vanoxerine has been researched along with Seizures in 4 studies
vanoxerine: structure given in first source
vanoxerine : An N-alkylpiperazine that consists of piperazine bearing 2-bis(4-fluorophenyl)methoxy]ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Effects of the GABA(B) receptor agonist ((+/-)-baclofen), antagonist (phaclofen), and their combination were tested against clonic seizures induced by cocaine (75 mg/kg)." | 7.72 | Pharmacological modulation of GABA(B) receptors affects cocaine-induced seizures in mice. ( Gasior, M; Kaminski, R; Witkin, JM, 2004) |
| " Initially, dose-response experiments were performed with intrahippocampal perfusions of GBR-12909 and citalopram, respectively, selective dopamine and serotonin re-uptake blockers." | 5.32 | Anticonvulsant action of GBR-12909 and citalopram against acute experimentally induced limbic seizures. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2004) |
| "Effects of the GABA(B) receptor agonist ((+/-)-baclofen), antagonist (phaclofen), and their combination were tested against clonic seizures induced by cocaine (75 mg/kg)." | 3.72 | Pharmacological modulation of GABA(B) receptors affects cocaine-induced seizures in mice. ( Gasior, M; Kaminski, R; Witkin, JM, 2004) |
| "We used assessment of seizure severity in the focal pilocarpine model, antidepressant-like activity within the rat forced swim and the mouse tail suspension tests, and locomotor activity in an open field as behavioural tests." | 1.35 | Direct enhancement of hippocampal dopamine or serotonin levels as a pharmacodynamic measure of combined antidepressant-anticonvulsant action. ( Clinckers, R; De Bundel, D; Ebinger, G; Meurs, A; Michotte, Y; Portelli, J; Smolders, I, 2008) |
| " Initially, dose-response experiments were performed with intrahippocampal perfusions of GBR-12909 and citalopram, respectively, selective dopamine and serotonin re-uptake blockers." | 1.32 | Anticonvulsant action of GBR-12909 and citalopram against acute experimentally induced limbic seizures. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gasior, M | 1 |
| Kaminski, R | 1 |
| Witkin, JM | 1 |
| Clinckers, R | 2 |
| Smolders, I | 2 |
| Meurs, A | 2 |
| Ebinger, G | 2 |
| Michotte, Y | 2 |
| De Bundel, D | 1 |
| Portelli, J | 1 |
| Damaj, MI | 1 |
| Slemmer, JE | 1 |
| Carroll, FI | 1 |
| Martin, BR | 1 |
4 other studies available for vanoxerine and Seizures
| Article | Year |
|---|---|
Pharmacological modulation of GABA(B) receptors affects cocaine-induced seizures in mice.
Topics: Animals; Baclofen; Cocaine; Dopamine Uptake Inhibitors; GABA-A Receptor Agonists; GABA-A Receptor An | 2004 |
Anticonvulsant action of GBR-12909 and citalopram against acute experimentally induced limbic seizures.
Topics: Acute Disease; Animals; Anticonvulsants; Biogenic Monoamines; Citalopram; Dopamine; Dopamine Antagon | 2004 |
Direct enhancement of hippocampal dopamine or serotonin levels as a pharmacodynamic measure of combined antidepressant-anticonvulsant action.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Antidepressive Agents, Tricyclic; Chromatography, L | 2008 |
Pharmacological characterization of nicotine's interaction with cocaine and cocaine analogs.
Topics: Animals; Body Temperature; Bupropion; Cocaine; Discrimination, Psychological; Female; Male; Membrane | 1999 |