Page last updated: 2024-10-24

verapamil and Albuminuria

verapamil has been researched along with Albuminuria in 20 studies

Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.

Albuminuria: The presence of albumin in the urine, an indicator of KIDNEY DISEASES.

Research Excerpts

ExcerptRelevanceReference
"The Bergamo Nephrologic Diabetes Complications Trial-B was a multicentre, prospective, double-blind, parallel-group trial comparing renal and cardiovascular outcomes in 281 hypertensive type 2 diabetes patients with microalbuminuria randomized to at least 2-year VeraTran (verapamil/trandolapril 180 mg/2 mg daily) or trandolapril (2 mg daily, identical image) treatment."9.15Effects of verapamil added-on trandolapril therapy in hypertensive type 2 diabetes patients with microalbuminuria: the BENEDICT-B randomized trial. ( Bossi, A; Chiurchiu, C; Cravedi, P; Ene-Iordache, B; Fassi, A; Gaspari, F; Gherardi, G; Iliev, IP; Ilieva, A; Motterlini, N; Perna, A; Remuzzi, G; Rubis, N; Ruggenenti, P; Trevisan, R, 2011)
"To compare responses of blood pressure to the calcium antagonist verapamil and the beta blocker metoprolol in black compared with white diabetics with hypertension and to monitor urinary albumin excretion in relation to fall in blood pressure."9.06Treating hypertension in black compared with white non-insulin dependent diabetics: a double blind trial of verapamil and metoprolol. ( Anderson, NM; Cruickshank, JK; Jepson, E; Wadsworth, J; Young, SM, 1988)
" Combination therapy of valsartan with either amlodipine or verapamil was equally effective in reducing blood pressure to valsartan monotherapy (valsartan + amlodipine 129 +/- 4 valsartan + verapamil 133 +/- 6 mmHg;) but was not as effective at reducing albuminuria."7.72Disparate effects of angiotensin II antagonists and calcium channel blockers on albuminuria in experimental diabetes and hypertension: potential role of nephrin. ( Allen, TJ; Cao, Z; Cooper, ME; Davis, BJ; de Gasparo, M; Kawachi, H, 2003)
"The aim of this study was to compare the effects of a dihidropiridin calcium channel blocker amlodipin and a non-dihidropiridin calcium channel blocker verapamil on nephropathy and serum pigment epithelium-derived factor (PEDF) levels of type 2 diabetic patients with hypertension."5.20The effects of calcium channel blockers on nephropathy and pigment epithelium-derived factor in the treatment of hypertensive patients with type 2 diabetes mellitus. ( Çelik, H; Korkmaz, H; Oğuz, E; Sabuncu, T; Tabur, S, 2015)
"The Bergamo Nephrologic Diabetes Complications Trial-B was a multicentre, prospective, double-blind, parallel-group trial comparing renal and cardiovascular outcomes in 281 hypertensive type 2 diabetes patients with microalbuminuria randomized to at least 2-year VeraTran (verapamil/trandolapril 180 mg/2 mg daily) or trandolapril (2 mg daily, identical image) treatment."5.15Effects of verapamil added-on trandolapril therapy in hypertensive type 2 diabetes patients with microalbuminuria: the BENEDICT-B randomized trial. ( Bossi, A; Chiurchiu, C; Cravedi, P; Ene-Iordache, B; Fassi, A; Gaspari, F; Gherardi, G; Iliev, IP; Ilieva, A; Motterlini, N; Perna, A; Remuzzi, G; Rubis, N; Ruggenenti, P; Trevisan, R, 2011)
" We hypothesized that a trandolapril/verapamil SR (T/V) fixed-dose combination (FDC) was superior to a benazepril/amlodipine (B/A) FDC for reducing albuminuria in 304 hypertensive diabetic nephropathy patients when treated for 36 weeks."5.13Effects of calcium channel blockers on proteinuria in patients with diabetic nephropathy. ( Bacher, P; Champion, A; Fakouhi, K; Tian, M; Toto, RD, 2008)
