ve-821 and Cell-Transformation--Neoplastic

Ataxia telangiectasia and Rad3-related (ATR) threonine serine kinase is one of the key elements in orchestrating the DNA damage response (DDR). As such, inhibition of ATR can amplify the effects of chemo- and radiation-therapy, and several ATR inhibitors (ATRi) have already undergone clinical testing in cancer. For more accurate patient selection, monitoring and staging, real-time in vivo imaging of ATR could be invaluable; the development of appropriate imaging agents has remained a major challenge.. 3-amino-N-(4-[. [

Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Brain Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; Fluorine Radioisotopes; Humans; Hydrophobic and Hydrophilic Interactions; Mice; Positron-Emission Tomography; Protein Kinase Inhibitors; Pyrazines; Radioactive Tracers; Radiochemistry; Sulfones; Tissue Distribution