verapamil and Aging studies

Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

Excerpt	Relevance	Reference
" In young Dahl/S rats, an angiotensin-converting enzyme inhibitor, imidapril, attenuated the development of proteinuria accompanied by a decrease in blood pressure."	7.70	Involvement of angiotensin II in development of spontaneous nephrosis in Dahl salt-sensitive rats. ( Fujimura, H; Nishiyama, S; Ohmachi, Y; Okumura, F; Toriumi, W; Yoneda, H, 1998)
"Aging decreases elimination of racemic verapamil but reports vary regarding effects of aging on clearance of individual verapamil enantiomers."	7.69	Verapamil stereoisomers during racemic verapamil administration: effects of aging and comparisons to administration of individual stereoisomers. ( Capili, H; Schwartz, JB; Wainer, IW, 1994)
" Allosteric modulation of [3H]-NTP binding by the phenylalkylamine, verapamil and the benzothiazepine, diltiazem were preserved in aging heart."	7.68	Density of 1,4-dihydropyridine receptors decreases in the hearts of aging hamsters. ( Howlett, SE; Nicholl, PA, 1992)
"The effects of aging on heart rate and atrioventricular (AV) conduction responses to verapamil (0-100 ng/ml) were studied in Langendorff perfused hearts from 12 mature (4-6 months) and 12 senescent (24 months) male Fischer 344 rats and in hearts from 10 mature and 9 senescent rats after reserpine administration (0."	7.68	The effects of aging on the electrophysiologic responses to verapamil in isolated perfused rat hearts. ( Garcia, J; Schmidlin, O; Schwartz, JB, 1991)
"This study investigated the cardiac responses and pharmacokinetics following the acute and chronic administration of verapamil in 14 middle-aged and elderly patients with ischemic heart disease (age range 42-76 years)."	6.67	Low-dose verapamil in middle-aged and elderly patients with angina pectoris: no evidence of increased susceptibility to the cardiac effects. ( Ahmed, JH; Elliott, HL; Meredith, PA; Reid, JL, 1992)
"0004) and elimination half-life values increased in an age-related manner from 347 +/- 97 minutes in young women to 453 +/- 153 minutes in elderly women (p < 0."	5.29	Aging of women alters S-verapamil pharmacokinetics and pharmacodynamics. ( Capili, H; Daugherty, J; Schwartz, JB, 1994)
"Verapamil clearance was found to be decreased in an age-related stereoselective manner, with significant reductions in l-verapamil clearance in older subjects (P < ."	5.29	Aging effects on stereoselective pharmacokinetics and pharmacodynamics of verapamil. ( Capili, H; Liu, S; Schwartz, JB; Troconiz, IF; Verotta, D, 1993)
"Increased V (T) of (R)-[(11)C]verapamil with aging was found in several large brain regions in men."	5.16	P-glycoprotein function at the blood-brain barrier: effects of age and gender. ( Boellaard, R; Lammertsma, AA; Lubberink, M; Scheltens, P; Schuit, RC; van Assema, DM; van Berckel, BN; Windhorst, AD, 2012)
" In young Dahl/S rats, an angiotensin-converting enzyme inhibitor, imidapril, attenuated the development of proteinuria accompanied by a decrease in blood pressure."	3.70	Involvement of angiotensin II in development of spontaneous nephrosis in Dahl salt-sensitive rats. ( Fujimura, H; Nishiyama, S; Ohmachi, Y; Okumura, F; Toriumi, W; Yoneda, H, 1998)
" Allosteric modulation of [3H]-NTP binding by the phenylalkylamine, verapamil and the benzothiazepine, diltiazem were preserved in aging heart."	3.68	Density of 1,4-dihydropyridine receptors decreases in the hearts of aging hamsters. ( Howlett, SE; Nicholl, PA, 1992)
"The influence of age on the pharmacokinetics of verapamil at steady state has been studied in 74 individuals, age range 19-79 years, including healthy normotensive volunteers and patients with essential hypertension."	3.68	The influence of age on the pharmacokinetics of verapamil. ( Ahmed, JH; Elliott, HL; Meredith, PA, 1991)
"The effects of aging on heart rate and atrioventricular (AV) conduction responses to verapamil (0-100 ng/ml) were studied in Langendorff perfused hearts from 12 mature (4-6 months) and 12 senescent (24 months) male Fischer 344 rats and in hearts from 10 mature and 9 senescent rats after reserpine administration (0."	3.68	The effects of aging on the electrophysiologic responses to verapamil in isolated perfused rat hearts. ( Garcia, J; Schmidlin, O; Schwartz, JB, 1991)
"We have previously described a method for inducing atrial ectopic tachycardia (AET) in the anesthetized adult rat using digoxin, 30 mg/kg s."	3.67	Age-related digoxin-verapamil interactions in the adult rat. ( Jarenwattananon, M; Kaplanski, J; Nudel, DB; Weinhouse, E, 1989)
" Calcium antagonists, including verapamil, are now used widely in the management of patients with hypertension."	3.67	Calcium antagonists and hypertension. ( Dillon, JS; Nayler, WG; Sturrock, WJ, 1988)
"It is now recognized that left ventricular hypertrophy (LVH), often associated with hypertension, is itself a risk factor for coronary disease in the elderly."	2.67	Left ventricular mass regression in elderly hypertensives. ( Gerstenblith, G, 1992)
"This study investigated the cardiac responses and pharmacokinetics following the acute and chronic administration of verapamil in 14 middle-aged and elderly patients with ischemic heart disease (age range 42-76 years)."	2.67	Low-dose verapamil in middle-aged and elderly patients with angina pectoris: no evidence of increased susceptibility to the cardiac effects. ( Ahmed, JH; Elliott, HL; Meredith, PA; Reid, JL, 1992)
" Pharmacokinetic parameters obtained after oral administration were not significantly different from those after intravenous dosing."	2.65	Pharmacokinetics of calcium blockers in patients with renal insufficiency and in geriatric patients. ( Larsen, A; Midtbø, K; Saevareid, L; Storstein, L, 1984)
