verapamil has been researched along with Arterial Occlusive Diseases in 32 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Arterial Occlusive Diseases: Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effectiveness of verapamil in the management of patients with unstable angina pectoris associated with obstructive coronary artery disease was evaluated in 2 double-blind placebo-controlled randomized clinical trials." | 9.05 | Verapamil therapy for unstable angina pectoris: review of double-blind placebo-controlled randomized clinical trials. ( Conti, CR; Mehta, J, 1982) |
| "The antiarrhythmic activity of the calcium entry blockers, verapamil, nifedipine and prenylamine, was assessed against arrhythmias occurring during 20 min of acute occlusion, or upon rapid reperfusion of the left anterior descending coronary artery (LAD) in anesthetized pigs." | 7.67 | Acute coronary artery occlusion-reperfusion arrhythmias in pigs: antiarrhythmic and antifibrillatory evaluation of verapamil, nifedipine, prenylamine and propranolol. ( Bergey, JL; McCallum, JD; Nocella, K; Wendt, RL, 1984) |
| "Splanchnic artery occlusion (SAO) shock made by clamping splanchnic arteries for 45 min was performed in female rats infused for 30 min with vehicle, nimodipine, and verapamil before, during, or after SAO." | 7.67 | Splanchnic artery occlusion shock in the rat: effects of the calcium entry blockers nimodipine and verapamil. ( Altavilla, D; Berlinghieri, MC; Caputi, AP; Squadrito, F; Sturniolo, R, 1988) |
| "The effectiveness of verapamil in the management of patients with unstable angina pectoris associated with obstructive coronary artery disease was evaluated in 2 double-blind placebo-controlled randomized clinical trials." | 5.05 | Verapamil therapy for unstable angina pectoris: review of double-blind placebo-controlled randomized clinical trials. ( Conti, CR; Mehta, J, 1982) |
| "The antiarrhythmic activity of the calcium entry blockers, verapamil, nifedipine and prenylamine, was assessed against arrhythmias occurring during 20 min of acute occlusion, or upon rapid reperfusion of the left anterior descending coronary artery (LAD) in anesthetized pigs." | 3.67 | Acute coronary artery occlusion-reperfusion arrhythmias in pigs: antiarrhythmic and antifibrillatory evaluation of verapamil, nifedipine, prenylamine and propranolol. ( Bergey, JL; McCallum, JD; Nocella, K; Wendt, RL, 1984) |
| "Splanchnic artery occlusion (SAO) shock made by clamping splanchnic arteries for 45 min was performed in female rats infused for 30 min with vehicle, nimodipine, and verapamil before, during, or after SAO." | 3.67 | Splanchnic artery occlusion shock in the rat: effects of the calcium entry blockers nimodipine and verapamil. ( Altavilla, D; Berlinghieri, MC; Caputi, AP; Squadrito, F; Sturniolo, R, 1988) |
| "2." | 1.28 | Effects of BRL 38227, sodium nitroprusside and verapamil on collateral perfusion following acute arterial occlusion in the rabbit isolated ear. ( Griffith, TM; Randall, MD, 1992) |
