verapamil has been researched along with Acute Kidney Injury in 42 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Acute Kidney Injury: Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The ability of the calcium entry blocker verapamil to ameliorate the effects of renal ischemia was studied in ten sheep." | 7.67 | Effect of the calcium entry blocker verapamil on renal ischemia. ( Barker, GR; Briggs, BA; Gingrich, GA; Jacobsen, WK; Martin, RD; Melashenko, RA; Stewart, SC; Woolley, JL, 1988) |
| "The possible alleviating effect of verapamil, a calcium entry blocker, on the resulting renal damage from the combination of a short episode of ischemia and CyA was studied in rats." | 7.67 | Calcium entry-blockade with verapamil in cyclosporine A plus ischemia induced acute renal failure in rats. ( Cohen, D; Eliahou, HE; Gavendo, S; Herzog, D; Iaina, A; Kapuler, S; Schiby, G; Serban, I, 1986) |
| "Review of the medication history indicates a temporal association between the addition of 3 drugs (simvastatin, verapamil, and digoxin) to the medication regimen already containing cyclosporine and the episode of rhabdomyolysis." | 3.70 | Rhabdomyolysis and acute renal failure in a cardiac transplant recipient due to multiple drug interactions. ( Dreisbach, AW; Kusus, M; Lertora, JJ; Simon, EE; Stapleton, DD, 2000) |
| "The ability of the calcium entry blocker verapamil to ameliorate the effects of renal ischemia was studied in ten sheep." | 3.67 | Effect of the calcium entry blocker verapamil on renal ischemia. ( Barker, GR; Briggs, BA; Gingrich, GA; Jacobsen, WK; Martin, RD; Melashenko, RA; Stewart, SC; Woolley, JL, 1988) |
| "The possible alleviating effect of verapamil, a calcium entry blocker, on the resulting renal damage from the combination of a short episode of ischemia and CyA was studied in rats." | 3.67 | Calcium entry-blockade with verapamil in cyclosporine A plus ischemia induced acute renal failure in rats. ( Cohen, D; Eliahou, HE; Gavendo, S; Herzog, D; Iaina, A; Kapuler, S; Schiby, G; Serban, I, 1986) |
| "This study was designed to determine whether verapamil protects renal function in experimental ischemia in the rat and, if so, whether the protection is mediated by verapamil's vasodilatory action or by an effect on renal cells independent of vascular perfusion." | 3.66 | Effects of verapamil in models of ischemic acute renal failure in the rat. ( Bonventre, JV; Cheung, JY; Leaf, A; Malis, CD, 1983) |
| "Verapamil has proven effective in preventing acute renal failure in animal models if given prior to the insult and hence possibly has a role in the preservation of cadaveric renal tissue for transplantation." | 2.66 | Verapamil prevents post-transplant oliguric renal failure. ( Charlesworth, JA; Duggan, KA; Macdonald, GJ; Pussell, BA, 1985) |
| " In experimental chronic renal failure, the long-term administration of verapamil protects against renal dysfunction and damage, independent of any effect on systemic mean arterial pressure." | 2.38 | Role of calcium channel blockers in protection against experimental renal injury. ( Schrier, RW, 1991) |