"In subjects with type 2 diabetes and hypertension but with normoalbuminuria, the use of trandolapril plus verapamil and trandolapril alone decreased the incidence of microalbuminuria to a similar extent."5.11Preventing microalbuminuria in type 2 diabetes. ( Arnoldi, F; Bossi, A; Bruno, S; Brusegan, V; Dodesini, AR; Ene-Iordache, B; Fassi, A; Ganeva, M; Gaspari, F; Gherardi, G; Iliev, IP; Ilieva, AP; Perna, A; Remuzzi, G; Rubis, N; Ruggenenti, P; Trevisan, R, 2004)
"To compare responses of blood pressure to the calcium antagonist verapamil and the beta blocker metoprolol in black compared with white diabetics with hypertension and to monitor urinary albumin excretion in relation to fall in blood pressure."5.06Treating hypertension in black compared with white non-insulin dependent diabetics: a double blind trial of verapamil and metoprolol. ( Anderson, NM; Cruickshank, JK; Jepson, E; Wadsworth, J; Young, SM, 1988)
" Combination therapy of valsartan with either amlodipine or verapamil was equally effective in reducing blood pressure to valsartan monotherapy (valsartan + amlodipine 129 +/- 4 valsartan + verapamil 133 +/- 6 mmHg;) but was not as effective at reducing albuminuria."3.72Disparate effects of angiotensin II antagonists and calcium channel blockers on albuminuria in experimental diabetes and hypertension: potential role of nephrin. ( Allen, TJ; Cao, Z; Cooper, ME; Davis, BJ; de Gasparo, M; Kawachi, H, 2003)
"Microalbuminuria is an early marker of diabetic nephropathy and its prevention is considered key for the primary prevention of diabetic nephropathy."2.71The BErgamo NEphrologic DIabetes Complications Trial (BENEDICT): design and baseline characteristics. ( , 2003)
"Verapamil was more effective than nifedipine in improving natriuresis and ANP release to saline load and in lowering the albumin excretion rate."1.28Effects of angiotensin converting enzyme inhibitors and calcium antagonists on atrial natriuretic peptide release and action and on albumin excretion rate in hypertensive insulin-dependent diabetic patients. ( Abaterusso, C; Brocco, E; Carraro, A; Cipollina, MR; Fioretto, P; Frigato, F; Muollo, B; Riva, F; Trevisan, M; Velussi, M, 1992)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19903 (15.00)18.7374
1990's1 (5.00)18.2507
2000's12 (60.00)29.6817
2010's4 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tabur, S1
Oğuz, E1
Sabuncu, T1
Korkmaz, H1
Çelik, H1
Toto, RD1
Tian, M1
Fakouhi, K1
Champion, A1
Bacher, P1
Zou, Z1
Xu, FY1
Wang, L1
An, MM1
Zhang, H1
Shi, XY1
Ruggenenti, P4
Fassi, A2
Ilieva, A1
Iliev, IP3
Chiurchiu, C1
Rubis, N3
Gherardi, G2
Ene-Iordache, B4
Gaspari, F3
Perna, A4
Cravedi, P1
Bossi, A3
Trevisan, R3
Motterlini, N2
Remuzzi, G4
Porrini, E1
Ilieva, AP2
Dodesini, AR2
Sampietro, G1
Capitoni, E1
Davis, BJ1
Cao, Z1
de Gasparo, M1
Kawachi, H1
Cooper, ME1
Allen, TJ1
Lehfeld, LS1
Silveira, LA1
Ghini, B1
Lopes de Faria, JB1
Bruno, S1
Brusegan, V1
Arnoldi, F1
Ganeva, M2
Logan, A1
Nitschmann, S1
Glassock, RJ1
Assel, E1
Neumann, KH1
Schurek, HJ1
Sonnenburg, C1
Stolte, H1
Fernández, R1
Puig, JG1
Rodríguez-Pérez, JC1
Garrido, J2
Redon, J1
Goicolea, I1
Fernández González, R1
Piniés, J1
Martínez, JM1
Armenteros, S1
Moreno Carretero, E1
Kedziora-Kornatowska, K1
Szram, S1
Kornatowski, T1
Szadujkis-Szadurski, L1
Kedziora, J1
Bartosz, G1
Fioretto, P1
Frigato, F1
Velussi, M1
Riva, F1
Muollo, B1
Carraro, A1
Brocco, E1
Cipollina, MR1
Abaterusso, C1
Trevisan, M1
Cruickshank, JK2
Anderson, NM2
Wadsworth, J2
Young, SM2
Jepson, E2