| "Diltiazem was not significantly different from placebo." | 1.27 | Comparative effects of calcium-channel blocking agents on left ventricular function during acute ischemia in dogs with and without congestive heart failure. ( Epstein, SE; Patterson, RE; Urquhart, J, 1985) |
| "A 7 year old girl with moyamoya disease presented with progressive right arm and leg weakness and muteness." | 1.27 | Treatment of acute deficits of moyamoya disease with verapamil. ( Gebarski, SS; Goldstein, GW; McLean, MJ; van der Spek, AF, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (53.13) | 18.7374 |
| 1990's | 10 (31.25) | 18.2507 |
| 2000's | 2 (6.25) | 29.6817 |
| 2010's | 3 (9.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dharma, S | 1 |
| Kedev, S | 1 |
| Patel, T | 1 |
| Rao, SV | 1 |
| Gilchrist, IC | 1 |
| Hizoh, I | 1 |
| Majoros, Z | 1 |
| Major, L | 1 |
| Gulyas, Z | 1 |
| Szabo, G | 1 |
| Kerecsen, G | 1 |
| Korda, A | 1 |
| Molnar, F | 1 |
| Kiss, RG | 1 |
| Lena, J | 1 |
| Eskandari, R | 1 |
| Infinger, L | 1 |
| Fargen, KM | 1 |
| Spiotta, A | 1 |
| Turk, A | 1 |
| Turner, RD | 1 |
| Chaudry, I | 1 |
| Lowe, HC | 1 |
| Macina, A | 1 |
| Torosoff, M | 1 |
| Millar, RD | 1 |
| Yu, XC | 1 |
| Wu, S | 1 |
| Chen, CF | 1 |
| Pang, KT | 1 |
| Wong, TM | 1 |
| Beinart, C | 1 |
| Sos, TA | 1 |
| Saddekni, S | 1 |
| Weiner, MA | 1 |
| Sniderman, KW | 1 |
| Bergey, JL | 1 |
| Wendt, RL | 1 |
| Nocella, K | 1 |
| McCallum, JD | 1 |
| Mehta, J | 1 |
| Conti, CR | 1 |
| Hashimoto, H | 1 |
| Suzuki, K | 1 |
| Miyake, S | 1 |
| Nakashima, M | 1 |
| Kékesi, V | 1 |
| Juhász-Nagy, A | 1 |
| Koller, A | 1 |
| Rubányi, G | 1 |
| Ligeti, L | 1 |
| Kovách, AG | 1 |
| da Luz, PL | 1 |
| Monteiro de Barros, LF | 1 |
| Leite, JJ | 1 |
| Pileggi, F | 1 |
| Décourt, LV | 1 |
| Elliott, WJ | 1 |
| Gamba, P | 2 |
| Pettenazzo, A | 2 |
| Kalapurackal, M | 1 |
| Saia, SO | 2 |
| Guglielmi, M | 1 |
| Block, F | 1 |
| Szabo, L | 1 |
| Jaspers, RM | 1 |
| Heim, C | 1 |
| Sontag, KH | 1 |
| Joshi, S | 1 |
| Young, WL | 1 |
| Pile-Spellman, J | 1 |
| Duong, DH | 1 |
| Hacein-Bey, L | 1 |
| Vang, MC | 1 |
| Marshall, RS | 1 |
| Ostapkovich, N | 1 |
| Jackson, T | 1 |
| Ergene, O | 1 |
| Tastan, A | 1 |
| Seyithanoglu, Y | 1 |
| Nazli, C | 1 |
| Kozan, O | 1 |
| Ergene, U | 1 |
| Keskin, V | 1 |
| Pastore, LR | 1 |
| Bartolo, M | 1 |
| Penco, M | 1 |
| Arata, L | 1 |
| Di Renzi, L | 1 |
| Randall, MD | 1 |
| Griffith, TM | 1 |
| Ishchenko, MM | 1 |
| Dorogiĭ, AN | 1 |
| Nechaĭ, EE | 1 |
| Shkrobot, SI | 1 |
| Vos, MA | 1 |
| Gorgels, AP | 1 |
| Leunissen, JD | 1 |
| Havenith, MG | 1 |
| Kriek, E | 1 |
| Smeets, JL | 1 |
| Wellens, HJ | 1 |
| Salmistraro, G | 1 |
| Feltrin, GP | 1 |
| Cohen, JR | 1 |
| Faust, G | 1 |
| Tenenbaum, N | 1 |
| Sarfati, I | 1 |
| Rogowsky, P | 1 |
| Wise, L | 1 |
| McLean, MJ | 2 |
| Gebarski, SS | 2 |
| van der Spek, AF | 2 |
| Goldstein, GW | 2 |
| Sturniolo, R | 1 |
| Altavilla, D | 1 |
| Berlinghieri, MC | 1 |
| Squadrito, F | 1 |
| Caputi, AP | 1 |
| Hakim, AM | 1 |
| Reimer, KA | 1 |
| Jennings, RB | 1 |
| Cobb, FR | 1 |
| Murdock, RH | 1 |
| Greenfield, JC | 1 |
| Becker, LC | 1 |
| Bulkley, BH | 1 |
| Hutchins, GM | 1 |
