Page last updated: 2024-09-05

varenicline and Depression

varenicline has been researched along with Depression in 29 studies

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (10.34)29.6817
2010's22 (75.86)24.3611
2020's4 (13.79)2.80

Authors

AuthorsStudies
Caldarone, BJ; Eaton, JB; Kozikowski, AP; Lukas, RJ; Yu, LF; Zhang, HK1
Anthenelli, RM; Beneventi, D; Blalock, JA; Cinciripini, PM; Green, C; Karam-Hage, M; Kypriotakis, G; Lawrence, D; Minnix, J; Morris, C1
Gilbert, E; Hussain, S; Le Foll, B; Selby, P; Veldhuizen, S; Zawertailo, L; Zhang, H1
Ashare, RL; Bauer, AM; Flitter, A; Gross, R; Leone, F; Lubitz, SF; Quinn, MH; Schnoll, R; Thompson, M1
Caldwell, DM; Dalili, MN; Keeney, E; López-López, JA; Munafò, MR; Phillippo, DM; Stevenson, M; Thomas, KH; Welton, NJ1
McKee, SA; Moore, K; Oberleitner, L; Picciotto, MR; Roberts, W; Verplaetse, TL1
Brown, VL; Cinciripini, PM; Engelmann, JM; Karam-Hage, M; Lam, C; Minnix, JA; Robinson, JD; Versace, F; Wetter, DW1
Ebbert, JO; Frye, MA; Geske, JR; Lineberry, TW; Patten, CA; Prince, CA1
Gibbons, RD; Mann, JJ1
Davies, NM; Gunnell, D; Martin, RM; Metcalfe, C; Thomas, KH; Windmeijer, F1
Kausch, O1
Hooten, WM; Warner, DO1
Ebbert, JO; Elrashidi, MY; Hong, AS; Schroeder, DR1
Gunnell, D; Higgins, JP; Knipe, DW; Martin, RM; Thomas, KH1
Kotz, D; Sheikh, A; Simpson, C; van Schayck, OC; Viechtbauer, W; West, R1
Davies, NM; Martin, RM; Munafò, MR; Taylor, AE; Taylor, G; Thomas, KH; Windmeijer, F1
Amiaz, R; Boules, S; Davis, JM; Guidotti, A; Jin, H; Lajtha, A; Li, C; Liu, Y; Maayan, L; Ren, J; Sershen, H; Si, TM; Smith, RC; Weiser, M; Youseff, M1
Brunner, D; Eaton, JB; Fedolak, A; Gunosewoyo, H; Kozikowski, AP; Lukas, RJ; Onajole, OK; Yu, LF; Zhang, HK1
D'Souza, G; Kim, D; McGregor, AL; Tingle, MD1
McIntyre, RS1
Coe, JW; Guanowsky, V; Mineur, YS; Picciotto, MR; Rollema, H; Seymour, PA; Shrikhande, A1
Chapin, DS; Freeman, J; Guanowsky, V; Hajós, M; Hoffmann, WE; Horner, WE; Johnson, DE; Kozak, R; Majchrzak, MJ; McLean, S; Rollema, H; Seymour, PA; Williams, KE1
Blendy, JA; Castellano, LM; Turner, JR1
Pelle, AJ; Smolderen, KG1
Chatterjee, A; Garza, D; Murphy, M; Riordan, HJ; Tseng, LJ1
Hayashi, K; Hori, H; Ikenouchi-Sugita, A; Katsuki, A; Nakamura, J; Umene-Nakano, W; Yoshii, C; Yoshimura, R1
Furberg, CD; Glenmullen, J; Maltsberger, JT; Moore, TJ; Singh, S1
Bechara, A; McNutt, A; Tranel, D1
Andreas, S; Chenot, JF; Diebold, R; Mann, K; Peachey, S1

Reviews

3 review(s) available for varenicline and Depression

ArticleYear
Recent developments in novel antidepressants targeting α4β2-nicotinic acetylcholine receptors.
    Journal of medicinal chemistry, 2014, Oct-23, Volume: 57, Issue:20

    Topics: Alkaloids; Antidepressive Agents; Azetidines; Azocines; Depression; Humans; Ligands; Molecular Targeted Therapy; Nicotinic Agonists; Nicotinic Antagonists; Quinolizines; Receptors, Nicotinic

2014
Cost-Effectiveness Analysis of Smoking Cessation Interventions in the United Kingdom Accounting for Major Neuropsychiatric Adverse Events.
    Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 2021, Volume: 24, Issue:6