| "The effects of folic acid-induced acute renal failure on the renal excretion of belotecan were investigated in rats after intravenous administration." | 1.35 | Decreased urinary secretion of belotecan in folic acid-induced acute renal failure rats due to down-regulation of Oat1 and Bcrp. ( Choi, MK; Chung, SJ; Jin, QR; Kim, DD; Shim, CK; Shim, WS; Song, IS; Tian, GY; Yang, SG, 2009) |
| "To study the influence of acute renal failure in ischemic-reperfusion injury on the heart, we used isolated Langendorff's hearts of guinea pigs with gentamicin-induced acute renal failure." | 1.32 | Mibefradil is more effective than verapamil for restoring post-ischemic function of isolated hearts of guinea pigs with acute renal failure. ( Budihna, MV; Grasic Kuhar, C; Pleskovic, RZ, 2004) |
| " From these findings, we concluded that a reduction of CsA bioavailability during ARF is caused by depression in bile excretion and renal function-dependent depression of uptake from intestinal tract via maybe P-gLycoprotein in enterocytes." | 1.31 | Factors that affect absorption behavior of cyclosporin a in gentamicin-induced acute renal failure in rats. ( Hoshino, N; Minouchi, T; Morimoto, J; Shibata, N; Yamaji, A, 2000) |
| "Acute renal failure following hemorrhagic shock was studied in awake rats." | 1.28 | Acute renal failure following hemorrhagic shock: protective and aggravating factors. ( Rocha, AS; Seguro, AC; Yu, L, 1992) |
| " Additional nutritional factors may play a crucial role in achieving the amelioration of this model of toxic nephropathy." | 1.28 | The effect of oral calcium load or verapamil on gentamicin-induced nephrotoxicity. ( Aladjem, M; Bogin, E; Tamir, A, 1989) |
| "Verapamil was the only calcium-blocking drug which attenuated the post-ischaemic renal dysfunction." | 1.27 | Variable results of calcium blockade in post-ischaemic renal failure. ( Fitzpatrick, JM; Leahy, AL; Wait, RB, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (47.62) | 18.7374 |
| 1990's | 13 (30.95) | 18.2507 |
| 2000's | 8 (19.05) | 29.6817 |
| 2010's | 1 (2.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cibickova, L | 1 |
| Caran, T | 1 |
| Dobias, M | 1 |
| Ondra, P | 1 |
| Vorisek, V | 1 |
| Cibicek, N | 1 |
| Jin, QR | 1 |
| Shim, WS | 1 |
| Choi, MK | 1 |
| Tian, GY | 1 |
| Song, IS | 1 |
| Yang, SG | 1 |
| Kim, DD | 1 |
| Chung, SJ | 1 |
| Shim, CK | 1 |
| Macías-Núñez, JF | 1 |
| Fernández, R | 1 |
| Calvo, C | 1 |
| Grande, J | 1 |
| Herrera, J | 1 |
| Bustamante, J | 1 |
| Garay, R | 1 |
| Robles, R | 1 |
| López-Novoa, JM | 1 |
| Grasic Kuhar, C | 2 |
| Budihna, MV | 2 |
| Pleskovic, RZ | 1 |
| Papadimitriou, M | 1 |
| Alexopoulos, E | 1 |
| Vargemezis, V | 1 |
| Sakellariou, G | 1 |
| Kosmidou, I | 1 |
| Metaxas, P | 1 |
| Kramer, HJ | 2 |
| Neumark, A | 1 |
| Schmidt, S | 1 |
| Klingmüller, D | 1 |
| Glänzer, K | 1 |
| Burke, TJ | 4 |
| Arnold, PE | 1 |
| Gordon, JA | 1 |
| Bulger, RE | 1 |
| Dobyan, DC | 1 |
| Schrier, RW | 5 |
| Cronin, RE | 1 |
| Malis, CD | 1 |
| Cheung, JY | 1 |
| Leaf, A | 1 |
| Bonventre, JV | 1 |
| Goldfarb, D | 1 |
| Iaina, A | 2 |
| Serban, I | 2 |
| Gavendo, S | 2 |
| Kapuler, S | 2 |
| Eliahou, HE | 2 |
| Wait, RB | 3 |
| White, G | 1 |
| Davis, JH | 1 |
| Alvarez, A | 1 |
| Martul, E | 1 |
| Veiga, F | 1 |
| Forteza, J | 1 |
| Tataranni, G | 1 |
| Malacarne, F | 1 |
| Farinelli, R | 1 |