| Schwartz, RP | 1 |
| Bailey, KR | 1 |
| Brown, BG | 1 |
| Karagueuzian, HS | 1 |
| Sugi, K | 1 |
| Ohta, M | 1 |
| Mandel, WJ | 1 |
| Peter, T | 1 |
| Urquhart, J | 1 |
| Epstein, SE | 1 |
| Patterson, RE | 1 |
| Kaski, JC | 1 |
| Plaza, LR | 1 |
| Meran, DO | 1 |
| Araujo, L | 1 |
| Chierchia, S | 1 |
| Maseri, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Omission of Prophylactic Verapamil Use in Transradial Coronary Interventions[NCT01402427] | 591 participants (Actual) | Interventional | 2011-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01402427)
Timeframe: The amount of contrast medium will be assessed within 1 minute after completion of coronary angiography or intervention.
| Intervention | milliliter (Median) |
|---|---|
| Verapamil | 75.0 |
| Placebo | 72.5 |
(NCT01402427)
Timeframe: Fluoroscopic time will be assessed within 1 minute after completion of coronary angiography or intervention.
| Intervention | minutes (Median) |
|---|---|
| Verapamil | 4.8 |
| Placebo | 4.4 |
(NCT01402427)
Timeframe: Procedural time will be assessed within 1 minute after completion of coronary angiography or intervention.
| Intervention | minutes (Median) |
|---|---|
| Verapamil | 17.0 |
| Placebo | 16.0 |
(NCT01402427)
Timeframe: Occurrence of access site conversion will be assessed within 1 minute after completion of coronary angiography or intervention.
| Intervention | participants (Number) |
|---|---|
| Verapamil | 2 |
| Placebo | 5 |
Code break: a composite of access site conversion and unplanned use of vasodilators. (NCT01402427)
Timeframe: Occurrence of code breaking will be assessed within 1 minute after completion of coronary angiography or intervention.
| Intervention | participants (Number) |
|---|---|
| Verapamil | 4 |
| Placebo | 10 |
(NCT01402427)
Timeframe: Vasodilator use will be assessed within 1 minute after completion of coronary angiography or intervention.
| Intervention | participants (Number) |
|---|---|
| Verapamil | 297 |
| Placebo | 6 |
Analysis of the rates of significant pain defined as pain score ≥4 on a semiquantitative scale ranging from 1 to 6. (NCT01402427)
Timeframe: Subjective pain will be assessed within 1 minute after completion of coronary angiography or intervention.
| Intervention | participants (Number) |
|---|---|
| Verapamil | 26 |
| Placebo | 21 |
2 reviews available for verapamil and Arterial Occlusive Diseases
| Article | Year |
|---|---|
Peripheral arterial occlusion in infants--a report of two cases treated conservatively.
Topics: Arterial Occlusive Diseases; Catheterization, Peripheral; Drug Therapy, Combination; Echocardiograph | 1991 |
Response of normal and diseased epicardial coronary arteries to vasoactive drugs: quantitative arteriographic studies.
Topics: Arterial Occlusive Diseases; Calcium Channel Blockers; Coronary Circulation; Coronary Disease; Coron | 1985 |
3 trials available for verapamil and Arterial Occlusive Diseases
| Article | Year |
|---|---|
Different Spasmolytic Regimens (Nitroglycerin vs Verapamil) and the Incidence of Radial Artery Occlusion After Transradial Catheterization.
