vendex and Myositis

The effect of instrument-assisted soft tissue mobilization (ISTM) on passive properties and inflammation in human skeletal muscle has not been evaluated. Passive properties of muscle, inflammatory myokines and subjective reporting of functional ability were used to identify the effects of ISTM on the plantar flexors. 11 healthy men were measured for passive musculotendinous stiffness (MTS), passive range of motion (PROM), passive resistive torque (PASTQ) and maximum voluntary contraction peak torque (MVCPT) for plantar flexor muscles of the lower leg. Interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) were measured from muscle biopsies from the gastrocnemius, and subjective measurements of functional ability were taken using the perception of functional ability questionnaire (PFAQ). MTS, PROM, PRT and MVCPT were measured in the treatment leg (TL) and control leg (CL) before, immediately after, 24 h, 48 h and 72 h following IASTM. Biopsies for IL-6 and TNF-α and PFAQ responses were collected before as well as 24 h, 48 h and 72 h after IASTM. There were no significant differences in MTS, PROM, PASTQ, MVCPT, IL-6 and TNF-α between the TL or CL. A significant decrease in the perception of function and a significant increase in pain for the TL were found following IASTM.

Topics: Activities of Daily Living; Adult; Electromyography; Exercise; Foot Injuries; Humans; Interleukin-6; Male; Muscle Contraction; Muscle, Skeletal; Myositis; Range of Motion, Articular; Therapy, Soft Tissue; Torque; Tumor Necrosis Factor-alpha; Young Adult

The purpose of this study was to determine if a moderate intensity whole-body vibration (WBV) body mass resistive exercise session causes additional muscle damage, soreness, and inflammation compared with the same exercise session without vibration (NoV). Ten recreationally active male university students completed 2 separate 24-hour study periods incorporating an exercise session with WBV or NoV. Muscle torque was measured (at 0, 60, and 240°·s-1 angular velocities), soreness (10-point scale) in the upper (UE [triceps]) and lower (LE [quadriceps]) extremities, and muscle inflammation markers (interleukin [IL]-1β, IL-6, IL-10) were measured at 4 time points (preexercise, immediately postexercise, 4 hours post, and 24 hours post). Diet was controlled. Compared with NoV, WBV increased (p < 0.01) muscle soreness at 24 hours postexercise in both the UE (2.2 ± 1.7 vs. 0.6 ± 0.9) and LE (2.0 ± 1.5 vs. 0.7 ± 0.7). Muscle torque was decreased immediately postexercise (p < 0.05) in the UE and LE at 0°·s and in the UE at 240°·s, but there was no difference between exercise treatments. The exercise session caused significant but small increases in IL-1β and IL-6 but with no differences between exercise treatments. Interleukin-10 was increased with WBV (2.9 ± 2.0 to 3.6 ± 1.9 pg·ml-1; p < 0.03). These data suggest that the addition of WBV to exercise has little effect on muscle function and damage, soreness, or inflammation.

Topics: Adult; Arm; Biomechanical Phenomena; Humans; Interleukin-10; Interleukin-1beta; Interleukin-6; Isometric Contraction; Male; Myalgia; Myositis; Physical Conditioning, Human; Quadriceps Muscle; Resistance Training; Torque; Vibration; Young Adult

The purpose of this study was to examine the time-course and relationships of technetium-99m (99mTc) neutrophils in muscle, interleukin-6 (IL-6), myosin heavy chain fragments (MHC), eccentric torque, and delayed onset muscle soreness (DOMS) following eccentric exercise in humans. Twelve male subjects completed a pre-test DOMS questionnaire, performed a strength test and had 100 ml blood withdrawn for analysis of plasma IL-6 and MHC content. The neutrophils were separated, labelled with 99mTc, and re-infused into the subjects immediately before the exercise. Following 300 eccentric repetitions of the right quadriceps muscles on an isokinetic dynamometer, the subjects had 10 ml of blood withdrawn with repeated the eccentric torque exercise tests and DOMS questionnaire at 0, 2, 4, 6, 20, 24, 48, 72 h, and 6 and 9 days. Bilateral images of the quadriceps muscles were taken at 2, 4, and 6 h. Computer analysis of regions of interest was used to determine the average count per pixel. The 99mTc neutrophils and IL-6 increased up to 6 h post-exercise (P < 0.05). The neutrophils were greater in the exercised muscle than the non-exercised muscle (P < 0.01). The DOMS was increased from 0 to 48 h, eccentric torque decreased from 2 to 24 h, and MHC peaked at 72 h post-exercise (P < 0.001). Significant relationships were found between IL-6 and 2 h and DOMS at 24 h post-exercise (r = 0.68) and assessment of the magnitude of change between IL-6 and MHC (r = 0.66). These findings suggest a relationship between damage to the contractile proteins and inflammation, and that DOMS is associated with inflammation but not with muscle damage.

Topics: Adult; Biomarkers; Humans; Interleukin-6; Male; Myofibrils; Myosin Heavy Chains; Myositis; Neutrophils; Pain; Physical Exertion; Technetium; Torque