verapamil has been researched along with Adenocarcinoma, Basal Cell in 74 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to assess the efficacy of verapamil (20 microM) and hyperthermia (42 degrees C) as modifiers of 5-fluorouracil (5-FU), used at different concentrations, in inhibiting the growth of gastric adenocarcinoma cells." | 7.69 | Antitumour activity of 5-fluorouracil, verapamil and hyperthermia against human gastric adenocarcinoma cell (AGS) in vitro. ( Brenner, RV; Buras, RR; Evans, SR; Nauta, RJ; Shabahang, M; Shchepotin, IB, 1994) |
| "The purpose of this study was to assess the efficacy of verapamil (20 microM) and hyperthermia (42 degrees C) as modifiers of mitomycin C (MMC), used at different concentrations, in inhibiting the growth of human gastric adenocarcinoma (AGS) cells." | 7.69 | Effect of mitomycin C, verapamil, and hyperthermia on human gastric adenocarcinoma. ( Buras, RR; Evans, SR; Nauta, RJ; Shabahang, M; Shchepotin, IB, 1994) |
| "Verapamil (Ver) is a well known, worldwide used drug to correct cardiac arrhythmias." | 5.38 | Verapamil-induced autophagy-like process in colon adenocarcinoma COLO 205 cells; the ultrastructural studies. ( Gajkowska, B; Kania, E; Orzechowski, A; Pająk, B, 2012) |
| "Verapamil has been shown to be a competitive inhibitor of Pgp, and was one of the first multidrug-resistant reversing agents identified." | 5.31 | Verapamil decreases accumulation of 99Tcm-MIBI and 99Tcm-tetrofosmin in human breast cancer and soft tissue sarcoma cell lines. ( Kalinowska, W; Rodrigues, M; Sinzinger, H; Zielinski, C, 2001) |
| "Verapamil was effective in combination with 5-FU, VCR or PEP on HSGc and with DTIC, VCR or PEP on KB." | 5.28 | [Chemo-sensitivity of a human salivary adenocarcinoma cell line to several anti-cancer drugs and enhancement of the antitumor effects by combination with filipin or verapamil]. ( Matsuya, T; Okura, M; Shirasuna, K; Sugiyama, M; Watatani, K, 1989) |
| "A Phase I trial was performed to determine the maximum tolerable dose (MTD) and dose limiting toxicities of verapamil by hepatic artery infusion, together with doxorubicin, to patients with hepatic metastases of colorectal cancer." | 5.07 | A phase I trial of intrahepatic verapamil and doxorubicin. Regional therapy to overcome multidrug resistance. ( Bertino, J; Keefe, D; Kelsen, D; Kemeny, N; Murphy, B; O'Brien, JP; Saltz, L; Tao, Y; Tong, W; Tzy-Jun, Y, 1994) |
| " We studied daunorubicin (DNR) subcellular distribution in the presence of an H+-ATPase pump inhibitor 7-chloro-4-nitrobenz-2-oxa-1,3-diazole (NBD) and verapamil (VPL) in two human breast adenocarcinoma MCF7 etoposide-resistant and adriamycin-resistant cell lines, overexpressing respectively MRP (MCF7/VP) and Pgp (MCF7/ADR)." | 3.70 | Role of the vacuolar H+-ATPase in daunorubicin distribution in etoposide-resistant MCF7 cells overexpressing the multidrug-resistance associated protein. ( Benderra, Z; Manfait, M; Morjani, H; Trussardi, A, 1998) |
| " In this study, a colchicine resistant subline (HCA-2/1cch) was selected from a human colon adenocarcinoma after a short period of drug exposure, as an in vitro model of drug resistance selection." | 3.70 | Multidrug resistance increment in a human colon carcinoma cell line by colchicine. ( Gil, L; Martínez Morillo, M; Ruiz Gómez, MJ; Souviron, A, 2000) |
| "The purpose of this study was to assess the efficacy of verapamil (20 microM) and hyperthermia (42 degrees C) as modifiers of 5-fluorouracil (5-FU), used at different concentrations, in inhibiting the growth of gastric adenocarcinoma cells." | 3.69 | Antitumour activity of 5-fluorouracil, verapamil and hyperthermia against human gastric adenocarcinoma cell (AGS) in vitro. ( Brenner, RV; Buras, RR; Evans, SR; Nauta, RJ; Shabahang, M; Shchepotin, IB, 1994) |
