, PJ	1
McCaig, D	1
De Jonckheere, S	1
Gupta, S	1
Meena, HS	1
Chopra, R	1
Bidani, R	1
Villanove, X	1
Tunon de Lara, JM	1
Johnson, PR	2
McKay, KO	1
Alouan, LA	1
Armour, CL	2
Black, JL	2
Ammit, AJ	1
Carlin, SM	1
Caughey, GH	1
Ben-Noun, L	1
Shi, Z	1
Luo, W	1
Xiu, Q	1
Ye, Y	1
Yan, Z	1
Zhu, Q	1
Elliott, WJ	1
Riska, H	3
Sovijärvi, AR	3
Ahonen, A	1
Salorinne, Y	1
Sundberg, S	1
Stenius-Aarniala, B	2
Imhof, E	1
Elsasser, S	1
Rosmus, B	1
Ha, HR	1
Follath, F	1
Perruchoud, AP	1
Provotorov, VM	2
Kuznetsov, SI	2
Harman, E	1
Hill, M	1
Pieper, JA	1
Hendeles, L	1
Kivity, S	1
Yarchovsky, J	1
Greif, J	1
Topilsky, M	1
Tsuda, T	1
Takeuchi, M	1
Ishikawa, K	1
Ando, H	1
Hanamura, Y	1
Takasu, H	1
Sharma, SK	2
Pande, JN	1
Ahmed, T	2
Abraham, WM	1
Zou, HL	1
Wei, EQ	1
Yang, W	1
Bian, RL	1
Ip, M	1
Palombo, C	1
Mian, M	1
Bertelli, A	1
Hofman, J	1
Siergiejko, Z	1
Chyrek-Borowska, S	1
Alekseev, VG	1
Sinopal'nikov, AI	1
Efimov, AV	1
Mapp, C	1
Boschetto, P	1
dal Vecchio, L	1
Crescioli, S	1
de Marzo, N	1
Paleari, D	1
Fabbri, LM	1
Frey, MJ	1
Boner, AL	3
Antolini, I	1
Andreoli, A	2
De Stefano, G	2
Sette, L	2
Roberts, JA	1
Rodger, IW	1
Thomson, NC	1
Vallone, G	1
Biancotto, R	1
Warner, JO	1
Jankowska, R	2
Jankowski, A	1
Małolepszy, J	2
Szyszka, Z	1
Wasek, Z	1
Stenius-Aaniala, B	1
Greenspon, LW	1
Levy, SF	1
Korach, ES	1
Carnathan, GW	1
Aspinall, RL	1
Sailo, JL	1
Guleria, JS	1
Larach, DR	1
Zelis, R	1
Norman, PS	1
Kardaszewicz, B	1
Danek, K	1
Brimkulov, NN	1
Minors, DS	1
Russi, E	1
Kim, CS	1
Danta, I	1
Krasnowska, M	1
Liebhart, E	1
Gianotti, A	1
Bottino, G	1
Fabel, H	1
Hills, EA	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Phase Ib/II Clinical Trial of Topical Verapamil Hydrochloride for Chronic Rhinosinusitis With Nasal Polyps[NCT03102190]	Phase 1	6 participants (Actual)	Interventional	2017-06-05	Terminated (stopped due to Phase II funding not available)
Randomized Double Blind Placebo Controlled Trial of Verapamil in Chronic Rhinosinusitis[NCT02454608]		29 participants (Actual)	Interventional	2015-05-31	Terminated (stopped due to Evidence that the dose is insufficient.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Dose Limiting Toxicity will be defined as a development of 2nd or 3rd degree heart block as measured by an EKG. (Phase Ib primary outcome) (NCT03102190)
Timeframe: 1-8 weeks

Diastolic Blood Pressure

Heart Rate

Objective Sinonasal Symptoms on Lund-Kennedy Score(LKS)

Intervention	Participants (Count of Participants)
Phase Ib	0

Intervention	mmHg (Mean)
Treatment	-0.6
Control	1

Intervention	beats per minute (Mean)
Treatment	-1.4
Control	4

Minimum Score: 0 Maximum Score: 12 Higher value represents worse outcome. (NCT02454608)
Timeframe: baseline to week 8