    Topics: Bupropion; Cost-Benefit Analysis; Depression; Drug Costs; Electronic Nicotine Delivery Systems; Humans; Markov Chains; Models, Economic; Monte Carlo Method; Network Meta-Analysis; Nicotinic Agonists; Quality-Adjusted Life Years; Recurrence; Risk Assessment; Risk Factors; Self-Injurious Behavior; Smoking; Smoking Cessation; Smoking Cessation Agents; Time Factors; Tobacco Use Cessation Devices; Treatment Outcome; United Kingdom; Varenicline

2021
Risk of neuropsychiatric adverse events associated with varenicline: systematic review and meta-analysis.
    BMJ (Clinical research ed.), 2015, Mar-12, Volume: 350

    Topics: Aggression; Benzazepines; Depression; Humans; Mental Disorders; Quinoxalines; Risk Factors; Sleep Wake Disorders; Suicide; Suicide, Attempted; Tobacco Use Cessation Devices; Varenicline

2015

Trials

9 trial(s) available for varenicline and Depression

ArticleYear
The effects of varenicline, bupropion, nicotine patch, and placebo on smoking cessation among smokers with major depression: A randomized clinical trial.
    Depression and anxiety, 2022, Volume: 39, Issue:5

    Topics: Bupropion; Depression; Depressive Disorder, Major; Female; Humans; Male; Middle Aged; Polyesters; Smokers; Smoking Cessation; Tobacco Use Cessation Devices; Treatment Outcome; Varenicline

2022
Effectiveness of Bupropion and Varenicline for Smokers With Baseline Depressive Symptoms.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2023, 04-06, Volume: 25, Issue:5

    Topics: Bupropion; Depression; Humans; Nicotinic Agonists; Smokers; Varenicline

2023
Effects of varenicline and bupropion sustained-release use plus intensive smoking cessation counseling on prolonged abstinence from smoking and on depression, negative affect, and other symptoms of nicotine withdrawal.
    JAMA psychiatry, 2013, Volume: 70, Issue:5

    Topics: Adolescent; Adult; Affect; Aged; Benzazepines; Bupropion; Combined Modality Therapy; Counseling; Delayed-Action Preparations; Depression; Female; Humans; Male; Middle Aged; Nicotine; Nicotinic Agonists; Quinoxalines; Smoking; Smoking Cessation; Substance Withdrawal Syndrome; Treatment Outcome; Varenicline; Young Adult

2013
A feasibility study of varenicline for smoking cessation in bipolar patients with subsyndromal depression.
    Journal of clinical psychopharmacology, 2013, Volume: 33, Issue:6

    Topics: Adult; Benzazepines; Bipolar Disorder; Depression; Feasibility Studies; Female; Humans; Male; Middle Aged; Nicotinic Agonists; Quinoxalines; Smoking Cessation; Varenicline

2013
Varenicline for opioid withdrawal in patients with chronic pain: a randomized, single-blinded, placebo controlled pilot trial.
    Addictive behaviors, 2015, Volume: 42

    Topics: Adult; Analgesics, Opioid; Benzazepines; Chronic Pain; Depression; Feasibility Studies; Female; Humans; Male; Middle Aged; Nicotinic Agonists; Opioid-Related Disorders; Pain Measurement; Pilot Projects; Quinoxalines; Single-Blind Method; Substance Withdrawal Syndrome; Treatment Outcome; Varenicline

2015
Depressive symptoms among patients receiving varenicline and bupropion for smoking cessation.
    Journal of substance abuse treatment, 2015, Volume: 52

    Topics: Adult; Bupropion; Depression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Smoking Cessation; Tobacco Use Cessation Devices; Varenicline

2015
Varenicline Effects on Smoking, Cognition, and Psychiatric Symptoms in Schizophrenia: A Double-Blind Randomized Trial.
    PloS one, 2016, Volume: 11, Issue:1

    Topics: Adult; Antipsychotic Agents; Cognition; Cotinine; Depression; Double-Blind Method; Female; Humans; Male; Middle Aged; Nausea; Nicotinic Agonists; Psychological Tests; Schizophrenia; Schizophrenic Psychology; Smoking; Smoking Cessation; Symptom Assessment; Tobacco Use Cessation Devices; Varenicline

2016
A double-blind randomized placebo-controlled pilot study of neuropsychiatric adverse events in abstinent smokers treated with varenicline or placebo.
    Biological psychiatry, 2011, Jun-01, Volume: 69, Issue:11

