Compounds > varespladib
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varespladib and Envenomation, Snakebite

varespladib has been researched along with Envenomation, Snakebite in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (27.27)24.3611
2020's8 (72.73)2.80

Authors

AuthorsStudies
Carter, R; Chowdhury, A; Fry, BG; Lewin, MR; Zdenek, CN1
Lingam, TMC; Tan, CH; Tan, KY1
Bickler, PE; Carter, RW; Fry, BG; Lewin, MR; Matteo, IA; Rao, S; Samuel, SP1
Akpunonu, PD; Bammigatti, C; Bhalla, A; Carter, RW; Gerardo, CJ; Kotehal, SD; Kumar, S; Lewin, MR; Manikath, N; Mukherjee, PP; Platts-Mills, TF; Samuel, SP; Shirazi, FM1
Barvaliya, M; Biradar, P; Dodakallanavar, J; Harish, DR; Hiremath, K; Mahadevamurthy, RK; Patil, VS; Roy, S; Sampat, GH1
Gutiérrez, JM; Lewin, MR; Lomonte, B; Williams, DJ1
Fontana Oliveira, IC; Gutiérrez, JM; Lewin, MR; Oshima-Franco, Y1
Alagón, A; Bénard-Valle, M; Dashevsky, D; Frank, N; Fry, BG; Neri-Castro, E; Portes-Junior, JA; Youngman, NJ; Zdenek, CN1
Huang, C; Wang, Y; Xiao, H; Xiong, S; Zhang, D; Zhang, J1
Huang, C; Li, H; Li, Y; Sun, S; Xiao, H; Zhang, D1
Bickler, P; Lewin, M; Merkel, J; Samuel, S1

Reviews

2 review(s) available for varespladib and Envenomation, Snakebite

ArticleYear
Varespladib in the Treatment of Snakebite Envenoming: Development History and Preclinical Evidence Supporting Advancement to Clinical Trials in Patients Bitten by Venomous Snakes.
    Toxins, 2022, 11-11, Volume: 14, Issue:11

    Topics: Antivenins; Biological Availability; Humans; India; Snake Bites

2022
Unraveling snake venom phospholipase A
    Pharmacological reports : PR, 2023, Volume: 75, Issue:6

    Topics: Acetates; Animals; Horses; Humans; Inflammation; Phospholipases A2; Sheep; Snake Bites; Snake Venoms

2023

Trials

1 trial(s) available for varespladib and Envenomation, Snakebite

ArticleYear
The BRAVO Clinical Study Protocol: Oral Varespladib for Inhibition of Secretory Phospholipase A2 in the Treatment of Snakebite Envenoming.
    Toxins, 2022, 12-28, Volume: 15, Issue:1

    Topics: Clinical Trials, Phase II as Topic; Female; Humans; Male; Multicenter Studies as Topic; Phospholipases A2, Secretory; Randomized Controlled Trials as Topic; Snake Bites

2022

Other Studies

8 other study(ies) available for varespladib and Envenomation, Snakebite

ArticleYear
The Relative Efficacy of Chemically Diverse Small-Molecule Enzyme-Inhibitors Against Anticoagulant Activities of African Spitting Cobra (
    Frontiers in immunology, 2021, Volume: 12

    Topics: Acetates; Africa; Animals; Antivenins; Enzyme Inhibitors; Hydroxamic Acids; In Vitro Techniques; Indoles; Keto Acids; Naja; Organic Chemicals; Snake Bites; Snake Venoms

2021
Varespladib (LY315920) rescued mice from fatal neurotoxicity caused by venoms of five major Asiatic kraits (Bungarus spp.) in an experimental envenoming and rescue model.
    Acta tropica, 2022, Volume: 227

    Topics: Acetates; Animals; Antivenins; Bungarotoxins; Bungarus; Elapid Venoms; Indoles; Keto Acids; Mice; Snake Bites

2022
Varespladib (LY315920) and Methyl Varespladib (LY333013) Abrogate or Delay Lethality Induced by Presynaptically Acting Neurotoxic Snake Venoms.
    Toxins, 2020, 02-20, Volume: 12, Issue:2

    Topics: Acetates; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Indoles; Keto Acids; Lethal Dose 50; Mice; Neurotoxicity Syndromes; Phospholipase A2 Inhibitors; Phospholipases A2; Snake Bites; Snake Venoms; Survival Analysis; Time Factors

2020
Varespladib (LY315920) inhibits neuromuscular blockade induced by Oxyuranus scutellatus venom in a nerve-muscle preparation.
    Toxicon : official journal of the International Society on Toxinology, 2020, Volume: 187

    Topics: Acetates; Antivenins; Elapid Venoms; Indoles; Keto Acids; Neuromuscular Blockade; Neuromuscular Diseases; Neuromuscular Junction; Neurotoxicity Syndromes; Neurotoxins; Snake Bites

2020
Anticoagulant Micrurus venoms: Targets and neutralization.
    Toxicology letters, 2021, Feb-01, Volume: 337

    Topics: Acetates; Animals; Anticoagulants; Blood Coagulation; Coral Snakes; Elapid Venoms; Humans; Indoles; Keto Acids; Mice; Phospholipase A2 Inhibitors; Receptors, Phospholipase A2; Snake Bites; Species Specificity; Thromboplastin; Whole Blood Coagulation Time

2021
Exploration of the Inhibitory Potential of Varespladib for Snakebite Envenomation.
    Molecules (Basel, Switzerland), 2018, Feb-12, Volume: 23, Issue:2

    Topics: Acetates; Alanine Transaminase; Animals; Antivenins; Aspartate Aminotransferases; Creatine Kinase; Crotalid Venoms; Crotalinae; Ecchymosis; Edema; Female; Indoles; Isoenzymes; Keto Acids; L-Lactate Dehydrogenase; Mice; Muscle, Skeletal; Phospholipase A2 Inhibitors; Phospholipases A2; Snake Bites

2018
Inactivation of Venom PLA₂ Alleviates Myonecrosis and Facilitates Muscle Regeneration in Envenomed Mice: A Time Course Observation.
    Molecules (Basel, Switzerland), 2018, Jul-31, Volume: 23, Issue:8

    Topics: Acetates; Angiopoietins; Animals; Antidotes; Crotalid Venoms; Crotalinae; Gene Expression Regulation; Hemorrhage; Indoles; Keto Acids; Male; Mice; Muscle, Skeletal; MyoD Protein; Myogenin; Necrosis; Nerve Growth Factor; Phospholipases A2, Cytosolic; Recovery of Function; Snake Bites; Ulcer

2018
Varespladib (LY315920) Appears to Be a Potent, Broad-Spectrum, Inhibitor of Snake Venom Phospholipase A2 and a Possible Pre-Referral Treatment for Envenomation.
    Toxins, 2016, 08-25, Volume: 8, Issue:9

    Topics: Acetates; Animals; Antidotes; Disease Models, Animal; Dose-Response Relationship, Drug; Elapid Venoms; Indoles; Keto Acids; Mice; Phospholipase A2 Inhibitors; Phospholipases A2; Prodrugs; Rats, Sprague-Dawley; Reptilian Proteins; Snake Bites; Time Factors; Viper Venoms

2016