Objective Sinonasal Symptoms on Lund-McKay Score(LMS)

Intervention	units on a scale (Least Squares Mean)
Treatment	-1.3
Control	-0.25

Minimum Score: 0 Maximum Score: 24 Higher value represents worse outcome. (NCT02454608)
Timeframe: Week 8

Subjective Sinonasal Symptoms on 10cm Visual Analogue Scale(VAS)

Intervention	units on a scale (Mean)
Treatment	12.5
Control	17.7

Minimum Score: 0 Maximum Score: 100 A higher score indicates a worse outcome. (NCT02454608)
Timeframe: baseline to week 8

Subjective Sinonasal Symptoms on Sinonasal Outcomes Test-22(SNOT-22)

Intervention	units on a scale (Least Squares Mean)
Treatment	-44.03
Control	-6.07

Minimum Score: 0 Maximum Score: 110 A higher score indicates a worse outcome (NCT02454608)
Timeframe: baseline to week 8

Systolic Blood Pressure

Subjective Sinonasal Symptoms on 10cm Visual Analogue Scale(VAS)

Intervention	units on a scale (Least Squares Mean)
Treatment	-27.3
Control	0.4

Intervention	mmHg (Mean)
Treatment	-4.5
Control	-6.6

Minimum Score: 0 Maximum Score: 100 A higher score indicates a worse outcome. (NCT02454608)
Timeframe: baseline to week 56

Subjective Sinonasal Symptoms on Sinonasal Outcomes Test-22(SNOT-22)

Intervention	units on a scale (Mean)
	Medicine Completers, baseline	Medicine Completers, week 56	Surgical Completers, baseline	Surgical Completers, week 12
Open Label	64.3	35.0	90.0	16.7

Minimum Score: 0 Maximum Score: 110 A higher score indicates a worse outcome (NCT02454608)
Timeframe: baseline to week 56

Article	Year
Role of calcium-channel blockers in obstructive airway disease. Chest, 1985, Volume: 88, Issue:2 Suppl Topics: Acetylcholine; Animals; Asthma; Asthma, Exercise-Induced; Calcium; Calcium Channel Blockers; Diltiaz	1985
Calcium channel blockers and asthma. Lung, 1986, Volume: 164, Issue:1 Topics: Animals; Asthma; Bronchi; Bronchodilator Agents; Calcium; Calcium Channel Blockers; Cell Adhesion; C	1986
[Calcium antagonists: accounts on new perspectives of their use and an update on side effects]. La Clinica terapeutica, 1989, Feb-15, Volume: 128, Issue:3 Topics: Adult; Animals; Asthma; Calcium Channel Blockers; Cardiovascular Diseases; Diltiazem; Esophageal Ach	1989
Advances in calcium blocker therapy. American journal of surgery, 1986, Volume: 151, Issue:4 Topics: Arrhythmias, Cardiac; Arteriosclerosis; Asthma; Blood Platelet Disorders; Calcium; Calcium Channel B	1986
[Use of calcium antagonists in the treatment of bronchial asthma]. Polskie Archiwum Medycyny Wewnetrznej, 1986, Volume: 75, Issue:2 Topics: Animals; Asthma; Bronchi; Bronchial Spasm; Bronchodilator Agents; Clinical Trials as Topic; Drug Eva	1986
Chronobiology: its importance in clinical medicine. Clinical science (London, England : 1979), 1985, Volume: 69, Issue:4 Topics: Airway Resistance; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Asthma; Biological Cloc	1985

