Compounds > vasopressin--1-deamino-4-val-8-arg-

vasopressin--1-deamino-4-val-8-arg- and Diabetes-Insipidus

vasopressin--1-deamino-4-val-8-arg- has been researched along with Diabetes-Insipidus* in 4 studies

Other Studies

4 other study(ies) available for vasopressin--1-deamino-4-val-8-arg- and Diabetes-Insipidus

ArticleYear
Effective antagonists of the antidiuretic action of vasopressin in rats.
    Annals of the New York Academy of Sciences, 1982, Volume: 394

    Topics: Adenylyl Cyclase Inhibitors; Animals; Arginine Vasopressin; Chemical Phenomena; Chemistry; Deamino Arginine Vasopressin; Diabetes Insipidus; Diuresis; Dose-Response Relationship, Drug; Oxytocin; Rats; Structure-Activity Relationship; Vasopressins

1982
Effects of vasopressin analogues (DDAVP, DVDAVP) in the form of sublingual tablets in central diabetes insipidus.
    International journal of clinical pharmacology, therapy, and toxicology, 1981, Volume: 19, Issue:2

    The effects of 1-deamino-8-D-arginine vasopressin (DDAVP), 1-deamino-4-valin-8-D-arginine vasopressin (DVDAVP) and 8-arginine vasopressin (AVP) on water metabolism have been examined in 18 patients suffering from central diabetes insipidus. The hormone derivatives were sublingually administered. It was established that DDAVP and DVDAVP significantly reduced diuresis and increased urine osmolarity. DVDAVP was found to be more effective than DDAVP. AVP administered in equal doses had no significant effect on water metabolism. The duration of the action of sublingually administered DDAVP was 12 hrs; after dosing DVDAVP the effect lasted even 6 hrs. During one week of DDAVP administration, the accumulation of the drug was indicated by the gradual decrease of diuresis and the increase of the urine osmolarity. The sublingual administration of both DDAVP and DVDAVP tablets (3 X 30 micrograms/day) had an adequate therapeutic effect.

    Topics: Adult; Aged; Arginine Vasopressin; Deamino Arginine Vasopressin; Diabetes Insipidus; Humans; Male; Middle Aged; Mouth Floor; Tablets; Valine; Vasopressins

1981
[Treatment of diabetes insipidus with synthetic vasopressin derivatives (effect of 1-deamino-8-D-arginine vasopressin and 1-deamino-valine-8-D-arginine vasopressin)].
    Orvosi hetilap, 1980, Mar-30, Volume: 121, Issue:13

    Topics: Adult; Aged; Arginine Vasopressin; Deamino Arginine Vasopressin; Diabetes Insipidus; Diuresis; Female; Humans; Male; Middle Aged; Valine

1980
Solid phase synthesis of (1-deamino,4-valine)-8-D-arginine-vasopressin (DVDAVP), a highly potent and specific antidiuretic agent possessing protracted effects.
    Journal of medicinal chemistry, 1973, Volume: 16, Issue:9

    Topics: Animals; Arginine; Blood Pressure; Deamination; Deamino Arginine Vasopressin; Diabetes Insipidus; Diuresis; Female; Muscle Contraction; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Uterus; Valine; Vasopressins

1973