| "The ability of the multidrug resistance modifiers R- and R,S-verapamil (VPL), cyclosporine A (CsA) and its non-immunosuppressive derivative SDZ PSC 833 (PSC 833) to inhibit P-glycoprotein (P-gp)-mediated transepithelial flux of tritiated vinblastine was investigated using tight and highly resistant (R > 1,400 omega cm2) monolayer cultures of intestinal adenocarcinoma-derived HCT-8 cells grown on permeable tissue-culture inserts." | 3.69 | Inhibition of P-glycoprotein-mediated vinblastine transport across HCT-8 intestinal carcinoma monolayers by verapamil, cyclosporine A and SDZ PSC 833 in dependence on extracellular pH. ( Bischof, G; Cosentini, EP; Ellinger, A; Hamilton, G; Koperna, T; Riegler, M; Schweitzer, M; Teleky, B; Thalhammer, T; Zacherl, J, 1994) |
| "The purpose of this study was to assess the efficacy of verapamil (20 microM) and hyperthermia (42 degrees C) as modifiers of mitomycin C (MMC), used at different concentrations, in inhibiting the growth of human gastric adenocarcinoma (AGS) cells." | 3.69 | Effect of mitomycin C, verapamil, and hyperthermia on human gastric adenocarcinoma. ( Buras, RR; Evans, SR; Nauta, RJ; Shabahang, M; Shchepotin, IB, 1994) |
| "Recombinant human-interferon-gamma (rH-IFN-gamma) and verapamil (VRP), either alone or in combination, were evaluated in MTT assay for their modification effects on adriamycin-induced cytotoxicity against MKN-45, human stomach adenocarcinoma cells." | 3.68 | Modification of adriamycin-induced cytotoxicity by recombinant human interferon-gamma and/or verapamil in human stomach cancer cells. ( Hong, WS; Kang, TW; Kim, CM; Lee, CT; Lee, JO, 1992) |
| "Phenoxazine and seven other structurally related compounds were investigated to determine whether they would increase accumulation of Vinca alkaloids in multidrug-resistant (MDR) GC3/C1 (human colon adenocarcinoma) and KB-ChR-8-5 (HeLa variant) cell lines." | 3.68 | Structural determinants of phenoxazine type compounds required to modulate the accumulation of vinblastine and vincristine in multidrug-resistant cell lines. ( Beck, WT; Horton, JK; Houghton, JA; Houghton, PJ; Qian, XD; Thimmaiah, KN, 1990) |
| " Saturable clearance may cause higher bioavailability and slower elimination of verapamil after acute oral overdoses." | 2.68 | Non-linear pharmacokinetics of high-dose intravenous verapamil. ( Boiocchi, M; De Cicco, M; Fantin, D; Frustaci, S; Gigante, M; Nicolosi, GL; Robieux, I; Toffoli, G, 1997) |
| "Verapamil (Ver) is a well known, worldwide used drug to correct cardiac arrhythmias." | 1.38 | Verapamil-induced autophagy-like process in colon adenocarcinoma COLO 205 cells; the ultrastructural studies. ( Gajkowska, B; Kania, E; Orzechowski, A; Pająk, B, 2012) |
| "Oral bioavailability is one of the important criteria for development of a drug-lead candidate." | 1.35 | Involvement of P-glycoprotein and multidrug resistance associated protein 1 on the transepithelial transport of a mercaptoacetamide-based histone-deacetylase inhibitor in Caco-2 cells. ( Jung, M; Konsoula, Z, 2009) |
| "Verapamil has been shown to be a competitive inhibitor of Pgp, and was one of the first multidrug-resistant reversing agents identified." | 1.31 | Verapamil decreases accumulation of 99Tcm-MIBI and 99Tcm-tetrofosmin in human breast cancer and soft tissue sarcoma cell lines. ( Kalinowska, W; Rodrigues, M; Sinzinger, H; Zielinski, C, 2001) |
| " Chronic use of Saint John's wort (SJW) has been shown to lower the bioavailability for a variety of co-administered drugs including indinavir, cyclosporin, and digoxin." | 1.31 | Saint John's wort: an in vitro analysis of P-glycoprotein induction due to extended exposure. ( Greenblatt, DJ; Perloff, MD; Shader, RI; Störmer, E; von Moltke, LL, 2001) |
