ver-49009 and Liver-Cirrhosis

ver-49009 has been researched along with Liver-Cirrhosis* in 1 studies

Other Studies

1 other study(ies) available for ver-49009 and Liver-Cirrhosis

Article	Year
Inhibition of hepatic stellate cell proliferation by heat shock protein 90 inhibitors in vitro. Molecular and cellular biochemistry, 2009, Volume: 330, Issue:1-2 Hepatic stellate cells (HSCs) play an important role in the development of hepatic fibrosis. Heat shock protein 90 (Hsp90) is essential for the maturation and activity of a varied group of proteins involved in signal transduction and cell cycle regulation. In this study, we found that two Hsp90 inhibitors, VER-49009 and its analog VER-49009M, inhibited the proliferation of hepatic stellate cell line CFSC cells, and both of them induced G2 phase arrest in CFSC cells. Akt expression was decreased by the treatment of Hsp90 inhibitors in CFSC cells. Based on these findings, we propose that the inhibition of Hsp90 might be a rational approach in the prevention of liver fibrosis. Topics: Animals; Cell Line; Cell Proliferation; G2 Phase; Hepatic Stellate Cells; HSP90 Heat-Shock Proteins; Liver Cirrhosis; Pyrazoles; Rats	2009

Article

Year

Inhibition of hepatic stellate cell proliferation by heat shock protein 90 inhibitors in vitro.

Molecular and cellular biochemistry, 2009, Volume: 330, Issue:1-2

Hepatic stellate cells (HSCs) play an important role in the development of hepatic fibrosis. Heat shock protein 90 (Hsp90) is essential for the maturation and activity of a varied group of proteins involved in signal transduction and cell cycle regulation. In this study, we found that two Hsp90 inhibitors, VER-49009 and its analog VER-49009M, inhibited the proliferation of hepatic stellate cell line CFSC cells, and both of them induced G2 phase arrest in CFSC cells. Akt expression was decreased by the treatment of Hsp90 inhibitors in CFSC cells. Based on these findings, we propose that the inhibition of Hsp90 might be a rational approach in the prevention of liver fibrosis.

Topics: Animals; Cell Line; Cell Proliferation; G2 Phase; Hepatic Stellate Cells; HSP90 Heat-Shock Proteins; Liver Cirrhosis; Pyrazoles; Rats

2009