| Tarroni, G | 1 |
| Gritti, G | 1 |
| Guberti, A | 1 |
| Tartari, S | 1 |
| Zavagli, G | 1 |
| Rosberg, J | 1 |
| Bäcker, A | 1 |
| Meyer-Lehnert, H | 1 |
| Dzgoeva, FU | 1 |
| Kutyrina, IM | 1 |
| Ivanov, AA | 1 |
| Burgova, EN | 1 |
| Vanin, AF | 1 |
| Matsumura, Y | 2 |
| Nishiura, M | 1 |
| Deguchi, S | 1 |
| Hashimoto, N | 1 |
| Ogawa, T | 1 |
| Seo, R | 1 |
| Shibata, N | 1 |
| Morimoto, J | 1 |
| Hoshino, N | 1 |
| Minouchi, T | 1 |
| Yamaji, A | 1 |
| Gokel, Y | 1 |
| Paydas, S | 1 |
| Duru, M | 1 |
| Kusus, M | 1 |
| Stapleton, DD | 1 |
| Lertora, JJ | 1 |
| Simon, EE | 1 |
| Dreisbach, AW | 1 |
| Yamashita, J | 1 |
| Itoh, M | 1 |
| Kuro, T | 1 |
| Kobayashi, Y | 1 |
| Ogata, M | 1 |
| Takaoka, M | 1 |
| Shi, JC | 1 |
| Rosansky, SJ | 1 |
| Yu, L | 1 |
| Seguro, AC | 1 |
| Rocha, AS | 1 |
| Greif, F | 1 |
| Anais, D | 1 |
| Frei, L | 1 |
| Arbeit, L | 1 |
| Sorroff, HS | 1 |
| Deray, G | 1 |
| Martinez, F | 1 |
| Cacoub, P | 1 |
| Baumelou, B | 1 |
| Baumelou, A | 1 |
| Jacobs, C | 1 |
| Capasso, G | 1 |
| Giordano, DR | 1 |
| de Tommaso, G | 1 |
| De Santo, NG | 1 |
| Massry, SG | 1 |
| Tamir, A | 1 |
| Aladjem, M | 1 |
| Bogin, E | 2 |
| Koller, J | 1 |
| Wieser, C | 1 |
| Kornberger, R | 1 |
| Furtwängler, W | 1 |
| Königsrainer, A | 1 |
| Margreiter, R | 1 |
| Vanholder, R | 1 |
| Laekman, G | 1 |
| Herman, A | 1 |
| Lámeire, N | 1 |
| Golueke, PJ | 1 |
| Kahng, KU | 1 |
| Lipkowitz, GS | 1 |
| O'Neill, PA | 1 |
| Agatstein, EH | 1 |
| Farrer, JH | 1 |
| Kaplan, LM | 1 |
| Randazzo, RF | 1 |
| Glassock, RJ | 1 |
| Kaufman, JJ | 1 |
| Woolley, JL | 1 |
| Barker, GR | 1 |
| Jacobsen, WK | 1 |
| Gingrich, GA | 1 |
| Stewart, SC | 1 |
| Briggs, BA | 1 |
| Martin, RD | 1 |
| Melashenko, RA | 1 |
| Leahy, AL | 1 |
| Fitzpatrick, JM | 1 |
| Chagnac, A | 1 |
| Jüppner, H | 1 |
| Levi, J | 1 |
| Herzog, D | 1 |
| Cohen, D | 1 |
| Schiby, G | 1 |
| Duggan, KA | 1 |
| Macdonald, GJ | 1 |
| Charlesworth, JA | 1 |
| Pussell, BA | 1 |
| Eisinger, DR | 1 |
| Suranyi, MG | 1 |
| Bracs, P | 1 |
| Farnsworth, A | 1 |
| Sheil, AG | 1 |
3 reviews available for verapamil and Acute Kidney Injury
| Article | Year |
|---|---|
New aspects in pathogenesis of acute renal failure.
Topics: Acute Kidney Injury; Animals; Calcium; Cell Hypoxia; Cytosol; Glycine; Humans; Ion Transport; Kidney | 1994 |
Role of calcium channel blockers in protection against experimental renal injury.
Topics: Acute Kidney Injury; Animals; Calcium; Disease Models, Animal; Dogs; Glomerular Filtration Rate; Hum | 1991 |
Calcium-channel blockers in experimental and human acute renal failure.
Topics: Acute Kidney Injury; Animals; Calcium; Calcium Channel Blockers; Humans; Rats; Verapamil | 1988 |
3 trials available for verapamil and Acute Kidney Injury
| Article | Year |
|---|---|
Verapamil reverts acute renal functional impairment induced by angiotensin II converting enzyme inhibitors.
Topics: Acute Kidney Injury; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Creatinine; | 2003 |
Beneficial effects of verapamil in renal-risk surgical patients.
Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Female; Humans; Intraoperative Care; Male; Middle Aged | 1994 |
Verapamil prevents post-transplant oliguric renal failure.