Article	Year
Inhaled sodium fluoride decreases airway responsiveness to acetylcholine analogs in vivo. Respiratory physiology & neurobiology, 2002, Aug-01, Volume: 131, Issue:3 Topics: Acetylcholine; Administration, Inhalation; Adult; Airway Resistance; Animals; Asthma; Blood Pressure	2002
Sodium cromoglycate and verapamil alone and in combination in exercise induced asthma. British medical journal (Clinical research ed.), 1983, Feb-19, Volume: 286, Issue:6365 Topics: Adult; Asthma; Asthma, Exercise-Induced; Cromolyn Sodium; Drug Therapy, Combination; Female; Humans;	1983
Calcium antagonists in exercise-induced asthma. British medical journal (Clinical research ed.), 1981, Mar-21, Volume: 282, Issue:6268 Topics: Adolescent; Adult; Asthma; Asthma, Exercise-Induced; Clinical Trials as Topic; Cromolyn Sodium; Fema	1981
Effect of aerosolised verapamil and nifedipine in bronchial asthma. The Journal of the Association of Physicians of India, 1993, Volume: 41, Issue:7 Topics: Administration, Inhalation; Adult; Aerosols; Asthma; Female; Humans; Nifedipine; Verapamil	1993
Effects of captopril on blood pressure and respiratory function compared to verapamil in patients with hypertension and asthma. Journal of cardiovascular pharmacology, 1990, Volume: 15, Issue:1 Topics: Aged; Asthma; Blood Pressure; Captopril; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged	1990
[Treatment of bronchial asthma by intrapulmonary administration of steroid hormones and calcium antagonists]. Sovetskaia meditsina, 1990, Issue:11 Topics: Adult; Asthma; Bronchodilator Agents; Calcium Channel Blockers; Female; Glucocorticoids; Humans; Mal	1990
Inhaled verapamil-induced bronchoconstriction in mild asthma. Chest, 1991, Volume: 100, Issue:1 Topics: Administration, Inhalation; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Exercis	1991
Comparison of the effects of an angiotensin converting enzyme inhibitor and a calcium channel blocker on blood pressure and respiratory function in patients with hypertension and asthma. Journal of cardiovascular pharmacology, 1987, Volume: 10 Suppl 10 Topics: Aged; Asthma; Blood Pressure; Captopril; Double-Blind Method; Electrocardiography; Female; Forced Ex	1987
Protective effect of antiasthma drugs on late asthmatic reactions and increased airway responsiveness induced by toluene diisocyanate in sensitized subjects. The American review of respiratory disease, 1987, Volume: 136, Issue:6 Topics: Asthma; Beclomethasone; Bronchial Provocation Tests; Clinical Trials as Topic; Cromolyn Sodium; Cyan	1987
Comparison of the effects of inhaled calcium antagonist verapamil, sodium cromoglycate and ipratropium bromide on exercise-induced bronchoconstriction in children with asthma. European journal of pediatrics, 1987, Volume: 146, Issue:4 Topics: Administration, Inhalation; Adolescent; Airway Resistance; Asthma; Asthma, Exercise-Induced; Atropin	1987
Nebulised sodium cromoglycate and verapamil in methacholine induced asthma. Archives of disease in childhood, 1987, Volume: 62, Issue:3 Topics: Adolescent; Asthma; Bronchial Provocation Tests; Child; Cromolyn Sodium; Female; Forced Expiratory V	1987
Comparison of the efficacy of an ACE-inhibitor and a calcium channel blocker in hypertensive asthmatics. A preliminiary report. Postgraduate medical journal, 1986, Volume: 62 Suppl 1 Topics: Aged; Asthma; Captopril; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hypertension	1986
Effects of different dosages of the calcium antagonist verapamil in exercise- and methacholine-induced bronchospasm in children with chronic asthma. The Journal of asthma : official journal of the Association for the Care of Asthma, 1987, Volume: 24, Issue:2 Topics: Adolescent; Asthma; Asthma, Exercise-Induced; Bronchial Provocation Tests; Child; Female; Forced Exp	1987
Immediate effect of verapamil on pulmonary functions in bronchial asthma. The Journal of asthma : official journal of the Association for the Care of Asthma, 1987, Volume: 24, Issue:3 Topics: Adolescent; Adult; Asthma; Female; Forced Expiratory Flow Rates; Humans; Lung; Lung Volume Measureme	1987
Effects of the calcium channel blocker, verapamil, on asthmatic airway responses to muscarinic, histaminergic, and allergenic stimuli. The American review of respiratory disease, 1986, Volume: 133, Issue:5 Topics: Adult; Allergens; Asthma; Calcium Channel Blockers; Forced Expiratory Volume; Histamine; Humans; Lun	1986
[Use of calcium antagonists in the treatment of bronchial asthma]. Polskie Archiwum Medycyny Wewnetrznej, 1986, Volume: 75, Issue:2 Topics: Animals; Asthma; Bronchi; Bronchial Spasm; Bronchodilator Agents; Clinical Trials as Topic; Drug Eva	1986
Iproveratril and bronchial asthma. The British journal of clinical practice, 1970, Volume: 24, Issue:3 Topics: Adolescent; Adult; Angina Pectoris; Anti-Arrhythmia Agents; Asthma; Clinical Trials as Topic; Female	1970