" The efficacy of MMF as an immunosuppressant and long-term safety in cats of this dosage regimen is unknown."	2.61	( Abrams, G; Adolfsson, E; Agarwal, PK; Akkan, AG; Al Alhareth, NS; Alves, VGL; Armentano, R; Bahroos, E; Baig, M; Baldridge, KK; Barman, S; Bartolucci, C; Basit, A; Bertoli, SV; Bian, L; Bigatti, G; Bobenko, AI; Boix, PP; Bokulic, T; Bolink, HJ; Borowiec, J; Bulski, W; Burciaga, J; Butt, NS; Cai, AL; Campos, AM; Cao, G; Cao, Y; Čapo, I; Caruso, ML; Chao, CT; Cheatum, CM; Chelminski, K; Chen, AJW; Chen, C; Chen, CH; Chen, D; Chen, G; Chen, H; Chen, LH; Chen, R; Chen, RX; Chen, X; Cherdtrakulkiat, R; Chirvony, VS; Cho, JG; Chu, K; Ciurlino, D; Coletta, S; Contaldo, G; Crispi, F; Cui, JF; D'Esposito, M; de Biase, S; Demir, B; Deng, W; Deng, Z; Di Pinto, F; Domenech-Ximenos, B; Dong, G; Drácz, L; Du, XJ; Duan, LJ; Duan, Y; Ekendahl, D; Fan, W; Fang, L; Feng, C; Followill, DS; Foreman, SC; Fortunato, G; Frew, R; Fu, M; Gaál, V; Ganzevoort, W; Gao, DM; Gao, X; Gao, ZW; Garcia-Alvarez, A; Garza, MS; Gauthier, L; Gazzaz, ZJ; Ge, RS; Geng, Y; Genovesi, S; Geoffroy, V; Georg, D; Gigli, GL; Gong, J; Gong, Q; Groeneveld, J; Guerra, V; Guo, Q; Guo, X; Güttinger, R; Guyo, U; Haldar, J; Han, DS; Han, S; Hao, W; Hayman, A; He, D; Heidari, A; Heller, S; Ho, CT; Ho, SL; Hong, SN; Hou, YJ; Hu, D; Hu, X; Hu, ZY; Huang, JW; Huang, KC; Huang, Q; Huang, T; Hwang, JK; Izewska, J; Jablonski, CL; Jameel, T; Jeong, HK; Ji, J; Jia, Z; Jiang, W; Jiang, Y; Kalumpha, M; Kang, JH; Kazantsev, P; Kazemier, BM; Kebede, B; Khan, SA; Kiss, J; Kohen, A; Kolbenheyer, E; Konai, MM; Koniarova, I; Kornblith, E; Krawetz, RJ; Kreouzis, T; Kry, SF; Laepple, T; Lalošević, D; Lan, Y; Lawung, R; Lechner, W; Lee, KH; Lee, YH; Leonard, C; Li, C; Li, CF; Li, CM; Li, F; Li, J; Li, L; Li, S; Li, X; Li, Y; Li, YB; Li, Z; Liang, C; Lin, J; Lin, XH; Ling, M; Link, TM; Liu, HH; Liu, J; Liu, M; Liu, W; Liu, YP; Lou, H; Lu, G; Lu, M; Lun, SM; Ma, Z; Mackensen, A; Majumdar, S; Martineau, C; Martínez-Pastor, JP; McQuaid, JR; Mehrabian, H; Meng, Y; Miao, T; Miljković, D; Mo, J; Mohamed, HSH; Mohtadi, M; Mol, BWJ; Moosavi, L; Mosdósi, B; Nabu, S; Nava, E; Ni, L; Novakovic-Agopian, T; Nyamunda, BC; Nyul, Z; Önal, B; Özen, D; Özyazgan, S; Pajkrt, E; Palazon, F; Park, HW; Patai, Á; Patai, ÁV; Patzke, GR; Payette, G; Pedoia, V; Peelen, MJCS; Pellitteri, G; Peng, J; Perea, RJ; Pérez-Del-Rey, D; Popović, DJ; Popović, JK; Popović, KJ; Posecion, L; Povall, J; Prachayasittikul, S; Prachayasittikul, V; Prat-González, S; Qi, B; Qu, B; Rakshit, S; Ravelli, ACJ; Ren, ZG; Rivera, SM; Salo, P; Samaddar, S; Samper, JLA; Samy El Gendy, NM; Schmitt, N; Sekerbayev, KS; Sepúlveda-Martínez, Á; Sessolo, M; Severi, S; Sha, Y; Shen, FF; Shen, X; Shen, Y; Singh, P; Sinthupoom, N; Siri, S; Sitges, M; Slovak, JE; Solymosi, N; Song, H; Song, J; Song, M; Spingler, B; Stewart, I; Su, BL; Su, JF; Suming, L; Sun, JX; Tantimavanich, S; Tashkandi, JM; Taurbayev, TI; Tedgren, AC; Tenhunen, M; Thwaites, DI; Tibrewala, R; Tomsejm, M; Triana, CA; Vakira, FM; Valdez, M; Valente, M; Valentini, AM; Van de Winckel, A; van der Lee, R; Varga, F; Varga, M; Villarino, NF; Villemur, R; Vinatha, SP; Vincenti, A; Voskamp, BJ; Wang, B; Wang, C; Wang, H; Wang, HT; Wang, J; Wang, M; Wang, N; Wang, NC; Wang, Q; Wang, S; Wang, X; Wang, Y; Wang, Z; Wen, N; Wesolowska, P; Willis, M; Wu, C; Wu, D; Wu, L; Wu, X; Wu, Z; Xia, JM; Xia, X; Xia, Y; Xiao, J; Xiao, Y; Xie, CL; Xie, LM; Xie, S; Xing, Z; Xu, C; Xu, J; Yan, D; Yan, K; Yang, S; Yang, X; Yang, XW; Ye, M; Yin, Z; Yoon, N; Yoon, Y; Yu, H; Yu, K; Yu, ZY; Zhang, B; Zhang, GY; Zhang, H; Zhang, J; Zhang, M; Zhang, Q; Zhang, S; Zhang, W; Zhang, X; Zhang, Y; Zhang, YW; Zhang, Z; Zhao, D; Zhao, F; Zhao, P; Zhao, W; Zhao, Z; Zheng, C; Zhi, D; Zhou, C; Zhou, FY; Zhu, D; Zhu, J; Zhu, Q; Zinyama, NP; Zou, M; Zou, Z, 2019)
" Concomitant intake of rifampicin (600 mg/die) induced especially the presystemic (prehepatic) metabolism of verapamil so that oral bioavailability approached zero and PD effects almost diminished."	2.40	Effect of age on pharmacokinetics and pharmacodynamics in man. ( Klotz, U, 1998)
" Nevertheless, this procedure may provide useful information for optimizing the dosage regimen of each patient as the pathological condition and drug therapy may be quite complex."	2.37	Pharmacokinetics of diltiazem and other calcium entry blockers. ( Hermann, P; Morselli, PL, 1985)
" The bioavailability of diltiazem and nifedipine has not been well studied, and no investigations of the absolute bioavailability of these compounds have been reported."	2.36	Calcium antagonists. Pharmacokinetic properties. ( Kates, RE, 1983)
"Oral treatment with verapamil or vehicle was started, 24 h post-intracerebroventricular (ICV) streptozotocin/(STZ), in 12-month-old animals and continued for 3 months."	1.62	Verapamil Prevents Development of Cognitive Impairment in an Aged Mouse Model of Sporadic Alzheimer's Disease. ( Ahmed, HA; Ishrat, T; Ismael, S; Mirzahosseini, G, 2021)
" Other pharmacokinetic parameters, such as volume of distribution and plasma protein binding did not show any statistical differences."	1.31	Pharmacokinetics of verapamil in New Zealand white rabbits during ontogeny. ( Aramayona, JJ; Bregante, MA; Fraile, LJ; Garcia, MA; Solans, C, 2000)
"Verapamil was added to pre- and post-smoking blood samples to yield a final concentration of 1 mg-1."	1.29	Effect of acute smoking on red blood cell deformability in healthy young and elderly non-smokers, and effect of verapamil on age- and acute smoking-induced change in red blood cell deformability. ( Salbaş, K, 1994)
"Verapamil disposition was also age related."	1.27	Verapamil pharmacodynamics and disposition in young and elderly hypertensive patients. Altered electrocardiographic and hypotensive responses. ( Abernethy, DR; Luchi, R; Schwartz, JB; Snow, E; Todd, EL, 1986)
" Therefore, even though there is little variation in the pharmacokinetic parameters between adult dogs and puppies, there is a marked reduction in the sensitivity of the puppies to the ECG effects of verapamil."	1.27	Age-related changes in the pharmacodynamics of verapamil. ( Arnold, TH; Tackett, RL; Vallner, JJ, 1985)
