Page last updated: 2024-10-28

velnacrine and Liver Dysfunction

velnacrine has been researched along with Liver Dysfunction in 2 studies

velnacrine: RN given refers to (+-)-isomer; RN for cpd without isomeric designation not available 8/88; structure in first source; potential Alzheimer's disease drug but trial halted due to abnormal liver tests

Research Excerpts

ExcerptRelevanceReference
" Direct liver injury, possibly associated with the production of a toxic metabolite, would be consistent with reports of aberrant xenobiotic metabolism in Alzheimer's disease patients."2.67Clinical trials with velnacrine: (PROPP) the physician reference of predicted probabilities--a statistical model for the estimation of hepatotoxicity risk with velnacrine maleate. ( Hardiman, S; Miller, K; Murphy, M, 1993)
"Clinical trials with tacrine (THA) and its principal (1-OH) metabolite (velnacrine) for the treatment of Alzheimer's disease have been hampered by adverse hepatic events that were undetected in preclinical studies."1.29Cytotoxicity of tacrine and velnacrine metabolites in cultured rat, dog and human hepatocytes. ( Curren, RD; Viau, CJ; Wallace, K, 1993)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hardiman, S1
Miller, K1
Murphy, M1
Viau, CJ1
Curren, RD1
Wallace, K1

Trials

1 trial available for velnacrine and Liver Dysfunction

ArticleYear
Clinical trials with velnacrine: (PROPP) the physician reference of predicted probabilities--a statistical model for the estimation of hepatotoxicity risk with velnacrine maleate.
    Acta neurologica Scandinavica. Supplementum, 1993, Volume: 149

    Topics: Age Factors; Aged; Alzheimer Disease; Chemical and Drug Induced Liver Injury; Cholinesterase Inhibit

1993

Other Studies

1 other study available for velnacrine and Liver Dysfunction

ArticleYear
Cytotoxicity of tacrine and velnacrine metabolites in cultured rat, dog and human hepatocytes.
    Drug and chemical toxicology, 1993, Volume: 16, Issue:3

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Cells, Cultur

1993