Article	Year
Ethnopharmacological basis and pharmacodynamics prospectives for folkloric claims of Rosa webbiana wall. Ex. Royle in diarrhea and asthma via In vitro, In vivo and In silico techniques. Journal of ethnopharmacology, 2023, Dec-05, Volume: 317 Topics: Animals; Antidiarrheals; Asthma; Bronchodilator Agents; Calcium; Calcium Channels; Diarrhea; Gastroi	2023
Curine inhibits eosinophil activation and airway hyper-responsiveness in a mouse model of allergic asthma. Toxicology and applied pharmacology, 2013, Nov-15, Volume: 273, Issue:1 Topics: Administration, Oral; Animals; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Calcium; Di	2013
[Ca2+]i oscillations in ASM: relationship with persistent airflow obstruction in asthma. Respirology (Carlton, Vic.), 2014, Volume: 19, Issue:5 Topics: Adult; Aged; Asthma; Biopsy; Caffeine; Calcium Signaling; Case-Control Studies; Female; Forced Expir	2014
Studies on antidiarrhoeal, antispasmodic and bronchodilator activities of Operculina turpethum Linn. BMC complementary and alternative medicine, 2014, Dec-12, Volume: 14 Topics: Animals; Antidiarrheals; Asthma; Bronchodilator Agents; Calcium; Calcium Channel Blockers; Carbachol	2014
Drug interactions between inhaled corticosteroids and enzymatic inhibitors. European journal of clinical pharmacology, 2009, Volume: 65, Issue:7 Topics: Administration, Inhalation; Adolescent; Adrenal Cortex Hormones; Adrenal Insufficiency; Adult; Aged;	2009
Red tide toxin produces in vitro depolarization of human airway smooth muscle. Clinical toxicology (Philadelphia, Pa.), 2010, Volume: 48, Issue:2 Topics: Acetylcholine; Adult; Asthma; Atropine; Bronchoconstriction; Dose-Response Relationship, Drug; Femal	2010
Effect of verapamil on bronchial goblet cells of asthma: an experimental study on sensitized animals. Pulmonary pharmacology & therapeutics, 2012, Volume: 25, Issue:2 Topics: Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Calcium Channel Blockers; Disease Models, An	2012
Effect of verapamil on bronchial goblet cells of asthma: an experimental study on sensitized animals. Pulmonary pharmacology & therapeutics, 2012, Volume: 25, Issue:2 Topics: Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Calcium Channel Blockers; Disease Models, An	2012
Effect of verapamil on bronchial goblet cells of asthma: an experimental study on sensitized animals. Pulmonary pharmacology & therapeutics, 2012, Volume: 25, Issue:2 Topics: Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Calcium Channel Blockers; Disease Models, An	2012
Effect of verapamil on bronchial goblet cells of asthma: an experimental study on sensitized animals. Pulmonary pharmacology & therapeutics, 2012, Volume: 25, Issue:2 Topics: Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Calcium Channel Blockers; Disease Models, An	2012
The calcium channel blocking and phosphodiesterase inhibitory activities of the extract of Andropogon muricatus explains its medicinal use in airways disorders. Phytotherapy research : PTR, 2012, Volume: 26, Issue:8 Topics: Andropogon; Animals; Asthma; Calcium Channel Blockers; Calcium Channels; Carbachol; Guinea Pigs; In	2012
Inhibition of smooth muscle contraction by magnolol and honokiol in porcine trachea. Planta medica, 2003, Volume: 69, Issue:6 Topics: Animals; Asthma; Biphenyl Compounds; Bronchodilator Agents; Calcium; Carbachol; Dose-Response Relati	2003
Role of calcium channel blocking agents in the treatment of allergic asthma. The Journal of asthma : official journal of the Association for the Care of Asthma, 1984, Volume: 21, Issue:6 Topics: Animals; Asthma; Basophils; Bronchial Provocation Tests; Bronchial Spasm; Calcium; Calcium Channel B	1984