| "Biopsy specimens of human breast tumors were investigated with the new method and functional activity of various efflux transporters was revealed: (1) only P-gp, (2) both P-gp and other ABC transporters, (3) only transporters different from P-gp, (4) no functional activity of efflux transporters." | 1.30 | [A new method for the intravital assessment of the functional activity of the membrane transporters performing the efflux of antitumor preparations from the cells of solid tumor specimens]. ( Bogush, EA; Bogush, TA; Robert, J; Smirnova, GB, 1999) |
| "Homoharringtonine (HHT) is a new drug with antileukemic activity which is currently tested for treatment of acute and chronic leukemias, either alone or in combination with other agents." | 1.29 | MDR-related P170-glycoprotein modulates cytotoxic activity of homoharringtonine. ( Baccarani, M; Candoni, A; Damiani, D; Marie, JP; Melli, C; Michelutti, A; Michieli, MG; Russo, D; Zhou, DC; Zittoun, R, 1995) |
| "Verapamil (VRP) is an effective modulator of P170-associated multidrug resistance (MDR), but its clinical application is limited by cardiovascular side-effects." | 1.29 | D-verapamil downmodulates P170-associated resistance to doxorubicin, daunorubicin and idarubicin. ( Baccarani, M; Cerno, M; Damiani, D; Melli, C; Michelutti, A; Michieli, M, 1993) |
| "The treatment of advanced metastatic prostate cancer by hormone manipulation or orchiectomy is frequently followed by the appearance of hormone-insensitive and highly chemoresistant tumor cells." | 1.29 | Role of the MDR-1-encoded multiple drug resistance phenotype in prostate cancer cell lines. ( Baumgartner, G; Hamilton, G; Schirmböck, M; Sherwood, ER; Thalhammer, T; Theyer, G, 1993) |
| "Treatment with verapamil, tamoxifen, nicergoline or cyclosporin A only partially restores the activity of FCE 24517 against LoVo/24517 cells." | 1.29 | Characterisation of a LoVo subline resistant to a benzoyl mustard derivative of distamycin A (FCE 24517). ( Broggini, M; Capolongo, L; Grandi, M; Melegaro, G; Mongelli, N, 1993) |
| "Colon cancer is one of the tumors most refractory to treatment by chemotherapy, and this may be due to inherent phenotypic instability of such tumor cells with respect to the biochemical determinants of drug sensitivity." | 1.28 | Phenotypic instability of drug sensitivity in a human colon carcinoma cell line. ( Cheng, YC; Ferguson, PJ, 1989) |
| "Verapamil was effective in combination with 5-FU, VCR or PEP on HSGc and with DTIC, VCR or PEP on KB." | 1.28 | [Chemo-sensitivity of a human salivary adenocarcinoma cell line to several anti-cancer drugs and enhancement of the antitumor effects by combination with filipin or verapamil]. ( Matsuya, T; Okura, M; Shirasuna, K; Sugiyama, M; Watatani, K, 1989) |
| "When verapamil was combined with DX it inhibited the rapid DX efflux from LoVo/DX and reversed the resistance in this cell line, but it had no significant activity on LoVo cells." | 1.27 | Intracellular doxorubicin concentrations and drug-induced DNA damage in a human colon adenocarcinoma cell line and in a drug-resistant subline. ( Broggini, M; D'Incalci, M; Geroni, C; Giuliani, FC; Grandi, M; Ubezio, P, 1988) |
| "NL-44, however, did not form pulmonary metastasis even after the tumor cells had formed heterotypic aggregates with platelets, suggesting that tumor metastasis is dependent on the intrinsic nature of tumor cells." | 1.27 | [Tumor-induced platelet aggregation and growth-promoting factors as determinants of probable tumor metastasis]. ( Tsuruo, T, 1987) |
| "Verapamil was administered as an i." | 1.26 | Effect of verapamil on malignant tissue blood flow in SMT-2A tumor-bearing rats. ( Jirtle, RL; Kaelin, WG; Shand, DG; Shrivastav, S, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (16.22) | 18.7374 |
| 1990's | 42 (56.76) | 18.2507 |
| 2000's | 12 (16.22) | 29.6817 |
| 2010's | 7 (9.46) | 24.3611 |
