vendex and Osteoporotic-Fractures

Osteoporotic fractures of the distal femur are an underestimated and increasing problem in trauma and orthopaedic surgery. Therefore, this study investigates the biomechanical potential of implant augmentation in the treatment of these fractures.. Twelve osteoporotic surrogate distal femora were randomly assigned to the augmented or non-augmented group. All specimens were fixed using the LCP DF. In the augmented group additionally 1ml Vertecem V+ was injected in each screw hole before screw positioning. The construct represents an AO 33 A3 fracture. Biomechanical testing was performed as sinusoidal axial loading between 50 and 500N with 2Hz for 45,000 cycles, followed by loading between 50 and 750N until failure.. The augmented group showed significant higher axial stiffness (36%). Additionally the displacement after 45,000 cycles was 3.4 times lower for the augmented group (0.68±0.2mm vs. 2.28±0.2mm). Failure occurred after 45,130 cycles (SD 99) in all of the non-augmented specimens and in two specimens of the augmented group after 69,675 cycles (SD 1729). Four of the augmented specimens showed no failure. The failure mode of all specimens in both groups was a medial cut-out.. This study shows a promising potential of implant augmentation in the treatment of osteoporotic distal femur fractures.

Topics: Aged; Aged, 80 and over; Biomechanical Phenomena; Bone Cements; Bone Plates; Bone Screws; Female; Femoral Fractures; Humans; Male; Materials Testing; Models, Biological; Osteoporotic Fractures; Stress, Mechanical; Torque

Percutaneous pedicle screw (PPS) can provide internal fixation of the thoracolumbar spine through a minimally invasive surgical procedure. PPS fixation has been widely used to treat various spinal diseases. Rigid fixation of PPS is essential for managing osteoporotic spine in order to prevent the risks of screw loosening and implant failure. We recently developed a novel augmentation method using hydroxyapatite (HA) granules for PPS fixation. The aim of this study was to evaluate the strength and stiffness of PPS fixation augmented with HA granules using an osteoporotic bone model.. Screws were inserted into uniform synthetic bone (sawbones) with and without augmentation. The uniaxial pullout strength and insertion torque of the screws were evaluated. In addition, each screw underwent cyclic toggling under incrementally increasing physiological loads until 2 mm of screwhead displacement occurred. The maximal pullout strength (N), maximal insertion torque (N·cm), number of toggle cycles and maximal load (N) required to achieve 2-mm screwhead displacement were compared between the screws with and without augmentation.. The maximal pullout strength was significantly stronger for screws with augmentation than for those without augmentation (302 ± 19 N vs. 254 ± 17 N, p < 0.05). In addition, the maximal insertion torque was significantly increased in screws with augmentation compared to those without augmentation (48 ± 4 N·cm vs. 26 ± 5 N·cm, p < 0.05). Furthermore, the number of toggle cycles and the maximal load required to reach 2 mm of displacement were significantly greater in screws with augmentation than in those without augmentation (106 ± 9 vs. 52 ± 10 cycles; 152 ± 4 N vs. 124 ± 5 N, p < 0.05).. Augmentation using HA granules significantly enhanced the rigidity of PPS fixation in the osteoporotic bone model. The present study suggested that novel augmentation with HA granules may be a useful technique for PPS fixation in patients with osteoporotic spine.

Topics: Biomechanical Phenomena; Bone Cements; Bone Substitutes; Durapatite; Feasibility Studies; Fracture Fixation, Internal; Humans; Lumbar Vertebrae; Materials Testing; Osteoporotic Fractures; Pedicle Screws; Spinal Fractures; Thoracic Vertebrae; Torque