"Norverapamil was measured in plasma after oral dosing, but was not detectable after intravenous dosing."	1.26	Prediction of steady-state verapamil plasma concentrations in children and adults. ( Rocchini, AP; Vasiliades, J; Wagner, JG, 1982)
"Verapamil has been studied extensively in adult animals."	1.26	The comparative electrophysiologic and hemodynamic effects of verapamil in puppies and adult dogs. ( Driscoll, D; Entman, ML; Gibson, R; Gillette, P; Hartley, C, 1981)

Timeframe	Studies, this research(%)	All Research%
pre-1990	36 (37.11)	18.7374
1990's	42 (43.30)	18.2507
2000's	10 (10.31)	29.6817
2010's	8 (8.25)	24.3611
2020's	1 (1.03)	2.80

Trial	Enrollment	Study Type	Start Date	Status
CID 0708 - Sex, Aging and Antiretroviral Pharmacokinetics[NCT00666055]	11 participants (Actual)	Observational	2008-03-31	Completed
Myocardial Ultrasonic Tissue Characterization in Patients With a Genetic Predisposition for the Development of Hypertrophic Cardiomyopathy[NCT00001632]	195 participants	Observational	1997-09-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Proceedings. Mathematical, physical, and engineering sciences, 2019, Volume: 475, Issue:2227 Topics: Acetylcholine; Acinetobacter baumannii; Actinobacteria; Action Potentials; Adalimumab; Adaptation, P	2019
11C-verapamil to assess P-gp function in human brain during aging, depression and neurodegenerative disease. Current topics in medicinal chemistry, 2010, Volume: 10, Issue:17 Topics: Aging; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain Diseases;	2010
Calcium influx blockers in the treatment of essential hypertension. Acta medica Scandinavica. Supplementum, 1984, Volume: 681 Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Animals; Drug Therapy, Combination; Forearm; Humans	1984
Calcium antagonists. Pharmacokinetic properties. Drugs, 1983, Volume: 25, Issue:2 Topics: Administration, Oral; Aging; Biological Availability; Calcium Channel Blockers; Chemical Phenomena;	1983
Do calcium channel blockers have renal protective effects? Drugs & aging, 1994, Volume: 5, Issue:4 Topics: Aging; Animals; Calcium Channel Blockers; Clinical Trials as Topic; Cyclosporine; Diabetic Nephropat	1994
Effect of age on pharmacokinetics and pharmacodynamics in man. International journal of clinical pharmacology and therapeutics, 1998, Volume: 36, Issue:11 Topics: Adolescent; Adult; Aged; Aging; Anti-Anxiety Agents; Area Under Curve; Calcium Channel Blockers; Hum	1998
Drug interchanges at the pharmacy: safe for cardiovascular disease? Hospital practice (Office ed.), 1991, Jul-15, Volume: 26, Issue:7 Topics: Aging; Biological Availability; Delayed-Action Preparations; Gastrointestinal Motility; Humans; Hydr	1991
Pharmacokinetics of diltiazem and other calcium entry blockers. Acta pharmacologica et toxicologica, 1985, Volume: 57 Suppl 2 Topics: Administration, Oral; Adult; Aged; Aging; Animals; Benzazepines; Blood Proteins; Calcium Channel Blo	1985

Article	Year
P-glycoprotein function at the blood-brain barrier: effects of age and gender. Molecular imaging and biology, 2012, Volume: 14, Issue:6 Topics: Adult; Aged; Aging; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Fe	2012
Effect of age on functional P-glycoprotein in the blood-brain barrier measured by use of (R)-[(11)C]verapamil and positron emission tomography. Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:6 Topics: Adult; Aged; Aging; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood	2006
Pharmacokinetics of calcium blockers in patients with renal insufficiency and in geriatric patients. Acta medica Scandinavica. Supplementum, 1984, Volume: 681 Topics: Administration, Oral; Adult; Aged; Aging; Diltiazem; Humans; Injections, Intravenous; Kinetics; Male	1984
Verapamil and norverapamil plasma levels in infants and children during chronic oral treatment. Therapeutic drug monitoring, 1995, Volume: 17, Issue:1 Topics: Administration, Oral; Adolescent; Aging; Cardiomyopathy, Dilated; Child; Child, Preschool; Female; H	1995
Age-related changes of antianginal effects of verapamil in patients with stable effort angina. A medium term randomized double-blind placebo controlled trial. Giornale italiano di cardiologia, 1993, Volume: 23, Issue:5 Topics: Adult; Aging; Angina Pectoris; Double-Blind Method; Exercise Test; Female; Humans; Male; Middle Aged	1993
Mixed-effect modeling for detection and evaluation of drug interactions: digoxin-quinidine and digoxin-verapamil combinations. Therapeutic drug monitoring, 1996, Volume: 18, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Aging; Anti-Arrhythmia Agents; Body Weight; Calcium Channel Blockers	1996
Gut wall metabolism of verapamil in older people: effects of rifampicin-mediated enzyme induction. British journal of clinical pharmacology, 1998, Volume: 45, Issue:3 Topics: Aged; Aging; Biological Availability; Calcium Channel Blockers; Humans; Intestinal Mucosa; Male; Ref	1998
Exercise gas transport determinants in elderly normotensive and hypertensive humans. Experimental physiology, 1999, Volume: 84, Issue:1 Topics: Adult; Aged; Aging; Biological Transport; Calcium Channel Blockers; Echocardiography, Doppler; Exerc	1999
Left ventricular diastolic filling and cardiovascular functional capacity in older men. Experimental physiology, 2000, Volume: 85, Issue:5 Topics: Aged; Aging; Anaerobic Threshold; Blood Flow Velocity; Blood Pressure; Calcium Channel Blockers; Exe	2000
Effects of verapamil in normal elderly individuals with left ventricular diastolic dysfunction. Echocardiography (Mount Kisco, N.Y.), 2001, Volume: 18, Issue:2 Topics: Aged; Aged, 80 and over; Aging; Calcium Channel Blockers; Cross-Over Studies; Diastole; Drug Adminis	2001
Left ventricular mass regression in elderly hypertensives. Journal of human hypertension, 1992, Volume: 6 Suppl 2 Topics: Aging; Atenolol; Blood Pressure; Coronary Circulation; Delayed-Action Preparations; Echocardiography	1992