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Qianyangyuyin Formula Prevent and Treat for Early Renal Injury in Hypertensive Patients[NCT04078711]Phase 2/Phase 3520 participants (Anticipated)Interventional2019-09-10Not yet recruiting
A Two-Phase Study for Primary and Secondary Prevention of Diabetic Nephropathy by Combined ACE Inhibition and Calcium Channel Blockade (BENEDICT)[NCT00235014]Phase 41,204 participants (Actual)Interventional1997-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for verapamil and Albuminuria

ArticleYear
Antihypertensive and renoprotective effects of trandolapril/verapamil combination: a meta-analysis of randomized controlled trials.
    Journal of human hypertension, 2011, Volume: 25, Issue:3

    Topics: Albuminuria; Antihypertensive Agents; Drug Therapy, Combination; Female; Humans; Hypertension; Indol

2011

Trials

12 trials available for verapamil and Albuminuria

ArticleYear
The effects of calcium channel blockers on nephropathy and pigment epithelium-derived factor in the treatment of hypertensive patients with type 2 diabetes mellitus.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2015, Volume: 37, Issue:3

    Topics: Aged; Albuminuria; Amlodipine; Blood Pressure; Calcium Channel Blockers; Creatinine; Diabetes Mellit

2015
Effects of calcium channel blockers on proteinuria in patients with diabetic nephropathy.
    Journal of clinical hypertension (Greenwich, Conn.), 2008, Volume: 10, Issue:10

    Topics: Aged; Albuminuria; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Be

2008
Effects of verapamil added-on trandolapril therapy in hypertensive type 2 diabetes patients with microalbuminuria: the BENEDICT-B randomized trial.
    Journal of hypertension, 2011, Volume: 29, Issue:2

    Topics: Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channe

2011
Effects of verapamil added-on trandolapril therapy in hypertensive type 2 diabetes patients with microalbuminuria: the BENEDICT-B randomized trial.
    Journal of hypertension, 2011, Volume: 29, Issue:2

    Topics: Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channe

2011
Effects of verapamil added-on trandolapril therapy in hypertensive type 2 diabetes patients with microalbuminuria: the BENEDICT-B randomized trial.
    Journal of hypertension, 2011, Volume: 29, Issue:2

    Topics: Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channe

2011
Effects of verapamil added-on trandolapril therapy in hypertensive type 2 diabetes patients with microalbuminuria: the BENEDICT-B randomized trial.
    Journal of hypertension, 2011, Volume: 29, Issue:2

    Topics: Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channe

2011
Measurable urinary albumin predicts cardiovascular risk among normoalbuminuric patients with type 2 diabetes.
    Journal of the American Society of Nephrology : JASN, 2012, Volume: 23, Issue:10

    Topics: Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Biomarkers; Cardiotonic Agents; Cardiov

2012
The BErgamo NEphrologic DIabetes Complications Trial (BENEDICT): design and baseline characteristics.
    Controlled clinical trials, 2003, Volume: 24, Issue:4

    Topics: Adult; Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium

2003
Preventing microalbuminuria in type 2 diabetes.
    The New England journal of medicine, 2004, Nov-04, Volume: 351, Issue:19

