verapamil has been researched along with Amyotrophic Lateral Sclerosis in 7 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Seventy-two patients with amyotrophic lateral sclerosis (ALS) were enrolled in a clinical trial of the efficacy of verapamil in the treatment of ALS." | 9.08 | A clinical trial of verapamil in amyotrophic lateral sclerosis. ( Brinkmann, JR; Graves, J; Mendoza, M; Miller, RG; Murphy, JR; Ringel, SP; Sands, ML; Smith, SA, 1996) |
| "Riluzole is currently one of two approved medications for the treatment of amyotrophic lateral sclerosis (ALS)." | 7.88 | Verapamil and riluzole cocktail liposomes overcome pharmacoresistance by inhibiting P-glycoprotein in brain endothelial and astrocyte cells: A potent approach to treat amyotrophic lateral sclerosis. ( Bai, S; Fernandes, T; Ferrill, L; Gallant, L; McGillicuddy, S; Schields, N; Yang, T, 2018) |
| "Seventy-two patients with amyotrophic lateral sclerosis (ALS) were enrolled in a clinical trial of the efficacy of verapamil in the treatment of ALS." | 5.08 | A clinical trial of verapamil in amyotrophic lateral sclerosis. ( Brinkmann, JR; Graves, J; Mendoza, M; Miller, RG; Murphy, JR; Ringel, SP; Sands, ML; Smith, SA, 1996) |
| "Riluzole is currently one of two approved medications for the treatment of amyotrophic lateral sclerosis (ALS)." | 3.88 | Verapamil and riluzole cocktail liposomes overcome pharmacoresistance by inhibiting P-glycoprotein in brain endothelial and astrocyte cells: A potent approach to treat amyotrophic lateral sclerosis. ( Bai, S; Fernandes, T; Ferrill, L; Gallant, L; McGillicuddy, S; Schields, N; Yang, T, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Anger, T | 1 |
| Madge, DJ | 1 |
| Mulla, M | 1 |
| Riddall, D | 1 |
| Chen, T | 1 |
| Benmohamed, R | 1 |
| Arvanites, AC | 1 |
| Ralay Ranaivo, H | 1 |
| Morimoto, RI | 1 |
| Ferrante, RJ | 1 |
| Watterson, DM | 1 |
| Kirsch, DR | 1 |
| Silverman, RB | 1 |
| Salado, IG | 1 |
| Redondo, M | 1 |
| Bello, ML | 1 |
| Perez, C | 1 |
| Liachko, NF | 1 |
| Kraemer, BC | 1 |
| Miguel, L | 1 |
| Lecourtois, M | 1 |
| Gil, C | 2 |
| Martinez, A | 3 |
| Perez, DI | 1 |
| Nozal, V | 1 |
| Martínez-González, L | 1 |
| Gomez-Almeria, M | 1 |
| Gonzalo-Consuegra, C | 1 |
| Santana, P | 1 |
| Chaikuad, A | 1 |
| Pérez-Cuevas, E | 1 |
| Knapp, S | 1 |
| Lietha, D | 1 |
| Ramírez, D | 1 |
| Petralla, S | 1 |
| Monti, B | 1 |
| Martín-Requero, A | 2 |
| Palomo, V | 1 |
| de Lago, E | 1 |
| Martín-Cámara, O | 1 |
| Arribas, M | 1 |
| Wells, G | 1 |
| Morales-Tenorio, M | 1 |
| Porras, G | 1 |
| Giorgi, G | 1 |
| López-Alvarado, P | 1 |
| Lastres-Becker, I | 1 |
| Menéndez, JC | 1 |
| Yang, T | 1 |
| Ferrill, L | 1 |
| Gallant, L | 1 |
| McGillicuddy, S | 1 |
| Fernandes, T | 1 |
| Schields, N | 1 |
| Bai, S | 1 |
| Miller, RG | 1 |
| Smith, SA | 1 |
| Murphy, JR | 1 |
| Brinkmann, JR | 1 |
| Graves, J | 1 |
| Mendoza, M | 1 |
| Sands, ML | 1 |
| Ringel, SP | 1 |
1 review available for verapamil and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Medicinal chemistry of neuronal voltage-gated sodium channel blockers.
Topics: Amyotrophic Lateral Sclerosis; Analgesics; Anticonvulsants; Epilepsy; Humans; Ion Channel Gating; Mo | 2001 |
1 trial available for verapamil and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
A clinical trial of verapamil in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Analysis of Variance; Arm; Calcium Channel Blockers; Female; Humans; | 1996 |
5 other studies available for verapamil and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Enzyme Inhibitors; Humans; Magnetic Resonance Spectroscopy; | 2011 |
Protein kinase CK-1 inhibitors as new potential drugs for amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modified; Benzothiazoles; Blood-Brain B | 2014 |
TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy.
Topics: Amyotrophic Lateral Sclerosis; Animals; Brain; Case-Control Studies; DNA-Binding Proteins; Humans; I | 2022 |
Multitarget Hybrid Fasudil Derivatives as a New Approach to the Potential Treatment of Amyotrophic Lateral Sclerosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Amyotrophic Lateral Sclerosis; Cell Line, Tumor | 2022 |
Verapamil and riluzole cocktail liposomes overcome pharmacoresistance by inhibiting P-glycoprotein in brain endothelial and astrocyte cells: A potent approach to treat amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; ATP Binding Cassette Transporter, Subfamily B, M | 2018 |