    Topics: Adolescent; Adult; Aged; Aggression; Anxiety; Benzazepines; Depression; Double-Blind Method; Female; Humans; Irritable Mood; Male; Middle Aged; Nicotinic Agonists; Pilot Projects; Psychiatric Status Rating Scales; Quinoxalines; Smoking; Smoking Cessation; Tobacco Use Disorder; Treatment Outcome; Varenicline

2011
Effectiveness of varenicline as an aid to smoking cessation in primary care: an observational study.
    European addiction research, 2013, Volume: 19, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Benzazepines; Comorbidity; Depression; Female; Germany; Humans; Hypertension; Incidence; Lung Diseases, Obstructive; Male; Middle Aged; Nicotinic Agonists; Observation; Primary Health Care; Quinoxalines; Smoking Cessation; Tobacco Use Cessation Devices; Tobacco Use Disorder; Varenicline

2013

Other Studies

17 other study(ies) available for varenicline and Depression

ArticleYear
Correlates of varenicline adherence among smokers with HIV and its association with smoking cessation.
    Addictive behaviors, 2020, Volume: 102

    Topics: Adult; Aged; Anxiety; Correlation of Data; Depression; Female; HIV Infections; Humans; Male; Medication Adherence; Middle Aged; Nicotinic Agonists; Randomized Controlled Trials as Topic; Sleep Initiation and Maintenance Disorders; Smoking Cessation; Tobacco Smoking; Varenicline

2020
Effects of varenicline on alcohol self-administration and craving in drinkers with depressive symptoms.
    Journal of psychopharmacology (Oxford, England), 2017, Volume: 31, Issue:7

    Topics: Adult; Alcohol Drinking; Alcoholism; Comorbidity; Craving; Depression; Female; Humans; Male; Middle Aged; Nicotinic Agonists; Outcome Assessment, Health Care; Varenicline

2017
Varenicline, smoking cessation, and neuropsychiatric adverse events.
    The American journal of psychiatry, 2013, Volume: 170, Issue:12

    Topics: Adult; Aggression; Akathisia, Drug-Induced; Benzazepines; Bupropion; Depression; Female; Humans; Male; Mental Disorders; Nausea; Observational Studies as Topic; Psychomotor Agitation; Quinoxalines; Randomized Controlled Trials as Topic; Risk Factors; Smoking Cessation; Suicidal Ideation; Suicide, Attempted; Tobacco Use Cessation Devices; Treatment Outcome; Varenicline

2013
Smoking cessation treatment and risk of depression, suicide, and self harm in the Clinical Practice Research Datalink: prospective cohort study.
    BMJ (Clinical research ed.), 2013, Oct-11, Volume: 347

    Topics: Adolescent; Adult; Aged; Benzazepines; Bupropion; Cohort Studies; Depression; England; Female; Humans; Male; Middle Aged; Prospective Studies; Quinoxalines; Risk Assessment; Risk Factors; Self-Injurious Behavior; Smoking; Smoking Cessation; Suicide; Tobacco Use Cessation Devices; Varenicline; Young Adult

2013
Treatment of depression in a former smoker with varenicline? A case report and discussion.
    The Journal of neuropsychiatry and clinical neurosciences, 2014, Apr-01, Volume: 26, Issue:2

    Topics: Benzazepines; Depression; Humans; Male; Middle Aged; Nicotinic Agonists; Quinoxalines; Smoking; Varenicline

2014
Cardiovascular and neuropsychiatric risks of varenicline: a retrospective cohort study.
    The Lancet. Respiratory medicine, 2015, Volume: 3, Issue:10

    Topics: Adult; Bupropion; Cardiovascular Diseases; Depression; Dopamine Uptake Inhibitors; Female; Humans; Male; Mental Disorders; Middle Aged; Nicotinic Agonists; Retrospective Studies; Smoking Cessation; Tobacco Use Cessation Devices; Varenicline

2015
What are the effects of varenicline compared with nicotine replacement therapy on long-term smoking cessation and clinically important outcomes? Protocol for a prospective cohort study.
    BMJ open, 2015, Nov-05, Volume: 5, Issue:11

    Topics: Anxiety; Depression; Humans; Logistic Models; Multivariate Analysis; Nicotinic Agonists; Prospective Studies; Psychiatric Status Rating Scales; Research Design; Smoking; Smoking Cessation; Socioeconomic Factors; Suicide; Tobacco Use Cessation Devices; Varenicline

