vaxfectin and Encephalitis--Japanese

vaxfectin has been researched along with Encephalitis--Japanese* in 1 studies

Other Studies

1 other study(ies) available for vaxfectin and Encephalitis--Japanese

Article	Year
Enhancing effect of vaxfectin on the ability of a Japanese encephalitis DNA vaccine to induce neutralizing antibody in mice. Viral immunology, 2003, Volume: 16, Issue:2 Vaxfectin, a recently developed adjuvant, was evaluated for its enhancing effect on immunogenicity of a Japanese encephalitis (JE) DNA vaccine plasmid encoding the JE virus premembrane (prM) and envelope (E) genes (designated pcJEME), using BALB/c and ICR mice. Formulation of pcJEME with Vaxfectin provided > or =8-fold higher neutralizing antibody titers than those induced by pcJEME alone and reduced the amount of pcJEME to one-tenth to induce comparable levels of neutralizing antibody. Use of Vaxfectin did not alter a Th1 type IgG isotype immune response (IgG1 < IgG2a) induced by pcJEME in mice. These results indicate that Vaxfectin has an ability to enhance immunogenicity of pcJEME and is considered as a useful adjuvant for DNA vaccines in murine experimental models. Topics: Adjuvants, Immunologic; Animals; Antibodies, Viral; Encephalitis Virus, Japanese; Encephalitis, Japanese; Immunoglobulin G; Japanese Encephalitis Vaccines; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Neutralization Tests; Phosphatidylethanolamines; Vaccines, DNA	2003

Article

Year

Enhancing effect of vaxfectin on the ability of a Japanese encephalitis DNA vaccine to induce neutralizing antibody in mice.

Viral immunology, 2003, Volume: 16, Issue:2

Vaxfectin, a recently developed adjuvant, was evaluated for its enhancing effect on immunogenicity of a Japanese encephalitis (JE) DNA vaccine plasmid encoding the JE virus premembrane (prM) and envelope (E) genes (designated pcJEME), using BALB/c and ICR mice. Formulation of pcJEME with Vaxfectin provided > or =8-fold higher neutralizing antibody titers than those induced by pcJEME alone and reduced the amount of pcJEME to one-tenth to induce comparable levels of neutralizing antibody. Use of Vaxfectin did not alter a Th1 type IgG isotype immune response (IgG1 < IgG2a) induced by pcJEME in mice. These results indicate that Vaxfectin has an ability to enhance immunogenicity of pcJEME and is considered as a useful adjuvant for DNA vaccines in murine experimental models.

Topics: Adjuvants, Immunologic; Animals; Antibodies, Viral; Encephalitis Virus, Japanese; Encephalitis, Japanese; Immunoglobulin G; Japanese Encephalitis Vaccines; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Neutralization Tests; Phosphatidylethanolamines; Vaccines, DNA

2003