| 2020's | 1 (1.35) | 2.80 |
| Authors | Studies |
|---|---|
| Perloff, MD | 2 |
| von Moltke, LL | 2 |
| Fahey, JM | 1 |
| Daily, JP | 1 |
| Greenblatt, DJ | 2 |
| Colabufo, NA | 1 |
| Abate, C | 1 |
| Contino, M | 1 |
| Inglese, C | 1 |
| Niso, M | 1 |
| Berardi, F | 1 |
| Perrone, R | 1 |
| Matos, AM | 1 |
| Reis, M | 1 |
| Duarte, N | 1 |
| Spengler, G | 3 |
| Molnár, J | 3 |
| Ferreira, MJ | 1 |
| Silva, CD | 1 |
| Ramalhete, C | 1 |
| Mulhovo, S | 1 |
| Ferreira, MU | 1 |
| Król, M | 1 |
| Pawłowski, KM | 1 |
| Majchrzak, K | 1 |
| Mucha, J | 1 |
| Motyl, T | 1 |
| Yang, B | 1 |
| Ma, YF | 1 |
| Liu, Y | 1 |
| Takács, D | 1 |
| Csonka, Á | 1 |
| Horváth, Á | 1 |
| Windt, T | 1 |
| Gajdács, M | 1 |
| Riedl, Z | 1 |
| Hajós, G | 1 |
| Amaral, L | 1 |
| Parumasivam, T | 1 |
| Chan, JG | 1 |
| Pang, A | 1 |
| Quan, DH | 1 |
| Triccas, JA | 1 |
| Britton, WJ | 1 |
| Chan, HK | 1 |
| Pires, MM | 1 |
| Emmert, D | 1 |
| Hrycyna, CA | 1 |
| Chmielewski, J | 1 |
| Konsoula, Z | 1 |
| Jung, M | 1 |
| Shi, D | 1 |
| Shi, G | 1 |
| Huang, G | 1 |
| Zhang, J | 1 |
| Lartigau, E | 1 |
| Lubelska, K | 1 |
| Misiewicz-Krzemińska, I | 1 |
| Milczarek, M | 1 |
| Krzysztoń-Russjan, J | 1 |
| Anuszewska, E | 1 |
| Modzelewska, K | 1 |
| Wiktorska, K | 1 |
| Pająk, B | 1 |
| Kania, E | 1 |
| Gajkowska, B | 1 |
| Orzechowski, A | 1 |
| Du, J | 1 |
| Pan, Y | 1 |
| Shi, Y | 1 |
| Guo, C | 1 |
| Jin, X | 1 |
| Sun, L | 1 |
| Liu, N | 1 |
| Qiao, T | 1 |
| Fan, D | 1 |
| Tsuruo, T | 3 |
| Iida, H | 1 |
| Naganuma, K | 1 |
| Tsukagoshi, S | 1 |
| Sakurai, Y | 1 |
| Kaelin, WG | 1 |
| Shrivastav, S | 1 |
| Shand, DG | 1 |
| Jirtle, RL | 1 |
| Merlin, JL | 3 |
| Marchal, S | 3 |
| Ramacci, C | 2 |
| Dieterlen, A | 1 |
| Schultz, G | 1 |
| Lucas, C | 2 |
| Poullain, MG | 2 |
| Berlion, M | 1 |
| Paraire, M | 1 |
| Russo, D | 1 |
| Michelutti, A | 2 |
| Melli, C | 2 |
| Damiani, D | 2 |
| Michieli, MG | 1 |
| Candoni, A | 1 |
| Zhou, DC | 1 |
| Marie, JP | 1 |
| Zittoun, R | 1 |
| Baccarani, M | 2 |
| Shchepotin, IB | 2 |
| Shabahang, M | 2 |
| Nauta, RJ | 2 |
| Buras, RR | 2 |
| Brenner, RV | 1 |
| Evans, SR | 2 |
| Zacherl, J | 1 |
| Hamilton, G | 4 |
| Thalhammer, T | 3 |
| Riegler, M | 1 |
| Cosentini, EP | 1 |
| Ellinger, A | 1 |
| Bischof, G | 1 |
| Schweitzer, M | 1 |
| Teleky, B | 1 |
| Koperna, T | 1 |
| Saltz, L | 1 |
| Murphy, B | 1 |
| Kemeny, N | 1 |
| Bertino, J | 1 |
| Tong, W | 1 |
| Keefe, D | 1 |
| Tzy-Jun, Y | 1 |
| Tao, Y | 1 |
| Kelsen, D | 1 |
| O'Brien, JP | 1 |
| Kunzelmann, K | 1 |
| Slotki, IN | 1 |
| Klein, P | 1 |
| Koslowsky, T | 1 |
| Ausiello, DA | 1 |
| Greger, R | 1 |
| Cabantchik, ZI | 1 |
| Benchekroun, NM | 1 |
| Myers, CE | 1 |
| Sinha, BK | 1 |
| Michieli, M | 1 |
| Cerno, M | 1 |
| Van de Vrie, W | 1 |
| Gheuens, EE | 1 |
| Durante, NM | 1 |
| De Bruijn, EA | 1 |
| Marquet, RL | 1 |
| Van Oosterom, AT | 1 |
| Eggermont, AM | 1 |
| Theyer, G | 2 |
| Schirmböck, M | 1 |
| Sherwood, ER | 1 |
| Baumgartner, G | 1 |
| Capolongo, L | 1 |
| Melegaro, G | 1 |
| Broggini, M | 2 |
| Mongelli, N | 1 |
| Grandi, M | 3 |
| Quesada, AR | 2 |
| Barbacid, MM | 1 |
| Mira, E | 1 |
| Aracil, M | 1 |
| Márquez, G | 1 |
| Kornek, G | 2 |
| Raderer, M | 3 |
| Schenk, T | 1 |
| Pidlich, J | 1 |
| Schulz, F | 1 |
| Globits, S | 1 |
| Tetzner, C | 2 |
| Scheithauer, W | 2 |
| Schuetz, EG | 1 |
| Beck, WT | 2 |
| Schuetz, JD | 1 |
| Koperna-Mach, K | 1 |
| Müller, C | 1 |
| Karner, J | 1 |
| Kastner, J | 1 |
| Drach, J | 1 |
| Gsur, A | 1 |
| Zhao, S | 1 |
| Angerler, J | 1 |
| Fiegl, M | 1 |
| Zojer, N | 1 |
| Haberl, I | 2 |
| Andreeff, M | 1 |
| Huber, H | 1 |
| García Grávalos, MD | 1 |
| Fernández Puentes, JL | 1 |
| Abderrabi, M | 1 |
| Pannocchia, A | 1 |
| Revelli, S | 1 |
| Tamponi, G | 1 |
| Giorgianni, A | 1 |
| Todde, R | 1 |