Topics: Arterial Occlusive Diseases; Cardiac Catheterization; Dose-Response Relationship, Drug; Female; Huma | 2018 |
Need for prophylactic application of verapamil in transradial coronary procedures: a randomized trial. The VITRIOL (is Verapamil In TransRadial Interventions OmittabLe?) trial.
Topics: Aged; Arterial Occlusive Diseases; Calcium Channel Blockers; Coronary Artery Disease; Double-Blind M | 2014 |
Verapamil therapy for unstable angina pectoris: review of double-blind placebo-controlled randomized clinical trials.
Topics: Adult; Aged; Angina Pectoris; Arterial Occlusive Diseases; Clinical Trials as Topic; Coronary Diseas | 1982 |
27 other studies available for verapamil and Arterial Occlusive Diseases
| Article | Year |
|---|---|
Basilar artery occlusion in a child treated successfully with mechanical thrombectomy using ADAPT.
Topics: Arterial Occlusive Diseases; Basilar Artery; Cerebral Angiography; Child; Combined Modality Therapy; | 2016 |
Recurrent spasm of radial artery graft mimicking fixed stenosis.
Topics: Arterial Occlusive Diseases; Blood Vessel Prosthesis Implantation; Cardiac Catheterization; Constric | 2002 |
Antihypertensive and anti-arrhythmic effects of an extract of Radix Stephaniae Tetrandrae in the rat.
Topics: Alkaloids; Animals; Arrhythmias, Cardiac; Arterial Occlusive Diseases; Benzylisoquinolines; Calcium | 2004 |
Arterial spasm during renal angioplasty.
Topics: Adolescent; Adult; Aged; Angioplasty, Balloon; Arterial Occlusive Diseases; Arteriosclerosis; Child; | 1983 |
Acute coronary artery occlusion-reperfusion arrhythmias in pigs: antiarrhythmic and antifibrillatory evaluation of verapamil, nifedipine, prenylamine and propranolol.
Topics: Animals; Arrhythmias, Cardiac; Arterial Occlusive Diseases; Blood Pressure; Calcium Channel Blockers | 1984 |
Effects of calcium antagonists on the electrical alternans of the ST segment and on associated mechanical alternans during acute coronary occlusion in dogs.
Topics: Acute Disease; Animals; Arterial Occlusive Diseases; Calcium Channel Blockers; Coronary Disease; Dil | 1983 |
Pharmacologic assessment of the functional state in stenosed coronary circulation of the dog.
Topics: Animals; Arterial Occlusive Diseases; Catheterization; Coronary Circulation; Coronary Disease; Depre | 1982 |
Inhibition of myocardial reactive hyperaemia but not of hypoxic coronary vasodilatation by constant verapamil infusion in the in situ dog heart.
Topics: Animals; Arterial Occlusive Diseases; Blood Flow Velocity; Coronary Circulation; Depression, Chemica | 1982 |
Effect of verapamil on regional coronary and myocardial perfusion during acute coronary occlusion.
Topics: Acute Disease; Animals; Arterial Occlusive Diseases; Blood Pressure; Coronary Circulation; Coronary | 1980 |
An individualized approach to the hypertensive patient with renal disease: six illustrative case studies.
Topics: Adrenergic alpha-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Arterial Occlusive Dis | 1995 |
Primary occlusion of the iliac and femoral artery in two newborn infants: efficacy of medical treatment.
Topics: Arterial Occlusive Diseases; Femoral Artery; Humans; Iliac Artery; Infant, Newborn; Male; Thrombolyt | 1993 |
Levemopamil reduces spatial learning deficit following transient occlusion of common carotid arteries in normotensive rats.
Topics: Animals; Arterial Occlusive Diseases; Brain; Carotid Arteries; Cerebrovascular Circulation; Ischemic | 1993 |
Manipulation of cerebrovascular resistance during internal carotid artery occlusion by intraarterial verapamil.