Low-dose verapamil in middle-aged and elderly patients with angina pectoris: no evidence of increased susceptibility to the cardiac effects. Cardiovascular drugs and therapy, 1992, Volume: 6, Issue:2 Topics: Administration, Oral; Adult; Aged; Aging; Angina Pectoris; Blood Pressure; Female; Half-Life; Heart	1992
Special considerations in the elderly patient. Journal of human hypertension, 1990, Volume: 4 Suppl 5 Topics: Age Factors; Aged; Aging; Atenolol; Blood Pressure; Cardiac Output; Cardiomegaly; Chlorthalidone; Do	1990
Treatment of isolated systolic hypertension in the elderly with verapamil slow-release 240 mg. Journal of cardiovascular pharmacology, 1989, Volume: 13 Suppl 4 Topics: Aged; Aging; Blood Pressure; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Met	1989
The effects of age on the pharmacodynamics and pharmacokinetics of two formulations of verapamil. Journal of cardiovascular pharmacology, 1989, Volume: 13 Suppl 4 Topics: Aged; Aging; Blood Pressure; Delayed-Action Preparations; Female; Humans; Hypertension; Male; Middle	1989

Article	Year
Increased calcium channel in the lamina propria of aging rat. Aging, 2019, 10-31, Volume: 11, Issue:20 Topics: Aging; Animals; Calcium Channel Blockers; Calcium Channels; Cell Line; Fibroblasts; Gene Expression	2019
Verapamil Prevents Development of Cognitive Impairment in an Aged Mouse Model of Sporadic Alzheimer's Disease. Molecular neurobiology, 2021, Volume: 58, Issue:7 Topics: Aging; Alzheimer Disease; Animals; Brain; Calcium Channel Blockers; Cognitive Dysfunction; Disease M	2021
Effect of I Bulletin of experimental biology and medicine, 2016, Volume: 161, Issue:6 Topics: Adrenergic alpha-Agonists; Age Factors; Aging; Animals; Animals, Newborn; Animals, Outbred Strains;	2016
Age dependency of cerebral P-gp function measured with (R)-[11C]verapamil and PET. European journal of clinical pharmacology, 2009, Volume: 65, Issue:9 Topics: Adult; Age Factors; Aged; Aging; Amygdala; ATP Binding Cassette Transporter, Subfamily B, Member 1;	2009
The aging heart: changes in the pharmacodynamic electrophysiological response to verapamil in aged rabbit hearts. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2010, Volume: 61, Issue:2 Topics: Age Factors; Aging; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Carbachol; Electrop	2010
Assessment of pulmonary function and serum substance levels in newborn and juvenile rats. Reproductive toxicology (Elmsford, N.Y.), 2010, Volume: 30, Issue:3 Topics: Administration, Inhalation; Aging; Animals; Animals, Newborn; Drug Evaluation, Preclinical; Drug-Rel	2010
Developmental changes in P-glycoprotein function in the blood-brain barrier of nonhuman primates: PET study with R-11C-verapamil and 11C-oseltamivir. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2011, Volume: 52, Issue:6 Topics: Aging; Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Bra	2011
Age-related changes of P-glycoprotein-mediated rhodamine 123 efflux in normal human bone marrow hematopoietic stem cells. Leukemia, 2003, Volume: 17, Issue:4 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; ATP Binding Cassette Transporter, Subfamily B, Me	2003
Oleandrin produces changes in intracellular calcium levels in isolated cardiomyocytes: a real-time fluorescence imaging study comparing adult to neonatal cardiomyocytes. Journal of toxicology and environmental health. Part A, 2007, Mar-15, Volume: 70, Issue:6 Topics: Aging; Animals; Animals, Newborn; Calcium; Calcium Channel Blockers; Cardenolides; Cells, Cultured;	2007
Blood-brain barrier P-glycoprotein function decreases in specific brain regions with aging: a possible role in progressive neurodegeneration. Neurobiology of aging, 2009, Volume: 30, Issue:11 Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aging; ATP Binding Cassette Transporter, Su	2009
Comparative effects of verapamil, nifedipine, and diltiazem on contractile function in the isolated immature and adult rabbit heart. Pediatric research, 1984, Volume: 18, Issue:10 Topics: Aging; Animals; Benzazepines; Calcium; Diltiazem; Dose-Response Relationship, Drug; Ion Channels; My	1984
Ventricular self-defibrillation in mammals: age and drug dependence. Age and ageing, 1980, Volume: 9, Issue:2 Topics: Aging; Animals; Calcium Gluconate; Cats; Dibenzazepines; Drug Therapy, Combination; Electric Stimula	1980
The role of alkaline protease in the development of cardiac lesions in myopathic hamsters: effect of verapamil treatment. Biochemical medicine, 1984, Volume: 32, Issue:2 Topics: Aging; Animals; Cardiomyopathies; Cricetinae; Endopeptidases; Female; Genes, Recessive; Muscles; Myo	1984
Transition from neurogenic to myogenic receptivity for thyrotropin-releasing hormone (TRH) in the duodenum of the neonatal rat. Endocrinology, 1981, Volume: 108, Issue:2 Topics: Acetylcholine; Aging; Animal Population Groups; Animals; Animals, Newborn; Animals, Suckling; Duoden	1981
Early biochemical events associated with lymphocyte activation in ageing. I. Evidence that Ca2+ dependent processes induced by PHA are impaired. Immunology, 1981, Volume: 42, Issue:1 Topics: Adult; Aged; Aging; Calcium; Cells, Cultured; Dose-Response Relationship, Immunologic; Edetic Acid;	1981
Prediction of steady-state verapamil plasma concentrations in children and adults. Clinical pharmacology and therapeutics, 1982, Volume: 32, Issue:2 Topics: Administration, Oral; Adolescent; Adult; Aging; Child; Female; Humans; Infusions, Parenteral; Inject	1982
The electrophysiological properties of normal neonatal and adult canine cardiac Purkinje fibers. Circulation research, 1981, Volume: 48, Issue:5 Topics: Action Potentials; Aging; Aminopyridines; Animals; Animals, Newborn; Dogs; Electric Stimulation; Ele	1981
The comparative electrophysiologic and hemodynamic effects of verapamil in puppies and adult dogs. Developmental pharmacology and therapeutics, 1981, Volume: 2, Issue:2 Topics: Aging; Animals; Blood Pressure; Dogs; Electrophysiology; Heart; Heart Rate; Hemodynamics; Regional B	1981
