vasoactive-intestinal-peptide and Exocrine-Pancreatic-Insufficiency

Topics: Bile Acids and Salts; Colonic Diseases; Diarrhea, Infantile; Exocrine Pancreatic Insufficiency; Gastrointestinal Neoplasms; Humans; Infant; Infant, Newborn; Intestinal Absorption; Intestinal Diseases; Intestinal Mucosa; Intestinal Secretions; Intestine, Small; Intestines; Protein-Energy Malnutrition; Rotavirus Infections; Vasoactive Intestinal Peptide

A case of duodenal somatostatinoma is described in a patient with Von Recklinghausen neurofibromatosis. The patient presented with exocrine pancreatic insufficiency, probably due to distal obstruction of the pancreatic duct by the tumor. Preoperative evaluation with calcium-pentagastrin and tolbutamide stimulation tests were nondiagnostic. At laparotomy, local excision of the tumor was performed. Pathological findings were compatible with duodenal somatostatinoma, causing pancreatic fibrosis. Somatostatin extracted from the tumor coeluted with the somatostatin-14 standard on high performance liquid chromatography (HPLC).

Topics: Adult; Biopsy; Chromatography, High Pressure Liquid; Duodenal Neoplasms; Exocrine Pancreatic Insufficiency; Female; Fibrosis; Gastrins; Glucagon; Humans; Microscopy, Electron; Neurofibromatosis 1; Pancreas; Pancreatic Polypeptide; Radioimmunoassay; Somatostatin; Somatostatinoma; Vasoactive Intestinal Peptide