The failure of osteoporotic fracture after internal fixation is mainly caused by the underlying bone loss and strength compromise. The aim of this study is to investigate whether absorbable internal fixation can provide adequate mechanical stability and a reduction in the incidence of failure of fixation caused by bone loss and stress shielding.. A low density cancellous bone model was selected to compare the insertion of screw (screw-in), removal of screw (screw -out) and pull - out strength of absorbable screw and metal screw. The long bone model of thin cortical bone was used to create the transverse fracture model. The model was fixed with absorbable plate-screw system and metal plate-screw system respectively. The fatigue test and static bending test were compared. Moreover, the size of screw hole area was assessed.. The maximal screw - in and screw - out torque of the absorbable screw was significantly greater than that of the metal screw (P < 0.05), but there was no significant difference in pull-out test (P > 0.05). No visible failure occurred in fatigue test. There was no significant difference between the maximum load of static bending test (P > 0.05). The screw hole area of absorbable samples was significantly smaller than that of metal samples (P < 0.05).. In this experimental set-up it was found that the stability of absorbable screws in osteoporotic bone was better than metal screws. The absorbable system tested can achieve good stability, and the destruction of osteoporotic bone is small, which can reduce the occurrence of bone failure. Considering that absorbable material avoids the need of second surgery (implant removal) and reduces the stress shielding effect, we believe that absorbable internal fixation can be considered for fixation treatment of osteoporotic fractures.

Topics: Biomechanical Phenomena; Bone Screws; Compressive Strength; Fracture Fixation, Internal; Humans; Materials Testing; Models, Anatomic; Osteoporotic Fractures; Torque

Screw stripping is a common situation in fracture fixation, particularly in osteopenic bone treatment. Surgeons' perception of screw stripping is relatively poor and the real number of loose screws in every plate-screw construct is unknown. The biomechanical and clinical implications of the different possible screw-stripping situations are also unidentified. In this study, construct stiffness in different scenarios of stripped screws is investigated.. A bone surrogate comminuted osteoporotic fracture was fixed with four screws in both sides of the fracture gap in 75 specimens. In four groups, one or two screws closest or distal to the gap were over-tightened and left in place in one part of the construct and the remaining screws were tightened with 0.3N m torque (four groups). In the fifth group (control), all the screws were tightened with 0.3N m torque. Construct stiffness was tested in terms of compression, bending, and torsion for 1000 cycles.. When one or two screws closest to the gap were stripped, stiffness only decreased by, respectively, 5.7% or 7.6% under compression and 4.7% or 6.7% under bending; however, stiffness in torsion was 15.1% or 32%, respectively, lower than the initial stiffness. When a screw distal to the gap was stripped, the stiffness decreased by 28% under bending and 10% under compression; no change was noted under torsion. When two screws distal to the gap were stripped, the stiffness decreased by 11% in compression, collapsed under bending, and decreased by 8% under torsion.. Position and number of stripped screws affect the biomechanical properties of a construct in different ways, depending on the acting forces.

Topics: Analysis of Variance; Biomechanical Phenomena; Bone and Bones; Bone Plates; Bone Screws; Equipment Design; Fracture Fixation, Internal; Fractures, Comminuted; Humans; Osteoporotic Fractures; Stress, Mechanical; Tensile Strength; Torque

Screw anchorage in osteoporotic bone is still limited and makes treatment of osteoporotic fractures challenging for surgeons. Conventional screws fail in poor bone quality due to loosening at the screw-bone interface. A new technology should help to improve this interface. In a novel constant amelioration process technique, a polymer sleeve is melted by ultrasound in the predrilled screw hole prior to screw insertion. The purpose of this study was to investigate in vitro the effect of the constant amelioration process platform technology on primary screw anchorage.. Fresh frozen femoral heads (n=6) and vertebrae (n=6) were used to measure the maximum screw insertion torque of reference and constant amelioration process augmented screws. Specimens were cut in cranio-caudal direction, and the screws (reference and constant amelioration process) were implanted in predrilled holes in the trabecular structure on both sides of the cross section. This allowed the pairwise comparison of insertion torque for constant amelioration process and reference screws (femoral heads n=18, vertebrae n=12). Prior to screw insertion, a micro-CT scan was made to ensure comparable bone quality at the screw placement location.. The mean insertion torque for the constant amelioration process augmented screws in both, the femoral heads (44.2 Ncm, SD 14.7) and the vertebral bodies (13.5 Ncm, SD 6.3) was significantly higher than for the reference screws of the femoral heads (31.7 Ncm, SD 9.6, p<0.001) and the vertebral bodies (7.1 Ncm, SD 4.5, p<0.001).. The interconnection of the melted polymer sleeve with the surrounding trabecular bone in the constant amelioration process technique resulted in a higher screw insertion torque and can improve screw anchorage in osteoporotic trabecular bone.

