Page last updated: 2024-10-28

velnacrine and Liver Neoplasms

velnacrine has been researched along with Liver Neoplasms in 1 studies

velnacrine: RN given refers to (+-)-isomer; RN for cpd without isomeric designation not available 8/88; structure in first source; potential Alzheimer's disease drug but trial halted due to abnormal liver tests

Liver Neoplasms: Tumors or cancer of the LIVER.

Research Excerpts

ExcerptRelevanceReference
"Clinical trials with tacrine (THA) and its principal (1-OH) metabolite (velnacrine) for the treatment of Alzheimer's disease have been hampered by adverse hepatic events that were undetected in preclinical studies."1.29Cytotoxicity of tacrine and velnacrine metabolites in cultured rat, dog and human hepatocytes. ( Curren, RD; Viau, CJ; Wallace, K, 1993)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Viau, CJ1
Curren, RD1
Wallace, K1

Other Studies

1 other study available for velnacrine and Liver Neoplasms

ArticleYear
Cytotoxicity of tacrine and velnacrine metabolites in cultured rat, dog and human hepatocytes.
    Drug and chemical toxicology, 1993, Volume: 16, Issue:3

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Cells, Cultur

1993