Cholinergic regulation of [Ca2+]i during cell division and differentiation in the mammalian retina. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:4 Topics: Aging; Animals; Animals, Newborn; Calcium; Calcium Channel Blockers; Carbachol; Cell Differentiation	1995
Effect of acute smoking on red blood cell deformability in healthy young and elderly non-smokers, and effect of verapamil on age- and acute smoking-induced change in red blood cell deformability. Scandinavian journal of clinical and laboratory investigation, 1994, Volume: 54, Issue:6 Topics: Adenosine Triphosphate; Adult; Aged; Aging; Erythrocyte Deformability; Humans; Male; Middle Aged; Sm	1994
Improvement of age-related impairment in left ventricular diastolic filling with verapamil in the normal human heart. Circulation, 1995, Feb-15, Volume: 91, Issue:4 Topics: Aged; Aging; Diastole; Humans; Ventricular Function, Left; Verapamil	1995
Influence of autonomic blockade and aging on AV conduction and responses to verapamil in the beagle. The journals of gerontology. Series A, Biological sciences and medical sciences, 1995, Volume: 50, Issue:2 Topics: Aging; Animals; Atrioventricular Node; Atropine; Autonomic Nervous System; Blood Pressure; Dogs; Dos	1995
Effect of calcium antagonists on isolated aorta from hypercholesterolemic Yoshida rats of different ages. General pharmacology, 1994, Volume: 25, Issue:7 Topics: Aging; Animals; Aorta, Thoracic; Dinoprostone; Hypercholesterolemia; In Vitro Techniques; Male; Musc	1994
Verapamil stereoisomers during racemic verapamil administration: effects of aging and comparisons to administration of individual stereoisomers. Clinical pharmacology and therapeutics, 1994, Volume: 56, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Aging; Analysis of Variance; Female; Humans; Infusions, Intravenous;	1994
Improvement of the age-related impairment in left ventricular diastolic filling with verapamil in the normal human heart. Circulation, 1994, Volume: 90, Issue:1 Topics: Adult; Aged; Aging; Blood Pressure; Coronary Circulation; Diastole; Female; Humans; Male; Middle Age	1994
Aging of women alters S-verapamil pharmacokinetics and pharmacodynamics. Clinical pharmacology and therapeutics, 1994, Volume: 55, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Aging; Female; Humans; Middle Aged; Stereoisomerism; Verapamil	1994
Influence of aging on the beta- and glucagon-receptor-mediated glycogenolysis in rat hepatocytes. Mechanisms of ageing and development, 1993, Aug-01, Volume: 70, Issue:1-2 Topics: Aging; Animals; Calcium; Egtazic Acid; Enzyme Activation; In Vitro Techniques; Liver; Liver Glycogen	1993
Calcium-dependent efflux of K+ ions from stimulated T lymphocytes of young and old mice. Mechanisms of ageing and development, 1993, Oct-01, Volume: 71, Issue:1-2 Topics: Aging; Animals; Calcimycin; Calcium; Concanavalin A; Female; Ionomycin; Male; Mice; Mice, Inbred BAL	1993
Stereoselective verapamil disposition and dynamics in aging during racemic verapamil administration. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:2 Topics: Adult; Aged; Aging; Humans; Male; Metabolic Clearance Rate; Stereoisomerism; Verapamil	1993
The effects of age and gender on the stereoselective pharmacokinetics of verapamil. Clinical pharmacology and therapeutics, 1993, Volume: 54, Issue:3 Topics: Adult; Aged; Aging; Analysis of Variance; Female; Half-Life; Humans; Male; Middle Aged; Sex Characte	1993
Early postnatal development of contractile performance and responsiveness to Ca2+, verapamil and ryanodine in the isolated rat heart. Journal of molecular and cellular cardiology, 1993, Volume: 25, Issue:6 Topics: Aging; Animals; Calcium; Calcium Channels; Dose-Response Relationship, Drug; Heart; Male; Myocardial	1993
Aging effects on stereoselective pharmacokinetics and pharmacodynamics of verapamil. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Aging; Blood Pressure; Electrocardiography; Female; Heart Rate; Huma	1993
Developmental differences in cardiac myocyte calcium homeostasis after steady-state potassium depolarization: mechanisms and implications for cardioplegia. The Journal of pediatrics, 1993, Volume: 122, Issue:6 Topics: Aging; Amiloride; Animals; Calcium; Cytosol; Electrophysiology; Fura-2; Heart; Heart Arrest, Induced	1993
The effects of verapamil and lidocaine on the duration of propofol and xylazine-ketamine anesthesia in broiler chickens. Veterinary and human toxicology, 1996, Volume: 38, Issue:3 Topics: Aging; Analysis of Variance; Anesthesia; Anesthetics; Animals; Calcium Channel Blockers; Chickens; D	1996
Myocardial ultrasonic tissue characterization in pediatric and adult patients with hypertrophic cardiomyopathy. Circulation, 1996, Dec-01, Volume: 94, Issue:11 Topics: Adult; Aging; Cardiomyopathy, Hypertrophic; Child; Child, Preschool; Echocardiography; Humans; Middl	1996
Quantification of Locusta diuretic hormone in the central nervous system and corpora cardiaca: influence of age and feeding status, and mechanism of release. Regulatory peptides, 1997, Mar-12, Volume: 69, Issue:1 Topics: Aging; Animals; Calcium Channel Blockers; Central Nervous System; Chromatography, High Pressure Liqu	1997
The relaxing effect of BDF 9148 on the KCl-contracted aorta isolated from normo- and hyper-tensive rats. Naunyn-Schmiedeberg's archives of pharmacology, 1998, Volume: 357, Issue:2 Topics: Aging; Animals; Aorta, Thoracic; Azetidines; Calcium Channel Blockers; Cardiotonic Agents; Electroph	1998
Involvement of angiotensin II in development of spontaneous nephrosis in Dahl salt-sensitive rats. European journal of pharmacology, 1998, Dec-04, Volume: 362, Issue:2-3 Topics: Aging; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; B	1998
Verapamil metabolite exposure in older and younger men during steady-state oral verapamil administration. Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:7 Topics: Administration, Oral; Adult; Aged; Aging; Area Under Curve; Biotransformation; Humans; Male; Referen	2000
