vanoxerine has been researched along with Hypoxia in 4 studies
vanoxerine: structure given in first source
vanoxerine : An N-alkylpiperazine that consists of piperazine bearing 2-bis(4-fluorophenyl)methoxy]ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Replacement of N2 by xenon in such a hypoxic atmosphere resulted in complete protection against cellular damage and prevention of hypoxia-induced dopamine release." | 7.72 | Xenon prevents cellular damage in differentiated PC-12 cells exposed to hypoxia. ( Blom, P; Kox, WJ; Müller, J; Petzelt, C; Schmehl, W, 2004) |
| " Replacement of N2 by xenon in such a hypoxic atmosphere resulted in complete protection against cellular damage and prevention of hypoxia-induced dopamine release." | 3.72 | Xenon prevents cellular damage in differentiated PC-12 cells exposed to hypoxia. ( Blom, P; Kox, WJ; Müller, J; Petzelt, C; Schmehl, W, 2004) |
| "Amphetamine treatment may be harmful in stroke recovery by making the brain more vulnerable to ischaemia." | 1.39 | Amphetamine makes caudate tissue more susceptible to oxygen and glucose deprivation. ( Davidson, C; Tana, A, 2013) |
| "We investigated DA balance during early anoxia when energy status in the turtle brain is compromised." | 1.33 | Adenosine and ATP-sensitive potassium channels modulate dopamine release in the anoxic turtle (Trachemys scripta) striatum. ( Lutz, PL; Milton, SL, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tana, A | 1 |
| Davidson, C | 1 |
| Petzelt, C | 1 |
| Blom, P | 1 |
| Schmehl, W | 1 |
| Müller, J | 1 |
| Kox, WJ | 1 |
| Milton, SL | 2 |
| Lutz, PL | 2 |
4 other studies available for vanoxerine and Hypoxia
| Article | Year |
|---|---|
Amphetamine makes caudate tissue more susceptible to oxygen and glucose deprivation.
Topics: Amphetamine; Animals; Caudate Nucleus; Central Nervous System Stimulants; Dopamine; Dopamine Antagon | 2013 |
Xenon prevents cellular damage in differentiated PC-12 cells exposed to hypoxia.
Topics: Analysis of Variance; Animals; Benzazepines; Calcium; Cells, Cultured; Chelating Agents; Dopamine; D | 2004 |
Adenosine and ATP-sensitive potassium channels modulate dopamine release in the anoxic turtle (Trachemys scripta) striatum.
Topics: Adenosine; Adenosine Triphosphate; Animals; Brain; Diacetyl; Dopamine; Dopamine Uptake Inhibitors; H | 2005 |
Low extracellular dopamine levels are maintained in the anoxic turtle (Trachemys scripta) striatum.
Topics: Animals; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Extracellular Space; Hypoxia; Kineti | 1998 |