Topics: Aged; Biomechanical Phenomena; Bone Screws; Cadaver; Equipment Design; Equipment Failure; Femur Head; Humans; Osteoporotic Fractures; Polymers; Spine; Torque; Ultrasonography

Sacroiliac screw fixation in elderly patients with pelvic fractures is prone to failure owing to impaired bone quality. Cement augmentation has been proposed as a possible solution, because in other anatomic areas this has been shown to reduce screw loosening. However, to our knowledge, this has not been evaluated for sacroiliac screws.. We investigated the potential biomechanical benefit of cement augmentation of sacroiliac screw fixation in a cadaver model of osteoporotic bone, specifically with respect to screw loosening, construct survival, and fracture-site motion.. Standardized complete sacral ala fractures with intact posterior ligaments in combination with ipsilateral upper and lower pubic rami fractures were created in osteoporotic cadaver pelves and stabilized by three fixation techniques: sacroiliac (n = 5) with sacroiliac screws in S1 and S2, cemented (n = 5) with addition of cement augmentation, and transsacral (n = 5) with a single transsacral screw in S1. A cyclic loading protocol was applied with torque (1.5 Nm) and increasing axial force (250-750 N). Screw loosening, construct survival, and sacral fracture-site motion were measured by optoelectric motion tracking. A sample-size calculation revealed five samples per group to be required to achieve a power of 0.80 to detect 50% reduction in screw loosening.. Screw motion in relation to the sacrum during loading with 250 N/1.5 Nm was not different among the three groups (sacroiliac: 1.2 mm, range, 0.6-1.9; cemented: 0.7 mm, range, 0.5-1.3; transsacral: 1.1 mm, range, 0.6-2.3) (p = 0.940). Screw subsidence was less in the cemented group (3.0 mm, range, 1.2-3.7) compared with the sacroiliac (5.7 mm, range, 4.7-10.4) or transsacral group (5.6 mm, range, 3.8-10.5) (p = 0.031). There was no difference with the numbers available in the median number of cycles needed until failure; this was 2921 cycles (range, 2586-5450) in the cemented group, 2570 cycles (range, 2500-5107) for the sacroiliac specimens, and 2578 cycles (range, 2540-2623) in the transsacral group (p = 0.153). The cemented group absorbed more energy before failure (8.2 × 10. The addition of cement to standard sacroiliac screw fixation seemed to change the mode and dynamics of failure in this cadaveric mechanical model. Although no advantages to cement were observed in terms of screw motion or cycles to failure among the different constructs, a cemented, two-screw sacroiliac screw construct resulted in less screw subsidence and greater energy absorbed to failure than an uncemented single transsacral screw.. In osteoporotic bone, the addition of cement to sacroiliac screw fixation might improve screw anchorage. However, larger mechanical studies using these findings as pilot data should be performed before applying these preliminary findings clinically.

Topics: Aged; Aged, 80 and over; Biomechanical Phenomena; Bone Cements; Bone Screws; Cadaver; Fracture Fixation, Internal; Humans; Ilium; Osteoporotic Fractures; Prosthesis Design; Prosthesis Failure; Pubic Bone; Sacrum; Spinal Fractures; Stress, Mechanical; Torque

Fragility hip fractures are increasingly common and hemiarthroplasty is one of the standard treatments. Although a common surgery, it should be performed with great caution because of the poor premorbid and bone quality in this demographic. Intra-operative fractures can occur while attempting press fit of the femoral implant. However; vigilance often steps down once the implant is secured and the hip reduced. This case report reminds surgeons that a large amount of torque can be transmitted during intra-operative positioning, such as during an attempt of hip dislocation. This torque, in addition to the risk factor of osteoporotic bone, can result in iatrogenic fractures. Published literature regarding management of an intra-operative fracture while the prosthetic hip is still reduced is lacking. The authors propose that temporary prophylactic cerclage wiring is a prudent and safe procedure prior to hip dislocation.

