verapamil and Affective Psychosis, Bipolar studies

Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.

Research Excerpts

Excerpt	Relevance	Reference
"All women who were prescribed verapamil for bipolar disorder (n = 37) were included."	7.71	Verapamil treatment for women with bipolar disorder. ( Baab, S; Hanusa, BH; Peindl, KS; Perel, JM; Piontek, CM; Wisner, KL, 2002)
"A dramatic improvement in a patient with tardive dystonia was obtained with verapamil after the failure of other medicines."	7.68	Treatment of persistent myoclonic tardive dystonia with verapamil. ( Abad, V; Ovsiew, F, 1993)
"All women who were prescribed verapamil for bipolar disorder (n = 37) were included."	3.71	Verapamil treatment for women with bipolar disorder. ( Baab, S; Hanusa, BH; Peindl, KS; Perel, JM; Piontek, CM; Wisner, KL, 2002)
"A dramatic improvement in a patient with tardive dystonia was obtained with verapamil after the failure of other medicines."	3.68	Treatment of persistent myoclonic tardive dystonia with verapamil. ( Abad, V; Ovsiew, F, 1993)
" In two elderly manic patients taking the medication in combination with lithium carbonate, profound bradycardia developed and was followed by a fatal myocardial infarction in one case."	3.67	Verapamil: a new antimanic drug with potential interactions with lithium. ( Allen, S; Dubovsky, SL; Franks, RD, 1987)
"Verapamil has shown antimanic activity in some but not all studies."	2.73	Verapamil augmentation of lithium treatment improves outcome in mania unresponsive to lithium alone: preliminary findings and a discussion of therapeutic mechanisms. ( Buttenfield, J; Frank, E; Haskett, R; Kupfer, DJ; Luckenbaugh, DA; Mallinger, AG; Manji, HK; Thase, ME, 2008)
"Twelve patients meeting DSM-IIIR criteria for mania received verapamil over a 2-week period, with dosing up to 360 mg/day."	1.29	Treatment of mania: relationship between response to verapamil and changes in plasma calcium and magnesium levels. ( Goodnick, PJ, 1996)
"The case of an adolescent with severe mental retardation, blindness, and a complex of behavioral symptoms consistent with mania is reported."	1.28	Verapamil and valproic acid treatment of prolonged mania. ( Friedman, DL; Kastner, T, 1992)

