velnacrine has been researched along with Aging in 2 studies
velnacrine: RN given refers to (+-)-isomer; RN for cpd without isomeric designation not available 8/88; structure in first source; potential Alzheimer's disease drug but trial halted due to abnormal liver tests
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "4) Velnacrine was shown to bind to both albumin and alpha 1-acid glycoprotein, but together they did not account for total binding." | 2.68 | Variability in the plasma protein binding of velnacrine (1-hydroxy tacrine hydrochloride). A potential agent for Alzheimer's disease. ( Ford, JM; Roberts, CJ; Wood, DM, 1996) |
| "Velnacrine maleate is a novel, orally active acetylcholinesterase inhibitor of the acridine class with a longer duration of action than physostigmine." | 1.29 | Velnacrine maleate improves delayed matching performance by aged monkeys. ( Buccafusco, JJ; Jackson, WJ; Rush, DK; Terry, AV; Turk, DJ, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jackson, WJ | 1 |
| Buccafusco, JJ | 1 |
| Terry, AV | 1 |
| Turk, DJ | 1 |
| Rush, DK | 1 |
| Wood, DM | 1 |
| Ford, JM | 1 |
| Roberts, CJ | 1 |
1 trial available for velnacrine and Aging
| Article | Year |
|---|---|
Variability in the plasma protein binding of velnacrine (1-hydroxy tacrine hydrochloride). A potential agent for Alzheimer's disease.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Binding, Compet | 1996 |
1 other study available for velnacrine and Aging
| Article | Year |
|---|---|
Velnacrine maleate improves delayed matching performance by aged monkeys.
Topics: Aging; Alzheimer Disease; Animals; Behavior, Animal; Cholinesterase Inhibitors; Dose-Response Relati | 1995 |