| Bosia, A | 1 |
| Ghigo, D | 1 |
| Kokubu, N | 1 |
| Cohen, D | 2 |
| Watanabe, T | 2 |
| Toffoli, G | 1 |
| Robieux, I | 1 |
| Fantin, D | 1 |
| Gigante, M | 1 |
| Frustaci, S | 1 |
| Nicolosi, GL | 1 |
| De Cicco, M | 1 |
| Boiocchi, M | 1 |
| Benderra, Z | 1 |
| Morjani, H | 1 |
| Trussardi, A | 1 |
| Manfait, M | 1 |
| Choi, SU | 1 |
| Lee, CO | 1 |
| Kim, KH | 1 |
| Choi, EJ | 1 |
| Park, SH | 1 |
| Shin, HS | 1 |
| Yoo, SE | 1 |
| Jung, NP | 1 |
| Lee, BH | 1 |
| Swatonek, H | 1 |
| Schaufler, K | 1 |
| Ulsperger, E | 1 |
| Wenzl, E | 1 |
| Chan, MW | 1 |
| Chiang, CD | 1 |
| Song, EJ | 1 |
| Yang, VC | 1 |
| Bogush, TA | 1 |
| Smirnova, GB | 1 |
| Bogush, EA | 1 |
| Robert, J | 1 |
| Berti, E | 1 |
| Carrara, M | 1 |
| Ragazzi, E | 1 |
| D'Ancona, S | 1 |
| Berti, T | 1 |
| Ruiz Gómez, MJ | 2 |
| Gil, L | 2 |
| Souviron, A | 2 |
| Martínez Morillo, M | 2 |
| Rodrigues, M | 1 |
| Kalinowska, W | 1 |
| Zielinski, C | 1 |
| Sinzinger, H | 1 |
| Liu, B | 1 |
| Staren, ED | 1 |
| Iwamura, T | 1 |
| Appert, HE | 1 |
| Howard, JM | 1 |
| Uchiyama-Kokubu, N | 1 |
| Störmer, E | 1 |
| Shader, RI | 1 |
| Hong, WS | 1 |
| Kim, CM | 1 |
| Lee, CT | 1 |
| Lee, JO | 1 |
| Kang, TW | 1 |
| Wasserman, L | 1 |
| Aviram, R | 1 |
| Levavi, H | 1 |
| Ovadia, J | 1 |
| Shneyuor, Y | 1 |
| Frisch, A | 1 |
| Blau, O | 1 |
| Beery, E | 1 |
| Novogrodsky, A | 1 |
| Nordenberg, J | 1 |
| Léonce, S | 1 |
| Pierré, A | 1 |
| Anstett, M | 1 |
| Pérez, V | 1 |
| Genton, A | 1 |
| Bizzari, JP | 1 |
| Atassi, G | 1 |
| Hunter, J | 1 |
| Hirst, BH | 2 |
| Simmons, NL | 2 |
| Schüller, HM | 1 |
| Orloff, M | 1 |
| Reznik, GK | 1 |
| Tzanakakis, GN | 1 |
| Agarwal, KC | 1 |
| Veronikis, DK | 1 |
| Vezeridis, MP | 1 |
| Nygren, P | 2 |
| Larsson, R | 2 |
| Rivoltini, L | 1 |
| Colombo, MP | 1 |
| Supino, R | 1 |
| Ballinari, D | 1 |
| Parmiani, G | 1 |
| Kaneski, CR | 1 |
| Constantopoulos, G | 1 |
| Brady, RO | 1 |
| Allen, CN | 1 |
| Harpur, ES | 1 |
| Gray, TJ | 1 |
| Tatsuta, M | 1 |
| Iishi, H | 1 |
| Baba, M | 1 |
| Nakaizumi, A | 1 |
| Uehara, H | 1 |
| Taniguchi, H | 1 |
| Thimmaiah, KN | 1 |
| Horton, JK | 1 |
| Qian, XD | 1 |
| Houghton, JA | 1 |
| Houghton, PJ | 1 |
| Ferguson, PJ | 1 |
| Cheng, YC | 1 |
| Soranzo, C | 1 |
| Ingrosso, A | 1 |
| Buffa, M | 1 |
| Della Torre, G | 1 |
| Gambetta, RA | 1 |
| Zunino, F | 1 |
| Sugiyama, M | 1 |
| Shirasuna, K | 1 |
| Okura, M | 1 |
| Watatani, K | 1 |
| Matsuya, T | 1 |
| Bénard, J | 1 |
| Da Silva, J | 1 |
| Teyssier, JR | 1 |
| Riou, G | 1 |
| Twentyman, PR | 2 |
| Fox, NE | 2 |
| Wright, KA | 1 |
| Bleehen, NM | 2 |
| Giuliani, FC | 2 |
| Ubezio, P | 1 |
| Geroni, C | 1 |
| D'Incalci, M | 1 |
| Chauffert, B | 1 |
| Rey, D | 1 |
| Coudert, B | 1 |
| Dumas, M | 1 |
| Martin, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparative Analysis of the Th17 Cellular Response in Active and Inactive Pemphigus Vulgaris Patients[NCT04096222] | 42 participants (Anticipated) | Observational | 2021-06-29 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 trials available for verapamil and Adenocarcinoma, Basal Cell
| Article | Year |
|---|---|
A phase I trial of intrahepatic verapamil and doxorubicin. Regional therapy to overcome multidrug resistance.
Topics: Adenocarcinoma; Adult; Aged; Colorectal Neoplasms; Doxorubicin; Drug Resistance, Multiple; Female; H | 1994 |
Phase I/II trial of dexverapamil, epirubicin, and granulocyte-macrophage-colony stimulating factor in patients with advanced pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; | 1995 |
Phase I/II trial of dexverapamil, epirubicin and granulocyte/macrophage-colony-stimulating factor in patients with advanced pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Calcium Channel Blockers; Drug | 1995 |
Non-linear pharmacokinetics of high-dose intravenous verapamil.
