verapamil has been researched along with Acute Lymphoid Leukemia in 21 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Etoposide was given daily (150 mg m-2 day-1) for three doses (each over 1 h); the first dose was given 12 h into the verapamil infusion." | 2.68 | Continuous-infusion verapamil with etoposide in relapsed or resistant paediatric cancers. ( Cowie, FJ; Dick, G; Flanagan, RJ; Judson, I; McCarthy, PT; Phillips, M; Pinkerton, CR, 1995) |
| "012) whereas the adverse effect of 25 microM genistein was median 1." | 1.30 | The modulating effect of PSC 833, cyclosporin A, verapamil and genistein on in vitro cytotoxicity and intracellular content of daunorubicin in childhood acute lymphoblastic leukemia. ( den Boer, ML; Henze, G; Janka-Schaub, GE; Kazemier, KM; Pieters, R; Veerman, AJ, 1998) |
| "Pgp was positive in 75% of acute nonlymphoblastic leukemia (ANLL) and 50% of acute lymphoblastic leukemia (ALL)." | 1.28 | P-glycoprotein expression in refractory hematological neoplasms and circumvention of resistance with verapamil or cyclosporine A containing protocols. ( Akan, H; Beksaç, M; Ertürk, S; Güneyli, A; Ikizünal, Y; Ilhan, O; Koç, H; Sardaş, OS, 1992) |
| "The vinblastine-resistant human lymphoblastic leukemia cell line CEM-VBL demonstrated minimal DNR uptake; simultaneous incubation with verapamil and DNR increased intracellular DNR uptake fourfold." | 1.28 | Comparative cellular pharmacology of daunorubicin and idarubicin in human multidrug-resistant leukemia cells. ( Berman, E; McBride, M, 1992) |
| " There was no apparent relationship between drug reversal of vcr resistance and the cytotoxic actions of the drug per se since the calcium channel blocker diltiazem (dil) significantly potentiated the actions of vcr on MDR L100 cells without being more toxic to these cells (compared to vcr-sensitive L0 cells)." | 1.28 | Pharmacological modification of multi-drug resistance (MDR) in vitro detected by a novel fluorometric microculture cytotoxicity assay. Reversal of resistance and selective cytotoxic actions of cyclosporin A and verapamil on MDR leukemia T-cells. ( Larsson, R; Nygren, P, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.76) | 18.7374 |
| 1990's | 16 (76.19) | 18.2507 |
| 2000's | 2 (9.52) | 29.6817 |
| 2010's | 2 (9.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nomme, J | 1 |
| Li, Z | 1 |
| Gipson, RM | 1 |
| Wang, J | 1 |
| Armijo, AL | 1 |
| Le, T | 1 |
| Poddar, S | 1 |
| Smith, T | 1 |
| Santarsiero, BD | 1 |
| Nguyen, HA | 1 |
| Czernin, J | 1 |
| Alexandrova, AN | 1 |
| Jung, ME | 1 |
| Radu, CG | 1 |
| Lavie, A | 1 |
| Lickliter, JD | 1 |
| Taylor, K | 1 |
| Szer, J | 1 |
| Grigg, A | 1 |
| Arthur, C | 1 |
| Hughes, TP | 1 |
| Durrant, S | 1 |
| Filshie, R | 1 |
| Irving, I | 1 |
| Seldon, M | 1 |
