vasoactive-intestinal-peptide and Intestinal-Pseudo-Obstruction

vasoactive-intestinal-peptide has been researched along with Intestinal-Pseudo-Obstruction* in 2 studies

Other Studies

2 other study(ies) available for vasoactive-intestinal-peptide and Intestinal-Pseudo-Obstruction

Article	Year
Pathophysiology of adynamic ileus. Digestive diseases and sciences, 1997, Volume: 42, Issue:4 We hypothesized that the inhibitory neurotransmitters nitric oxide (NO) and vasoactive intestinal peptide (VIP) may play a role in the disrupted gastrointestinal motility of endotoxemia. Strain gauge transducers on the stomach and small intestine of dogs determined interdigestive gastrointestinal motility. Tissue levels of NO synthase and VIP and serum levels of nitrite/nitrate (NO(2)-/NO(3)-) and VIP were measured. Following completion of the baseline studies, dogs were given a single dose of E. coli lipopolysaccharide, 200 microg/kg intravenously, and the studies were repeated for the next three days. Following endotoxin bolus, the migrating motor complex (MMC) was delayed for two days while serum VIP was increased on postendotoxin day 1 and serum NO(2)-/NO(3)- was increased on postendotoxin day 2. There were no changes in gut smooth muscle levels of NO synthase or VIP. We conclude that a single, sublethal dose of endotoxin results in prolongation of the MMC with distinct but independent increases in serum levels of VIP and NO(2)-/NO(3)-. Topics: Animals; Dogs; Escherichia coli; Gastrointestinal Motility; Intestinal Pseudo-Obstruction; Intestine, Small; Lipopolysaccharides; Muscle, Smooth; Myoelectric Complex, Migrating; Neurotransmitter Agents; Nitric Oxide; Nitric Oxide Synthase; Vasoactive Intestinal Peptide	1997
Autonomic innervation of the intestine from a baby with megacystis microcolon intestinal hypoperistalsis syndrome: I. Immunohistochemical study. Journal of pediatric surgery, 1989, Volume: 24, Issue:12 A typical case of megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS) is reported. The patient, an infant girl, was fed only by total intravenous nutrition and is now 3 years old. The distribution of several gut peptides was examined in the resected small intestine using an immunohistochemical method. Vasoactive intestinal polypeptide (VIP) and peptide histidine methionine (PHM)-containing nerve fibers were decreased; however, substance P- and leucine enkephalin (Leu-ENK)-containing fibers were increased. The imbalance between several kinds of gut peptides might be one the causes of aperistalsis in MMIHS. This is the first report about the gut peptides of MMIHS. Topics: Autonomic Nervous System; Colon; Colonic Pseudo-Obstruction; Cystitis; Female; Follow-Up Studies; Humans; Hypertrophy; Infant, Newborn; Intestinal Pseudo-Obstruction; Intestine, Small; Peristalsis; Syndrome; Vasoactive Intestinal Peptide	1989

Article

Year

Digestive diseases and sciences, 1997, Volume: 42, Issue:4

We hypothesized that the inhibitory neurotransmitters nitric oxide (NO) and vasoactive intestinal peptide (VIP) may play a role in the disrupted gastrointestinal motility of endotoxemia. Strain gauge transducers on the stomach and small intestine of dogs determined interdigestive gastrointestinal motility. Tissue levels of NO synthase and VIP and serum levels of nitrite/nitrate (NO(2)-/NO(3)-) and VIP were measured. Following completion of the baseline studies, dogs were given a single dose of E. coli lipopolysaccharide, 200 microg/kg intravenously, and the studies were repeated for the next three days. Following endotoxin bolus, the migrating motor complex (MMC) was delayed for two days while serum VIP was increased on postendotoxin day 1 and serum NO(2)-/NO(3)- was increased on postendotoxin day 2. There were no changes in gut smooth muscle levels of NO synthase or VIP. We conclude that a single, sublethal dose of endotoxin results in prolongation of the MMC with distinct but independent increases in serum levels of VIP and NO(2)-/NO(3)-.

Topics: Animals; Dogs; Escherichia coli; Gastrointestinal Motility; Intestinal Pseudo-Obstruction; Intestine, Small; Lipopolysaccharides; Muscle, Smooth; Myoelectric Complex, Migrating; Neurotransmitter Agents; Nitric Oxide; Nitric Oxide Synthase; Vasoactive Intestinal Peptide

1997

Autonomic innervation of the intestine from a baby with megacystis microcolon intestinal hypoperistalsis syndrome: I. Immunohistochemical study.

Journal of pediatric surgery, 1989, Volume: 24, Issue:12

A typical case of megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS) is reported. The patient, an infant girl, was fed only by total intravenous nutrition and is now 3 years old. The distribution of several gut peptides was examined in the resected small intestine using an immunohistochemical method. Vasoactive intestinal polypeptide (VIP) and peptide histidine methionine (PHM)-containing nerve fibers were decreased; however, substance P- and leucine enkephalin (Leu-ENK)-containing fibers were increased. The imbalance between several kinds of gut peptides might be one the causes of aperistalsis in MMIHS. This is the first report about the gut peptides of MMIHS.

Topics: Autonomic Nervous System; Colon; Colonic Pseudo-Obstruction; Cystitis; Female; Follow-Up Studies; Humans; Hypertrophy; Infant, Newborn; Intestinal Pseudo-Obstruction; Intestine, Small; Peristalsis; Syndrome; Vasoactive Intestinal Peptide

1989