Topics: Acute Kidney Injury; Adult; Anuria; Creatinine; Humans; Kidney Transplantation; Middle Aged; Oliguri | 1985 |
36 other studies available for verapamil and Acute Kidney Injury
| Article | Year |
|---|---|
Multi-drug intoxication fatality involving atorvastatin: A case report.
Topics: Acute Kidney Injury; Aged; Alcoholics; Anthraquinones; Anti-Inflammatory Agents; Antihypertensive Ag | 2015 |
Decreased urinary secretion of belotecan in folic acid-induced acute renal failure rats due to down-regulation of Oat1 and Bcrp.
Topics: Acridines; Acute Kidney Injury; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Su | 2009 |
Mibefradil is more effective than verapamil for restoring post-ischemic function of isolated hearts of guinea pigs with acute renal failure.
Topics: Acute Kidney Injury; Animals; Blood Pressure; Calcium Channel Blockers; Calcium Channels, L-Type; Ca | 2004 |
The effect of preventive administration of verapamil on acute ischaemic renal failure in dogs.
Topics: Acute Kidney Injury; Animals; Diuresis; Dogs; Ischemia; Kidney; Kidney Transplantation; Verapamil | 1983 |
Renal functional and metabolic studies on the role of preventive measures in experimental acute ischemic renal failure.
Topics: Acute Kidney Injury; Animals; Female; Furosemide; Ischemia; Kidney; Mannitol; Rats; Rats, Inbred Str | 1983 |
Protective effect of intrarenal calcium membrane blockers before or after renal ischemia. Functional, morphological, and mitochondrial studies.
Topics: Acute Kidney Injury; Animals; Calcium; Calcium Channel Blockers; Cytoplasm; Disease Models, Animal; | 1984 |
Changes in tissue calcium content during gentamicin acute renal failure.
Topics: Acute Kidney Injury; Animals; Calcium; Creatinine; Gentamicins; Kidney Cortex; Rats; Rats, Inbred St | 1984 |
Ischemic acute renal failure--pathogenetic steps leading to acute tubular necrosis.
Topics: Acute Kidney Injury; Adenosine Triphosphate; Animals; Calcium; Dogs; Epinephrine; Glomerular Filtrat | 1983 |
Effects of verapamil in models of ischemic acute renal failure in the rat.
Topics: Acute Kidney Injury; Animals; Ischemia; Kidney; Kinetics; Male; Norepinephrine; Rats; Rats, Inbred S | 1983 |
Beneficial effect of verapamil in ischemic acute renal failure in the rat.
Topics: Acute Kidney Injury; Animals; Constriction; Creatinine; Female; Ischemia; Nephrectomy; Propranolol; | 1983 |
Beneficial effects of verapamil on postischemic renal failure.
Topics: Acute Kidney Injury; Animals; Diuresis; Dogs; Female; Infusions, Intra-Arterial; Inulin; Ischemia; K | 1983 |
Functional, histologic, and ultrastructural study of the protective effects of verapamil in experimental ischemic acute renal failure in the rabbit.
Topics: Acute Kidney Injury; Animals; Ischemia; Kidney; Kidney Function Tests; Kidney Tubules, Proximal; Mal | 1994 |
Calcium entry and 5-HT2 receptor blockade in oliguric ischaemic acute renal failure: effects of levemopamil in conscious rats.
Topics: Acute Kidney Injury; Animals; Calcium; Calcium Channel Blockers; Female; Kidney; Kidney Function Tes | 1996 |
[The role of nitric oxide in mechanisms of the nephrotoxic effect of verografin].
Topics: Acute Kidney Injury; Animals; Calcium Channel Blockers; Contrast Media; Diatrizoate Meglumine; Kidne | 1997 |
Protective effect of FK409, a spontaneous nitric oxide releaser, on ischemic acute renal failure in rats.
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Calcium Channel Blockers; Creatinine; Kidney Medu | 1998 |
Factors that affect absorption behavior of cyclosporin a in gentamicin-induced acute renal failure in rats.
Topics: Absorption; Acute Kidney Injury; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, | 2000 |
Effects of mibefradil and verapamil on ischemic-reperfusion in the hearts of guinea pigs with acute renal failure.
Topics: Acute Kidney Injury; Animals; Calcium Channel Blockers; Coronary Circulation; Female; Guinea Pigs; L | 2000 |
High-dose verapamil-trandolapril induced rhabdomyolysis and acute renal failure.