2015
Synthesis and biological evaluation of novel hybrids of highly potent and selective α4β2-Nicotinic acetylcholine receptor (nAChR) partial agonists.
    European journal of medicinal chemistry, 2016, Nov-29, Volume: 124

    Topics: Animals; Behavior; Depression; Inhibitory Concentration 50; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Nicotinic Agonists; Receptors, Nicotinic; Swimming; Varenicline

2016
Varenicline improves motor and cognitive deficits and decreases depressive-like behaviour in late-stage YAC128 mice.
    Neuropharmacology, 2017, Volume: 116

    Topics: Animals; Anxiety; Cell Proliferation; Cognition Disorders; Corpus Striatum; Depression; Disease Models, Animal; Female; Hippocampus; Huntington Disease; Male; Maze Learning; Memory; Mice, Transgenic; Motor Activity; Movement Disorders; Neural Stem Cells; Neuroprotective Agents; Nicotinic Agonists; Varenicline

2017
Varenicline and suicidality: a new era in medication safety surveillance.
    Expert opinion on drug safety, 2008, Volume: 7, Issue:5

    Topics: Adverse Drug Reaction Reporting Systems; Benzazepines; Depression; Drug Labeling; Humans; Psychomotor Agitation; Quinoxalines; Smoking Cessation; Suicide; Suicide Prevention; Varenicline

2008
Varenicline has antidepressant-like activity in the forced swim test and augments sertraline's effect.
    European journal of pharmacology, 2009, Mar-01, Volume: 605, Issue:1-3

    Topics: Animals; Antidepressive Agents; Benzazepines; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Nicotinic Agonists; Quinoxalines; Receptors, Nicotinic; Selective Serotonin Reuptake Inhibitors; Sertraline; Swimming; Varenicline

2009
Preclinical pharmacology of the alpha4beta2 nAChR partial agonist varenicline related to effects on reward, mood and cognition.
    Biochemical pharmacology, 2009, Oct-01, Volume: 78, Issue:7

    Topics: Affect; Alcohol Drinking; Animals; Attention; Benzazepines; Cerebral Cortex; Cognition; Depression; Drug Partial Agonism; Hippocampus; Humans; Male; Mice; Mice, Inbred C57BL; Neurotransmitter Agents; Nicotinic Agonists; Quinoxalines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Nicotinic; Recognition, Psychology; Reflex, Startle; Reward; Tobacco Use Disorder; Varenicline

2009
Nicotinic partial agonists varenicline and sazetidine-A have differential effects on affective behavior.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 334, Issue:2

    Topics: Animals; Anxiety; Azetidines; Behavior, Animal; Benzazepines; Chimera; Depression; Drug Partial Agonism; Male; Mice; Mood Disorders; Nicotine; Nicotinic Agonists; Pyridines; Quinoxalines; Varenicline

2010
Letter by Smolderen and Pelle regarding article, "Efficacy and safety of varenicline for smoking cessation in patients with cardiovascular disease: a randomized trial".
    Circulation, 2010, Aug-31, Volume: 122, Issue:9

    Topics: Benzazepines; Cardiovascular Diseases; Depression; Humans; Nicotinic Agonists; Patient Selection; Quinoxalines; Randomized Controlled Trials as Topic; Risk Factors; Smoking; Smoking Cessation; Varenicline

2010
Plasma levels of metabolites of catecholamine in nicotine-dependent patients treated with varenicline.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2012, Volume: 14, Issue:4

    Topics: Adult; Benzazepines; Catecholamines; Depression; Female; Homovanillic Acid; Humans; Male; Methoxyhydroxyphenylglycol; Middle Aged; Nicotinic Agonists; Quinoxalines; Smoking; Smoking Cessation; Tobacco Use Disorder; Varenicline

2012
Suicidal behavior and depression in smoking cessation treatments.
    PloS one, 2011, Volume: 6, Issue:11

    Topics: Adult; Benzazepines; Bupropion; Depression; Female; Humans; Male; Middle Aged; Nicotine; Nicotinic Agonists; Quinoxalines; Smoking Cessation; Suicide; Varenicline

2011
Smoking cessation after brain damage does not lead to increased depression: implications for understanding the psychiatric complications of varenicline.
    Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology, 2012, Volume: 25, Issue:1

    Topics: Adult; Benzazepines; Brain Injury, Chronic; Depression; Female; Humans; Male; Middle Aged; MMPI; Nicotinic Agonists; Psychiatric Status Rating Scales; Quinoxalines; Smoking; Smoking Cessation; Varenicline

2012