vasotocin--desgly(nh2)(9)d(ch2)5-tyr(me)(2)-thr(4)-orn(8)- and Myocardial-Infarction

vasotocin--desgly(nh2)(9)d(ch2)5-tyr(me)(2)-thr(4)-orn(8)- has been researched along with Myocardial-Infarction* in 1 studies

Other Studies

1 other study(ies) available for vasotocin--desgly(nh2)(9)d(ch2)5-tyr(me)(2)-thr(4)-orn(8)- and Myocardial-Infarction

ArticleYear
Central oxytocin modulation of acute stress-induced cardiovascular responses after myocardial infarction in the rat.
    Stress (Amsterdam, Netherlands), 2009, Volume: 12, Issue:6

    The present study was aimed at determining the role of centrally released oxytocin in regulation of blood pressure and heart rate (HR) under resting conditions and during an acute air-jet stress in rats with a myocardial infarction and controls infarcted. Four weeks after ligation of a coronary artery or sham surgery, conscious Sprague Dawley rats were subjected to one of the following intracerebroventricular (ICV) infusions: (1) 0.9% NaCl (control), (2) oxytocin, (3) oxytocin receptor antagonist {desGly-NH(2)-d(CH(2))(5)[D-Tyr(2)Thr(4)]OVT}(OXYANT). Resting arterial blood pressure and HR were not affected by any of the ICV infusions either in the infarcted or sham-operated rats. In the control experiments, the pressor and tachycardic responses to the air jet of infarcted rats were significantly greater than in the sham-operated rats. OXYANT significantly enhanced the cardiovascular responses to stress only in the sham-operated rats whereas oxytocin significantly attenuated both responses in the infarcted but not in the sham-operated rats. The results suggest that centrally released endogenous oxytocin significantly reduces the cardiovascular responses to the acute stressor in control rats. This buffering function of the brain-oxytocin system is not efficient during the post-myocardial infarction state, however it may be restored by central administration of exogenous oxytocin.

    Topics: Animals; Blood Pressure; Heart Rate; Injections, Intraventricular; Male; Myocardial Infarction; Ornipressin; Oxytocin; Rats; Rats, Sprague-Dawley; Receptors, Oxytocin; Stress, Physiological

2009