Page last updated: 2024-10-24

verapamil and ANS (Autonomic Nervous System) Diseases

verapamil has been researched along with ANS (Autonomic Nervous System) Diseases in 3 studies

Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.

Research Excerpts

ExcerptRelevanceReference
"Trigeminal autonomic cephalalgias (TACs) are a group of primary headache syndromes characterised by two main clinical characteristics: pain and oculofacial autonomic phenomena."2.42Strategies for the treatment of autonomic trigeminal cephalalgias. ( Broggi, G; Bussone, G; Curone, M; D'Amico, D; D'Andrea, G; Franzini, A; Grazzi, L; Leone, M; Mea, E; Tullo, V, 2004)
"A case of orthostatic hypotension due to the combination of hypertrophic obstructive cardiomyopathy and autonomic failure is described."1.27Orthostatic hypotension due to hypertrophic cardiomyopathy and autonomic failure. ( Mader, SL; Wong, M, 1987)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19901 (33.33)18.7374
1990's0 (0.00)18.2507
2000's2 (66.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Leone, M1
Franzini, A1
D'Amico, D1
Grazzi, L1
Mea, E1
Curone, M1
Tullo, V1
Broggi, G1
D'Andrea, G1
Bussone, G1
Forslund, L1
Björkander, I1
Ericson, M1
Held, C1
Kahan, T1
Rehnqvist, N1
Hjemdahl, P1
Mader, SL1
Wong, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Verapamil as Adjunctive Seizure Therapy for Children and Young Adults With Dravet Syndrome[NCT01607073]Phase 22 participants (Actual)Interventional2012-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Number of Absence Seizures From Week 8 (Baseline) to Week 12

The secondary outcome measure is the change in number of absence seizures from Week 8 (Baseline) to Week 12 (NCT01607073)
Timeframe: Week 8 to Week 12

InterventionAbscence seizures (Number)
Week 8 Baseline165
Week 12 Verapamil 4mg/kg/Day101

Change in Number of General Tonic-clonic Seizures From Week 8 (Baseline) Visit to Week 12 Visit

The primary study endpoint is the change in number of seizures from baseline. Since we only had one participant finish the study, the endpoint was changed to Week 12 visit. Participants were on verapamil for 4 weeks at Week 12. (NCT01607073)
Timeframe: Week 8 (baseline) to Week 12

InterventionGeneral tonic-clonic seizures (Number)
Week 8 Baseline39
Week 12 Verapamil 4mg/kg/Day14

Change in Number of Myoclonic Seizures From Week 8 (Baseline) to Week 12

The secondary outcome is the change in number of myoclonic seizures between baseline Week 8 visit and Week 12 visit. (NCT01607073)
Timeframe: Week 8 (baseline) to Week 12

InterventionMyoclonic seizures (Number)
Week 8 Baseline116
Week 12 Verapamil 4mg/kg/Day175

Reviews

1 review available for verapamil and ANS (Autonomic Nervous System) Diseases

ArticleYear
Strategies for the treatment of autonomic trigeminal cephalalgias.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2004, Volume: 25 Suppl 3

    Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Autonomic Nervous System Diseases; Calcium Channe

2004

Trials

1 trial available for verapamil and ANS (Autonomic Nervous System) Diseases

ArticleYear
Prognostic implications of autonomic function assessed by analyses of catecholamines and heart rate variability in stable angina pectoris.
    Heart (British Cardiac Society), 2002, Volume: 87, Issue:5

    Topics: Adult; Aged; Angina Pectoris; Anti-Arrhythmia Agents; Autonomic Nervous System Diseases; Biomarkers;

2002

Other Studies

1 other study available for verapamil and ANS (Autonomic Nervous System) Diseases

ArticleYear
Orthostatic hypotension due to hypertrophic cardiomyopathy and autonomic failure.
    The American journal of medicine, 1987, Volume: 82, Issue:6

    Topics: Aged; Aged, 80 and over; Autonomic Nervous System Diseases; Cardiomyopathy, Hypertrophic; Echocardio

1987