Pharmacokinetics of verapamil in New Zealand white rabbits during ontogeny. Biology of the neonate, 2000, Volume: 78, Issue:4 Topics: Aging; Animals; Animals, Newborn; Kinetics; Liver; NADP; Oxidoreductases, N-Demethylating; Rabbits;	2000
Age-dependent variation in contractility of adult cardiac myocytes. The international journal of biochemistry & cell biology, 2001, Volume: 33, Issue:2 Topics: Aging; Animals; Body Weight; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T	2001
Age-related changes in Purkinje fiber action potentials of adult dogs. Circulation research, 1978, Volume: 43, Issue:6 Topics: Action Potentials; Aging; Animals; Carbamates; Dogs; Electrocardiography; Female; Heart Conduction S	1978
Density of 1,4-dihydropyridine receptors decreases in the hearts of aging hamsters. Journal of molecular and cellular cardiology, 1992, Volume: 24, Issue:8 Topics: Aging; Allosteric Site; Animals; Calcium Channels; Cricetinae; Dihydropyridines; Diltiazem; In Vitro	1992
Measurements of intracellular calcium in sensory neurons of adult and old rats. Neuroscience, 1992, Volume: 50, Issue:4 Topics: Aging; Animals; Calcium; Cytosol; Fluorometry; Fura-2; Ganglia, Spinal; Homeostasis; In Vitro Techni	1992
Cerebral vascular changes associated with hemorrhagic stroke in hypertension. Canadian journal of physiology and pharmacology, 1992, Volume: 70, Issue:4 Topics: Aging; Animals; Cerebral Arteries; Cerebral Hemorrhage; Cerebrovascular Circulation; Cerebrovascular	1992
Age-related effects of ischemia, lidocaine and verapamil on overdrive-induced suppression of ventricular pacemakers in isolated rat heart. Aging (Milan, Italy), 1992, Volume: 4, Issue:2 Topics: Aging; Animals; Coronary Disease; In Vitro Techniques; Lidocaine; Male; Rats; Rats, Inbred Strains;	1992
Aging and the response of the isolated perfused rat liver to vasoactive drugs. Biochemical pharmacology, 1992, Feb-18, Volume: 43, Issue:4 Topics: Aging; Animals; Blood Flow Velocity; Blood Pressure; Female; Liver; Liver Circulation; Norepinephrin	1992
Differential age-dependent attenuation of reflex tachycardia by verapamil in rats. Mechanisms of ageing and development, 1991, Volume: 58, Issue:2-3 Topics: Aging; Animals; Atropine; Female; Heart Rate; Nitroprusside; Parasympathetic Nervous System; Phenyle	1991
The influence of age on the pharmacokinetics of verapamil. Pharmacological research, 1991, Volume: 24, Issue:3 Topics: Adult; Aged; Aging; Body Weight; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Hy	1991
[Beta-adrenoblockaders and calcium antagonists in the treatment of patients with ischemic heart disease combined with hypertension]. Vrachebnoe delo, 1990, Issue:11 Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Calcium Channel Blockers; Coronary Disease; Drug Ev	1990
The effects of aging on the electrophysiologic responses to verapamil in isolated perfused rat hearts. The Journal of pharmacology and experimental therapeutics, 1991, Jul-01, Volume: 258, Issue:1 Topics: Aging; Animals; Drug Interactions; Electrophysiology; Heart Conduction System; Injections, Intraperi	1991
Aging alters verapamil elimination and dynamics: single dose and steady-state responses. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Aging; Atrioventricular Node; Blood Pressure; Cold Temperature; Elec	1990
Effect of aging on calcium cytosolic concentration in rat cortical synaptosomes. Annali dell'Istituto superiore di sanita, 1990, Volume: 26, Issue:1 Topics: Aging; Animals; Calcium; Cerebral Cortex; Cytosol; Male; Rats; Sodium; Synaptosomes; Verapamil	1990
Age-dependent increase in [3H]verapamil binding to rat cortical membranes. Neuroscience letters, 1985, Oct-24, Volume: 61, Issue:1-2 Topics: Age Factors; Aging; Animals; Binding, Competitive; Calcium; Cerebral Cortex; Ion Channels; Male; Mem	1985
The prostaglandin response in guinea-pig taenia caeci and trachea smooth muscle of different ages. European journal of pharmacology, 1988, Mar-01, Volume: 147, Issue:2 Topics: Aging; Animals; Carbachol; Cecum; Dinoprost; Dinoprostone; Guinea Pigs; In Vitro Techniques; Ion Cha	1988
Relationship between cytosolic free calcium concentration and 2-deoxyglucose uptake in adipocytes isolated from 2- and 12-month-old rats. Endocrinology, 1988, Volume: 122, Issue:6 Topics: Adipose Tissue; Aging; Animals; Calcium; Cytosol; Deoxy Sugars; Deoxyglucose; Glyburide; Insulin; Io	1988
Treatment of mild to moderate hypertension with verapamil slow-release in outpatients. Collaborative Group of the Spanish League for the Fight Against Hypertension. Journal of cardiovascular pharmacology, 1989, Volume: 13 Suppl 4 Topics: Aged; Aging; Blood Pressure; Delayed-Action Preparations; Female; Heart Rate; Humans; Hypertension;	1989
Effect of age and of hypertrophy on cardiac Ca2+ antagonist binding sites. Journal of cardiovascular pharmacology, 1989, Volume: 14, Issue:2 Topics: Aging; Animals; Blood Pressure; Body Weight; Calcium Channels; Cardiomegaly; Cell Membrane; Dihydrop	1989
Verapamil disposition and cardiovascular effects in elderly patients after single intravenous and oral doses. Cardiovascular drugs and therapy, 1989, Volume: 3, Issue:3 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aging; Blood Pressure; Electrocardiography; Fe	1989
Effect of age on K+-induced cytosolic Ca2+ changes in rat cortical synaptosomes. Journal of neurochemistry, 1989, Volume: 53, Issue:2 Topics: Aging; Animals; Calcium; Cerebral Cortex; Cytosol; Fluorescence; Male; Microscopy, Electron; Potassi	1989
Age-related digoxin-verapamil interactions in the adult rat. Methods and findings in experimental and clinical pharmacology, 1989, Volume: 11, Issue:6 Topics: Aging; Animals; Digoxin; Drug Interactions; Electrocardiography; Heart Rate; Male; Rats; Rats, Inbre	1989
The effects of aging on responses to verapamil in isolated right atria. Journal of gerontology, 1989, Volume: 44, Issue:6 Topics: Aging; Animals; Atrial Function; Cardiac Pacing, Artificial; Dose-Response Relationship, Drug; Heart	1989