| Ellacott, J | 1 |
| Boyd, AW | 1 |
| D'Rozario, J | 1 |
| Rooney, K | 1 |
| Lynch, K | 1 |
| Bradstock, K | 1 |
| Barakat, S | 1 |
| Gayet, L | 1 |
| Dayan, G | 1 |
| Labialle, S | 1 |
| Lazar, A | 1 |
| Oleinikov, V | 1 |
| Coleman, AW | 1 |
| Baggetto, LG | 1 |
| Chao, CC | 1 |
| Cowie, FJ | 1 |
| Pinkerton, CR | 1 |
| Phillips, M | 1 |
| Dick, G | 1 |
| Judson, I | 1 |
| McCarthy, PT | 1 |
| Flanagan, RJ | 1 |
| Miniero, R | 1 |
| Massara, FM | 1 |
| Saroglia, EM | 1 |
| Soldano, S | 1 |
| Barisone, E | 1 |
| Leone, L | 1 |
| Arrighini, A | 1 |
| Andolina, M | 1 |
| Brach del Prever, A | 1 |
| Madon, E | 1 |
| Maslak, P | 1 |
| Hegewisch-Becker, S | 1 |
| Godfrey, L | 1 |
| Andreeff, M | 2 |
| Mukhammed, A | 1 |
| Turkina, AG | 1 |
| Al'pidovskiĭ, VK | 1 |
| Sidorova, TA | 1 |
| Golenko, OD | 1 |
| Gerasimova, GK | 1 |
| Roller, E | 1 |
| Klumpp, B | 1 |
| Krause, J | 1 |
| Eichelbaum, M | 1 |
| Schumacher, K | 1 |
| Broxterman, HJ | 2 |
| Sonneveld, P | 1 |
| Feller, N | 1 |
| Ossenkoppele, GJ | 1 |
| Währer, DC | 1 |
| Eekman, CA | 1 |
| Schoester, M | 1 |
| Lankelma, J | 1 |
| Pinedo, HM | 1 |
| Löwenberg, B | 1 |
| Schuurhuis, GJ | 1 |
| den Boer, ML | 1 |
| Pieters, R | 2 |
| Kazemier, KM | 1 |
| Janka-Schaub, GE | 1 |
| Henze, G | 1 |
| Veerman, AJ | 2 |
| De Moerloose, B | 1 |
| Dhooge, C | 1 |
| Philippé, J | 1 |
| Bebawy, M | 1 |
| Morris, MB | 1 |
| Roufogalis, BD | 1 |
| Hongo, T | 1 |
| Loonen, AH | 1 |
| Huismans, DR | 1 |
| Hählen, K | 1 |
| Beksaç, M | 1 |
| Akan, H | 1 |
| Koç, H | 1 |
| Ilhan, O | 1 |
| Ertürk, S | 1 |
| Güneyli, A | 1 |
| Ikizünal, Y | 1 |
| Sardaş, OS | 1 |
| Berman, E | 1 |
| McBride, M | 1 |
| Solary, E | 1 |
| Bidan, JM | 1 |
| Calvo, F | 1 |
| Chauffert, B | 1 |
| Caillot, D | 1 |
| Mugneret, F | 1 |
| Gauville, C | 1 |
| Tsuruo, T | 1 |
| Carli, PM | 1 |
| Guy, H | 1 |
| Larsson, R | 1 |
| Nygren, P | 1 |
| Redner, A | 1 |
| Hegewisch, S | 1 |
| Haimi, J | 1 |
| Steinherz, P | 1 |
| Jhanwar, S | 1 |
| Cairo, MS | 1 |
| Toy, C | 1 |
| Sender, L | 1 |
| Bennetts, G | 1 |
| van de Ven, C | 1 |
| Sweet, P | 1 |
| Chan, PK | 1 |
| Slater, LM | 1 |
2 trials available for verapamil and Acute Lymphoid Leukemia
| Article | Year |
|---|---|
An imatinib-only window followed by imatinib and chemotherapy for Philadelphia chromosome-positive acute leukemia: long-term results of the CMLALL1 trial.
Topics: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy | 2015 |
Continuous-infusion verapamil with etoposide in relapsed or resistant paediatric cancers.
Topics: Adolescent; Adult; Bone Neoplasms; Child; Child, Preschool; Drug Administration Schedule; Drug Resis | 1995 |
19 other studies available for verapamil and Acute Lymphoid Leukemia
| Article | Year |
|---|---|
Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability.
