verapamil has been researched along with ALS - Amyotrophic Lateral Sclerosis in 7 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Seventy-two patients with amyotrophic lateral sclerosis (ALS) were enrolled in a clinical trial of the efficacy of verapamil in the treatment of ALS." | 9.08 | A clinical trial of verapamil in amyotrophic lateral sclerosis. ( Brinkmann, JR; Graves, J; Mendoza, M; Miller, RG; Murphy, JR; Ringel, SP; Sands, ML; Smith, SA, 1996) |
| "Riluzole is currently one of two approved medications for the treatment of amyotrophic lateral sclerosis (ALS)." | 7.88 | Verapamil and riluzole cocktail liposomes overcome pharmacoresistance by inhibiting P-glycoprotein in brain endothelial and astrocyte cells: A potent approach to treat amyotrophic lateral sclerosis. ( Bai, S; Fernandes, T; Ferrill, L; Gallant, L; McGillicuddy, S; Schields, N; Yang, T, 2018) |
| "Seventy-two patients with amyotrophic lateral sclerosis (ALS) were enrolled in a clinical trial of the efficacy of verapamil in the treatment of ALS." | 5.08 | A clinical trial of verapamil in amyotrophic lateral sclerosis. ( Brinkmann, JR; Graves, J; Mendoza, M; Miller, RG; Murphy, JR; Ringel, SP; Sands, ML; Smith, SA, 1996) |
| "Riluzole is currently one of two approved medications for the treatment of amyotrophic lateral sclerosis (ALS)." | 3.88 | Verapamil and riluzole cocktail liposomes overcome pharmacoresistance by inhibiting P-glycoprotein in brain endothelial and astrocyte cells: A potent approach to treat amyotrophic lateral sclerosis. ( Bai, S; Fernandes, T; Ferrill, L; Gallant, L; McGillicuddy, S; Schields, N; Yang, T, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Anger, T | 1 |
| Madge, DJ | 1 |
| Mulla, M | 1 |
| Riddall, D | 1 |
| Chen, T | 1 |
| Benmohamed, R | 1 |
| Arvanites, AC | 1 |
| Ralay Ranaivo, H | 1 |
| Morimoto, RI | 1 |
| Ferrante, RJ | 1 |
| Watterson, DM | 1 |
| Kirsch, DR | 1 |
| Silverman, RB | 1 |
| Salado, IG | 1 |
| Redondo, M | 1 |
| Bello, ML | 1 |
| Perez, C | 1 |
| Liachko, NF | 1 |
| Kraemer, BC | 1 |
| Miguel, L | 1 |
| Lecourtois, M | 1 |
| Gil, C | 2 |
| Martinez, A | 3 |
| Perez, DI | 1 |
| Nozal, V | 1 |
| Martínez-González, L | 1 |
| Gomez-Almeria, M | 1 |
| Gonzalo-Consuegra, C | 1 |
| Santana, P | 1 |
| Chaikuad, A | 1 |
| Pérez-Cuevas, E | 1 |
| Knapp, S | 1 |
| Lietha, D | 1 |
| Ramírez, D | 1 |
| Petralla, S | 1 |
| Monti, B | 1 |
| Martín-Requero, A | 2 |
| Palomo, V | 1 |
| de Lago, E | 1 |
| Martín-Cámara, O | 1 |
| Arribas, M | 1 |
| Wells, G | 1 |
| Morales-Tenorio, M | 1 |
| Porras, G | 1 |
| Giorgi, G | 1 |
| López-Alvarado, P | 1 |
| Lastres-Becker, I | 1 |
| Menéndez, JC | 1 |
| Yang, T | 1 |
| Ferrill, L | 1 |
| Gallant, L | 1 |
| McGillicuddy, S | 1 |
| Fernandes, T | 1 |
| Schields, N | 1 |
| Bai, S | 1 |
| Miller, RG | 1 |
| Smith, SA | 1 |
| Murphy, JR | 1 |
| Brinkmann, JR | 1 |
| Graves, J | 1 |
| Mendoza, M | 1 |
| Sands, ML | 1 |
| Ringel, SP | 1 |
1 review available for verapamil and ALS - Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Medicinal chemistry of neuronal voltage-gated sodium channel blockers.
Topics: Amyotrophic Lateral Sclerosis; Analgesics; Anticonvulsants; Epilepsy; Humans; Ion Channel Gating; Mo | 2001 |
1 trial available for verapamil and ALS - Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
A clinical trial of verapamil in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Analysis of Variance; Arm; Calcium Channel Blockers; Female; Humans; | 1996 |
5 other studies available for verapamil and ALS - Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Enzyme Inhibitors; Humans; Magnetic Resonance Spectroscopy; | 2011 |
Protein kinase CK-1 inhibitors as new potential drugs for amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modified; Benzothiazoles; Blood-Brain B | 2014 |
TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy.
Topics: Amyotrophic Lateral Sclerosis; Animals; Brain; Case-Control Studies; DNA-Binding Proteins; Humans; I | 2022 |
Multitarget Hybrid Fasudil Derivatives as a New Approach to the Potential Treatment of Amyotrophic Lateral Sclerosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Amyotrophic Lateral Sclerosis; Cell Line, Tumor | 2022 |
Verapamil and riluzole cocktail liposomes overcome pharmacoresistance by inhibiting P-glycoprotein in brain endothelial and astrocyte cells: A potent approach to treat amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; ATP Binding Cassette Transporter, Subfamily B, M | 2018 |