Calcium antagonists and hypertension. Clinical and experimental pharmacology & physiology, 1988, Volume: 15, Issue:2 Topics: Aging; Aniline Compounds; Animals; Blood Pressure; Calcium Channel Blockers; Catecholamines; Dihydro	1988
Release of endogenous taurine and gamma-aminobutyric acid from brain slices from the adult and developing mouse. Journal of neurochemistry, 1989, Volume: 52, Issue:4 Topics: Aging; Animals; Brain; Calcium; Female; gamma-Aminobutyric Acid; In Vitro Techniques; Magnesium; Mal	1989
[Clinical pharmacology of calcium antagonists]. Schweizerische medizinische Wochenschrift, 1987, Mar-28, Volume: 117, Issue:13 Topics: Aging; Arrhythmias, Cardiac; Biological Availability; Calcium Channel Blockers; Diltiazem; Drug Inte	1987
Verapamil and nifedipine effect on K+-induced contractions of guinea pig ileum during postnatal development. Developmental pharmacology and therapeutics, 1987, Volume: 10, Issue:6 Topics: Aging; Animals; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth;	1987
Physiological, pharmacological and pathological factors affecting the pharmacokinetics of calcium entry blockers. Giornale italiano di cardiologia, 1987, Volume: 17, Issue:9 Topics: Aging; Animals; Calcium Channel Blockers; Diltiazem; Drug Administration Schedule; Guinea Pigs; Huma	1987
Age-dependent cardiovascular effects of verapamil in newborn swine. Pediatric research, 1986, Volume: 20, Issue:5 Topics: Aging; Animals; Animals, Newborn; Blood Pressure; Heart Rate; Hemodynamics; Myocardial Contraction;	1986
Verapamil pharmacodynamics and disposition in young and elderly hypertensive patients. Altered electrocardiographic and hypotensive responses. Annals of internal medicine, 1986, Volume: 105, Issue:3 Topics: Administration, Oral; Adult; Aged; Aging; Blood Pressure; Electrocardiography; Heart Rate; Humans; H	1986
Effects of verapamil on acetylcholine and field stimulation induced contraction in postnatal development of guinea-pig ileum. Research communications in chemical pathology and pharmacology, 1986, Volume: 53, Issue:2 Topics: Acetylcholine; Aging; Animals; Electric Stimulation; Female; Guinea Pigs; Ileum; Male; Muscle Contra	1986
Ontogenetic differences in cardiac sensitivity to verapamil in rats. Pediatric cardiology, 1986, Volume: 7, Issue:1 Topics: Aging; Animals; Animals, Newborn; Depression, Chemical; Dose-Response Relationship, Drug; Heart; In	1986
Age-related changes in the sensitivity to verapamil and sodium nitroprusside of vascular smooth muscle of rabbit aorta. British journal of pharmacology, 1985, Volume: 85, Issue:1 Topics: Aging; Animals; Animals, Newborn; Aorta, Thoracic; Female; Ferricyanides; In Vitro Techniques; Male;	1985
Age-related changes in the pharmacodynamics of verapamil. American heart journal, 1985, Volume: 110, Issue:5 Topics: Administration, Oral; Aging; Anesthesia; Animals; Blood Pressure; Dogs; Electrocardiography; Electro	1985
[Arrhythmias in the elderly patients: atrial fibrillation]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 1985, Volume: 22, Issue:4 Topics: Aged; Aging; Atrial Fibrillation; Coronary Disease; Diltiazem; Humans; Hypertension; Mitral Valve In	1985

verapamil and Aging

Research Excerpts

Research

Studies (97)

Authors

Clinical Trials (2)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Bobenko, AI	1
Heller, S	1
Schmitt, N	1
Cherdtrakulkiat, R	1
Lawung, R	1
Nabu, S	1
Tantimavanich, S	1
Sinthupoom, N	1
Prachayasittikul, S	1
Prachayasittikul, V	1
Zhang, B	1
Wu, C	1
Zhang, Z	2
Yan, K	1
Li, C	2
Li, Y	4
Li, L	3
Zheng, C	1
Xiao, Y	1
He, D	1
Zhao, F	1
Su, JF	1
Lun, SM	1
Hou, YJ	1
Duan, LJ	1
Wang, NC	1
Shen, FF	1
Zhang, YW	1
Gao, ZW	1
Li, J	5
Du, XJ	1
Zhou, FY	1
Yin, Z	1
Zhu, J	2
Yan, D	1
Lou, H	1
Yu, H	1
Feng, C	1
Wang, Z	1
Wang, Y	4
Hu, X	1
Li, Z	2
Shen, Y	2
Hu, D	1
Chen, H	1
Wu, X	1
Duan, Y	1
Zhi, D	1
Zou, M	2
Zhao, Z	1
Zhang, X	2
Yang, X	2
Zhang, J	2
Wang, H	1
Popović, KJ	1
Popović, DJ	1
Miljković, D	1
Lalošević, D	1
Čapo, I	1
Popović, JK	1
Liu, M	1
Song, H	2
Xing, Z	1
Lu, G	1
Chen, D	1
Valentini, AM	1
Di Pinto, F	1
Coletta, S	1
Guerra, V	1
Armentano, R	1
Caruso, ML	1
Gong, J	1
Wang, N	1
Bian, L	1
Wang, M	1
Ye, M	1
Wen, N	1
Fu, M	1
Fan, W	1
Meng, Y	1
Dong, G	1
Lin, XH	1
Liu, HH	1
Gao, DM	1
Cui, JF	1
Ren, ZG	1
Chen, RX	1
Önal, B	1
Özen, D	1
Demir, B	1
Akkan, AG	1
Özyazgan, S	1
Payette, G	1
Geoffroy, V	1
Martineau, C	1
Villemur, R	1
Jameel, T	1
Baig, M	1
Gazzaz, ZJ	1
Tashkandi, JM	1
Al Alhareth, NS	1
Khan, SA	1
Butt, NS	1
Wang, J	2
Geng, Y	1
Zhang, Y	3
Wang, X	2
Liu, J	2
Basit, A	1
Miao, T	1
Liu, W	1
Jiang, W	1
Yu, ZY	1
Wu, L	2
Qu, B	1
Sun, JX	1
Cai, AL	1
Xie, LM	1
Groeneveld, J	1
Ho, SL	1
Mackensen, A	1
Mohtadi, M	1
Laepple, T	1
Genovesi, S	1
Nava, E	1
Bartolucci, C	1
Severi, S	1
Vincenti, A	1
Contaldo, G	1
Bigatti, G	1
Ciurlino, D	1
Bertoli, SV	1
Slovak, JE	1
Hwang, JK	1
Rivera, SM	1
Villarino, NF	1
Li, S	1
Cao, G	1
Ling, M	1
Ji, J	1
Zhao, D	1
Sha, Y	1
Gao, X	1
Liang, C	2
Guo, Q	1
Zhou, C	1
Ma, Z	1
Xu, J	1
Wang, C	1
Zhao, W	1
Xia, X	1
Jiang, Y	1
Peng, J	1
Jia, Z	1
Li, F	1
Chen, X	2
Mo, J	1
Zhang, S	2
Li, X	1
Huang, T	1
Zhu, Q	1
Wang, S	1
Ge, RS	1
Fortunato, G	1
Lin, J	2
Agarwal, PK	1
Kohen, A	1
Singh, P	1
Cheatum, CM	1
Zhu, D	1
Hayman, A	1
Kebede, B	1
Stewart, I	1
Chen, G	1
Frew, R	1
Guo, X	1
Gong, Q	1
Borowiec, J	1
Han, S	1
Zhang, M	1
Willis, M	1
Kreouzis, T	1
Yu, K	1
Chirvony, VS	1
Sekerbayev, KS	1
Pérez-Del-Rey, D	1
Martínez-Pastor, JP	1
Palazon, F	1
Boix, PP	1
Taurbayev, TI	1
Sessolo, M	1
Bolink, HJ	1
Lu, M	1
Lan, Y	1
Xiao, J	1
Song, M	1
Chen, C	1
Huang, Q	1
Cao, Y	1
Ho, CT	1
Qi, B	1
Wang, Q	1
Zhang, W	1
Fang, L	1
Xie, CL	1
Chen, R	1
Yang, S	1
Xia, JM	1
Zhang, GY	1
Chen, CH	1
Yang, XW	1
Domenech-Ximenos, B	1
Garza, MS	1
Prat-González, S	1
Sepúlveda-Martínez, Á	1
Crispi, F	1
Perea, RJ	1
Garcia-Alvarez, A	1
Sitges, M	1
Kalumpha, M	1
Guyo, U	1
Zinyama, NP	1
Vakira, FM	1
Nyamunda, BC	1
Varga, M	1
Drácz, L	1
Kolbenheyer, E	1
Varga, F	1
Patai, ÁV	1
Solymosi, N	1
Patai, Á	1
Kiss, J	1
Gaál, V	1
Nyul, Z	1
Mosdósi, B	1
Valdez, M	1
Moosavi, L	1
Heidari, A	1
Novakovic-Agopian, T	1
Kornblith, E	1
Abrams, G	1
McQuaid, JR	1