Topics: Aged, 80 and over; Bone Wires; Female; Femoral Neck Fractures; Hemiarthroplasty; Hip Dislocation; Humans; Intraoperative Complications; Male; Osteoporotic Fractures; Periprosthetic Fractures; Prosthesis Failure; Risk Factors; Torque

Osteoporotic bone with poor mechanical capacity provides limited stability after fixation of ankle fractures. Stabilization with an implant providing increased fixation strength in osteoporotic bone could reduce failure rates of fixation and allow a more functional treatment. The purpose of this study was to evaluate a locking contoured plate for fixation of distal fibular fractures in comparison with a conventional contoured plate in an osteoporotic bone model. Eighty cylinders of osteoporotic bone surrogates were fixed with the two plates. We performed torque-to-failure and cyclic testing experiments using screws of different length with a Zwick/Roell testing machine. The locking system showed higher torque-to-failure and maximum torque levels as compared with the conventional plate in torque-to-failure experiments and torsional cyclic testing. The locking contoured plate provides improved fixation strength in the osteoporotic bone model. The locking system may be appropriate for fixation of distal fibular fractures, especially in osteoporotic bone with poor mechanical capacity.

Topics: Ankle Fractures; Bone Plates; Bone Screws; Compressive Strength; Equipment Design; Equipment Failure Analysis; Fibula; Fracture Fixation, Internal; Friction; Humans; Osteoporotic Fractures; Tensile Strength; Torque

Bone cement augmentation of modified cannulated locking screws shows biomechanically and clinically good results for osteoporotic fracture management. Nevertheless, complications need to be considered. Therefore implant removal should be tested for feasibility.. Implant removal was simulated in 7 pairs of osteoporotic cadaveric humeri: During screw removal from an angular stable proximal humerus plate, we measured the maximum torque of 14 augmented screws and the corresponding 14 non-augmented screws on the contralateral humeri. After screw removal, specimens were cut along the screw axes to macroscopically investigate the impact of screw removal on the surrounding bone. In addition, we established a technique for cement removal in cases in which the screw head is obstructed with cement and therefore disables the insertion of the screwdriver.. The screw extraction torque measurements showed no significant differences between the two groups regarding one screw (screw 4 augmented: 1.52Nm, SD 0.25Nm vs. screw 4 non-augmented: 1.80Nm, SD 0.40Nm; P=0.20), whereas torque values for the second screw in the augmented group were lower than in the control group (screw 5 augmented: 0.72Nm, 0.31Nm vs. screw 5 non-augmented: 1.42Nm, 0.52Nm; P=0.009). Macroscopy of the bone showed no damage to the trabeculae within the humeral head due to the removal.. The removal of cannulated, polymethylmethacrylate-augmented, 2.8mm titanium screws from an angular stable plate was uncomplicated, without the need for special instruments or increased torque for screw removal. No additional damage was visible at the bone-cement interface.

Topics: Biomechanical Phenomena; Bone Cements; Bone Plates; Bone Screws; Cadaver; Device Removal; Feasibility Studies; Female; Fracture Fixation, Internal; Humans; Humeral Head; Osteoporosis; Osteoporotic Fractures; Polymethyl Methacrylate; Reoperation; Shoulder Fractures; Torque

To determine whether locking plates offer an advantage in fixation of fractures in osteoporotic humeral bone.. Biomechanical testing of 18 matched pairs of osteoporotic human cadaver humeri plated posteriorly with either all locked or all nonlocked screws. An established protocol was used to test the constructs with torque applied to a peak of ±10 Nm for 1000 cycles at 0.3 Hz or until failure. Eighteen pairs were tested for failure, 11 pairs were tested for cycles survived, and 10 pairs were tested for stiffness.. University biomechanical laboratory.. Percentage surviving testing, mean cycles survived, and stiffness.. We observed catastrophic failure of the constructs in 47% of the samples. Humeri plated with nonlocking plates failed at a higher rate than those with locking plates (67% nonlocking vs 28% locking, n = 18 pairs, P = 0.008). Locking constructs also outperformed nonlocking constructs in mean cycles survived (707 cycles locking, 345 cycles nonlocking, n = 11 pairs, P < 0.05) and stiffness at 10 cycles (0.853 Nm/degree locking vs 0.416 Nm/degree nonlocking, n = 10 pairs, P < 0.001).. Locking plates were shown to provide improved mechanical performance over nonlocking plates in torsional cyclic loading in a osteoporotic cadaveric fracture model. Our results confirm general conclusions of previous work that used a synthetic bone model of osteoporosis, but we found a high rate of catastrophic failure, questioning the validity of the previously published synthetic model of osteoporosis (overdrilling of synthetic bone) for this application.

