vasoactive-intestinal-peptide and Uremia

vasoactive-intestinal-peptide has been researched along with Uremia* in 3 studies

Other Studies

3 other study(ies) available for vasoactive-intestinal-peptide and Uremia

ArticleYear
The effects of experimental uremia in rats on duodenal VIP levels and the interaction of VIP with duodenal epithelial cells.
    Bioscience reports, 1989, Volume: 9, Issue:2

    The effects of experimental uremia on the concentration of vasoactive intestinal peptide (VIP) in duodenum as well as on the interaction of this neuropeptide with the corresponding epithelial cells were studied in rats. Duodenal VIP concentration was significantly decreased in uremic rats as compared to control animals. The specific binding of VIP to duodenal epithelial cells increased in rats with uremia due to an increase in the number of VIP receptors rather than a change in the binding affinity or in the extent of VIP degradation. On the other hand, the efficacy but not the potency of VIP upon cyclic AMP generation varied in parallel to that observed at the receptor level.

    Topics: Animals; Cyclic AMP; Duodenum; Epithelial Cells; Epithelium; Ligation; Male; Radioimmunoassay; Rats; Rats, Inbred Strains; Uremia; Ureter; Vasoactive Intestinal Peptide

1989
Plasma vasoactive intestinal peptide in uremic patients.
    The International journal of artificial organs, 1989, Volume: 12, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Renal Dialysis; Uremia; Vasoactive Intestinal Peptide

1989
Circulating endogenous vasoactive intestinal polypeptide (VIP) in patients with uraemia and liver cirrhosis.
    European journal of clinical investigation, 1986, Volume: 16, Issue:3

    The concentration of vasoactive intestinal polypeptide (VIP) in peripheral venous plasma was median 6.0 pmol l-1 (range 0-20) in 112 normal subjects. In fifty-three patients with decreased kidney function plasma VIP was significantly increased (median 15.0 pmol l-1, range 0.5-70, P less than 0.0001) and positively correlated to serum creatinine concentration (r = 0.51, P less than 0.001). In 133 patients with liver cirrhosis peripheral venous VIP was slightly elevated (median 7.0 pmol l-1 range 0-86, P less than 0.01). Samples obtained during a central venous catheterization showed significant renal extraction of circulating VIP in control subjects (median extraction fraction 23%, P less than 0.05, n = 6) and in patients with cirrhosis (median 60%, P less than 0.02, n = 8), but not in uraemic patients (median 0%, NS n = 5). In control subjects and patients with cirrhosis the concentration of VIP in the hepatic vein was significantly below that of systemic plasma (-42%, P less than 0.05, n = 6 and -45%, P less than 0.01, n = 10, respectively). On the contrary, in uraemic patients hepatic venous VIP was almost similar to systemic VIP (-4%, NS, n = 7). The results indicate that in normal subjects and patients with cirrhosis both the liver and kidneys are involved in the biodegradation of VIP. The elevated level of circulating VIP in uraemic patients may in part be due to decreased renal and hepatic biodegradation but increased neuronal release of VIP, especially in the splanchnic system, may also contribute to the increased plasma VIP in this condition.

    Topics: Adult; Aged; Creatinine; Female; Humans; Kidney; Liver; Liver Circulation; Liver Cirrhosis; Male; Metabolic Clearance Rate; Middle Aged; Renal Circulation; Uremia; Vasoactive Intestinal Peptide

1986