vendex and Hemolysis

vendex has been researched along with Hemolysis* in 4 studies

Other Studies

4 other study(ies) available for vendex and Hemolysis

ArticleYear
Numerical and Experimental Approach to Characterize a BLDC Motor with Different Radial-gap to Improve Hemocompatibility Performance.
    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2020, Volume: 2020

    Left ventricular assist devices (LVADs) have increasingly been used clinically to treat heart failure patients. However, hemolysis, pump thrombosis, infection and bleeding still persist as major limitations of LVAD technology. Assessing LVAD hemocompatibility using a blood shear stress device (BSSD) has clear advantages, as the BSSD could provide a better experimental platform to develop reliable, quantifiable blood trauma assays to perform iterative testing of LVAD designs. In this study, a BSSD was proposed with short blood exposure time and no seals or contact bearings to reduce blood trauma caused by the test platform. Enlarged air-gap drive motor in BSSD is essential to avoid high shear stress; however, it would significantly reduce the motor torque, which may result in inadequate force to drive the entire system. In order to evaluate and optimize the drive motor air-gap to ensure adequate motor torque as well as acceptable range for blood exposure time and shear stress, a numerical brushless DC (BLDC) motor model was established using finite element method (FEM) in numerical simulation software COMSOL. The model was first validated by the experimental results. Then numerical model with different air-gap was evaluated on the torque and speed constant changes. In the end, two equations were generated based on the curves derived from the torque and speed constant calculations. Determining these relationships between motor performance and motor air-gap will facilitate the development of an appropriate BLDC motor size for the BSSD, considering the design limitations in our future work.

    Topics: Animals; Heart Failure; Heart-Assist Devices; Hemolysis; Humans; Stress, Mechanical; Torque

2020
A magnetically levitated centrifugal blood pump with a simple-structured disposable pump head.
    Artificial organs, 2008, Volume: 32, Issue:7

    A magnetically levitated centrifugal blood pump (MedTech Dispo) has been developed for use in a disposable extracorporeal system. The design of the pump is intended to eliminate mechanical contact with the impeller, to facilitate a simple disposable mechanism, and to reduce the blood-heating effects that are caused by motors and magnetic bearings. The bearing rotor attached to the impeller is suspended by a two degrees-of-freedom controlled radial magnetic bearing stator, which is situated outside the rotor. In the space inside the ringlike rotor, a magnetic coupling disk is placed to rotate the rotor and to ensure that the pump head is thermally isolated from the motor. In this system, the rotor can exhibit high passive stiffness due to the novel design of the closed magnetic circuits. The disposable pump head, which has a priming volume of 23 mL, consists of top and bottom housings, an impeller, and a rotor with a diameter of 50 mm. The pump can provide a head pressure of more than 300 mm Hg against a flow of 5 L/min. The normalized index of hemolysis of the MedTech Dispo is 0.0025 +/- 0.0005 g/100 L at 5 L/min against 250 mm Hg. This is one-seventh of the equivalent figure for a Bio Pump BPX-80 (Medtronic, Inc., Minneapolis, MN, USA), which has a value of 0.0170 +/- 0.0096 g/100 L. These results show that the MedTech Dispo offers high pumping performance and low blood trauma.

    Topics: Centrifugation; Disposable Equipment; Heart-Assist Devices; Hemolysis; Humans; Magnetics; Prosthesis Design; Torque

2008
VentrAssist hydrodynamically suspended, open, centrifugal blood pump.
    Artificial organs, 2000, Volume: 24, Issue:6

    A novel design is presented for an implantable centrifugal blood pump in which hydrodynamic forces acting on tapered edges of thick blades are used to suspend the impeller. The pump has no shaft, seals, or "spiders" and has clean flow lines with no stagnant zones. At 5 L/min and 100 mm Hg differential pressure, the measured hemolysis was in the range NIH 0.002-.005 g/100 L and the system efficiency was 19%.

    Topics: Animals; Centrifugation; Dogs; Electromagnetic Phenomena; Equipment Design; Heart-Assist Devices; Hemolysis; Hemorheology; Titanium; Torque

2000
Measurements of gap pressure and wall shear stress of a blood pump model.
    Medical engineering & physics, 2000, Volume: 22, Issue:3

    The centrifugal blood pump with a magnetically suspended impeller has shown its superiority as compared to other artificial hearts. However, there is still insufficient understanding of fluid mechanics related issues in the clearance gap. The design nature of the pump requires sufficient washout in the clearance between the impeller and stationary surfaces. As the gap is only 0.2 mm in width, it is very difficult to conduct measurements with present instrumentation. An enlarged model with 5:1 ratio of the pump has been designed and constructed according to specifications. Dimensionless gap pressure measurements of the model are very close to the prototype. The measurements of wall shear stress of the fluid flow in the clearance gap between the impeller face and inlet casing of a blood pump model were accomplished through hot-wire anemometry and rotating disk apparatus. Regions of relatively high and low shear stresses are identified. These correspond to spots where the likelihood of hemolysis and thrombus formation is high. With the use of dimensional analysis, it is found that the highest wall shear stress is equivalent to 146 Pa which is much lower than the threshold value of 400 Pa for hemolysis reported in the literature.

    Topics: Blood Flow Velocity; Calibration; Equipment Design; Heart, Artificial; Hemolysis; Hemorheology; Humans; Laser-Doppler Flowmetry; Materials Testing; Pressure; Stress, Mechanical; Thrombosis; Torque; Transducers, Pressure

2000