Topics: Adenocarcinoma; Adult; Blood Pressure; Calcium Channel Blockers; Chemotherapy, Adjuvant; Colorectal | 1997 |
Amiodarone is more efficient than verapamil in reversing resistance to anthracyclines in tumour cells.
Topics: Adenocarcinoma; Amiodarone; Animals; Antibiotics, Antineoplastic; Cell Line; Colonic Neoplasms; Dose | 1987 |
69 other studies available for verapamil and Adenocarcinoma, Basal Cell
| Article | Year |
|---|---|
Induction of P-glycoprotein expression by HIV protease inhibitors in cell culture.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbamates; Cell Line, Tran | 2000 |
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma.
Topics: Adenocarcinoma; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; | 2008 |
Epoxylathyrol Derivatives: Modulation of ABCB1-Mediated Multidrug Resistance in Human Colon Adenocarcinoma and Mouse T-Lymphoma Cells.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP B | 2015 |
Triterpenes from Momordica balsamina (African pumpkin): ABCB1 inhibition and synergistic interaction with doxorubicin in resistant cancer cells.
Topics: Adenocarcinoma; Animals; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Colonic Ne | 2022 |
Canine mammary carcinoma cell line are resistant to chemosensitizers: verapamil and cyclosporin A.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Cell | 2014 |
Elevated Expression of Nrf-2 and ABCG2 Involved in Multi-drug Resistance of Lung Cancer SP Cells.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; ATP Binding Cassette Transporter, Sub | 2015 |
Reversal of ABCB1-related Multidrug Resistance of Colonic Adenocarcinoma Cells by Phenothiazines.
Topics: Adenocarcinoma; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Colonic | 2015 |
In Vitro Evaluation of Inhalable Verapamil-Rifapentine Particles for Tuberculosis Therapy.
Topics: Adenocarcinoma; Administration, Inhalation; Aerosols; Anti-Arrhythmia Agents; Antibiotics, Antituber | 2016 |
Inhibition of P-glycoprotein-mediated paclitaxel resistance by reversibly linked quinine homodimers.
Topics: Adenocarcinoma; Adenosine Triphosphatases; Affinity Labels; ATP Binding Cassette Transporter, Subfam | 2009 |
Involvement of P-glycoprotein and multidrug resistance associated protein 1 on the transepithelial transport of a mercaptoacetamide-based histone-deacetylase inhibitor in Caco-2 cells.
Topics: Adenocarcinoma; Analysis of Variance; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calci | 2009 |
Chemosensitivity of radioresistant cells in the multicellular spheroids of A549 lung adenocarcinoma.
Topics: Adenocarcinoma; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Ca | 2009 |
Isothiocyanate-drug interactions in the human adenocarcinoma cell line Caco-2.
Topics: Active Transport, Cell Nucleus; Adenocarcinoma; Anti-Arrhythmia Agents; ATP Binding Cassette Transpo | 2012 |
Verapamil-induced autophagy-like process in colon adenocarcinoma COLO 205 cells; the ultrastructural studies.
Topics: Adenocarcinoma; Apoptosis; Autophagy; Cell Line, Tumor; Cell Membrane; Chromatin; Colonic Neoplasms; | 2012 |
Overexpression and significance of prion protein in gastric cancer and multidrug-resistant gastric carcinoma cell line SGC7901/ADR.
Topics: Adenocarcinoma; Antibiotics, Antineoplastic; Apoptosis; Calcium Channel Blockers; Doxorubicin; Drug | 2005 |
Promotion by verapamil of vincristine responsiveness in tumor cell lines inherently resistant to the drug.
Topics: Adenocarcinoma; Animals; Cell Line; Colonic Neoplasms; Drug Evaluation, Preclinical; Drug Synergism; | 1983 |
Effect of verapamil on malignant tissue blood flow in SMT-2A tumor-bearing rats.
Topics: Adenocarcinoma; Animals; Blood Pressure; Cardiac Output; Female; Heart Rate; Mammary Neoplasms, Expe | 1982 |
Influence of S9788, a new modulator of multidrug resistance, on the cellular accumulation and subcellular distribution of daunorubicin in P-glycoprotein-expressing MCF7 human breast adenocarcinoma cells.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Nucl | 1995 |
[Effect of the modality of exposure on the action of S9788 on the modulation of multidrug resistance of human tumor cell lines].
Topics: Adenocarcinoma; Antineoplastic Agents; Breast Neoplasms; Cyclosporine; Daunorubicin; Drug Resistance | 1994 |
MDR-related P170-glycoprotein modulates cytotoxic activity of homoharringtonine.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Colonic Neoplasms; Cyclospo | 1995 |
Antitumour activity of 5-fluorouracil, verapamil and hyperthermia against human gastric adenocarcinoma cell (AGS) in vitro.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cell Count; Combined Modality Therap | 1994 |
Inhibition of P-glycoprotein-mediated vinblastine transport across HCT-8 intestinal carcinoma monolayers by verapamil, cyclosporine A and SDZ PSC 833 in dependence on extracellular pH.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Su | 1994 |
Effects of P-glycoprotein expression on cyclic AMP and volume-activated ion fluxes and conductances in HT-29 colon adenocarcinoma cells.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chlorides; Colforsin; Colon | 1994 |
Free radical formation by ansamycin benzoquinone in human breast tumor cells: implications for cytotoxicity and resistance.