Timeframe	Studies, this research(%)	All Research%
pre-1990	28 (50.91)	18.7374
1990's	20 (36.36)	18.2507
2000's	5 (9.09)	29.6817
2010's	2 (3.64)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
McCarthy, MJ	1
Le Roux, MJ	1
Wei, H	1
Beesley, S	1
Kelsoe, JR	1
Welsh, DK	1
Cipriani, A	1
Saunders, K	1
Attenburrow, MJ	1
Stefaniak, J	1
Panchal, P	1
Stockton, S	1
Lane, TA	1
Tunbridge, EM	1
Geddes, JR	1
Harrison, PJ	1
Mallinger, AG	1
Thase, ME	1
Haskett, R	1
Buttenfield, J	1
Luckenbaugh, DA	1
Frank, E	1
Kupfer, DJ	1
Manji, HK	1
Giannini, AJ	5
Houser, WL	2
Loiselle, RH	3
Giannini, MC	1
Price, WA	2
Höschl, C	4
Blahos, J	1
Kabes, J	1
Hessler, M	1
Vanĕcek, T	1
Gitlin, MJ	3
Weiss, J	1
Weinrauch, LA	1
Belok, S	1
D'Elia, JA	1
Lewis, HA	1
Bacher, NM	1
Dubovsky, SL	4
Franks, RD	4
Lifschitz, M	1
Coen, P	1
Lenzi, A	1
Marazziti, D	1
Raffaelli, S	1
Cassano, GB	1
Oesterheld, JR	1
Shader, RI	1
Abad, V	1
Ovsiew, F	1
Goodnick, PJ	2
Warner, JP	1
Dassylva, B	1
Walton, SA	1
Berk, M	1
Brook, S	1
Janicak, PG	2
Sharma, RP	1
Pandey, G	1
Davis, JM	1
Boerlin, HL	1
Zoellner, LA	1
Hammen, CL	1
Nakoneczie, AM	1
Melemis, SM	1
Ventresco, J	1
Condon, M	1
Levy, NA	1
Lüttmann, RJ	1
Frese, A	1
Erfurth, A	1
Husstedt, IW	1
Evers, S	1
Wisner, KL	1
Peindl, KS	1
Perel, JM	1
Hanusa, BH	1
Piontek, CM	1
Baab, S	1
De Beaurepaire, R	1
Vacková, J	1
Janda, B	1
Kastner, T	1
Friedman, DL	1
Garza-Treviño, ES	1
Overall, JE	1
Hollister, LE	1
Wright, BA	1
Jarrett, DB	1
Bell, A	1
el-Mallakh, RS	1
Jaziri, WA	1
Deicken, RF	1
Sandyk, R	1
Gillman, MA	1
Nurnberger, J	1
Simmons-Alling, S	1
Helmuth, D	1
Ljaljevic, Z	1
Ramirez, L	1
Meltzer, HY	1
Kozený, J	1
Cookson, JC	2
Allen, S	2
Barton, BM	1
Taraszewski, R	1
DiMarzio, LR	1
Dinan, TG	1
Silverstone, T	1
Murphy, J	1
Dose, M	1
Emrich, HM	1
Cording-Tömmel, C	1
von Zerssen, D	1
Patterson, JF	1
Ostow, M	1
Solomon, L	1
Williamson, P	1
Kerr, L	1
Kennedy, S	1
Ozersky, S	1
Robillard, M	1
Renwart, N	1
Frances, H	1
Simon, P	1
Jacobsen, FM	1
Sack, DA	1
James, SP	1
Minors, DS	1
Brotman, AW	1
Farhadi, AM	1
Gelenberg, AJ	1
Schrier, D	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Pharmacotherapy of Treatment-Resistant Mania[NCT00518947]			Phase 3	45 participants (Actual)	Interventional	1994-11-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
A systematic review of calcium channel antagonists in bipolar disorder and some considerations for their future development. Molecular psychiatry, 2016, Volume: 21, Issue:10 Topics: Bipolar Disorder; Calcium Channel Blockers; Calcium Channels, L-Type; Double-Blind Method; Humans; I	2016
Calcium channel antagonists for the treatment of bipolar disorder. Bipolar disorders, 2000, Volume: 2, Issue:2 Topics: Antimanic Agents; Bipolar Disorder; Calcium Channel Blockers; Diltiazem; Double-Blind Method; Drug T	2000
Do calcium antagonists have a place in the treatment of mood disorders? Drugs, 1991, Volume: 42, Issue:5 Topics: Affective Disorders, Psychotic; Bipolar Disorder; Calcium; Calcium Channel Blockers; Dihydropyridine	1991
Calcium channel blockers in affective illness: role of sodium-calcium exchange. Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:3 Topics: Bipolar Disorder; Brain; Calcium Channels; Clinical Trials as Topic; Depressive Disorder; Double-Bli	1990
Drug treatment of bipolar depression and mania. British journal of hospital medicine, 1985, Volume: 34, Issue:3 Topics: Antidepressive Agents; Antipsychotic Agents; Bipolar Disorder; Bromocriptine; Carbamazepine; Choline	1985
Chronobiology: its importance in clinical medicine. Clinical science (London, England : 1979), 1985, Volume: 69, Issue:4 Topics: Airway Resistance; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Asthma; Biological Cloc	1985