Effect of calcium antagonists in experimental asthma. Allergy, 1982, Volume: 37, Issue:7 Topics: Anaphylaxis; Animals; Asthma; Calcium Channel Blockers; Depression, Chemical; Disease Models, Animal	1982
Calcium channel blocking agents in bronchial hyperreactivity. The Journal of asthma : official journal of the Association for the Care of Asthma, 1984, Volume: 21, Issue:6 Topics: Airway Resistance; Asthma; Asthma, Exercise-Induced; Bronchial Provocation Tests; Bronchial Spasm; C	1984
The use of cromolyn in the management of hyperreactive airways and exercise. The Journal of allergy and clinical immunology, 1984, Volume: 73, Issue:5 Pt 2 Topics: Adult; Aerosols; Angioedema; Asthma; Asthma, Exercise-Induced; Bronchial Spasm; Child; Cold Temperat	1984
Use of inhaled calcium channel blocking agents in the treatment of asthma. The Journal of asthma : official journal of the Association for the Care of Asthma, 1984, Volume: 21, Issue:6 Topics: Aerosols; Airway Resistance; Allergens; Asthma; Asthma, Exercise-Induced; Bronchial Provocation Test	1984
Effects of calcium channel blockade on histamine induced bronchoconstriction in mild asthma. Thorax, 1984, Volume: 39, Issue:8 Topics: Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Dou	1984
Immediate effect of verapamil on the respiratory functions in bronchial asthma. The Journal of the Association of Physicians of India, 1984, Volume: 32, Issue:9 Topics: Adult; Asthma; Female; Humans; Lung Volume Measurements; Male; Middle Aged; Verapamil	1984
Calcium channel antagonists in the treatment of asthma. The Journal of asthma : official journal of the Association for the Care of Asthma, 1984, Volume: 21, Issue:6 Topics: Airway Resistance; Animals; Asthma; Biological Transport; Calcium; Calcium Channel Blockers; Diltiaz	1984
Modification of allergic bronchoconstriction by a calcium antagonist: mode of action. The American review of respiratory disease, 1984, Volume: 129, Issue:1 Topics: Animals; Antigens; Asthma; Bronchi; Dogs; Humans; Verapamil	1984
Calcium channel blocking agents. Council on scientific affairs. JAMA, 1983, Nov-11, Volume: 250, Issue:18 Topics: Angina Pectoris; Animals; Arrhythmias, Cardiac; Asthma; Calcium Channel Blockers; Cardiomyopathy, Hy	1983
The effect of inhaled verapamil on allergen-induced bronchoconstriction. Clinical allergy, 1983, Volume: 13, Issue:2 Topics: Adolescent; Adult; Allergens; Asthma; Bronchi; Female; Humans; Male; Mast Cells; Verapamil	1983
Effect of verapamil on allergen-induced asthma in patients with respiratory allergy. Annals of allergy, 1983, Volume: 51, Issue:2 Pt 1 Topics: Administration, Oral; Adult; Aerosols; Allergens; Asthma; Basophils; Bronchial Provocation Tests; Cy	1983
Calcium antagonists in experimental asthma. Clinical allergy, 1982, Volume: 12 Suppl Topics: Adolescent; Adult; Asthma; Asthma, Exercise-Induced; Bronchial Provocation Tests; Calcium Channel Bl	1982
Effect of calcium antagonists on allergen-induced asthma. Clinical allergy, 1982, Volume: 12, Issue:6 Topics: Adolescent; Allergens; Asthma; Bronchial Provocation Tests; Calcium Channel Blockers; Forced Expirat	1982
The effect of verapamil on histamine and methacholine-induced bronchoconstriction. Clinical allergy, 1981, Volume: 11, Issue:5 Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Female; Forced Expiratory V	1981
Role of protein kinase C in nonsensitized and passively sensitized human isolated bronchial smooth muscle. The American journal of physiology, 1995, Volume: 268, Issue:6 Pt 1 Topics: Alkaloids; Allergens; Asthma; Bronchi; Dose-Response Relationship, Drug; Enzyme Activation; Humans;	1995