Topics: Acute Kidney Injury; Adult; Antihypertensive Agents; Calcium Channel Blockers; Creatine Kinase; Dose | 2000 |
Rhabdomyolysis and acute renal failure in a cardiac transplant recipient due to multiple drug interactions.
Topics: Acute Kidney Injury; Anti-Arrhythmia Agents; Cyclosporine; Digoxin; Drug Interactions; Enzyme Inhibi | 2000 |
Pre- or post-ischemic treatment with a novel Na+/Ca2+ exchange inhibitor, KB-R7943, shows renal protective effects in rats with ischemic acute renal failure.
Topics: Acute Kidney Injury; Animals; Blood Pressure; Blood Urea Nitrogen; Blotting, Western; Calcium Channe | 2001 |
[Preventive and therapeutic effects of hirudo on incipient acute tubular necrosis in rats].
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Glycerol; Kidney Tubular Necrosis, Acute; Leeches | 1992 |
Verapamil toxicity and renal failure.
Topics: Acute Kidney Injury; Humans; Liver Diseases; Verapamil | 1992 |
Acute renal failure following hemorrhagic shock: protective and aggravating factors.
Topics: Acute Kidney Injury; Allopurinol; Animals; Calcium; Dehydration; Free Radicals; Gentamicins; Kidney; | 1992 |
Blocking the calcium cascade in experimental acute renal failure.
Topics: Acute Kidney Injury; Animals; Calcium; Calmodulin; Etidronic Acid; Male; Rats; Rats, Inbred Strains; | 1990 |
A role for adenosine calcium and ischemia in radiocontrast-induced intrarenal vasoconstriction.
Topics: Acute Kidney Injury; Adenosine; Animals; Biological Transport, Active; Calcium; Contrast Media; Diat | 1990 |
Parathyroidectomy has a beneficial effect on experimental cisplatin nephrotoxicity.
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Calcium; Cisplatin; Male; Nephrons; Parathyroid H | 1990 |
The effect of oral calcium load or verapamil on gentamicin-induced nephrotoxicity.
Topics: Acute Kidney Injury; Animals; Calcium, Dietary; Creatinine; Drug Interactions; Gentamicins; Glomerul | 1989 |
Does systemic pretreatment with verapamil prevent acute tubular necrosis after renal transplantation?
Topics: Acute Kidney Injury; Cadaver; Humans; Kidney; Kidney Transplantation; Kidney Tubular Necrosis, Acute | 1988 |
Influence of vasoactive substances on early toxic acute renal failure in the dog.
Topics: Acute Kidney Injury; Animals; Captopril; Dogs; Glomerular Filtration Rate; Imidazoles; Mercuric Chlo | 1987 |
Effect of verapamil on posttransplant acute renal failure in the canine kidney.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Dogs; Female; Kidney; Kidney Transplantation; | 1988 |
The effect of verapamil in reducing the severity of acute tubular necrosis in canine renal autotransplants.
Topics: Acute Kidney Injury; Animals; Cold Temperature; Dogs; Ischemia; Kidney; Kidney Transplantation; Kidn | 1987 |
Effect of the calcium entry blocker verapamil on renal ischemia.
Topics: Acute Kidney Injury; Animals; Creatinine; Disease Models, Animal; Ischemia; Kidney; Sheep; Verapamil | 1988 |
Variable results of calcium blockade in post-ischaemic renal failure.
Topics: Acute Kidney Injury; Animals; Calcium Channel Blockers; Flunarizine; Ischemia; Kidney; Male; Nifedip | 1988 |
Effect of verapamil on plasma parathyroid hormone.
Topics: Acute Kidney Injury; Animals; Calcium; Male; Parathyroid Hormone; Rats; Rats, Inbred Strains; Urea; | 1987 |
Calcium entry-blockade with verapamil in cyclosporine A plus ischemia induced acute renal failure in rats.
Topics: Acute Kidney Injury; Animals; Body Weight; Cyclosporins; Female; Ischemia; Kidney; Kidney Function T | 1986 |
Effects of verapamil in the prevention of warm ischaemia induced acute renal failure in dogs.
Topics: Acute Kidney Injury; Animals; Dogs; Female; Ischemia; Kidney; Kidney Transplantation; Male; Organ Pr | 1985 |