Posecion, L	1
Burciaga, J	1
D'Esposito, M	1
Chen, AJW	1
Samy El Gendy, NM	1
Wesolowska, P	1
Georg, D	1
Lechner, W	1
Kazantsev, P	1
Bokulic, T	1
Tedgren, AC	1
Adolfsson, E	1
Campos, AM	1
Alves, VGL	1
Suming, L	1
Hao, W	1
Ekendahl, D	1
Koniarova, I	1
Bulski, W	1
Chelminski, K	1
Samper, JLA	1
Vinatha, SP	1
Rakshit, S	1
Siri, S	1
Tomsejm, M	1
Tenhunen, M	1
Povall, J	1
Kry, SF	1
Followill, DS	1
Thwaites, DI	1
Izewska, J	1
Kang, JH	1
Yoon, Y	1
Song, J	1
Van de Winckel, A	1
Gauthier, L	1
Chao, CT	1
Lee, YH	1
Li, CM	1
Han, DS	1
Huang, JW	1
Huang, KC	1
Ni, L	1
Güttinger, R	1
Triana, CA	1
Spingler, B	1
Baldridge, KK	1
Patzke, GR	1
Shen, X	1
Wang, B	1
Xie, S	1
Deng, W	1
Wu, D	1
Zhang, Q	1
Voskamp, BJ	1
Peelen, MJCS	1
Ravelli, ACJ	1
van der Lee, R	1
Mol, BWJ	1
Pajkrt, E	1
Ganzevoort, W	1
Kazemier, BM	1
Tibrewala, R	1
Bahroos, E	1
Mehrabian, H	1
Foreman, SC	1
Link, TM	1
Pedoia, V	1
Majumdar, S	1
Jablonski, CL	1
Leonard, C	1
Salo, P	1
Krawetz, RJ	1
Yoon, N	1
Hong, SN	1
Cho, JG	1
Jeong, HK	1
Lee, KH	1
Park, HW	1
Barman, S	1
Konai, MM	1
Samaddar, S	1
Haldar, J	1
Mohamed, HSH	1
Li, CF	1
Hu, ZY	1
Deng, Z	1
Chen, LH	1
Su, BL	1
Chu, K	1
Liu, YP	1
Li, YB	1
Zhang, H	1
Xu, C	1
Zou, Z	1
Wu, Z	1
Xia, Y	1
Zhao, P	1
Wang, HT	1
de Biase, S	1
Pellitteri, G	1
Gigli, GL	1
Valente, M	1
Kim, JM	1
Heo, HS	1
Shin, SC	1
Kwon, HK	1
Lee, JC	1
Sung, ES	1
Kim, HS	1
Park, GC	1
Lee, BJ	1
Ahmed, HA	1
Ismael, S	1
Mirzahosseini, G	1
Ishrat, T	1
Zefirov, TL	1
Kuptsova, AM	1
Biktemirova, RG	1
Ziyatdinova, NI	1
Zefirov, AL	1
Bauer, M	1
Karch, R	1
Neumann, F	1
Abrahim, A	1
Wagner, CC	1
Kletter, K	1
Müller, M	1
Zeitlinger, M	1
Langer, O	1
Salameh, A	1
Dhein, S	1
Fleischmann, B	1
Grohe, C	1
Hescheler, J	1
Linz, KW	1
Meyer, R	1
Lewin, G	1
Hoymann, HG	1
Fuhst, R	1
Berger-Preiss, E	1
Pohlmann, G	1
Buschmann, J	1
Bartels, AL	2
de Klerk, OL	2
Kortekaas, R	2
de Vries, JJ	2
Leenders, KL	2
Takashima, T	1
Yokoyama, C	1
Mizuma, H	1
Yamanaka, H	1
Wada, Y	1
Onoe, K	1
Nagata, H	1
Tazawa, S	1
Doi, H	1
Takahashi, K	1
Morita, M	1
Kanai, M	1
Shibasaki, M	1
Kusuhara, H	1
Sugiyama, Y	1
Onoe, H	1
Watanabe, Y	1
van Assema, DM	1
Lubberink, M	2
Boellaard, R	1
Schuit, RC	1
Windhorst, AD	1
Scheltens, P	1
Lammertsma, AA	2
van Berckel, BN	2
Calado, RT	1
Machado, CG	1
Carneiro, JJ	1
Garcia, AB	1
Falcão, RP	1
Toornvliet, R	1
Luurtsema, G	1
Geldof, AA	1
Bosch, TM	1
Oerlemans, R	1
Franssen, EJ	1
Poindexter, BJ	1
Feng, W	1
Dasgupta, A	1
Bick, RJ	1
Bart, J	1
Willemsen, AT	1
van Oostrom, JC	1
Boucek, RJ	1
Shelton, M	1
Artman, M	1
Mushlin, PS	1
Starnes, VA	1
Olson, RD	1
Manoach, M	1
Netz, H	1
Erez, M	1
Weinstock, M	1
Hulthén, UL	1
Bolli, P	1
Bühler, FR	1
Kates, RE	1
Kuo, TH	1
Ho, KL	1
Wiener, J	1
Storstein, L	1
Larsen, A	1
Midtbø, K	1
Saevareid, L	1
Tonoue, T	1
Furukawa, K	1
Nomoto, T	1
Kennes, B	1
Hubert, C	1
Brohee, D	1
Neve, P	1
Wagner, JG	1
Rocchini, AP	1
Vasiliades, J	1
Reder, RF	2
Miura, DS	1
Danilo, P	2
Rosen, MR	2
Gibson, R	1
Driscoll, D	1
Gillette, P	1
Hartley, C	1
Entman, ML	1
Wong, RO	1
Piovan, D	2
Padrini, R	2
Svalato Moreolo, G	1
Magnolfi, G	1
Milanesi, O	1
Zordan, R	1
Pellegrino, PA	1
Ferrari, M	2
Salbaş, K	1
Reams, GP	1
Monsuez, JJ	1
Lachurie, ML	1
Passeron, J	1
Schwartz, JB	8
Shen, C	1
Garcia, J	2
Capili, H	4
Sniezek, M	1
Ragazzi, E	1
Chinellato, A	1
Pandolfo, L	1
Froldi, G	1
Caparrotta, L	1
Fassina, G	1
Wainer, IW	3
Arrighi, JA	1
Dilsizian, V	1
Perrone-Filardi, P	1
Diodati, JG	1
Bacharach, SL	1
Bonow, RO	2
Daugherty, J	1
Fraeyman, N	1
van Ermen, A	1
Witkowski, JM	1
Acanfora, D	1
De Caprio, L	1
Di Palma, A	1
Lirato, C	1
Parlati, S	1
Furgi, G	1
Guerra, N	1
Odierna, L	1
Nicolino, A	1
Rengo, F	3
Abernethy, DR	3
Longstreth, JA	1
Andrawis, NS	1
Sasaki, M	1
Tateishi, T	1
Ebihara, A	1
Ostádalová, I	1
Kolár, F	1
Ostádal, B	2
Rohlícek, V	1
Rohlícek, J	1
Procházka, J	2
Troconiz, IF	1
Verotta, D	1
Liu, S	1
Cyran, SE	1
Phillips, J	1
Ditty, S	1
Baylen, BG	1
Cheung, J	1
LaNoue, K	1
Roder, JD	1
Sangiah, S	1
Bauer, LA	1
Horn, JR	1
Pettit, H	1
Vitale, DF	1
Calabrò, R	1
De Cristofaro, M	1
Pacileo, G	1
Caso, P	1
Gerundo, G	1
Bordini, C	1
Losi, MA	1
Rengo, C	1
Audsley, N	1
Goldsworthy, GJ	1
Coast, GM	1
Fromm, MF	1
Dilger, K	1
Busse, D	1
Kroemer, HK	1
Eichelbaum, M	1
Klotz, U	2
Doggrell, SA	1
Liang, LC	1
Yoneda, H	1
Toriumi, W	1
Ohmachi, Y	1
Okumura, F	1
Fujimura, H	1
Nishiyama, S	1
Petrella, RJ	2
Cunningham, DA	2
Paterson, DH	2
Anacleto, AI	1
Solans, C	1
Bregante, MA	1
Aramayona, JJ	1
Fraile, LJ	1
Garcia, MA	1
Nair, RR	1
Nair, P	1
Hung, MJ	1
Cherng, WJ	1
Wang, CH	1
Kuo, LT	1
Hordof, AJ	1
Davies, M	1
Gerstenblith, G	2
Howlett, SE	1
Nicholl, PA	1
Ahmed, JH	2
Elliott, HL	2
Meredith, PA	3
Reid, JL	1
Kirischuk, S	1
Pronchuk, N	1
Verkhratsky, A	1
Smeda, JS	1
Abete, P	1
Ferrara, N	1
Leosco, D	1
Caccese, P	1
Landino, P	1
Sederino, S	1
Balbi, R	1
Le Couteur, D	1
Rivory, LP	1
Roberts, MS	1
Pond, SM	1
Barringer, DL	1
Buñag, RD	1
Andrushchenko, EV	1
Chmir, VP	1
Krasovskaia, EA	1
Malanchuk, TA	1
Polishchuk, II	1
Iashchenko, OB	1
McCue, JD	1
Schmidlin, O	1
Pepeu, G	2
Giovannelli, L	2
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Govoni, S	1
Rius, RA	1
Trabucchi, M	1
Vermue, NA	1
Den Hertog, A	1
Draznin, B	1
Sussman, KE	1
Kao, M	1
Sherman, N	1
Böhmer, F	1
Barousch, R	1
Reinfrank, J	1
Gómez Pajuelo, C	1
Pérez Naranjo, J	1
Ruiz Martínez, I	1
Hosie, J	1
Hosie, G	1
Dillon, JS	2
Gu, XH	1
Nayler, WG	2
Carosella, L	1
Menichelli, P	1
Alimenti, M	1
Zuccala, G	1
Gemma, A	1
Cocchi, A	1
Carbonin, PU	1
Weinhouse, E	1
Kaplanski, J	1
Jarenwattananon, M	2
Nudel, DB	1
Sturrock, WJ	1
Oja, SS	1
Kontro, P	1
Lauterburg, BH	1
Carvajal, A	2
Franganillo, AM	2
Alvarez, FJ	2
Bova, S	1
Moretto, R	1
Cargnelli, G	1
Buckley, BJ	1
Gootman, N	1
Kaplan, NA	1
Todd, EL	1
Luchi, R	1
Snow, E	1
Skovránek, J	1
Pelouch, V	1
Hermann, P	1
Morselli, PL	1
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Nakagawa, H	1
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Arnold, TH	1
Vallner, JJ	1
Tackett, RL	1
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Noda, S	1
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Ito, E	1