[Airway epithelium affects relaxing effect of verapamil]. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 1994, Volume: 17, Issue:4 Topics: Acetylthiocholine; Animals; Asthma; Biological Factors; Bronchi; Bronchial Hyperreactivity; Epitheli	1994
Effects of two Ca2+ modulators in normal and albumin-sensitized guinea-pig trachea. European journal of pharmacology, 1993, Nov-02, Volume: 249, Issue:1 Topics: Acetylcholine; Albumins; Animals; Asthma; Calcium; Disease Models, Animal; Guinea Pigs; Immunization	1993
Sensitization decreases relaxation in human isolated airways. The American review of respiratory disease, 1993, Volume: 148, Issue:1 Topics: Asthma; Benzopyrans; Bronchi; Bucladesine; Carbachol; Colforsin; Cromakalim; Dose-Response Relations	1993
Mast cell tryptase potentiates histamine-induced contraction in human sensitized bronchus. The European respiratory journal, 1997, Volume: 10, Issue:1 Topics: Acetylcholine; Adolescent; Adult; Aged; Asthma; Bronchi; Bronchial Provocation Tests; Bronchoconstri	1997
Acute asthma associated with sustained-release verapamil. The Annals of pharmacotherapy, 1997, Volume: 31, Issue:5 Topics: Acute Disease; Aged; Asthma; Blood Pressure; Calcium Channel Blockers; Delayed-Action Preparations;	1997
Effects of BRL 55 834 on allergen-induced bronchoconstriction and airway inflammation in sensitized guinea pigs. Chinese medical journal, 1999, Volume: 112, Issue:11 Topics: Animals; Asthma; Benzopyrans; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchodilator Agen	1999
Timing treatment to the rhythm of disease. A short course in chronotherapeutics. Postgraduate medicine, 2001, Volume: 110, Issue:2 Topics: Antineoplastic Agents; Asthma; Cardiovascular Diseases; Chronotherapy; Circadian Rhythm; Humans; Hyd	2001
Verapamil in the prophylaxis of bronchial asthma. Is the bronchoprotective effect related to the plasma level? European journal of clinical pharmacology, 1991, Volume: 41, Issue:4 Topics: Administration, Inhalation; Administration, Oral; Adolescent; Adult; Asthma; Female; Histamine; Huma	1991
Combined effect of inhaled verapamil and sodium cromoglycate on the airway response to hypertonic saline. Annals of allergy, 1990, Volume: 64, Issue:2 Pt 1 Topics: Administration, Inhalation; Adolescent; Adult; Asthma; Cromolyn Sodium; Drug Therapy, Combination; F	1990
[The treatment of bronchial asthma patients with intrapulmonary injections of metipred and finoptin using a needle jet injector]. Vrachebnoe delo, 1990, Issue:3 Topics: Adult; Asthma; Bronchodilator Agents; Female; Glucocorticoids; Humans; Injections, Intralesional; In	1990
Bronchodilating effect of inhaled or orally administered calcium channel blocking agents on methacholine-induced bronchoconstriction. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1990, Volume: 37, Issue:4 Pt 2 Topics: Administration, Inhalation; Administration, Oral; Adolescent; Adult; Airway Resistance; Asthma; Bron	1990
Effect of verapamil inhalation on bronchial asthma. The Journal of asthma : official journal of the Association for the Care of Asthma, 1990, Volume: 27, Issue:1 Topics: Administration, Inhalation; Adolescent; Adult; Asthma; Blood Gas Analysis; Female; Humans; Male; Res	1990
[Effect of verapamil on the action of isoproterenol]. Yao xue xue bao = Acta pharmaceutica Sinica, 1985, Volume: 20, Issue:3 Topics: Animals; Asthma; Biological Transport; Calcium; Drug Synergism; Guinea Pigs; Histamine Release; Isop	1985
The influence of the calcium channel antagonist verapamil on histamine release from target cells. Archivum immunologiae et therapiae experimentalis, 1989, Volume: 37, Issue:1-2 Topics: Asthma; Basophils; Calcium Channel Blockers; Histamine; Humans; Verapamil	1989
