vedelianin has been researched along with Ovarian-Neoplasms* in 1 studies
1 other study(ies) available for vedelianin and Ovarian-Neoplasms
| Article | Year |
|---|---|
Antiproliferative prenylated stilbenes and flavonoids from Macaranga alnifolia from the Madagascar rainforest.
Bioassay-guided fractionation of an extract of the fruit of Macaranga alnifolia from Madagascar led to the isolation of four new prenylated stilbenes, schweinfurthins E-H (1-4), and one new geranylated dihydroflavonol, alnifoliol (5). The known prenylated stilbene vedelianin (6) and the known geranylated flavonoids bonanniol A (7), diplacol (8), bonannione A (9), and diplacone (10) were also isolated. All 10 compounds were tested for antiproliferative activity in the A2780 human ovarian cancer cell line assay. Vedelianin (IC50 = 0.13 microM) exhibited the greatest activity among all isolates, while schweinfurthin E (IC50 = 0.26 microM) was the most potent of the new compounds. Topics: Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Euphorbiaceae; Female; Flavonoids; Humans; Madagascar; Ovarian Neoplasms; Plants, Medicinal; Stilbenes; Tumor Cells, Cultured | 2007 |