Topics: Adenocarcinoma; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1 | 1994 |
Effect of mitomycin C, verapamil, and hyperthermia on human gastric adenocarcinoma.
Topics: Adenocarcinoma; Combined Modality Therapy; Drug Therapy, Combination; Female; Humans; Hyperthermia, | 1994 |
D-verapamil downmodulates P170-associated resistance to doxorubicin, daunorubicin and idarubicin.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cell Surv | 1993 |
In vitro and in vivo chemosensitizing effect of cyclosporin A on an intrinsic multidrug-resistant rat colon tumour.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transp | 1993 |
Role of the MDR-1-encoded multiple drug resistance phenotype in prostate cancer cell lines.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transpo | 1993 |
Characterisation of a LoVo subline resistant to a benzoyl mustard derivative of distamycin A (FCE 24517).
Topics: Adenocarcinoma; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carr | 1993 |
Chemosensitization and drug accumulation assays as complementary methods for the screening of multidrug resistance reversal agents.
Topics: Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; ATP Binding C | 1996 |
Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Blotting, No | 1996 |
Involvement of P-glycoprotein in the transmembrane transport of interleukin-2 (IL-2), IL-4, and interferon-gamma in normal human T lymphocytes.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cyclo | 1996 |
Polyaromatic alkaloids from marine invertebrates as cytotoxic compounds and inhibitors of multidrug resistance caused by P-glycoprotein.
Topics: Adenocarcinoma; Alkaloids; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemoth | 1996 |
Comparative in vitro evaluation of dithiane analogs of tiapamil, Ro 11-2933, Ro 44-5911 and Ro 44-5912 as multidrug resistance modulators.
Topics: Adenocarcinoma; Breast Neoplasms; Calcium Channel Blockers; Daunorubicin; Drug Resistance, Multiple; | 1996 |
Reversal of doxorubicin resistance by the amiloride analogue EIPA in multidrug resistant human colon carcinoma cells.
Topics: Adenocarcinoma; Amiloride; Anti-Arrhythmia Agents; Antibiotics, Antineoplastic; Cell Division; Colon | 1996 |
Functional modulation of ATPase of P-glycoprotein by C219, a monoclonal antibody against P-glycoprotein.
Topics: Adenocarcinoma; Adenosine Triphosphatases; Adenosine Triphosphate; Antibodies, Monoclonal; ATP Bindi | 1997 |
Role of the vacuolar H+-ATPase in daunorubicin distribution in etoposide-resistant MCF7 cells overexpressing the multidrug-resistance associated protein.
Topics: 4-Chloro-7-nitrobenzofurazan; Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member | 1998 |
Reversal of multidrug resistance by novel verapamil analogs in cancer cells.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Calcium Channel Blockers; Drug Resistance, Multiple; | 1998 |
P-glycoprotein-mediated multidrug resistance is modulated by pretreatment with chemosensitizers in HCT-8 carcinoma cells in vitro.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cyclo | 1998 |
Effects of cytoskeletal inhibitors on the accumulation of vincristine in a resistant human lung cancer cell line with high level of polymerized tubulin.
Topics: Adenocarcinoma; Cell Survival; Colchicine; Cyclosporine; Cytochalasin B; Cytochalasin D; Cytoskeleto | 1998 |
[A new method for the intravital assessment of the functional activity of the membrane transporters performing the efflux of antitumor preparations from the cells of solid tumor specimens].
Topics: Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Tr | 1999 |
A comparison of the modulation of antiblastics cytotoxicity by verapamil and dipyridamole in a human colon carcinoma cell line.
Topics: Adenocarcinoma; Antibiotics, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transporter | 1999 |
Multidrug resistance increment in a human colon carcinoma cell line by colchicine.
Topics: Adenocarcinoma; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Colc | 2000 |
Verapamil decreases accumulation of 99Tcm-MIBI and 99Tcm-tetrofosmin in human breast cancer and soft tissue sarcoma cell lines.
Topics: Adenocarcinoma; Breast Neoplasms; Calcium Channel Blockers; Cell Line; Cell Survival; Female; Humans | 2001 |
Mechanisms of taxotere-related drug resistance in pancreatic carcinoma.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Antineopla | 2001 |
Intracellular levels of two cyclosporin derivatives valspodar (PSC 833) and cyclosporin a closely associated with multidrug resistance-modulating activity in sublines of human colorectal adenocarcinoma HCT-15.
Topics: Adenocarcinoma; Anticarcinogenic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bi | 2001 |
Saint John's wort: an in vitro analysis of P-glycoprotein induction due to extended exposure.
Topics: Adenocarcinoma; Anthracenes; Antidepressive Agents; ATP Binding Cassette Transporter, Subfamily B, M | 2001 |
Verapamil sensitisation to alkaloids on colchicine-selected human colon adenocarcinoma cells.
Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Cell Survival; Colchicine; Colonic Neoplasms; Dru | 2001 |
Modification of adriamycin-induced cytotoxicity by recombinant human interferon-gamma and/or verapamil in human stomach cancer cells.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Doxorubicin; Drug Int | 1992 |
A cell line with unusual characteristics from an ovarian carcinoma patient: modulation of sensitivity to antitumour drugs.