Topics: Animals; Antineoplastic Agents; Binding Sites; Chemistry, Pharmaceutical; Computer Simulation; Cryst | 2014 |
Multidrug-resistant cancer cells contain two populations of P-glycoprotein with differently stimulated P-gp ATPase activities: evidence from atomic force microscopy and biochemical analysis.
Topics: Adenosine Triphosphatases; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Mem | 2005 |
Lack of elevated drug efflux in adriamycin-resistant immunoblastic B lymphoma cells with mdr1 overexpression.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Blott | 1995 |
[Use of cyclosporin and verapamil in association with chemotherapy in the treatment of pediatric patients with advanced-stage neoplasms. A pilot study].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cerebellar Neoplasms; Ch | 1994 |
Flow cytometric determination of the multidrug-resistant phenotype in acute leukemia.
Topics: Acute Disease; Adolescent; Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemoth | 1994 |
[The use of verapamil in tests for determining the drug resistance of leukemic blasts].
Topics: Adolescent; Adult; Aged; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Leukemia, Myeloi | 1993 |
Influence of sequential exposure to R-verapamil or B8509-035 on rhodamine 123 accumulation in human lymphoblastoid cell lines.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Differentiation | 1993 |
Quality control of multidrug resistance assays in adult acute leukemia: correlation between assays for P-glycoprotein expression and activity.
Topics: Acute Disease; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; | 1996 |
The modulating effect of PSC 833, cyclosporin A, verapamil and genistein on in vitro cytotoxicity and intracellular content of daunorubicin in childhood acute lymphoblastic leukemia.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Ca | 1998 |
Discordance of P-glycoprotein expression and function in acute leukemia.
Topics: Adolescent; Adult; Age Factors; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bone Marrow | 1999 |
Selective modulation of P-glycoprotein-mediated drug resistance.
Topics: Allosteric Regulation; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamil | 2001 |
Different types of non-P-glycoprotein mediated multiple drug resistance in children with relapsed acute lymphoblastic leukaemia.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Death; Child; D | 1992 |
P-glycoprotein expression in refractory hematological neoplasms and circumvention of resistance with verapamil or cyclosporine A containing protocols.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, | 1992 |
Comparative cellular pharmacology of daunorubicin and idarubicin in human multidrug-resistant leukemia cells.
Topics: Cell Division; Daunorubicin; Drug Resistance; Humans; Idarubicin; Leukemia, Myeloid, Acute; Precurso | 1992 |
P-glycoprotein expression and in vitro reversion of doxorubicin resistance by verapamil in clinical specimens from acute leukaemia and myeloma.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Doxorubicin; Drug Resistance; Humans; Leuke | 1991 |
Pharmacological modification of multi-drug resistance (MDR) in vitro detected by a novel fluorometric microculture cytotoxicity assay. Reversal of resistance and selective cytotoxic actions of cyclosporin A and verapamil on MDR leukemia T-cells.
Topics: Benzimidazoles; Cell Division; Cell Line; Cell Survival; Cyclosporins; Cytological Techniques; Dose- | 1990 |
A study of multidrug resistance and cell kinetics in a child with near-haploid acute lymphoblastic leukemia.
Topics: Cell Cycle; Chromosome Aberrations; Daunorubicin; Drug Resistance; Haplotypes; Humans; Membrane Glyc | 1990 |
Combination chemotherapy and verapamil to purge drug resistant leukemia cells from human bone marrow.
Topics: Bone Marrow; Bone Marrow Transplantation; Cell Division; Cells, Cultured; Colony-Forming Units Assay | 1990 |
Cyclosporin A and verapamil enhancement of daunorubicin-produced nucleolar protein B23 translocation in daunorubicin-resistant and -sensitive human and murine tumor cells.
Topics: Animals; Cell Line; Cyclosporins; Daunorubicin; Drug Resistance; Humans; Liver Neoplasms, Experiment | 1989 |