vasoactive-intestinal-peptide and Rett-Syndrome

vasoactive-intestinal-peptide has been researched along with Rett-Syndrome* in 2 studies

Other Studies

2 other study(ies) available for vasoactive-intestinal-peptide and Rett-Syndrome

ArticleYear
Developmental loss of MeCP2 from VIP interneurons impairs cortical function and behavior.
    eLife, 2020, 04-28, Volume: 9

    Rett Syndrome is a devastating neurodevelopmental disorder resulting from mutations in the gene

    Topics: Animals; Disease Models, Animal; GABAergic Neurons; Interneurons; Methyl-CpG-Binding Protein 2; Mice, Transgenic; Rett Syndrome; Vasoactive Intestinal Peptide

2020
Substance P immunoreactivity in the enteric nervous system in Rett syndrome.
    Brain & development, 2001, Volume: 23 Suppl 1

    Rett syndrome is associated with profound mental retardation and motor disability in girls. It has a characteristic clinical phenotype which includes abnormalities of the autonomic nervous system. Feeding impairment and severe constipation are two symptoms of this autonomic dysfunction. Substance P, an important peptide in the autonomic nervous system, is decreased in the cerebrospinal fluid of Rett syndrome. We have demonstrated that substance P immunoreactivity is significantly decreased in Rett syndrome brain-stem and may be related to the autonomic dysfunction. In this study, we have continued the investigation of substance P in the enteric nervous system. We immunohistochemically examined the normal developing bowel in 22 controls (ages, 14 gestational weeks to 31 years) using formalin fixed tissue, with antibodies to substance P, tyrosine hydroxylase and vasoactive intestinal peptide. We compared the immunoreactivity of normal controls with 14 cases of Rett syndrome (ages, 5-41 years) and observed that the expression of substance P, tyrosine hydroxylase and vasoactive intestinal peptide immunoreactivity in the bowel in Rett syndrome was not significantly different from that of controls. This suggests that the feeding impairment and constipation in Rett syndrome relate to dysfunction of the autonomic nervous system originating outside of the bowel, in the brain-stem, as suggested by our previous study.

    Topics: Adolescent; Adult; Aging; Catecholamines; Child; Child, Preschool; Digestive System; Enteric Nervous System; Female; Gastrointestinal Diseases; Humans; Immunohistochemistry; Infant; Infant, Newborn; Neurons; Rett Syndrome; Substance P; Sympathetic Fibers, Postganglionic; Tyrosine 3-Monooxygenase; Vasoactive Intestinal Peptide

2001