velnacrine has been researched along with Liver Dysfunction in 2 studies
velnacrine: RN given refers to (+-)-isomer; RN for cpd without isomeric designation not available 8/88; structure in first source; potential Alzheimer's disease drug but trial halted due to abnormal liver tests
Excerpt | Relevance | Reference |
---|---|---|
" Direct liver injury, possibly associated with the production of a toxic metabolite, would be consistent with reports of aberrant xenobiotic metabolism in Alzheimer's disease patients." | 2.67 | Clinical trials with velnacrine: (PROPP) the physician reference of predicted probabilities--a statistical model for the estimation of hepatotoxicity risk with velnacrine maleate. ( Hardiman, S; Miller, K; Murphy, M, 1993) |
"Clinical trials with tacrine (THA) and its principal (1-OH) metabolite (velnacrine) for the treatment of Alzheimer's disease have been hampered by adverse hepatic events that were undetected in preclinical studies." | 1.29 | Cytotoxicity of tacrine and velnacrine metabolites in cultured rat, dog and human hepatocytes. ( Curren, RD; Viau, CJ; Wallace, K, 1993) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 2 (100.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Hardiman, S | 1 |
Miller, K | 1 |
Murphy, M | 1 |
Viau, CJ | 1 |
Curren, RD | 1 |
Wallace, K | 1 |
1 trial available for velnacrine and Liver Dysfunction
Article | Year |
---|---|
Clinical trials with velnacrine: (PROPP) the physician reference of predicted probabilities--a statistical model for the estimation of hepatotoxicity risk with velnacrine maleate.
Topics: Age Factors; Aged; Alzheimer Disease; Chemical and Drug Induced Liver Injury; Cholinesterase Inhibit | 1993 |
1 other study available for velnacrine and Liver Dysfunction
Article | Year |
---|---|
Cytotoxicity of tacrine and velnacrine metabolites in cultured rat, dog and human hepatocytes.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Cells, Cultur | 1993 |