Topics: Adult; Aged; Arterial Occlusive Diseases; Carotid Artery Diseases; Carotid Artery, Internal; Cerebro | 1997 |
Catheter-induced vasospasm in the right external iliac and femoral arteries during a cardiac diagnostic procedure.
Topics: Angina, Unstable; Arterial Occlusive Diseases; Catheterization, Peripheral; Chest Pain; Cineangiogra | 1999 |
[Regional hemodynamic and metabolic effects of calcium antagonists].
Topics: Adult; Aged; Arterial Occlusive Diseases; Calcium; Hemodynamics; Humans; Leg; Male; Middle Aged; Reg | 1979 |
Effects of BRL 38227, sodium nitroprusside and verapamil on collateral perfusion following acute arterial occlusion in the rabbit isolated ear.
Topics: Animals; Arginine; Arterial Occlusive Diseases; Benzopyrans; Cromakalim; Ear, External; In Vitro Tec | 1992 |
[Vasoactive and cardiotonic drugs in the treatment of initial manifestations of cerebrovascular insufficiency in occlusive diseases of major blood vessels of the head].
Topics: Adult; Aged; Aminophylline; Arterial Occlusive Diseases; Carotid Artery Diseases; Cerebrovascular Di | 1991 |
Programmed electrical stimulation and drugs identify two subgroups of ventricular tachycardias occurring 16-24 hours after occlusion of the left anterior descending artery.
Topics: Animals; Arterial Occlusive Diseases; Cardiac Pacing, Artificial; Coronary Disease; Dogs; Electrocar | 1992 |
The calcium messenger system and the kinetics of elastase release from human neutrophils in patients with abdominal aortic aneurysms.
Topics: Aorta, Abdominal; Aortic Aneurysm; Arterial Occlusive Diseases; Biological Transport, Active; Calciu | 1990 |
Response of moyamoya disease to verapamil.
Topics: Arterial Occlusive Diseases; Child; Child, Preschool; Female; Humans; Male; Moyamoya Disease; Verapa | 1985 |
Splanchnic artery occlusion shock in the rat: effects of the calcium entry blockers nimodipine and verapamil.
Topics: Animals; Arterial Occlusive Diseases; Female; Leukocyte Count; Leukocytes; Nimodipine; Phagocytosis; | 1988 |
Cerebral acidosis in focal ischemia: II. Nimodipine and verapamil normalize cerebral pH following middle cerebral artery occlusion in the rat.
Topics: Acidosis; Animals; Arterial Occlusive Diseases; Brain; Brain Diseases; Brain Ischemia; Calcium Chann | 1986 |
Animal models for protecting ischemic myocardium: results of the NHLBI Cooperative Study. Comparison of unconscious and conscious dog models.
Topics: Anesthesia; Animal Testing Alternatives; Animals; Arterial Occlusive Diseases; Coronary Circulation; | 1985 |
The efficacy of lidocaine and verapamil alone and in combination on spontaneously occurring automatic ventricular tachycardia in conscious dogs one day after right coronary artery occlusion.
Topics: Animals; Arterial Occlusive Diseases; Blood Pressure; Cardiac Pacing, Artificial; Coronary Disease; | 1986 |
Comparative effects of calcium-channel blocking agents on left ventricular function during acute ischemia in dogs with and without congestive heart failure.
Topics: Animals; Arterial Occlusive Diseases; Calcium Channel Blockers; Coronary Circulation; Coronary Disea | 1985 |
Treatment of acute deficits of moyamoya disease with verapamil.
Topics: Arterial Occlusive Diseases; Cerebral Angiography; Cerebrovascular Circulation; Child; Female; Human | 1985 |
Improved coronary supply: prevailing mechanism of action of nitrates in chronic stable angina.
Topics: Adult; Aged; Angina Pectoris; Arterial Occlusive Diseases; Cardiac Volume; Chronic Disease; Coronary | 1985 |