verapamil has been researched along with Angioblastic Meningioma in 6 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previous in vitro and in vivo results suggested that hydroxyurea (HU) and verapamil could suppress meningioma growth individually and synergistically." | 9.22 | Combined Hydroxyurea and Verapamil in the Clinical Treatment of Refractory Meningioma: Human and Orthotopic Xenograft Studies. ( Barth, T; Burt, L; Dunson, W; Gillespie, DL; Hoang, N; Jensen, RL; Karsy, M, 2016) |
| "In order to investigate the effects of verapamil on the proliferation of meningiomas cells in vitro and in vivo, the cultured meningiomas cells were cultured with verapamil at different concentrations for 24 h and the inhibitory effects of verapamil on cell proliferation were observed by MTT method." | 7.74 | Experimental study on the inhibitory effects of verapamil on the proliferation of meningiomas cells. ( Chen, J; Wang, H; Zhang, H, 2007) |
| "Previous in vitro and in vivo results suggested that hydroxyurea (HU) and verapamil could suppress meningioma growth individually and synergistically." | 5.22 | Combined Hydroxyurea and Verapamil in the Clinical Treatment of Refractory Meningioma: Human and Orthotopic Xenograft Studies. ( Barth, T; Burt, L; Dunson, W; Gillespie, DL; Hoang, N; Jensen, RL; Karsy, M, 2016) |
| "We outline the clinical presentation of a 56-year-old female with spontaneous subarachnoid hemorrhage with intraventricular extension in a coma from a petroclival meningioma taking escitalopram for depression and high-dose estrogen replacement therapy for menopause." | 3.96 | Intracranial Hemorrhage from Meningioma: 2 Novel Risk Factors. ( Patel, NJ; Penn, D; Pressman, E, 2020) |
| "In order to investigate the effects of verapamil on the proliferation of meningiomas cells in vitro and in vivo, the cultured meningiomas cells were cultured with verapamil at different concentrations for 24 h and the inhibitory effects of verapamil on cell proliferation were observed by MTT method." | 3.74 | Experimental study on the inhibitory effects of verapamil on the proliferation of meningiomas cells. ( Chen, J; Wang, H; Zhang, H, 2007) |
| "Treatment with verapamil had similar effects; however, there are no statistically significant dose dependent decreases in growth with increasing verapamil doses." | 1.31 | Calcium channel antagonists inhibit growth of subcutaneous xenograft meningiomas in nude mice. ( Jensen, RL; Wurster, RD, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Pressman, E | 1 |
| Penn, D | 1 |
| Patel, NJ | 1 |
| Wilisch-Neumann, A | 1 |
| Pachow, D | 1 |
| Wallesch, M | 1 |
| Petermann, A | 1 |
| Böhmer, FD | 1 |
| Kirches, E | 1 |
| Mawrin, C | 1 |
| Karsy, M | 1 |
| Hoang, N | 1 |
| Barth, T | 1 |
| Burt, L | 1 |
| Dunson, W | 1 |
| Gillespie, DL | 1 |
| Jensen, RL | 2 |
| Amuluru, K | 1 |
| Al-Mufti, F | 1 |
| Singh, IP | 1 |
| Frohman, LP | 1 |
| Gandhi, CD | 1 |
| Liu, JK | 1 |
| Chen, J | 1 |
| Zhang, H | 1 |
| Wang, H | 1 |
| Wurster, RD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Combination of Hydroxyurea and Verapamil for Refractory Meningiomas[NCT00706810] | Phase 2 | 8 participants (Actual) | Interventional | 2007-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Response and progression will be evaluated in this study using measurements from the MRI/CT scans. Measurements will be made of the image slice with the largest cross sectional area. Two orthogonal measures will be made to determine maximal AP and lateral dimensions. Progression of disease will be defined as a greater than 25% increase of largest cross sectional area by two orthogonal measurements, taking as reference the smallest sum recorded since the treatment started or the appearance of one or more new lesions. (NCT00706810)
Timeframe: 31 months
| Intervention | months (Median) |
|---|---|
| All Participants | 8.0 |
Adverse Events assessed in accordance with CTCAE (NCI Common Terminology Criteria for Adverse Events) Version 3.0. (NCT00706810)
Timeframe: two years
| Intervention | participants (Number) |
|---|---|
| All Groups | 0 |
1 trial available for verapamil and Angioblastic Meningioma
| Article | Year |
|---|---|
Combined Hydroxyurea and Verapamil in the Clinical Treatment of Refractory Meningioma: Human and Orthotopic Xenograft Studies.
Topics: Adult; Aged; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biologi | 2016 |
5 other studies available for verapamil and Angioblastic Meningioma
| Article | Year |
|---|---|
Intracranial Hemorrhage from Meningioma: 2 Novel Risk Factors.
Topics: Basilar Artery; Cerebral Intraventricular Hemorrhage; Citalopram; Coma; Computed Tomography Angiogra | 2020 |
Re-evaluation of cytostatic therapies for meningiomas in vitro.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Dacarbazine; DNA Methylation; DNA Modification M | 2014 |
Reversal of Visual Impairment Associated with Vasospasm After Resection of Sphenoclinoidocavernous Meningioma with Intra-Arterial Verapamil.
Topics: Adrenal Cortex Hormones; Female; Humans; Magnetic Resonance Angiography; Magnetic Resonance Imaging; | 2016 |
Experimental study on the inhibitory effects of verapamil on the proliferation of meningiomas cells.
Topics: Animals; Cell Nucleus; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Female | 2007 |
Calcium channel antagonists inhibit growth of subcutaneous xenograft meningiomas in nude mice.
Topics: Animals; Antineoplastic Agents; Biocompatible Materials; Calcium Channel Blockers; Collagen; Diltiaz | 2001 |