[Use of calcium antagonists in therapy of bronchial asthma]. Terapevticheskii arkhiv, 1989, Volume: 61, Issue:3 Topics: Asthma; Calcium Channel Blockers; Drug Synergism; Humans; Nifedipine; Sympathomimetics; Verapamil	1989
Effects of the calcium channel blocker, verapamil, on asthmatic airway responses to muscarinic, histaminergic, and allergenic stimuli. The American review of respiratory disease, 1986, Volume: 134, Issue:6 Topics: Adrenergic beta-Antagonists; Asthma; Humans; Verapamil	1986
Effect of verapamil and sodium cromoglycate on leukotriene D4 induced bronchoconstriction in patients with asthma. Thorax, 1986, Volume: 41, Issue:10 Topics: Adult; Airway Resistance; Asthma; Cromolyn Sodium; Dose-Response Relationship, Drug; Female; Humans;	1986
[Effect of verapamil on the granulocyte activity studied by the NBT test in patients with hay fever and non-atopic bronchial asthma]. Pneumonologia polska, 1988, Volume: 56, Issue:8 Topics: Adolescent; Adult; Asthma; Culture Media; Granulocytes; Humans; In Vitro Techniques; Middle Aged; Ni	1988
[Calcium channel blockers and their value in the treatment of bronchial asthma]. Pneumonologia polska, 1988, Volume: 56, Issue:10 Topics: Asthma; Bronchi; Bronchodilator Agents; Diltiazem; Drug Evaluation; Humans; Nifedipine; Verapamil	1988
The effect of aerosolized verapamil on the response to isoproterenol in asthmatics. The American review of respiratory disease, 1988, Volume: 137, Issue:3 Topics: Adult; Aerosols; Asthma; Bronchi; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Dru	1988
The effect of calcium antagonists on allergic pulmonary distress in actively sensitized rats. Allergy, 1987, Volume: 42, Issue:8 Topics: Administration, Oral; Aerosols; Animals; Asthma; Calcium Channel Blockers; Diltiazem; Female; Nifedi	1987
[Acute hemodynamic effects of finoptin in patients with bronchial asthma complicated by pulmonary hypertension]. Terapevticheskii arkhiv, 1987, Volume: 59, Issue:3 Topics: Adult; Asthma; Blood Pressure; Female; Hemodynamics; Humans; Hypertension, Pulmonary; Male; Middle A	1987
Comparative effects of oral and inhaled verapamil on antigen-induced bronchoconstriction. Chest, 1985, Volume: 88, Issue:2 Topics: Administration, Oral; Adult; Airway Resistance; Asthma; Bronchi; Bronchial Provocation Tests; Constr	1985
[Effect of verapamil on spirometric parameters during an attack of dyspnea in patients with bronchial asthma]. Pneumonologia polska, 1985, Volume: 53, Issue:3 Topics: Adolescent; Adult; Asthma; Dyspnea; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Res	1985
[Effects of the inhalation of verapamil in bronchial asthma]. La Clinica terapeutica, 1985, Oct-31, Volume: 115, Issue:2 Topics: Adult; Aerosols; Asthma; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Verapamil	1985
[Beta-receptor blockaders and asthma bronchiale]. Deutsche medizinische Wochenschrift (1946), 1971, Jan-29, Volume: 96, Issue:5 Topics: Adrenergic beta-Antagonists; Asthma; Humans; Prenylamine; Verapamil	1971

verapamil and Asthma

Research Excerpts

Research

Studies (73)

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Clinical Trials (2)

Trial Overview

Trial Outcomes

Number of Participants With Dose Limiting Toxicity

Diastolic Blood Pressure

Heart Rate

Objective Sinonasal Symptoms on Lund-Kennedy Score(LKS)

Objective Sinonasal Symptoms on Lund-McKay Score(LMS)

Subjective Sinonasal Symptoms on 10cm Visual Analogue Scale(VAS)

Subjective Sinonasal Symptoms on Sinonasal Outcomes Test-22(SNOT-22)

Systolic Blood Pressure

Subjective Sinonasal Symptoms on 10cm Visual Analogue Scale(VAS)

Subjective Sinonasal Symptoms on Sinonasal Outcomes Test-22(SNOT-22)

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