Topics: Adenocarcinoma; Antigens, Neoplasm; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfami | 1992 |
Effects of a new triazinoaminopiperidine derivative on adriamycin accumulation and retention in cells displaying P-glycoprotein-mediated multidrug resistance.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Membe | 1992 |
Epithelial secretion of vinblastine by human intestinal adenocarcinoma cell (HCT-8 and T84) layers expressing P-glycoprotein.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell | 1991 |
Antiproliferative effects of the Ca2+/calmodulin antagonist B859-35 and the Ca(2+)-channel blocker verapamil on human lung cancer cell lines.
Topics: Adenocarcinoma; Antineoplastic Agents; Calcium Channel Blockers; Carcinoid Tumor; Cell Division; Dih | 1991 |
Effects of antiplatelet agents alone or in combinations on platelet aggregation and on liver metastases from a human pancreatic adenocarcinoma in the nude mouse.
Topics: Adenocarcinoma; Animals; Colforsin; Drug Interactions; Humans; Indomethacin; Ketoconazole; Liver Neo | 1991 |
Verapamil and cyclosporin A sensitize human kidney tumor cells to vincristine in absence of membrane P-glycoprotein and without apparent changes in the cytoplasmic free Ca2+ concentration.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium; Cell Division; Cyc | 1990 |
Modulation of multidrug resistance by verapamil or mdr1 anti-sense oligodeoxynucleotide does not change the high susceptibility to lymphokine-activated killers in mdr-resistant human carcinoma (LoVo) line.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Colonic Neoplasms; Doxorubi | 1990 |
Effect of dimethylsulfoxide on the proliferation and glycosaminoglycan synthesis of rat prostate adenocarcinoma cells (PAIII) in vitro: isolation and characterization of DMSO-resistant cells.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Division; Dimethyl Sulfoxide; Drug Resistance; | 1991 |
Differential in vitro sensitivity of human tumor and normal cells to chemotherapeutic agents and resistance modulators.
Topics: Adenocarcinoma; Antineoplastic Agents; Buthionine Sulfoximine; Cell Division; Cell Line; Cell Surviv | 1991 |
Efflux of bis-carboxyethyl-carboxyfluorescein (BCECF) by a novel ATP-dependent transport mechanism in epithelial cells.
Topics: Adenocarcinoma; Adenosine Triphosphate; Animals; Cell Line; Epithelium; Fluoresceins; Fluorescent Dy | 1990 |
Effect of calcium channel blockers on gastric carcinogenesis and caerulein enhancement of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats.
Topics: Adenocarcinoma; Animals; Calcium Channel Blockers; Ceruletide; DNA; Gastric Juice; Gastrins; Hydroge | 1990 |
Structural determinants of phenoxazine type compounds required to modulate the accumulation of vinblastine and vincristine in multidrug-resistant cell lines.
Topics: Adenocarcinoma; Biological Transport; Cell Line; Colonic Neoplasms; Drug Resistance; HeLa Cells; Hum | 1990 |
Phenotypic instability of drug sensitivity in a human colon carcinoma cell line.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Colonic Neoplasms; Doxorubi | 1989 |
Changes in the three-dimensional organization of LoVo cells associated with resistance to doxorubicin.
Topics: Adenocarcinoma; Cell Aggregation; Cell Division; Colonic Neoplasms; Cyclosporins; Doxorubicin; Drug | 1989 |
[Chemo-sensitivity of a human salivary adenocarcinoma cell line to several anti-cancer drugs and enhancement of the antitumor effects by combination with filipin or verapamil].
Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line; Drug Screening Assays, A | 1989 |
Over-expression of MDR1 gene with no DNA amplification in a multiple-drug-resistant human ovarian carcinoma cell line.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Chromosome Deletion; Dactinomycin; Doxorubicin; Drug | 1989 |
Derivation and preliminary characterisation of adriamycin resistant lines of human lung cancer cells.
Topics: Adenocarcinoma; Carcinoma, Small Cell; Cell Line; Cytological Techniques; Doxorubicin; Drug Resistan | 1986 |
Drug resistance in human lung cancer cell lines: cross-resistance studies and effects of the calcium transport blocker, verapamil.
Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma, Small Cell; Cell Line; Drug Resistance; Humans; In | 1986 |
Reduced cytotoxicity of tetracyclines to a multi-drug resistant human cell line.
Topics: Adenocarcinoma; Cell Division; Cell Survival; Colonic Neoplasms; Demeclocycline; Doxorubicin; Drug R | 1988 |
Intracellular doxorubicin concentrations and drug-induced DNA damage in a human colon adenocarcinoma cell line and in a drug-resistant subline.
Topics: Adenocarcinoma; Cell Line; Cell Survival; Cisplatin; Colonic Neoplasms; Cytarabine; Dactinomycin; DN | 1988 |
[Tumor-induced platelet aggregation and growth-promoting factors as determinants of probable tumor metastasis].
Topics: Adenocarcinoma; Animals; Cell Line; Clone Cells; Colonic Neoplasms; Growth Substances; Lung Neoplasm | 1987 |