Article	Year
Verapamil augmentation of lithium treatment improves outcome in mania unresponsive to lithium alone: preliminary findings and a discussion of therapeutic mechanisms. Bipolar disorders, 2008, Volume: 10, Issue:8 Topics: Adult; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Calcium Channel Blockers; Double-Bl	2008
Antimanic effects of verapamil. The American journal of psychiatry, 1984, Volume: 141, Issue:12 Topics: Adult; Bipolar Disorder; Clinical Trials as Topic; Humans; Lithium; Lithium Carbonate; Male; Placebo	1984
Effectiveness of the combination verapamil and chlorpromazine in the treatment of severe manic or mixed patients. Progress in neuro-psychopharmacology & biological psychiatry, 1995, Volume: 19, Issue:3 Topics: Adolescent; Adult; Bipolar Disorder; Chlorpromazine; Drug Administration Schedule; Drug Therapy, Com	1995
Superiority of lithium over verapamil in mania: a randomized, controlled, single-blind trial. The Journal of clinical psychiatry, 1996, Volume: 57, Issue:11 Topics: Acute Disease; Adolescent; Adult; Bipolar Disorder; Female; Hospitalization; Hospitals, Psychiatric;	1996
Verapamil for the treatment of acute mania: a double-blind, placebo-controlled trial. The American journal of psychiatry, 1998, Volume: 155, Issue:7 Topics: Acute Disease; Adult; Bipolar Disorder; Calcium Channel Blockers; Double-Blind Method; Drug Administ	1998
Bipolar depression and antidepressant-induced mania: a naturalistic study. The Journal of clinical psychiatry, 1998, Volume: 59, Issue:7 Topics: Adult; Ambulatory Care; Antidepressive Agents; Antidepressive Agents, Tricyclic; Bipolar Disorder; C	1998
Magnesium oxide augmentation of verapamil maintenance therapy in mania. Psychiatry research, 2000, Feb-14, Volume: 93, Issue:1 Topics: Adult; Antimanic Agents; Bipolar Disorder; Diet; Drug Therapy, Combination; Humans; Magnesium; Male;	2000
Verapamil versus lithium in acute mania. The American journal of psychiatry, 1992, Volume: 149, Issue:1 Topics: Acute Disease; Adult; Bipolar Disorder; Double-Blind Method; Female; Humans; Lithium Carbonate; Male	1992
Calcium channel blockers in affective illness: role of sodium-calcium exchange. Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:3 Topics: Bipolar Disorder; Brain; Calcium Channels; Clinical Trials as Topic; Depressive Disorder; Double-Bli	1990
Verapamil in affective disorders: a controlled, double-blind study. Biological psychiatry, 1989, Jan-15, Volume: 25, Issue:2 Topics: Adult; Amitriptyline; Anxiety Disorders; Bipolar Disorder; Clinical Trials as Topic; Depressive Diso	1989
Verapamil in treatment-resistant mania: an open trial. Journal of clinical psychopharmacology, 1987, Volume: 7, Issue:2 Topics: Adult; Bipolar Disorder; Clinical Trials as Topic; Drug Resistance; Humans; Male; Verapamil	1987
Verapamil and lithium in maintenance therapy of manic patients. Journal of clinical pharmacology, 1987, Volume: 27, Issue:12 Topics: Adult; Bipolar Disorder; Clinical Trials as Topic; Double-Blind Method; Humans; Lithium; Male; Psych	1987
Calcium antagonists in mania: a double-blind study of verapamil. Psychiatry research, 1986, Volume: 18, Issue:4 Topics: Adult; Bipolar Disorder; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle	1986
Use of calcium antagonists in mania. Psychoneuroendocrinology, 1986, Volume: 11, Issue:2 Topics: Bipolar Disorder; Clinical Trials as Topic; Double-Blind Method; Humans; Verapamil	1986
Clonidine and verapamil in the treatment of mania. The Journal of clinical psychiatry, 1986, Volume: 47, Issue:11 Topics: Bipolar Disorder; Clonidine; Humans; Verapamil	1986

