vasoactive-intestinal-peptide and Sexual-Dysfunction--Physiological

Dysfunction of female sexual desire, arousal, or orgasm affects approximately 30% of women. Early attempts to treat female sexual dysfunction arose out of programs developed for male erectile dysfunction and have proven largely unsuccessful. A new wave of targets is now being pursued; many of these targets are postulated to modulate central pathways. Classical neurotransmitter systems, such as dopamine and serotonin, as well as the neuropeptide melanocortin, are receiving the most attention. Early clinical data look promising; however, clinical trial methodology in female sexual dysfunction is not well developed and only further testing will determine whether these treatments meet regulatory hurdles and satisfy patient need.

Topics: Alprostadil; Dopamine Agonists; Drug Design; Female; Humans; Neprilysin; Phosphodiesterase 5 Inhibitors; Receptors, Melanocortin; Serotonin 5-HT1 Receptor Agonists; Sexual Dysfunction, Physiological; Sexual Dysfunctions, Psychological; Vasoactive Intestinal Peptide

The following review outlines the physiological outcome of VIP and VIP gene manipulations. Previously, we reviewed the various VIP receptors associated with biological functions ranging from growth regulation, sexual function, bronchodilation, vasodilation and immune interactions to neurotrophism. VIP-based drug design is discussed below.

Topics: Animals; Bronchi; Bronchodilator Agents; Circadian Rhythm; Drug Design; Female; Humans; Male; Mice; Mice, Knockout; Neuropeptides; Pituitary Adenylate Cyclase-Activating Polypeptide; Prostatic Neoplasms; Rats; Receptors, Vasoactive Intestinal Peptide; Sexual Dysfunction, Physiological; Signal Transduction; Vasoactive Intestinal Peptide

Topics: Animals; Autonomic Nervous System; Ejaculation; Electric Stimulation; Humans; Male; Sexual Dysfunction, Physiological; Splanchnic Nerves; Sympathetic Nervous System; Vasoactive Intestinal Peptide

Topics: Adrenocorticotropic Hormone; Adult; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Neuropathies; Erectile Dysfunction; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Humans; Infertility; Luteinizing Hormone; Male; Melanocyte-Stimulating Hormones; Middle Aged; Prolactin; Reproduction; Sexual Dysfunction, Physiological; Thyrotropin-Releasing Hormone; Urodynamics; Vasoactive Intestinal Peptide

Topics: Androgens; Drug Combinations; Female; Humans; Male; Phentolamine; Phosphodiesterase Inhibitors; Sexual Dysfunction, Physiological; Vasoactive Intestinal Peptide

Gabapentin has been used effectively for neuropathic pain with mild side effects. Two cases of gabapentin-induced sexual dysfunction are reported and discussed.

Topics: Adolescent; Amines; Analgesics; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Libido; Male; Middle Aged; Neuralgia; Nitric Oxide; Peripheral Nerves; Peripheral Nervous System Diseases; Sexual Dysfunction, Physiological; Sexual Dysfunctions, Psychological; Up-Regulation; Vasoactive Intestinal Peptide; Weight Gain; Withholding Treatment