velnacrine has been researched along with Acute Liver Injury, Drug-Induced in 4 studies
velnacrine: RN given refers to (+-)-isomer; RN for cpd without isomeric designation not available 8/88; structure in first source; potential Alzheimer's disease drug but trial halted due to abnormal liver tests
| Excerpt | Relevance | Reference |
|---|---|---|
| " Direct liver injury, possibly associated with the production of a toxic metabolite, would be consistent with reports of aberrant xenobiotic metabolism in Alzheimer's disease patients." | 2.67 | Clinical trials with velnacrine: (PROPP) the physician reference of predicted probabilities--a statistical model for the estimation of hepatotoxicity risk with velnacrine maleate. ( Hardiman, S; Miller, K; Murphy, M, 1993) |
| " The two drugs are special as the dosage of them is guided mainly by side effects and not by therapeutic effects in contrast to most drugs used for psychiatric disorders." | 2.38 | Side effects of long acting cholinesterase inhibitors. ( Beermann, B, 1993) |
| "Clinical trials with tacrine (THA) and its principal (1-OH) metabolite (velnacrine) for the treatment of Alzheimer's disease have been hampered by adverse hepatic events that were undetected in preclinical studies." | 1.29 | Cytotoxicity of tacrine and velnacrine metabolites in cultured rat, dog and human hepatocytes. ( Curren, RD; Viau, CJ; Wallace, K, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hardiman, S | 1 |
| Miller, K | 1 |
| Murphy, M | 1 |
| Beermann, B | 1 |
| Viau, CJ | 1 |
| Curren, RD | 1 |
| Wallace, K | 1 |
| Shutske, GM | 1 |
| Pierrat, FA | 1 |
| Cornfeldt, ML | 1 |
| Szewczak, MR | 1 |
| Huger, FP | 1 |
| Bores, GM | 1 |
| Haroutunian, V | 1 |
| Davis, KL | 1 |
1 review available for velnacrine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Side effects of long acting cholinesterase inhibitors.
Topics: Alzheimer Disease; Chemical and Drug Induced Liver Injury; Cholinesterase Inhibitors; Clinical Trial | 1993 |
1 trial available for velnacrine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Clinical trials with velnacrine: (PROPP) the physician reference of predicted probabilities--a statistical model for the estimation of hepatotoxicity risk with velnacrine maleate.
Topics: Age Factors; Aged; Alzheimer Disease; Chemical and Drug Induced Liver Injury; Cholinesterase Inhibit | 1993 |
2 other studies available for velnacrine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cytotoxicity of tacrine and velnacrine metabolites in cultured rat, dog and human hepatocytes.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Cells, Cultur | 1993 |
(+/-)-9-Amino-1,2,3,4-tetrahydroacridin-1-ol. A potential Alzheimer's disease therapeutic of low toxicity.
Topics: Alzheimer Disease; Aminoacridines; Animals; Chemical and Drug Induced Liver Injury; Chemical Phenome | 1988 |