    Topics: Adult; Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium

2004
BENEDICT in the treatment of hypertension.
    Current hypertension reports, 2005, Volume: 7, Issue:2

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Blood Glucose; Blood Pressure; Calcium Channe

2005
Impact of blood pressure control and angiotensin-converting enzyme inhibitor therapy on new-onset microalbuminuria in type 2 diabetes: a post hoc analysis of the BENEDICT trial.
    Journal of the American Society of Nephrology : JASN, 2006, Volume: 17, Issue:12

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Calc

2006
Effect of two antihypertensive combinations on metabolic control in type-2 diabetic hypertensive patients with albuminuria: a randomised, double-blind study.
    Journal of human hypertension, 2001, Volume: 15, Issue:12

    Topics: Aged; Albuminuria; Analysis of Variance; Antihypertensive Agents; Diabetes Mellitus, Type 2; Double-

2001
[Effect of antihypertensive combinations on arterial pressure, albuminuria, and glycemic control in patients with type II diabetic nephropathy: a randomized study].
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2002, Volume: 22, Issue:2

    Topics: Aged; Albuminuria; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antih

2002
Treating hypertensive diabetics: a comparison of verapamil and metoprolol in black and white patients.
    Journal of cardiovascular pharmacology, 1987, Volume: 10 Suppl 10

    Topics: Albuminuria; Black People; Blood Glucose; Blood Pressure; Cholesterol; Diabetes Complications; Diabe

1987
Treating hypertension in black compared with white non-insulin dependent diabetics: a double blind trial of verapamil and metoprolol.
    BMJ (Clinical research ed.), 1988, Nov-05, Volume: 297, Issue:6657

    Topics: Aged; Albuminuria; Black or African American; Clinical Trials as Topic; Diabetes Mellitus, Type 2; D

1988

Other Studies

7 other studies available for verapamil and Albuminuria

ArticleYear
Disparate effects of angiotensin II antagonists and calcium channel blockers on albuminuria in experimental diabetes and hypertension: potential role of nephrin.
    Journal of hypertension, 2003, Volume: 21, Issue:1

    Topics: Albuminuria; Amlodipine; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood P

2003
Early blood pressure normalization independent of the class of antihypertensive agent prevents augmented renal fibronectin and albuminuria in experimental diabetic nephropathy.
    Kidney & blood pressure research, 2004, Volume: 27, Issue:2

    Topics: Albuminuria; Amlodipine; Animals; Antihypertensive Agents; Blood Glucose; Blood Pressure; Body Weigh

2004
[Prevention of microalbuminuria in type 2 diabetes. BENEDICT study].
    Der Internist, 2006, Volume: 47, Issue:2

    Topics: Adult; Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium

2006
Prevention of microalbuminuria in type 2 diabetes: millimeters or milligrams?
    Journal of the American Society of Nephrology : JASN, 2006, Volume: 17, Issue:12

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Bloc

2006
Glomerular albumin leakage and morphology after neutralization of polyanions. I. Albumin clearance and sieving coefficient in the isolated perfused rat kidney.
    Renal physiology, 1984, Volume: 7, Issue:6

    Topics: Albumins; Albuminuria; Animals; Glomerular Filtration Rate; Heparin; Kidney; Kidney Glomerulus; Male

1984
The effect of verapamil on the antioxidant defence system in diabetic kidney.
    Clinica chimica acta; international journal of clinical chemistry, 2002, Volume: 322, Issue:1-2

    Topics: Albuminuria; Animals; Antioxidants; Basement Membrane; Blood Glucose; Body Weight; Catalase; Diabete

2002
Effects of angiotensin converting enzyme inhibitors and calcium antagonists on atrial natriuretic peptide release and action and on albumin excretion rate in hypertensive insulin-dependent diabetic patients.
    American journal of hypertension, 1992, Volume: 5, Issue:11

    Topics: Adult; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Atrial Natriuretic Factor; Calcium Cha

1992