vanoxerine has been researched along with Hypomania in 1 studies
vanoxerine: structure given in first source
vanoxerine : An N-alkylpiperazine that consists of piperazine bearing 2-bis(4-fluorophenyl)methoxy]ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Using the GBR 12909 mania model, we observed the classical hyperactivity phenotype, along with low depressive-like but high anxiety-like behaviors." | 1.72 | Assessing positive and negative valence systems to refine animal models of bipolar disorders: the example of GBR 12909-induced manic phenotype. ( Alonso, M; Bigot, M; Henry, C; Lledo, PM; Vicq, E, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bigot, M | 1 |
| Vicq, E | 1 |
| Lledo, PM | 1 |
| Alonso, M | 1 |
| Henry, C | 1 |
1 other study available for vanoxerine and Hypomania
| Article | Year |
|---|---|
Assessing positive and negative valence systems to refine animal models of bipolar disorders: the example of GBR 12909-induced manic phenotype.
Topics: Animals; Bipolar Disorder; Mania; Mice; Models, Animal; Phenotype; Piperazines | 2022 |