verapamil has been researched along with ANS (Autonomic Nervous System) Diseases in 3 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Trigeminal autonomic cephalalgias (TACs) are a group of primary headache syndromes characterised by two main clinical characteristics: pain and oculofacial autonomic phenomena." | 2.42 | Strategies for the treatment of autonomic trigeminal cephalalgias. ( Broggi, G; Bussone, G; Curone, M; D'Amico, D; D'Andrea, G; Franzini, A; Grazzi, L; Leone, M; Mea, E; Tullo, V, 2004) |
| "A case of orthostatic hypotension due to the combination of hypertrophic obstructive cardiomyopathy and autonomic failure is described." | 1.27 | Orthostatic hypotension due to hypertrophic cardiomyopathy and autonomic failure. ( Mader, SL; Wong, M, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Leone, M | 1 |
| Franzini, A | 1 |
| D'Amico, D | 1 |
| Grazzi, L | 1 |
| Mea, E | 1 |
| Curone, M | 1 |
| Tullo, V | 1 |
| Broggi, G | 1 |
| D'Andrea, G | 1 |
| Bussone, G | 1 |
| Forslund, L | 1 |
| Björkander, I | 1 |
| Ericson, M | 1 |
| Held, C | 1 |
| Kahan, T | 1 |
| Rehnqvist, N | 1 |
| Hjemdahl, P | 1 |
| Mader, SL | 1 |
| Wong, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Verapamil as Adjunctive Seizure Therapy for Children and Young Adults With Dravet Syndrome[NCT01607073] | Phase 2 | 2 participants (Actual) | Interventional | 2012-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The secondary outcome measure is the change in number of absence seizures from Week 8 (Baseline) to Week 12 (NCT01607073)
Timeframe: Week 8 to Week 12
| Intervention | Abscence seizures (Number) |
|---|---|
| Week 8 Baseline | 165 |
| Week 12 Verapamil 4mg/kg/Day | 101 |
The primary study endpoint is the change in number of seizures from baseline. Since we only had one participant finish the study, the endpoint was changed to Week 12 visit. Participants were on verapamil for 4 weeks at Week 12. (NCT01607073)
Timeframe: Week 8 (baseline) to Week 12
| Intervention | General tonic-clonic seizures (Number) |
|---|---|
| Week 8 Baseline | 39 |
| Week 12 Verapamil 4mg/kg/Day | 14 |
The secondary outcome is the change in number of myoclonic seizures between baseline Week 8 visit and Week 12 visit. (NCT01607073)
Timeframe: Week 8 (baseline) to Week 12
| Intervention | Myoclonic seizures (Number) |
|---|---|
| Week 8 Baseline | 116 |
| Week 12 Verapamil 4mg/kg/Day | 175 |
1 review available for verapamil and ANS (Autonomic Nervous System) Diseases
| Article | Year |
|---|---|
Strategies for the treatment of autonomic trigeminal cephalalgias.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Autonomic Nervous System Diseases; Calcium Channe | 2004 |
1 trial available for verapamil and ANS (Autonomic Nervous System) Diseases
| Article | Year |
|---|---|
Prognostic implications of autonomic function assessed by analyses of catecholamines and heart rate variability in stable angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Anti-Arrhythmia Agents; Autonomic Nervous System Diseases; Biomarkers; | 2002 |
1 other study available for verapamil and ANS (Autonomic Nervous System) Diseases
| Article | Year |
|---|---|
Orthostatic hypotension due to hypertrophic cardiomyopathy and autonomic failure.
Topics: Aged; Aged, 80 and over; Autonomic Nervous System Diseases; Cardiomyopathy, Hypertrophic; Echocardio | 1987 |