verapamil and Affective Psychosis, Bipolar

Research Excerpts

Research

Studies (55)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
Calcium channel genes associated with bipolar disorder modulate lithium's amplification of circadian rhythms. Neuropharmacology, 2016, Volume: 101 Topics: Adult; Aged; Animals; Bipolar Disorder; Boron Compounds; Calcium Channel Blockers; Calcium Channels;	2016
[Use of calcium channel blockers in psychiatry. Hypothesis and the first results]. Casopis lekaru ceskych, 1984, Sep-07, Volume: 123, Issue:36 Topics: Adult; Bipolar Disorder; Depressive Disorder; Female; Humans; Male; Verapamil	1984
Verapamil as maintenance treatment in bipolar illness: a case report. Journal of clinical psychopharmacology, 1984, Volume: 4, Issue:6 Topics: Adult; Antidepressive Agents; Bipolar Disorder; Female; Humans; Verapamil	1984
Decreased serum lithium during verapamil therapy. American heart journal, 1984, Volume: 108, Issue:5 Topics: Aged; Atrial Fibrillation; Bipolar Disorder; Cardiomyopathy, Hypertrophic; Female; Humans; Lithium;	1984
Verapamil and depression. The American journal of psychiatry, 1984, Volume: 141, Issue:4 Topics: Bipolar Disorder; Carbamazepine; Depressive Disorder; Drug Therapy, Combination; Dyskinesia, Drug-In	1984
Effectiveness of verapamil in the treatment of a manic patient. The American journal of psychiatry, 1982, Volume: 139, Issue:4 Topics: Affective Disorders, Psychotic; Bipolar Disorder; Female; Humans; Middle Aged; Verapamil	1982
The verdant octogenarian. Journal of clinical psychopharmacology, 1994, Volume: 14, Issue:5 Topics: Aged; Aged, 80 and over; Bipolar Disorder; Digoxin; Drug Therapy, Combination; Female; Humans; Metab	1994
Treatment of persistent myoclonic tardive dystonia with verapamil. The British journal of psychiatry : the journal of mental science, 1993, Volume: 162 Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Dyskinesia, Drug-Induced; Dystonia; Humans; Male; Neu	1993
Verapamil prophylaxis in pregnant women with bipolar disorder. The American journal of psychiatry, 1993, Volume: 150, Issue:10 Topics: Adult; Bipolar Disorder; Delayed-Action Preparations; Female; Humans; Pregnancy; Pregnancy Complicat	1993
Verapamil in mania. The American journal of psychiatry, 1993, Volume: 150, Issue:3 Topics: Bipolar Disorder; Clinical Trials as Topic; Double-Blind Method; Humans; Placebos; Research Design;	1993
Verapamil may cause depression. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1993, Volume: 38, Issue:4 Topics: Bipolar Disorder; Depressive Disorder; Drug Therapy, Combination; Female; Humans; Middle Aged; Phene	1993
Treatment of mania: relationship between response to verapamil and changes in plasma calcium and magnesium levels. Southern medical journal, 1996, Volume: 89, Issue:2 Topics: Adult; Analysis of Variance; Antipsychotic Agents; Bipolar Disorder; Calcium; Calcium Channel Blocke	1996
Verapamil maintenance therapy in bipolar patients. The Journal of clinical psychiatry, 1996, Volume: 57, Issue:3 Topics: Bipolar Disorder; Cross-Over Studies; Humans; Lithium Carbonate; Treatment Outcome; Verapamil	1996
Corticosteroid-induced acute mania during a cluster headache episode. Cephalalgia : an international journal of headache, 2001, Volume: 21, Issue:8 Topics: Acute Disease; Adolescent; Age of Onset; Antimanic Agents; Bipolar Disorder; Cluster Headache; Gluco	2001
Verapamil treatment for women with bipolar disorder. Biological psychiatry, 2002, May-01, Volume: 51, Issue:9 Topics: Anti-Arrhythmia Agents; Bipolar Disorder; Female; Humans; Pregnancy; Psychiatric Status Rating Scale	2002
Treatment of neuroleptic-resistant mania and schizoaffective disorders. The American journal of psychiatry, 1992, Volume: 149, Issue:11 Topics: Antipsychotic Agents; Bipolar Disorder; Drug Synergism; Drug Therapy, Combination; Haloperidol; Huma	1992