Topics: Aged; Aged, 80 and over; Bone Plates; Bone Screws; Cadaver; Equipment Design; Equipment Failure; Equipment Failure Analysis; Female; Fracture Fixation, Internal; Humans; Humeral Fractures; Male; Middle Aged; Osteoporotic Fractures; Tensile Strength; Torque; Treatment Outcome

To examine the impact of number and position of locking screws in the diaphyseal portion of an osteoporotic distal femoral fracture model with hybrid fixation.. Four groups containing 5 osteoporotic bone models were used with varying combinations of diaphyseal screw fixation: 4 nonlocking screws (control); 1 locking screw adjacent to the osteotomy and 3 nonlocking screws; 1 locking screw in the most proximal screw hole of the plate and 3 nonlocking screws; and 2 locking screws at opposite ends of the diaphyseal fixation with 2 nonlocking screws in between. Fixation in the distal articular segment was identical in all constructs. Testing was performed for 50,000 cycles at 2 Hz using simultaneous axial compression (700 N) and bidirectional torque (±5 Nm) applied along the long axis of the bone. All screws were inserted with 4 Nm of torque.. The extraction torque for nonlocking screws in those specimens that had a locking screw nearest the osteotomy was significantly greater than those that did not (P = 0.037). In addition, the 10 constructs with a locking screw nearest the osteotomy had no failures compared with 5 of 10 failures in those without a locking screw in this position (P = 0.033).. The placement of a locking screw adjacent to the osteotomy was more beneficial in protecting against failure and maintaining the extraction torque of neighboring proximal nonlocking screws. No benefit in adjacent screw extraction torque was seen with a locking screw proximal in the diaphysis. Two locking screws at opposite ends of the diaphyseal fixation were not superior to a single locking screw adjacent to the osteotomy in failure rates or screw extraction torque.

Topics: Bone Screws; Femoral Fractures; Fracture Fixation, Internal; Humans; Models, Biological; Osteoporotic Fractures; Torque

After surgical treatment of osteoporotic hip fractures, complications such as implant cut-out are reported to be high and implant failure often is associated with poor bone quality. As augmentation is reported to enhance implant anchorage, the aim of our study was to investigate the effect of bone cement augmentation on the rotational stability and the pull-out resistance of the Proximal Femur Nail Antirotation™ (PFNa) blade.. A total of 18 fresh-frozen femoral heads (mean age 68 years, standard deviation (SD) 8.2) were scanned with quantitative computed tomography (qCT) for bone mineral density (BMD) measurements and instrumented with a PFNa blade. Nine specimens were augmented with a mean volume of 4.4 ml Traumacem V+. After cement consolidation, the blade was rotated for 60° for the rotational test. Subsequently, the blade was extracted from the specimens. Force, torque, displacement and angle were recorded constantly.. In the rotational test, the mean maximum torque in the augmented group (17.2 Nm, SD 5.0) was significantly higher (p=0.017) than in the non-augmented group (11.7 Nm, SD 3.5). The pull-out test also yielded a significant difference (p=0.047) between the augmented (maximum pullout force: 2315.2N, SD 1060.6) and the non-augmented group (1180.4N, SD 1171.4).. Augmentation of femoral heads yielded a significantly superior rotational stability, as well as an enhanced pull-out resistance, compared to the non-augmented state. However, the higher the BMD of the specimens, the lower was the effect of augmentation on the rotational stability. Therefore, augmentation can be a good clinical tool to enhance implant anchorage in osteoporotic bone.

Topics: Aged; Aged, 80 and over; Analysis of Variance; Biomechanical Phenomena; Bone Cements; Bone Density; Bone Nails; Bone Screws; Female; Femur Head; Humans; Male; Materials Testing; Osteoporotic Fractures; Polymethyl Methacrylate; Prosthesis Failure; Rotation; Tomography, X-Ray Computed; Torque