Mood stabilizing effect of verapamil. Bratislavske lekarske listy, 1992, Volume: 93, Issue:4 Topics: Adult; Aged; Bipolar Disorder; Depressive Disorder; Female; Humans; Male; Middle Aged; Verapamil	1992
Verapamil and valproic acid treatment of prolonged mania. Journal of the American Academy of Child and Adolescent Psychiatry, 1992, Volume: 31, Issue:2 Topics: Adolescent; Arousal; Bipolar Disorder; Drug Therapy, Combination; Humans; Intellectual Disability; M	1992
Lithium and calcium channel blockers: possible neurotoxicity. Biological psychiatry, 1991, Sep-15, Volume: 30, Issue:6 Topics: Bipolar Disorder; Drug Therapy, Combination; Female; Humans; Hypertension; Lithium Carbonate; Middle	1991
Calcium channel blockers. The Australian and New Zealand journal of psychiatry, 1990, Volume: 24, Issue:4 Topics: Aged; Atrial Fibrillation; Bipolar Disorder; Combined Modality Therapy; Electroconvulsive Therapy; H	1990
Verapamil treatment of bipolar depression. Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:2 Topics: Acute Disease; Adult; Bipolar Disorder; Humans; Male; Verapamil	1990
How does verapamil exert an antimanic effect? The American journal of psychiatry, 1986, Volume: 143, Issue:3 Topics: Bipolar Disorder; Endorphins; Humans; Ion Channels; Receptors, Serotonin; Verapamil	1986
Mediation of "calcium antagonist" effects by dopamine receptor blockade. The American journal of psychiatry, 1987, Volume: 144, Issue:7 Topics: Bipolar Disorder; Diltiazem; Humans; Ion Channels; Receptors, Dopamine; Verapamil	1987
Choreoathetosis induced by verapamil and lithium treatment. Journal of clinical psychopharmacology, 1989, Volume: 9, Issue:6 Topics: Aged; Athetosis; Bipolar Disorder; Chorea; Drug Therapy, Combination; Humans; Lithium; Lithium Carbo	1989
Verapamil: a new antimanic drug with potential interactions with lithium. The Journal of clinical psychiatry, 1987, Volume: 48, Issue:9 Topics: Aged; Arrhythmias, Cardiac; Bipolar Disorder; Bradycardia; Drug Interactions; Drug Therapy, Combinat	1987
Verapamil-carbamazepine neurotoxicity. The Journal of clinical psychiatry, 1988, Volume: 49, Issue:2 Topics: Bipolar Disorder; Carbamazepine; Drug Synergism; Drug Therapy, Combination; Female; Humans; Middle A	1988
Cortisol, prolactin and growth hormone levels with clinical ratings in manic patients treated with verapamil. International clinical psychopharmacology, 1988, Volume: 3, Issue:2 Topics: Adult; Bipolar Disorder; Growth Hormone; Humans; Hydrocortisone; Middle Aged; Prolactin; Verapamil	1988
Treatment of acute mania with verapamil. Journal of clinical psychopharmacology, 1987, Volume: 7, Issue:3 Topics: Acute Disease; Aged; Bipolar Disorder; Humans; Male; Verapamil	1987
Verapamil and bipolar illness. Journal of clinical psychopharmacology, 1987, Volume: 7, Issue:4 Topics: Bipolar Disorder; Humans; Verapamil	1987
Verapamil in bipolar illness. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1986, Volume: 31, Issue:5 Topics: Aged; Bipolar Disorder; Female; Humans; Male; Middle Aged; Verapamil	1986
Refractory bipolar illness may not respond to verapamil. Journal of clinical psychopharmacology, 1986, Volume: 6, Issue:5 Topics: Adult; Bipolar Disorder; Female; Humans; Male; Verapamil	1986
The calcium entry blockers: anti-manic drugs? Progress in neuro-psychopharmacology & biological psychiatry, 1986, Volume: 10, Issue:6 Topics: Amphetamines; Animals; Bipolar Disorder; Calcium Channel Blockers; Diltiazem; Hyperkinesis; Male; Mi	1986
Delirium induced by verapamil. The American journal of psychiatry, 1987, Volume: 144, Issue:2 Topics: Adult; Bipolar Disorder; Delirium; Female; Humans; Verapamil	1987
Verapamil treatment of acute mania. The Journal of clinical psychiatry, 1986, Volume: 47, Issue:3 Topics: Acute Disease; Adolescent; Adult; Bipolar Disorder; Female; Hospitalization; Humans; Male; Middle Ag	1986
Phenelzine-induced hypomania: effect of verapamil. Biological psychiatry, 1985, Volume: 20, Issue:9 Topics: Bipolar Disorder; Female; Humans; Middle Aged; Phenelzine; Verapamil	1985